The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Magnitude and Duration of the Effect of Sepsis on Survival
Abstract
OBJECTIVE: To determine the magnitude and duration of the effects of sepsis on survival. DESIGN: Cohort study. SETTING: The 10 Department of Veterans Affairs Medical Centers of the Systemic Sepsis Cooperative Studies Group, which from 1983 to 1986 conducted the Department of Veterans Affairs Cooperative Study of Corticosteroids in Systemic Sepsis. PATIENTS: The septic population consisted of 1505 patients with evaluable data from the screening log of the Cooperative Study of Corticosteroids in Systemic Sepsis. All 91830 nonpsychiatric, noninfected patients discharged from the participating medical centers between October 1, 1984, and September 30, 1985, were included in the control population. MAIN OUTCOME MEASURE: Death through 8 years after the index hospitalization. RESULTS: On the basis of a proportional hazards model constructed from the demographic and illness characteristics of the control population, the septic population was at significant risk of dying of nonseptic causes (26% predicted 1-year mortality). In the septic population, the daily risk of dying exceeded predictions from this model for 5 years, and the hazard rate rose with increasing severity of the septic episode throughout the first year (P<.05). Among 30-day survivors, sepsis reduced the remaining mean life span from a predicted 8.03 years to 4.08 years. CONCLUSIONS: Sepsis not only causes deaths acutely, but also increases the risk of death for up to 5 years after the septic episode even after comorbidities are accounted for. The risk of late death during the first year is associated with the severity of the septic episode.
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The natural history of the systemic inflammatory response syndrome (SIRS). A prospective study
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Ziegler, E. J., Fisher, C. J., Sprung, C. L., Straube, R. C., Sadoff, J. C., Foulke, G. E., Wortel, C. H., Fink, M. P., Dellinger, R. P., Teng, N. N. H., et al. (1991) · New England Journal of Medicine · doi:10.1056/nejm199102143240701 · Cited by 1,611
Bone, R. C., Fisher, C. J., Clemmer, T. P., Slotman, G. J., Metz, C. A., Balk, R. A., & The Methylprednisolone Severe Sepsis Study Group (1987) · New England Journal of Medicine · doi:10.1056/nejm198709103171101 · Cited by 1,440
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Cited by
Angus, D. C., Linde-Zwirble, W. T., Lidicker, J., Clermont, G., Carcillo, J., & Pinsky, M. R. (2001) · Critical Care Medicine · doi:10.1097/00003246-200107000-00002 · Cited by 8,503
New Approaches to Sepsis: Molecular Diagnostics and Biomarkers
Reinhart, K., Bauer, M., Riedemann, N. C., & Hartog, C. S. (2012) · Clinical Microbiology Reviews · doi:10.1128/cmr.00016-12 · Cited by 533
Vlachopoulos, C., Dima, I., Aznaouridis, K., Vasiliadou, C., Ioakeimidis, N., Aggeli, C., Toutouza, M., & Stefanadis, C. (2005) · Circulation · doi:10.1161/circulationaha.105.535435 · Cited by 492
C-Reactive Protein/Albumin Ratio Predicts 90-Day Mortality of Septic Patients
Ranzani, O. T., Zampieri, F. G., Forte, D. N., Azevedo, L. C. P., & Park, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059321 · Cited by 466
Iwashyna, T. J., Odden, A., Rohde, J., Bonham, C., Kuhn, L., Malani, P., Chen, L., & Flanders, S. (2014) · Medical Care · doi:10.1097/mlr.0b013e318268ac86 · Cited by 358
Metadata
- Authors
- Quartin, A. A.
- Venue
- JAMA: The Journal of the American Medical Association
- Publisher
- American Medical Association (AMA)
- Published
- 1997-04-02
- Volume
- 277
- Issue
- 13
- Pages
- 1058
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2074503728
- Cited by
- 417
- References
- 30
- FWCI
- 8.78
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
