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A TEST FOR ADRENAL CORTICAL INSUFFICIENCY: The Response to Pituitary Andrenocorticotropic Hormone
Abstract
The recent preparation of a purified pituitary adrenocorticotropic hormone in sufficient quantity for use in human subjects1has provided an opportunity to stimulate directly the human adrenal cortex.2It appeared likely that, in patients suffering from primary adrenal cortical insufficiency, the normal response to this specific stimulus would fail to occur. This expectation has been substantiated by clinical studies.3The development of a simple test for adrenal cortical insufficiency based on the failure of patients with Addison's disease to secrete cortical hormones in response to the pituitary adrenocorticotropic hormone has been the aim of this study. Among the numerous metabolic3and hematologic4changes which follow administration of the hormone in subjects with an intact adrenal cortex, two have been selected as the basis for a clinical test for adrenal cortical reserve because of their simplicity of determination and magnitude of change: (1) a fall in
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Citations
Cited by
HENCH, P. S. (1950) · Archives of Internal Medicine · doi:10.1001/archinte.1950.00230100002001 · Cited by 501
A rapid test of adrenocortical function
Wood, J. B., James, V. H. T., Frankland, A. W., & Landon, J. (1965) · The Lancet · doi:10.1016/s0140-6736(65)91526-6 · Cited by 312
The Clinical Usefulness of ACTH and Cortisone
Thorn, G. W., Forsham, P. H., Frawley, T. F., Hill, S. R., Roche, M., Staehelin, D., & Wilson, D. L. (1950) · New England Journal of Medicine · doi:10.1056/nejm195005252422105 · Cited by 305
Self-citationUse of ACTH in the diagnosis of adrenal cortical insufficiency
Jenkins, D., Forsham, P. H., Laidlaw, J. C., Reddy, W. J., & Thorn, G. W. (1955) · The American Journal of Medicine · doi:10.1016/0002-9343(55)90200-x · Cited by 127
Self-citationKawahara, T., Tsuji, M., Tominaga, N., Toyama, N., & Toda, M. (2022) · Journal of the Endocrine Society · doi:10.1210/jendso/bvac119 · Cited by 13
Metadata
- Authors
- Thorn, G. W.
- Venue
- Journal of the American Medical Association
- Publisher
- American Medical Association (AMA)
- Published
- 1948-07-17
- Volume
- 137
- Issue
- 12
- Pages
- 1005
- ISSN
- 0002-9955 (ISSN-L)
- OpenAlex
- W2059835145
- Cited by
- 334
- References
- 0
- FWCI
- 65.82
- Type
- journal article
- Language
- en
- Open access
- closed
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- Thorn, G. W. (1948). A TEST FOR ADRENAL CORTICAL INSUFFICIENCY: The Response to Pituitary Andrenocorticotropic Hormone. Journal of the American Medical Association. https://doi.org/10.1001/jama.1948.02890460001001
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