Cardiac-arrest after intravenous administration of levothyroxine
Abstract
To the Editor.— Myxedema coma is a medical emergency with high mortality. 1 The accepted treatment of this condition is immediate intravenous administration of thyroxine (T 4 ) in the form of levothyroxine sodium, and supportive measures. Survival improves when levothyroxine is administered promptly in large doses, even in patients with cardiac disease. 2 We have seen a case of cardiorespiratory arrest after intravenous administration of levothyroxine. Report of a Case.— A 63-year-old woman had development of hypothyroidism in the year before admission. On admission she was alert and responsive but confused. Her temperature was 35.7 °C orally; blood pressure, 120/80 mm Hg; pulse rate, 80 beats per minute; and weight, 64 kg. She had typical features of severe myxedema. The serum T 4 level was 1.2 μg/dL, with a triiodothyronine (T 3 ) resin uptake of 28% (normal, 4.7 to 12.2 μg/dL, and 25% to 35%, respectively), and levels of BUN
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
LT4 IV injection can augment the calorigenic effect of norepinephrine within minutes and thus exerts direct, rapid effects on the myocardium, which may lead to cardiac arrest.
“LT4 IV injection can augment the calorigenic effect of norepinephrine within minutes and thus exerts direct, rapid effects on the myocardium, which may lead to cardiac arrest (238).”
From Levothyroxine: conventional and novel drug delivery formulations. (2023) · cites this paper as [238]
Cites
Thyroid Hormone Action at the Cell Level
Sterling, K. (1979) · New England Journal of Medicine · doi:10.1056/nejm197901183000304 · Cited by 211 · see citing works
Treatment of Myxedema Coma With Intravenous Thyroxine
Holvey, D. N. (1964) · Archives of Internal Medicine · doi:10.1001/archinte.1964.00280070091015 · Cited by 123 · see citing works
Cycloleucine Transport in Isolated Rat Thymocytes:In VitroEffects of Triiodothyronine and Thyroxine
Goldfine, I. D., SIMONS, C. G., Smith, G. J., et al. (1975) · Endocrinology · doi:10.1210/endo-96-4-1030 · Cited by 63 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Levothyroxine: conventional and novel drug delivery formulations.
Liu, H., Li, W., Zhang, W., Sun, S., & Chen, C. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnac030 · Cited by 63 · see citing works
- Authors
- Bacci, V.
- Corresponding author
- Bacci, Vicenzo
- Venue
- JAMA: The Journal of the American Medical Association
- Publisher
- American Medical Association (AMA)
- Published
- 1981-03-06
- Volume
- 245
- Issue
- 9
- Pages
- 920
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W1985737419
- Cited by
- 9
- References
- 3
- Citations by year
- 2024: 1 · 2022: 1 · 2020: 1 · 2019: 1
- FWCI
- 1.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Emergency Medicine › Poisoning and overdose treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Keywords
- levothyroxine, myxedema coma, cardiac arrest, hypothyroidism, thyroxine therapy
- MeSH terms
- Female, Heart Arrest, Humans, Injections, Intravenous, Middle Aged, Myxedema, Thyroxine
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
