Recognition of impending ketoacidosis delayed by ketone reagent strip failure
Abstract
During a one-year period, six patients were admitted to the hospital in diabetic ketoacidosis following 12 to 24 hours of illness at home. Urine testing with strips impregnated with sodium nitroprusside had indicated that no ketone bodies were present. Nine of 11 bottles of reagent strips in use for less than three months by these and other patients contained totally unreactive strips. Nitroprusside tablets exposed more than three months continued to give accurate readings. (JAMA240:2462-2464, 1978)
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Urine test reagents deteriorate when exposed to air, producing false-negative readings.
“Urine test reagents deteriorate with exposure to air, giving false-negative readings; therefore, testing material should be stored in tightly sealed containers and discarded after the expiration date on the manufacturer's label (189).”
From Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus (2011) · cites this paper as [189]
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Sacks, D. B., Arnold, M., Bakris, G. L., Bruns, D. E., Horvath, A. R., Kirkman, M. S., Lernmark, A., Metzger, B. E., & Nathan, D. M. (2011) · Clinical Chemistry · doi:10.1373/clinchem.2010.161596 · Cited by 1,360 · see citing works
Sacks, D. B., Arnold, M., Bakris, G. L., Bruns, D. E., Horvath, A. R., Kirkman, M. S., Lernmark, A., Metzger, B. E., & Nathan, D. M. (2011) · Diabetes Care · doi:10.2337/dc11-9998 · Cited by 718 · see citing works
- Authors
- Rosenbloom, A. L.
- Corresponding author
- Rosenbloom, Arlan L.
- ORCID
- Rosenbloom, Arlan L.
- Venue
- JAMA: The Journal of the American Medical Association
- Publisher
- American Medical Association (AMA)
- Published
- 1978-11-24
- Volume
- 240
- Issue
- 22
- Pages
- 2462
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W4299943813
- Cited by
- 21
- References
- 0
- Citations by year
- 2023: 1 · 2022: 1 · 2020: 1 · 2019: 1 · 2016: 2 · 2014: 1 · 2013: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Forensic Toxicology and Drug Analysis
- Keywords
- diabetic ketoacidosis, sodium nitroprusside, delayed diagnosis, diabetes mellitus
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