Cited by 914Genetic Associations and EpidemiologyGenetics and Physical PerformanceObesity, Physical Activity, Diet

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A Twin Study of Human Obesity

Stunkard, Albert J.·1986·JAMA: The Journal of the American Medical Association

DOI 10.1001/jama.1986.03380010055024

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Abstract

Height, weight, and body mass index (BMI) were assessed in a sample of 1974 monozygotic and 2097 dizygotic male twin pairs. Concordance rates for different degrees of overweight were twice as high for monozygotic twins as for dizygotic twins. Classic twin methods estimated a high heritability for height, weight, and BMI, both at age 20 years (.80, .78, and .77, respectively) and at a 25-year follow-up (.80, .81, and .84, respectively). Height, weight, and BMI were highly correlated across time, and a path analysis suggested that the major part of that covariation was genetic. These results are similar to those of other twin studies of these measures and suggest that human fatness is under substantial genetic control.

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Authors: Stunkard, A. J.
Corresponding author: Stunkard, Albert J.
Venue: JAMA: The Journal of the American Medical Association
Publisher: American Medical Association (AMA)
Published: 1986-07-04
Volume: 256
Issue: 1
Pages: 51
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.1986.03380010055024
OpenAlex: W2001913879
Cited by: 912
References: 29
Citations by year: 2026: 3 · 2025: 13 · 2024: 11 · 2023: 19 · 2022: 17 · 2021: 28 · 2020: 18 · 2019: 27 · 2018: 21 · 2017: 32 · 2016: 37 · 2015: 44 · 2014: 39 · 2013: 53 · 2012: 46
FWCI: 9.37
Type: journal article
Language: en
Open access: closed
Locations: JAMA (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5k05mh000245-13)
National Institute of Mental Health (5-KO5-MH-00245)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Physical Performance
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
Keywords: obesity, heritability, monozygotic twins, dizygotic twins, body mass index, height, weight, concordance rate, path analysis
MeSH terms: Adult, Body Height, Body Weight, Diseases in Twins, Follow-Up Studies, Humans, Male, Mathematics, Military Personnel, National Academy of Sciences, U.S., Obesity, Registries, Twins, Dizygotic, Twins, Monozygotic, United States

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