A rapid test of adrenocortical function

Wood, J.B.; James, V.H.T.; Frankland, A.W.; Landon, J.

doi:10.1016/s0140-6736(65)91526-6

Cited by 312Adrenal Hormones and DisordersStress Responses and CortisolClinical Laboratory Practices and Quality Control

A rapid test of adrenocortical function

Wood, J.B., James, V.H.T., Frankland, A.W., Landon, J.·1965·The Lancet

DOI 10.1016/s0140-6736(65)91526-6

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Low plasma cortisol in a Synacthen test is diagnostic for adrenal insufficiency.
“Low plasma cortisol in a Synacthen test is diagnostic for AI (4).”
From Salivary Cortisol and Cortisone Can Circumvent Confounding Effects of Oral Contraceptives in the Short Synacthen Test (2024) · cites this paper as [4]

A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma
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“The corticotropin stimulation test is currently regarded as the diagnostic “gold standard” for the diagnosis of primary (but not secondary) adrenal insufficiency because it has been reasonably well studied and is validated against the insulin tolerance test for diagnostic accuracy (21–25).”
Background
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Authors: Wood, J. B., James, V. H. T., Frankland, A. W., & Landon, J.
Affiliations: St Mary's Hospital (GB)
Venue: The Lancet
Publisher: Elsevier BV
Published: 1965-01
Volume: 285
Issue: 7379
Pages: 243-245
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/s0140-6736(65)91526-6
OpenAlex: W2086621727
Cited by: 312
References: 13
Citations by year: 2026: 1 · 2025: 1 · 2024: 3 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 6 · 2018: 5 · 2017: 2 · 2016: 3 · 2015: 2 · 2014: 6 · 2013: 6 · 2012: 7
FWCI: 22.85
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
Keywords: adrenocortical function, adrenal cortex, rapid testing, adrenal function testing
MeSH terms: Hypoadrenocorticism, Familial, Addison Disease, Adrenal Cortex Hormones, Adrenal Insufficiency, Adrenocorticotropic Hormone, Blood, Hydrocortisone, Peptides, Pharmacology, Pituitary-Adrenal Function Tests

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