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Therapeutic Response to Lovastatin (Mevinolin) in Nonfamilial Hypercholesterolemia: A Multicenter Study
Abstract
Lovastatin (mevinolin), a potent inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, was investigated in a double-blind, placebo-controlled multicenter study of 101 patients with nonfamilial primary hypercholesterolemia. Dosages varied from 10 to 80 mg/d in single or divided doses. Patients receiving 40 mg twice a day experienced mean total and low-density lipoprotein cholesterol reductions of 32% and 39%, respectively. High-density lipoprotein cholesterol levels tended to rise slightly and plasma triglyceride levels were moderately decreased. Adverse effects attributable to lovastatin were infrequent and no patient was withdrawn from therapy. In this study, lovastatin was a well tolerated and effective agent for the treatment of nonfamilial hypercholesterolemia.
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Kim, R. G., Loomba, R., Prokop, L. J., & Singh, S. (2017) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2017.04.039 · Cited by 174
Stein, E. A., Giugliano, R. P., Koren, M. J., Raal, F. J., Roth, E. M., Weiss, R., Sullivan, D., Wasserman, S. M., Somaratne, R., Kim, J. B., et al. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu085 · Cited by 130
Metadata
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 1986-11-28
- Volume
- 256
- Issue
- 20
- Pages
- 2829
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W4248137340
- Cited by
- 168
- References
- 0
- FWCI
- 26.61
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Therapeutic Response to Lovastatin (Mevinolin) in Nonfamilial Hypercholesterolemia: A Multicenter Study. https://app.cochat.ai/papers/10.1001/jama.1986.03380200067023
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- Therapeutic Response to Lovastatin (Mevinolin) in Nonfamilial Hypercholesterolemia: A Multicenter Study. (1986). JAMA. https://doi.org/10.1001/jama.1986.03380200067023
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