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Cited by 229Menopause: Health Impacts and TreatmentsHormonal and reproductive studiesEstrogen and related hormone effects

The DOI matches its Crossref record; 101 of the 101 references it cites were found in a registry or an index.

Patient-Specific Decisions About Hormone Replacement Therapy in Postmenopausal Women

Col, Nananda F.·1997·JAMA: The Journal of the American Medical Association
DOI 10.1001/jama.1997.03540380054031
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Abstract

Objective To examine the effect of hormone replacement therapy on life expectancy in postmenopausal women with different risk profiles for heart disease, breast cancer, and hip fracture. Design Decision analysis using a Markov model. Published regression models were used to link risk factors to disease incidence and to estimate the lifetime risks of developing coronary heart disease (CHD), breast cancer, hip fracture, and endometrial cancer. The impact of hormone therapy on disease incidence was estimated from published epidemiologic studies. Setting Mathematical model applicable to primary care. Interventions Treatment with hormone replacement therapy or no hormone replacement therapy. Main outcome measure Life expectancy. Results Hormone replacement therapy should increase life expectancy for nearly all postmenopausal women, with some gains exceeding 3 years, depending mainly on an individual's risk factors for CHD and breast cancer. For women with at least 1 risk factor for CHD, hormone therapy should extend life expectancy, even for women having first-degree relatives with breast cancer. Women without any risk factors for CHD or hip fracture, but who have 2 first-degree relatives with breast cancer, however, should not receive hormone therapy. Conclusions The benefit of hormone replacement therapy in reducing the likelihood of developing CHD appears to outweigh the risk of breast cancer for nearly all women in whom this treatment might be considered. Our analysis supports…

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Crossref · 10.1001/jama.1997.03540380054031

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Metadata

Authors
Col, N. F.
Affiliations
Tufts University (US)
Corresponding author
Col, Nananda F.
ORCID
Col, Nananda F.
Venue
JAMA: The Journal of the American Medical Association
Publisher
American Medical Association (AMA)
Published
1997-04-09
Volume
277
Issue
14
Pages
1140
ISSN
  • 0002-9955 (ISSN-L)
  • 0098-7484
DOI
10.1001/jama.1997.03540380054031
OpenAlex
W1983608420
Cited by
229
References
101
Citations by year
2023: 2 · 2022: 1 · 2021: 1 · 2020: 2 · 2018: 3 · 2017: 1 · 2016: 1 · 2015: 4 · 2014: 4 · 2013: 1 · 2012: 4
FWCI
27.40
Type
journal article
Language
en
Open access
closed
Locations
  • JAMA (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Agency for Healthcare Research and Quality (1 PO1 HS 06503)
  • U.S. National Library of Medicine (LM07092, T15LM007092)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Keywords
hormone replacement therapy, postmenopausal women, life expectancy, coronary artery disease, breast cancer, hip fracture, endometrial cancer, cardiovascular risk factors, family history of breast cancer, individualized treatment decision-making
MeSH terms
Aged, Breast Neoplasms, Coronary Disease, Decision Support Techniques, Female, Hip Fractures, Humans, Life Expectancy, Middle Aged, Models, Theoretical, Risk, Risk Factors, Sensitivity and Specificity, Estrogen Replacement Therapy, Endometrial Neoplasms, Postmenopause, Black People, White People

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