The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
(±3,4-Methylenedioxymethamphetamine Selectively Damages Central Serotonergic Neurons in Nonhuman Primates
Abstract
(+/-)3,4-Methylenedioxymethamphetamine (MDMA) is a popular recreational drug that has been proposed to be useful as an adjunct to psychotherapy. This study assessed the neurotoxic potential of MDMA in nonhuman primates. Monkeys were repeatedly administered doses (2.50, 3.75, and 5.00 mg/kg) of MDMA subcutaneously and analyzed for regional brain content of serotonin and 5-hydroxyindoleacetic acid two weeks later. In all regions of the monkey brain examined, MDMA produced a selective dose-related depletion of serotonin and 5-hydroxyindoleacetic acid. These neurochemical deficits were associated with evidence of structural damage to serotonergic nerve fibers. In addition, MDMA produced pathological changes in nerve cell bodies in the dorsal, but not median, raphe nucleus. These results indicate that MDMA is a selective serotonergic neurotoxin in nonhuman primates and that humans using this drug may be at risk for incurring central serotonergic neuronal damage.
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Cites
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A PHA-L analysis of ascending projections of the dorsal raphe nucleus in the rat
Vertes, R. P. (1991) · Journal of Comparative Neurology · doi:10.1002/cne.903130409 · Cited by 842
Hatzidimitriou, G., McCann, U. D., & Ricaurte, G. A. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-12-05096.1999 · Cited by 339
Self-citationSTEELE, T. D., McCANN, U. D., & RICAURTE, G. A. (1994) · Addiction · doi:10.1111/j.1360-0443.1994.tb03330.x · Cited by 289
Self-citationNeurotoxicity of substituted amphetamines: Molecular and cellular mechanisms
Cadet, J. L., Krasnova, I. N., Jayanthi, S., & Lyles, J. (2007) · Neurotoxicity Research · doi:10.1007/bf03033567 · Cited by 272
Metadata
- Authors
- Ricaurte, G. A.
- Venue
- JAMA: The Journal of the American Medical Association
- Publisher
- American Medical Association (AMA)
- Published
- 1988-07-01
- Volume
- 260
- Issue
- 1
- Pages
- 51
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2059491341
- Cited by
- 300
- References
- 25
- FWCI
- 21.03
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ricaurte, G. A. (1988). (±3,4-Methylenedioxymethamphetamine Selectively Damages Central Serotonergic Neurons in Nonhuman Primates. JAMA: The Journal of the American Medical Association. https://doi.org/10.1001/jama.1988.03410010059035
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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