The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Clinical Experience With Theophylline: Relationships Between Dosage, Serum Concentration, and Toxicity
Abstract
Relationships between theophylline dosage, serum theophylline concentration, and theophylline toxicity were evaluated retrospectively in 47 hospitalized adults. The amount of theophylline administered daily varied more than sixfold, from 6 to 38 mg/kg. The serum theophylline concentrations, however, varied 24-fold from 2 to 49 mug/ml. The relationship between daily dosage and serum concentration was unpredictable in an individual patient. Fourteen patients (30%) had a toxic reaction to theophylline. Toxic symptoms, which were not always gastrointestinal, occurred commonly with serum concentrations over 25 mug/ml but were not noted with concentrations below 15 mug/ml. High serum theophylline concentrations and a toxic reaction developed just as often with the oral route as when the drug was given intravenously. In six patients, measurement of serum theophylline concentration disclosed subtherapeutic concentrations. Serum theophylline determination appears to be important clinically in guiding effective and safe usage of theophylline.
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Citations
Cites
Rational Intravenous Doses of Theophylline
Mitenko, P. A., & Ogilvie, R. I. (1973) · New England Journal of Medicine · doi:10.1056/nejm197309202891202 · Cited by 647
Pharmacokinetics of theophylline; Application to adjustment of the clinical dose of aminophylline
Jenne, J. W., Wyze, E., Rood, F. S., & MacDonald, F. M. (1972) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt1972133349 · Cited by 496
Theophylline-Induced Seizures in Adults: Correlation with Serum Concentrations
ZWILLICH, C. W., SUTTON, F. D., NEFF, T. A., COHN, W. M., MATTHAY, R. A., & WEINBERGER, M. M. (1975) · Annals of Internal Medicine · doi:10.7326/0003-4819-82-6-784 · Cited by 418
Schack, J. A., & Waxler, S. H. (1949) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)03717-6 · Cited by 209
Pharmacokinetics of intravenous theophylline
Mitenko, P. A., & Ogilvie, R. I. (1973) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt1973144part1509 · Cited by 178
Study of Theophylline Plasma Levels after Oral Administration of New Theophylline Compounds
Turner-Warwick, M. E. H. (1957) · BMJ · doi:10.1136/bmj.2.5036.67 · Cited by 120
Truitt, E. B., McKusick, V. A., & Krantz, J. C. (1950) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)04287-9 · Cited by 66
Theophylline Toxicity due to Impaired Theophylline Degradation
Jacobs, M. H., & Senior, R. M. (1974) · American Review of Respiratory Disease · doi:10.1164/arrd.1974.110.3.342 · Cited by 47
Self-citation
Cited by
Theophylline A “State of the Art” Review
Hendeles, L., & Weinberger, M. (1983) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/j.1875-9114.1983.tb04531.x · Cited by 342
Metadata
- Authors
- Jacobs, M. H.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 1976-05-03
- Volume
- 235
- Issue
- 18
- Pages
- 1983
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2061140153
- Cited by
- 269
- References
- 8
- FWCI
- 14.94
- Type
- journal article
- Language
- en
- Open access
- closed
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