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A Mass Vaccination Program in Taiwan Against Hepatitis B Virus Infection in Infants of Hepatitis B Surface Antigen—Carrier Mothers
Abstract
To combat hepatitis B virus (HBV) infection in Taiwan, a mass immunoprophylaxis program was launched on July 1, 1984, aiming first at prevention of chronic HBV carriage from perinatal mother-to-infant infection. In the first 15-month period, 352,721 (78%) of 450,585 pregnant women were screened for hepatitis B surface antigen (HBsAg); HBsAg was present in 62,359 (18%), with 50% of them categorized as highly infectious. Infants born to HBsAg-positive women were given 5 micrograms of a plasma-derived hepatitis B vaccine at ages 1, 5, and 9 weeks, with a booster at age 12 months. Infants of highly infectious carrier mothers received an additional 0.5 mL of hepatitis B immune globulin within 24 hours after birth. The coverage rate of the hepatitis B immune globulin was 77% in 27,375 infants born to highly infectious mothers, and that of the first, second, third, and the fourth doses of vaccine was 88%, 86%, 84%, and 71%, respectively, in infants of 55,620 carrier mothers. The reported untoward reactions to immunization were negligible. We conclude that a mass hepatitis B vaccination program is feasible in hyperendemic areas such as Taiwan; this should be a significant step toward the effective control of HBV infection in these areas.
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Cited by
Chang, M.-H., Chen, C.-J., Lai, M.-S., Hsu, H.-M., Wu, T.-C., Kong, M.-S., Liang, D.-C., Shau, W.-Y., & Chen, D.-S. (1997) · New England Journal of Medicine · doi:10.1056/nejm199706263362602 · Cited by 1,883
Self-citationEvidence-based, cost-effective interventions: How many newborn babies can we save?
Darmstadt, G. L., Bhutta, Z. A., Cousens, S., Adam, T., Walker, N., & de Bernis, L. (2005) · The Lancet · doi:10.1016/s0140-6736(05)71088-6 · Cited by 1,541
Chen, C.-H., Yang, P.-M., Huang, G.-T., Lee, H.-S., Sung, J.-L., & Sheu, J.-C. (2007) · Journal of the Formosan Medical Association · doi:10.1016/s0929-6646(09)60231-x · Cited by 271
Hepatitis B vaccination: The key towards elimination and eradication of hepatitis B
Chen, D.-S. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2009.01.002 · Cited by 261
Self-citationLong-term Effects of Hepatitis B Immunization of Infants in Preventing Liver Cancer
Chang, M.-H., You, S.-L., Chen, C.-J., Liu, C.-J., Lai, M.-W., Wu, T.-C., Wu, S.-F., Lee, C.-M., Yang, S.-S., Chu, H.-C., et al. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.05.048 · Cited by 258
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Metadata
- Authors
- Chen, D.-S.
- Venue
- JAMA: The Journal of the American Medical Association
- Publisher
- American Medical Association (AMA)
- Published
- 1987-05-15
- Volume
- 257
- Issue
- 19
- Pages
- 2597
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2000962513
- Cited by
- 333
- References
- 0
- FWCI
- 7.81
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chen, D.-S. (1987). A Mass Vaccination Program in Taiwan Against Hepatitis B Virus Infection in Infants of Hepatitis B Surface Antigen—Carrier Mothers. JAMA: The Journal of the American Medical Association. https://doi.org/10.1001/jama.1987.03390190075023
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