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Epidemiologic Assessment of the Role of Blood Pressure in Stroke: The Framingham Study
Abstract
Control of hypertension, labile or fixed, systolic or diastolic, at any age, in either sex appears to be central to prevention of atherothrombotic brain infarction (ABI). Prospectively, hypertension proved the most common and potent precursor of ABI's. Its contribution was direct and could not be attributed to factors related both to stroke and hypertension. Asymptomatic, causal "hypertension" was associated with a risk of ABI about four times that of normotensives. The probability of occurrence of an ABI was predicted no better with both blood pressure measurements or the mean arterial pressure than with systolic alone. Since there was no diminishing impact of systolic pressure with advancing age, the concept that systolic elevations are, even in the aged, innocuous is premature. Comparing normotensives and hypertensives in each sex, women did not tolerate hypertension better than men.
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“In two other studies, investigators found that elevated systolic blood pressure was a predictor of cerebrovascular accidents as well as heart failure, and that diastolic pressure was not superiorly associated with these events. 43,44”
From The Framingham Heart Study and the epidemiology of cardiovascular disease: a historical perspective (2014) · cites this paper as [44]
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The Framingham Heart Study and the epidemiology of cardiovascular disease: a historical perspective
Mahmood, S. S., Levy, D., Vasan, R. S., & Wang, T. J. (2014) · The Lancet · doi:10.1016/s0140-6736(13)61752-3 · Cited by 1,622
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Metadata
- Authors
- Kannel, W. B.
- Corresponding author
- Kannel, William B.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 1970-10-12
- Volume
- 214
- Issue
- 2
- Pages
- 301
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W7214241799
- Cited by
- 2
- References
- 0
- FWCI
- 0.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- hypertension, stroke, atherothrombotic brain infarction, blood pressure, systolic blood pressure, mean arterial pressure, asymptomatic hypertension, stroke risk factors, sex differences, aging, hypertension control
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