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Cited by 261

The DOI matches its Crossref record; 97 of the 97 references it cites were found in a registry or an index.

Hepatitis B vaccination: The key towards elimination and eradication of hepatitis B

Open access
Chen, Ding-Shinn·2009·Journal of Hepatology

Abstract

Hepatitis B virus infection is a global health problem. Worldwide, about 360 million people are chronically infected with the virus. They continue to spread the virus to others and are themselves at risk of chronic liver diseases and hepatocellular carcinoma. The infection can now be treated by antivirals or interferons and the transmission route can be interrupted. Nevertheless, the most effective means is to immunize all susceptible individuals, especially young children, with safe and efficacious vaccines. The combined efforts of vaccination, effective treatment and interruption of transmission make elimination of the infection plausible and may eventually lead to eradication of the virus. Because hepatitis B vaccination has a key role in the control of hepatitis B, properties of this vaccine, its effectiveness in pre-exposure and post-exposure settings, duration of protection after vaccination and the need of booster doses are discussed. Mass hepatitis B vaccination in children decreases the carriage of the virus, and the diseases associated with acute and chronic infection, including hepatocellular carcinoma. Challenges that need to be solved to expand mass vaccination, and the strategies towards elimination and eventual eradication of hepatitis B in the world are also discussed.

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Metadata

Authors
Chen, D.-S.
Venue
Journal of Hepatology
Publisher
Elsevier BV
Published
2009-04
Volume
50
Issue
4
Pages
805-816
ISSN
0168-8278 (ISSN-L)
OpenAlex
W2038452027
Cited by
261
References
97
FWCI
12.13
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Hepatitis B vaccination: The key towards elimination and eradication of hepatitis B. https://app.cochat.ai/papers/10.1016/j.jhep.2009.01.002
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Chen, D.-S. (2009). Hepatitis B vaccination: The key towards elimination and eradication of hepatitis B. Journal of Hepatology. https://doi.org/10.1016/j.jhep.2009.01.002

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.