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Effects of Hypoglycemic Agents on Vascular Complications in Patients With Adult-Onset Diabetes: VII. Mortality and Selected Nonfatal Events With Insulin Treatment
Abstract
The University Group Diabetes Program is a long-term prospective clinical trial designed to evaluate the effects of various hypoglycemic agents on vascular complications in patients with asymptomatic adult-onset diabetes. Mortality and blood glucose levels were determined as well as certain nonfatal events for patients assigned to diet alone or to either of two insulin treatment regimens. Lower levels of blood glucose with mean values close to normoglycemia were achieved in the treatment group in which the insulin dosage was adjusted to achieve normoglycemia compared with the levels achieved in patients treated with diet alone or with a fixed dose of insulin. In spite of differences in blood glucose levels among the treatment groups, there were only minor differences in the occurrence of fatal or nonfatal events. (JAMA240:37-42, 1978)
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“although diabetes mellitus and elevated glucose levels clearly predict CHD risk, lowering of glucose by drug treatment generally has not produced anticipated reductions in CHD events, 11,12,12a”
From Beyond Established and Novel Risk Factors: Lifestyle Risk Factors for Cardiovascular Disease (2008) · cites this paper as [11]
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ESTIMATING THE MICROVASCULAR BENEFITS OF SCREENING FOR TYPE 2 DIABETES MELLITUS
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“While a 10% one-time reduction in HbA1c fits the data published from the randomized trials, we also estimated a model in which we used the absolute mean effect from the trials (about one percentage point drop in HbA1c), regardless of the starting level (5;12;18).”
BackgroundMethodInfluentialShould We Use Intensive Insulin Therapy After Oral Agent Failure in Type II Diabetes?
Colwell, J. (1996) · Diabetes Care · doi:10.2337/diacare.19.8.896 · Cited by 10
“group of recently diagnosed type II diabetic patients (12).”
BackgroundBriganti, E. M., Kerr, P. G., Shaw, J. E., Zimmet, P., & Atkins, R. C. (2005) · Nephrology · doi:10.1111/j.1440-1797.2005.00357.x · Cited by 9
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Controlling type 2 diabetes: are the benefits worth the costs?
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Is insulin a factor in the genesis of the vascular complications of diabetes?
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Self-citationZheng, L., Buchanan, T. A., Hodis, H. N., Li, Y., Torres, M., & Mack, W. J. (2003) · Atherosclerosis · doi:10.1016/s0021-9150(03)00291-0 · Cited by 8
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Medical Treatment of Peripheral Artery Disease
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BackgroundProliferative Diabetic Retinopathy
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ResultAggressive Management of Blood Glucose
Kilo, C. (2007) · doi:10.17925/use.2007.00.1.24 · Cited by 1
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Pregnancy glycemia to vascular risk: Nonglycemic diabetes?
Cruickshank, J., & Banerjee, M. (2009) · Canadian Medical Association Journal · doi:10.1503/cmaj.091396
Insulinothérapie et prévention des complications cardiovasculaires : quel rationnel?
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Self-citationJss (1978) · Diabetes Care · doi:10.2337/diacare.1.5.328
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Medical Treatment of Peripheral Arterial Disease
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Metadata
- Authors
- Knatterud, G. L.
- Corresponding author
- Knatterud, Genell L.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 1978-07-07
- Volume
- 240
- Issue
- 1
- Pages
- 37
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W7214171970
- Cited by
- 0
- References
- 0
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- type 2 diabetes, antidiabetic drugs, insulin therapy, dietary therapy, glycemic control, normoglycemia, vascular complications, mortality, University Group Diabetes Program
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