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Protective Efficacy of Pneumococcal Polysaccharide Vaccines
Abstract
Clinical studies of 6- and 12-valent pneumococcal capsular polysaccharide vaccines were carried out in controlled studies among novice gold miners in South Africa. In the studies 1,523 persons received pneumococcal vaccine, and 3,171 were included as controls. In the great majority of subjects given pneumococcal vaccine, antibodies developed against the capsular types included in the vaccine. The 6-valent vaccine afforded 76% reduction in cases of laboratory-verified pneumococcal pneumonia caused by the homologous types, and there was 92% reduction in the cases afforded by the 12-valent vaccine. The vaccines were well tolerated and offer great promise for effective control of illnesses caused by pneumococci.
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Citations
Cited by
Hao (2015) · doi:10.1002/14651858 · Cited by 11,321
The Protective Efficacy of Polyvalent Pneumococcal Polysaccharide Vaccine
Shapiro, E. D., Berg, A. T., Austrian, R., Schroeder, D., Parcells, V., Margolis, A., Adair, R. K., & Clemens, J. D. (1991) · New England Journal of Medicine · doi:10.1056/nejm199111213252101 · Cited by 1,051
Multilocus Sequence Typing of Bacteria
Maiden, M. C. J. (2006) · Annual Review of Microbiology · doi:10.1146/annurev.micro.59.030804.121325 · Cited by 915
Pneumococcal Disease during HIV Infection: Epidemiologic, Clinical, and Immunologic Perspectives
Janoff, E. N., Breiman, R. F., Daley, C. L., & Hopewell, P. C. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-117-4-314 · Cited by 323
The Clinical Effectiveness of Pneumococcal Vaccine in the Elderly
SIMS, R. V., STEINMANN, W. C., MCCONVILLE, J. H., KING, L. R., ZWICK, W. C., & SCHWARTZ, J. S. (1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-108-5-653 · Cited by 317
Metadata
- Authors
- Smit, P.
- Venue
- JAMA: The Journal of the American Medical Association
- Publisher
- American Medical Association (AMA)
- Published
- 1977-12-12
- Volume
- 238
- Issue
- 24
- Pages
- 2613
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2099947481
- Cited by
- 350
- References
- 0
- FWCI
- 15.60
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
