CoChat
Sign Up
Cited by 840Influenza Virus Research StudiesRespiratory Support and MechanismsCOVID-19 Clinical Research Studies

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

Critically Ill Patients With 2009 Influenza A(H1N1) in Mexico

Domínguez-Cherit, Guillermo·2009·JAMA
DOI 10.1001/jama.2009.1536
Open this paper in CoChat — free account

Abstract

CONTEXT: In March 2009, novel 2009 influenza A(H1N1) was first reported in the southwestern United States and Mexico. The population and health care system in Mexico City experienced the first and greatest early burden of critical illness. OBJECTIVE: To describe baseline characteristics, treatment, and outcomes of consecutive critically ill patients in Mexico hospitals that treated the majority of such patients with confirmed, probable, or suspected 2009 influenza A(H1N1). DESIGN, SETTING, AND PATIENTS: Observational study of 58 critically ill patients with 2009 influenza A(H1N1) at 6 hospitals between March 24 and June 1, 2009. Demographic data, symptoms, comorbid conditions, illness progression, treatments, and clinical outcomes were collected using a piloted case report form. MAIN OUTCOME MEASURES: The primary outcome measure was mortality. Secondary outcomes included rate of 2009 influenza (A)H1N1-related critical illness and mechanical ventilation as well as intensive care unit (ICU) and hospital length of stay. RESULTS: Critical illness occurred in 58 of 899 patients (6.5%) admitted to the hospital with confirmed, probable, or suspected 2009 influenza (A)H1N1. Patients were young (median, 44.0 [range, 10-83] years); all presented with fever and all but 1 with respiratory symptoms. Few patients had comorbid respiratory disorders, but 21 (36%) were obese. Time from hospital to ICU admission was short (median, 1 day [interquartile range {IQR}, 0-3 days]), and all patients but 2 received mechanical ventilation for severe acute respiratory distress syndrome and refractory hypoxemia (median day 1 ratio of Pao(2) to fraction of inspired oxygen, 83 [IQR, 59-145] mm Hg). By 60 days, 24 patients had died (41.4%; 95% confidence interval, 28.9%-55.0%). Patients who died had greater initial severity of illness, worse hypoxemia, higher creatine kinase levels, higher creatinine levels, and ongoing organ dysfunction. After adjusting for a reduced opportunity of patients dying early to receive neuraminidase inhibitors, neuraminidase inhibitor treatment (vs no treatment) was associated with improved survival (odds ratio, 8.5; 95% confidence interval, 1.2-62.8). CONCLUSION: Critical illness from 2009 influenza A(H1N1) in Mexico occurred in young individuals, was associated with severe acute respiratory distress syndrome and shock, and had a high case-fatality rate.

Overview

Integrity signals

Registry

Crossref · 10.1001/jama.2009.1536

Cites

27 of 27 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 25 references

Cited by

Sorted by citations

Items 601–700 of 839

Related

See all

Metadata

Authors
Domínguez-Cherit, G.
Venue
JAMA
Publisher
American Medical Association (AMA)
Published
2009-11-04
Volume
302
Issue
17
Pages
1880
ISSN
  • 0002-9955 (ISSN-L)
  • 0098-7484
DOI
10.1001/jama.2009.1536
OpenAlex
W2168691128
Cited by
840
References
25
Citations by year
2026: 1 · 2025: 7 · 2024: 9 · 2023: 11 · 2022: 14 · 2021: 27 · 2020: 39 · 2019: 18 · 2018: 23 · 2017: 24 · 2016: 36 · 2015: 37 · 2014: 40 · 2013: 66 · 2012: 89
FWCI
108.76
Type
journal article
Language
en
Open access
closed
Locations
  • JAMA (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
  • Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
Keywords
pandemic influenza, critical illness, mortality, mechanical ventilation, acute respiratory distress syndrome, refractory hypoxemia, neuraminidase inhibitors, ICU length of stay, obesity, organ dysfunction, Mexico City, hospitalized patients, mortality risk factors, treatment outcomes, clinical outcomes, comorbidities, creatine kinase, creatinine
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, Hypoxia, Antiviral Agents, Child, Female, Hospitalization, Humans, Influenza, Human, Male, Mexico, Middle Aged, Multiple Organ Failure, Neuraminidase, Respiration, Artificial, Respiratory Distress Syndrome, Retrospective Studies, Critical Illness, Age Distribution, APACHE, Influenza A Virus, H1N1 Subtype, Kaplan-Meier Estimate, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review