The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
The Clinical Effectiveness of Pneumococcal Vaccine in the Elderly
Abstract
The effectiveness of pneumococcal vaccine in the immunocompetent elderly remains controversial. We report the results of a multicenter, case-control study of 244 controls and 122 patients, aged 55 years and older, hospitalized during a 5-year period with pneumococcal bacteremia, meningitis, or other bacteriologically confirmed pneumococcal infection. Two controls per patient were matched on the basis of admission date, hospital records, and underlying diseases. All subjects were selected without knowledge of immunization status with pneumococcal vaccine, and were excluded if there was evidence for immunosuppression due to disease or iatrogenic causes. The clinical effectiveness of the vaccine was calculated to be 70% (95% confidence intervals [CI], 37% to 86%) in this population, based on a Mantel-Haenszel point estimate of the odds ratio of 0.30 (95% CI, 0.14% to 0.63%; P less than 0.005). The clinical effectiveness of pneumococcal vaccine in preventing pneumococcal infection in the immunocompetent elderly approximates the vaccine's effectiveness in the general immunocompetent population.
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Citations
Cites
7. Prevention of Pneumococcal Pneumonia by Vaccination
Austrian, R., Douglas, R. M., Schiffman, G., Coetzee, A. M., Koornhof, H. J., Hayden-Smith, S., & Reid, R. D. W. (1985) · Life with the Pneumococcus · doi:10.9783/9781512800135-009 · Cited by 401
Efficacy of Pneumococcal Vaccine in High-Risk Patients
Simberkoff, M. S., Cross, A. P., Al-Ibrahim, M., Baltch, A. L., Geiseler, P. J., Nadler, J., Richmond, A. S., Smith, R. P., Schiffman, G., Shepard, D. S., et al. (1986) · New England Journal of Medicine · doi:10.1056/nejm198611203152104 · Cited by 395
Protective Efficacy of Pneumococcal Polysaccharide Vaccines
Smit, P. (1977) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1977.03280250039019 · Cited by 350
Austrian, R. (1981) · Clinical Infectious Diseases · doi:10.1093/clinids/3.supplement_1.s1 · Cited by 292
Pneumococcal Vaccine Efficacy in Selected Populations in the United States
BOLAN, G., BROOME, C. V., FACKLAM, R. R., PLIKAYTIS, B. D., FRASER, D. W., & SCHLECH, W. F. (1986) · Annals of Internal Medicine · doi:10.7326/0003-4819-104-1-1 · Cited by 261
SHAPIRO, E. D., & CLEMENS, J. D. (1984) · Annals of Internal Medicine · doi:10.7326/0003-4819-101-3-325 · Cited by 259
Inefficacy of pneumococcal vaccine in a high-risk population
Forrester, H. L., Jahnigen, D. W., & Marc Laforce, F. (1987) · The American Journal of Medicine · doi:10.1016/0002-9343(87)90751-0 · Cited by 168
Pneumococcal Vaccine: Clinical Efficacy and Effectiveness
Schwartz, J. S. (1982) · Annals of Internal Medicine · doi:10.7326/0003-4819-96-2-208 · Cited by 134
Self-citationPneumococcal Disease in a Medium-Sized Community in the United States
Mufson, M. A. (1982) · JAMA · doi:10.1001/jama.1982.03330120044028 · Cited by 129
PNEUMOCOCCAL BACTEREMIA IN CHARLESTON COUNTY, SOUTH CAROLINA1
FILICE, G. A., Darby, C. P., & Fraser, D. W. (1980) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a113055 · Cited by 123
Cited by
Hao (2015) · doi:10.1002/14651858 · Cited by 11,321
The Protective Efficacy of Polyvalent Pneumococcal Polysaccharide Vaccine
Shapiro, E. D., Berg, A. T., Austrian, R., Schroeder, D., Parcells, V., Margolis, A., Adair, R. K., & Clemens, J. D. (1991) · New England Journal of Medicine · doi:10.1056/nejm199111213252101 · Cited by 1,051
Bacterial Infection in Chronic Obstructive Pulmonary Disease
Murphy, T. F., & Sethi, S. (1992) · American Review of Respiratory Disease · doi:10.1164/ajrccm/146.4.1067 · Cited by 580
Loeb, M., McGeer, A., McArthur, M., Walter, S., & Simor, A. E. (1999) · Archives of Internal Medicine · doi:10.1001/archinte.159.17.2058 · Cited by 346
Melegaro, A., & Edmunds, W. J. (2004) · European Journal of Epidemiology · doi:10.1023/b:ejep.0000024701.94769.98 · Cited by 185
Metadata
- Authors
- SIMS, R. V., STEINMANN, W. C., MCCONVILLE, J. H., KING, L. R., ZWICK, W. C., & SCHWARTZ, J. S.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1988-05-01
- Volume
- 108
- Issue
- 5
- Pages
- 653-657
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2028743553
- Cited by
- 317
- References
- 12
- FWCI
- 13.56
- Type
- journal article
- Language
- en
- Open access
- closed
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- SIMS, R. V., STEINMANN, W. C., MCCONVILLE, J. H., KING, L. R., ZWICK, W. C., & SCHWARTZ, J. S. (1988). The Clinical Effectiveness of Pneumococcal Vaccine in the Elderly. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-108-5-653
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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