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The Coronary Drug Project: Findings Leading to Further Modifications of Its Protocol With Respect to Dextrothyroxine
Abstract
As noted in the first definitive report from the Coronary Drug Project,1physicians face a difficult dilemma concerning pharmacologic therapy of hyperlipidemia in an attempt to prevent first or recurrent episodes of clinical coronary heart disease (CHD). They know that susceptibility to premature CHD is directly related to serum levels of cholesterol, and of low-density and very-low-density lipoproteins. They are also aware that elevated serum lipids-lipoproteins frequently can be reduced over long periods of time by available drugs. However, they lack answers to key questions about these pharmaceutical agents: Do they prevent CHD and prolong life? Are they reasonably safe in long-term usage? The scarcity of scientific data on these critical questions is especially troublesome in view of the fact that prevention or treatment of coronary disease by control of hyperlipidemia makes sense only as long-term therapy, and questions about drug toxicity are especially gnawing under this circumstance. The
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Cited by
Fifteen year mortality in Coronary Drug Project patients: long-term benefit with niacin
Canner, P. L., Berge, K. G., Wenger, N. K., Stamler, J., Friedman, L., Prineas, R. J., & Friedewald, W. (1986) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(86)80293-5 · Cited by 1,824
Effects of fibrates on cardiovascular outcomes: a systematic review and meta-analysis
Jun, M., Foote, C., Lv, J., Neal, B., Patel, A., Nicholls, S. J., Grobbee, D. E., Cass, A., Chalmers, J., & Perkovic, V. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60656-3 · Cited by 927
Thyroid hormones and cardiovascular disease
Jabbar, A., Pingitore, A., Pearce, S. H. S., Zaman, A., Iervasi, G., & Razvi, S. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.174 · Cited by 729
Hulley, S. B., Rosenman, R. H., Bawol, R. D., & Brand, R. J. (1980) · New England Journal of Medicine · doi:10.1056/nejm198006193022503 · Cited by 702
Brensike, J. F., Levy, R. I., Kelsey, S. F., Passamani, E. R., Richardson, J. M., Loh, I. K., Stone, N. J., Aldrich, R. F., Battaglini, J. W., & Moriarty, D. J. (1984) · Circulation · doi:10.1161/01.cir.69.2.313 · Cited by 668
Metadata
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 1972-05-15
- Volume
- 220
- Issue
- 7
- Pages
- 996
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2748276396
- Cited by
- 307
- References
- 0
- FWCI
- 21.94
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
