Cited by 802Cardiac Health and Mental HealthAcute Myocardial Infarction ResearchCardiovascular and exercise physiology

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Cardiac Rehabilitation After Myocardial Infarction: Combined Experience of Randomized Clinical Trials

Oldridge, Neil B.·1988·JAMA

DOI 10.1001/jama.1988.03410070073031

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Abstract

Randomized clinical trials of cardiac rehabilitation following myocardial infarction have typically demonstrated a lower mortality in treated patients, but with a statistically significant reduction in only one trial. To overcome the problem of not being able to detect small but clinically important benefits in mortality in randomized clinical trials of exercise and risk factor rehabilitation after myocardial infarction with small numbers of patients, we carried out a meta-analysis on the combined results of ten randomized clinical trials that included 4347 patients (control, 2145 patients; rehabilitation, 2202 patients). The pooled odds ratios of 0.76 (95% confidence intervals, 0.63 to 0.92) for all-cause death and of 0.75 (95% confidence intervals, 0.62 to 0.93) for cardiovascular death were significantly lower in the rehabilitation group than in the control group, with no significant difference for nonfatal recurrent myocardial infarction. These results suggest that, for appropriately selected patients, comprehensive cardiac rehabilitation has a beneficial effect on mortality but not on nonfatal recurrent myocardial infarction. (JAMA1988;260:945-950)

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Authors: Oldridge, N. B.
Corresponding author: Oldridge, Neil B.
ORCID: Oldridge, Neil B.
Venue: JAMA
Publisher: American Medical Association (AMA)
Published: 1988-08-19
Volume: 260
Issue: 7
Pages: 945
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.1988.03410070073031
OpenAlex: W4322695695
Semantic Scholar: 656a77909d183420d453da7a6da80630db202005
Cited by: 800
References: 0
Citations by year: 2026: 2 · 2025: 10 · 2024: 8 · 2023: 10 · 2022: 11 · 2021: 12 · 2020: 17 · 2019: 16 · 2018: 16 · 2017: 18 · 2016: 25 · 2015: 28 · 2014: 25 · 2013: 26 · 2012: 12
FWCI: 8.98
Type: journal article
Language: en
Open access: closed
Locations: JAMA (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Keywords: cardiac rehabilitation, myocardial infarction, all-cause mortality, cardiovascular mortality, reinfarction, exercise therapy

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Cardiac Rehabilitation After Myocardial Infarction: Combined Experience of Randomized Clinical Trials

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