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Pharmacokinetics of intravenous theophylline
Abstract
Plasma theophylline concentrations were measured after single intravenous infusions of aminophylline to asthmatic patients and normal volunteers. Using two‐compartment kinetic analysis, no basic differences in drug disposition were found. For the 16 subiects studied the overall mean plasma clearance rate was 0.0719 I per kilogram per hour, and overall mean beta or slow disposition constant was 0.159 hr−1, corresponding to a plasma half‐time of 4.36 hr. This information should be useful in determining precise dosage requirements for theophylline in clinical situations.
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Citations
Cited by
Rational Intravenous Doses of Theophylline
Mitenko, P. A., & Ogilvie, R. I. (1973) · New England Journal of Medicine · doi:10.1056/nejm197309202891202 · Cited by 647
Self-citationPrediction of in vivo drug metabolism in the human liver from in vitro metabolism data
Iwatsubo, T., Hirota, N., Ooie, T., Suzuki, H., Shimada, N., Chiba, K., Ishizaki, T., Green, C. E., Tyson, C. A., & Sugiyama, Y. (1997) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(96)00184-2 · Cited by 479
Theophylline A “State of the Art” Review
Hendeles, L., & Weinberger, M. (1983) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/j.1875-9114.1983.tb04531.x · Cited by 342
Influence of food and diet on gastrointestinal drug absorption: A review
Welling, P. G. (1977) · Journal of Pharmacokinetics and Biopharmaceutics · doi:10.1007/bf01061694 · Cited by 307
Jacobs, M. H. (1976) · JAMA · doi:10.1001/jama.1976.03260440035019 · Cited by 269
Metadata
- Authors
- Mitenko, P. A., & Ogilvie, R. I.
- Venue
- Clinical Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 1973-07
- Volume
- 14
- Issue
- 4part1
- Pages
- 509-513
- ISSN
- 0009-9236 (ISSN-L)
- 1532-6535
- OpenAlex
- W2398325927
- Cited by
- 178
- References
- 0
- FWCI
- 9.07
- Type
- journal article
- Language
- en
- Open access
- closed
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