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Cited by 42Spinal Dysraphism and MalformationsFolate and B Vitamins ResearchGestational Diabetes Research and Management

Prepregnancy weight and pregnancy outcome

Goldenberg, Robert L.·1996·JAMA: The Journal of the American Medical Association
DOI 10.1001/jama.1996.03530380069034
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Abstract

In this issue ofTHE JOURNAL, there are two articles that describe the relationship between maternal size and a pregnancy with a neural tube defect (NTD).1,2Both investigations are population-based, case-controlled studies involving more than 500 NTD cases and controls. Information on maternal characteristics, including pregnancy events, prepregnancy weight, and dietary intake, was obtained by in-person interviews with each mother within 5 to 6 months of delivery. The risk of NTD-affected pregnancy was estimated after adjusting for multiple confounders. These two groups of investigators independently reached a similar conclusion: women who are obese (ie, women who have a body mass index [BMI] of >29 kg/m2or body weight of more than 80 kg) at the beginning of pregnancy are more likely to have infants with NTDs and this association is independent of folate intake. Since previous studies have indicated similar relationships,3,4it is likely that this association

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Crossref · 10.1001/jama.1996.03530380069034

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  • Obese women are more likely to have infants with congenital anomalies such as neural-tube defects, and these infants are more likely to be delivered preterm.

    “Obese women are more likely to have infants with congenital anomalies, such as neural-tube defects, and these infants are more likely to be delivered preterm.39”

    From Epidemiology and causes of preterm birth (2008) · cites this paper as [39]

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Authors
Goldenberg, R. L.
Corresponding author
Goldenberg, Robert L.
ORCID
Goldenberg, Robert L.
Venue
JAMA: The Journal of the American Medical Association
Publisher
American Medical Association (AMA)
Published
1996-04-10
Volume
275
Issue
14
Pages
1127
ISSN
  • 0002-9955 (ISSN-L)
  • 0098-7484
DOI
10.1001/jama.1996.03530380069034
OpenAlex
W2001032332
Cited by
42
References
19
Citations by year
2025: 2 · 2024: 1 · 2022: 1 · 2021: 1 · 2019: 1 · 2018: 3 · 2017: 1 · 2014: 1 · 2013: 3 · 2012: 2
FWCI
1.48
Type
journal article
Language
en
Open access
closed
Locations
  • JAMA (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Spinal Dysraphism and Malformations
  • Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
Keywords
pre-pregnancy weight, maternal obesity, neural tube defects, pregnancy outcomes, body mass index, folate intake, maternal body size, birth defects risk
MeSH terms
Body Weight, Female, Folic Acid, Humans, Neural Tube Defects, Obesity, Pregnancy, Pregnancy Complications, Pregnancy Outcome, Risk Factors, Zinc

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