Critically Ill Patients With 2009 Influenza A(H1N1) Infection in Canada
Abstract
CONTEXT: Between March and July 2009, the largest number of confirmed cases of 2009 influenza A(H1N1) infection occurred in North America. OBJECTIVE: To describe characteristics, treatment, and outcomes of critically ill patients in Canada with 2009 influenza A(H1N1) infection. DESIGN, SETTING, AND PATIENTS: A prospective observational study of 168 critically ill patients with 2009 influenza A(H1N1) infection in 38 adult and pediatric intensive care units (ICUs) in Canada between April 16 and August 12, 2009. MAIN OUTCOME MEASURES: The primary outcome measures were 28-day and 90-day mortality. Secondary outcomes included frequency and duration of mechanical ventilation and duration of ICU stay. RESULTS: Critical illness occurred in 215 patients with confirmed (n = 162), probable (n = 6), or suspected (n = 47) community-acquired 2009 influenza A(H1N1) infection. Among the 168 patients with confirmed or probable 2009 influenza A(H1N1), the mean (SD) age was 32.3 (21.4) years; 113 were female (67.3%) and 50 were children (29.8%). Overall mortality among critically ill patients at 28 days was 14.3% (95% confidence interval, 9.5%-20.7%). There were 43 patients who were aboriginal Canadians (25.6%). The median time from symptom onset to hospital admission was 4 days (interquartile range [IQR], 2-7 days) and from hospitalization to ICU admission was 1 day (IQR, 0-2 days). Shock and nonpulmonary acute organ dysfunction was common (Sequential Organ Failure Assessment mean [SD] score of 6.8 [3.6] on day 1). Neuraminidase inhibitors were administered to 152 patients (90.5%). All patients were severely hypoxemic (mean [SD] ratio of Pao(2) to fraction of inspired oxygen [Fio(2)] of 147 [128] mm Hg) at ICU admission. Mechanical ventilation was received by 136 patients (81.0%). The median duration of ventilation was 12 days (IQR, 6-20 days) and ICU stay was 12 days (IQR, 5-20 days). Lung rescue therapies included neuromuscular blockade (28% of patients), inhaled nitric oxide (13.7%), high-frequency oscillatory ventilation (11.9%), extracorporeal membrane oxygenation (4.2%), and prone positioning ventilation (3.0%). Overall mortality among critically ill patients at 90 days was 17.3% (95% confidence interval, 12.0%-24.0%; n = 29). CONCLUSION: Critical illness due to 2009 influenza A(H1N1) in Canada occurred rapidly after hospital admission, often in young adults, and was associated with severe hypoxemia, multisystem organ failure, a requirement for prolonged mechanical ventilation, and the frequent use of rescue therapies.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In a Canadian study (N=168), secondary bacterial infection was attributed as a leading cause of death in the 29 (17.3%) fatalities.
“A Canadian study (N = 168) attributed secondary bacterial infection as a leading cause of death in the 29 (17.3%) fatalities that occurred in this cohort [33].”
From The role of pneumonia and secondary bacterial infection in fatal and serious outcomes of pandemic influenza a(H1N1)pdm09. (2018) · cites this paper as [33]
Bacterial co-infection was detected in ~30% of cases in the 2009 H1N1 pandemic, with high mortality rates despite administration of appropriate antibiotics.
“Bacterial co-infection was also detected in ~30% of cases in the 2009 H1N1 pandemic, with high mortality rates despite administration of appropriate antibiotics”
From Respiratory viral infection-induced microbiome alterations and secondary bacterial pneumonia. (2018) · cites this paper as [14]
Cites
APACHE II-A Severity of Disease Classification System
Knaus, W. A., Draper, E. A., Wagner, D. P., & Zimmerman, J. E. (1986) · Critical Care Medicine · doi:10.1097/00003246-198608000-00028 · Cited by 13,379 · see citing works
Kumar, A., Roberts, D., Wood, K. E., Light, B., Parrillo, J. E., Sharma, S., Suppes, R., Feinstein, D., Zanotti, S., Taiberg, L., et al. (2006) · Critical Care Medicine · doi:10.1097/01.ccm.0000217961.75225.e9 · Cited by 6,109 · see citing works
Self-citationThe epidemiology of sepsis in the United States from 1979 through 2000
Martin, G. S., Mannino, D. M., Eaton, S., & Moss, M. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022139 · Cited by 5,841 · see citing works
Emergence of a Novel Swine-Origin Influenza A (H1N1) Virus in Humans
Novel Swine-Origin Influenza A (H1N1) Virus Investigation Team (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0903810 · Cited by 3,047 · see citing works
Influenza-Associated Hospitalizations in the United States
Thompson, W. W. (2004) · JAMA · doi:10.1001/jama.292.11.1333 · Cited by 2,213 · see citing works
Updating the accounts: global mortality of the 1918–1920 "Spanish" influenza pandemic.
Johnson, N. P. A. S., & Mueller, J. (2002) · Bulletin of the History of Medicine · doi:10.1353/bhm.2002.0022 · Cited by 1,980 · see citing works
Pollack, M. M., Patel, K. M., & Ruttimann, U. E. (1996) · Critical Care Medicine · doi:10.1097/00003246-199605000-00004 · Cited by 1,761 · see citing works
Kaplan, J. E., Benson, C. A., Holmes, K. K., Brooks, J. T., Pau, A. K., & Masur, H. (2009) · PsycEXTRA Dataset · doi:10.1037/e537722009-001 · Cited by 1,341 · see citing works
APACHE II-A Severity of Disease Classification System
Gall, J. L., Loirat, P., & Alpcrovitch, A. (1986) · Critical Care Medicine · doi:10.1097/00003246-198608000-00027 · Cited by 1,253 · see citing works
Krinsley, J. S. (2003) · Mayo Clinic Proceedings · doi:10.4065/78.12.1471 · Cited by 1,165 · see citing works
Swine influenza A (H1N1) infection in two children--Southern California, March-April 2009.
Ginsberg, M. M., Hopkins, J., Maroufi, A., Dunne, G., Sunega, D. R., Giessick, J., McVay, P., Lopez, K., Kriner, P., Munday, S. W., et al. (2009) · PubMed · Cited by 840 · see citing works
Global Epidemiology of Influenza: Past and Present
Cox, N. J., & Subbarao, K. (2000) · Annual Review of Medicine · doi:10.1146/annurev.med.51.1.407 · Cited by 840 · see citing works
Avian Influenza A (H5N1) in 10 Patients in Vietnam
Hien, T. T., Liem, N. T., Dung, N. T., Luong, S. T., Mai, P. P., Châu, N. V. V., Suu, P. T., Dong, V. C., Mai, L. T. Q., Thi, N. T., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040419 · Cited by 839 · see citing works
Pandemic versus Epidemic Influenza Mortality: A Pattern of Changing Age Distribution
Simonsen, L., Clarke, M. J., Schonberger, L. B., Arden, N. H., Cox, N. J., & Fukuda, K. (1998) · The Journal of Infectious Diseases · doi:10.1086/515616 · Cited by 705 · see citing works
Swine influenza A (H1N1) infection in two children--Southern California, March-April 2009.
(2009) · PubMed · Cited by 571 · see citing works
The epidemiology of sepsis in the United States from 1979 through 2000*
(2003) · Obstetrics and Gynecology · doi:10.1097/00006250-200308000-00038 · Cited by 547 · see citing works
The 1918 Influenza Pandemic: Insights for the 21st Century
Morens, D. M., & Fauci, A. S. (2007) · The Journal of Infectious Diseases · doi:10.1086/511989 · Cited by 536 · see citing works
Viral Loads and Duration of Viral Shedding in Adult Patients Hospitalized with Influenza
Lee, N. L. S., Chan, P. K. S., Hui, D. S. C., Rainer, T. H., Wong, E., Choi, K., Lui, G. C.-Y., Wong, B. C. K., Wong, R. Y. K., Lam, W., et al. (2009) · The Journal of Infectious Diseases · doi:10.1086/600383 · Cited by 522 · see citing works
Katz, J. D., Hancock, K., Veguilla, V., Zhong, W., Lü, X., Sun, H., Butler, E. N., Dong, L., Liu, F., Li, Z. N., et al. (2009) · MMWR Morbidity and Mortality Weekly Report · Cited by 499 · see citing works
Adhikari, N. K. J., Burns, K. E. A., Friedrich, J. O., Granton, J. T., Cook, D. J., & Meade, M. O. (2007) · BMJ · doi:10.1136/bmj.39139.716794.55 · Cited by 465 · see citing works
Outbreak of swine-origin influenza A (H1N1) virus infection - Mexico, March-April 2009.
(2009) · PubMed · Cited by 447 · see citing works
Intensive-care patients with severe novel influenza A (H1N1) virus infection - Michigan, June 2009.
Napolitano, L., Park, P. K., Sihler, K. C., Papadimos, T. J., Chenoweth, C. E., Cinti, S. K., Zalewski, C. A., Sharangpani, R., Somsel, P. A., Wells, E., et al. (2009) · MMWR Morbidity and Mortality Weekly Report · Cited by 365 · see citing works
Critically Ill Patients With Severe Acute Respiratory Syndrome
Fowler, R. (2003) · JAMA · doi:10.1001/jama.290.3.367 · Cited by 315 · see citing works
Intensive-care patients with severe novel influenza A (H1N1) virus infection - Michigan, June 2009.
(2009) · PubMed · Cited by 244 · see citing works
OXFORD, J. S. (2000) · Reviews in Medical Virology · doi:10.1002/(sici)1099-1654(200003/04)10:2 · Cited by 222 · see citing works
Influence of Overweight on ICU Mortality
Goulenok, C., Monchi, M., Chiche, J.-D., Mira, J.-P., Dhainaut, J.-F., & Cariou, A. (2004) · Chest · doi:10.1378/chest.125.4.1441 · Cited by 175 · see citing works
Obesity is associated with increased morbidity but not mortality in critically ill patients
Sakr, Y. L., Madl, C., Filipescu, D. C., Moreno, R. P., Groeneveld, J., Artigas, A., Reinhart, K., & Vincent, J. (2008) · Intensive Care Medicine · doi:10.1007/s00134-008-1243-0 · Cited by 169 · see citing works
Influenza: historical aspects of epidemics and pandemics
Cunha, B. A. (2004) · Infectious Disease Clinics of North America · doi:10.1016/s0891-5520(03)00095-3 · Cited by 142 · see citing works
Valdez, R. A., Narayan, K. M. V., Geiss, L. S., & Engelgau, M. M. (1999) · American Journal of Public Health · doi:10.2105/ajph.89.11.1715 · Cited by 141 · see citing works
Cassedy, J. H., & Crosby, A. W. (1977) · The American Historical Review · doi:10.2307/1857383 · Cited by 91 · see citing works
Hiền, T. T., Nguyen, T., Nguyen, T., Luong, T. S., Pham, P., & Nguyen, V.-T. (2004) · Cited by 63 · see citing works
Pandemic Influenza 1700-1900: A Study in Historical Epidemiology
Gold, E. (1987) · JAMA · doi:10.1001/jama.1987.03390190134045 · Cited by 56 · see citing works
Pandemic Influenza, 1700-1900: A Study in Historical Epidemiology
Curtin, P. D., & Patterson, K. D. (1988) · The American Historical Review · doi:10.2307/1868110 · Cited by 52 · see citing works
The Eskimos of northeast Labrador : a history of Eskimo-White relations 1771-1955
Kleivan, H. (1966) · NORA - Norwegian Open Research Archives · Cited by 38 · see citing works
Pandemic Influenza and Pregnancy
Beigi, R. H. (2007) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000262051.71925.ac · Cited by 37 · see citing works
New influenza A(H1N1) virus infections: global surveillance summary, May 2009.
(2009) · PubMed · Cited by 33 · see citing works
Health of the original Canadians, 1867-1967.
Graham-Cumming, G. (1967) · PubMed · Cited by 28 · see citing works
Avian Influenza: The Next Pandemic?
McFee, R. B. (2007) · Disease-a-Month · doi:10.1016/j.disamonth.2007.05.006 · Cited by 24 · see citing works
High-frequency oscillation for ARDS.
Guervilly, C., Roch, A., & Papazian, L. (2013) · PubMed · doi:10.1056/nejmc1304344 · Cited by 22 · see citing works
Influence of Overweight on ICU Mortality: A Prospective Study.
Goulenok, C., Monchi, M., Chiche, J., Mira, J. P., Dhainaut, J.-F., & Cariou, A. (2004) · Cardiopulmonary Physical Therapy Journal · doi:10.1097/01823246-200415030-00012 · Cited by 12 · see citing works
The effect of Asian influenza on pregnancy.
Lj, A. (1958) · PubMed · Cited by 11 · see citing works
The etiology and epidemiology of influenza: an analysis of the 1957 epidemic.
CHU, C. M. (1958) · PubMed · Cited by 8 · see citing works
THE EFFECT OF ASIAN INFLUENZA ON PREGNANCY
ABRAMOWITZ, L. J. (1959) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-195904000-00012 · Cited by 7 · see citing works
Avian influenza: the next pandemic?
Moellering, R. C. (2006) · Clinical Microbiology Newsletter · doi:10.1016/j.clinmicnews.2006.06.001 · Cited by 7 · see citing works
Meade, M., Cook, D., Mehta, S., Arabi, Y., Keenan, S., Ronco, J. J., Adhikari, N., Jacka, M., Freitag, A. P., Friedrich, J. O., et al. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a1559 · Cited by 7 · see citing works
New influenza A(H1N1) virus--update.
(2009) · PubMed · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Yang, X., Yu, Y., Xu, J., Shu, H., Xia, J., Liu, H., Wu, Y., Zhang, L., Yu, Z., Fang, M., et al. (2020) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(20)30079-5 · Cited by 10,066 · see citing works
Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock
Dellinger, R. P., Levy, M. M., Rhodes, A., Annane, D., Gerlach, H., Opal, S. M., Sevransky, J. E., Sprung, C. L., Douglas, I. S., Jaeschke, R., et al. (2013) · Critical Care Medicine · doi:10.1097/ccm.0b013e31827e83af · Cited by 9,694 · see citing works
Dellinger, R. P., Levy, M. M., Rhodes, A., Annane, D., Gerlach, H., Opal, S. M., Sevransky, J., Sprung, C. L., Douglas, I. S., Jaeschke, R., et al. (2013) · Intensive Care Medicine · doi:10.1007/s00134-012-2769-8 · Cited by 7,282 · see citing works
Kidney disease is associated with in-hospital death of patients with COVID-19
Cheng, Y., Luo, R., Wang, K., Zhang, M., Wang, Z., Dong, L., Li, J., Yao, Y., Ge, S., & Xu, G. (2020) · Kidney International · doi:10.1016/j.kint.2020.03.005 · Cited by 2,957 · see citing works
Grohskopf, L. A., Sokolow, L. Z., Broder, K. R., Walter, E. B., Fry, A. M., & Jernigan, D. B. (2018) · MMWR Recommendations and Reports · doi:10.15585/mmwr.rr6703a1 · Cited by 1,635 · see citing works
Langford, B. J., So, M., Raybardhan, S., Leung, V., Westwood, D. J., MacFadden, D. R., Soucy, J.-P. R., & Daneman, N. (2020) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2020.07.016 · Cited by 1,587 · see citing works
Critical care and the global burden of critical illness in adults
Adhikari, N. K. J., Fowler, R., Bhagwanjee, S., & Rubenfeld, G. D. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60446-1 · Cited by 1,310 · see citing works
Ruuskanen, O., Lahti, E., Jennings, L., & Murdoch, D. R. (2011) · The Lancet · doi:10.1016/s0140-6736(10)61459-6 · Cited by 1,194 · see citing works
Clinical Aspects of Pandemic 2009 Influenza A (H1N1) Virus Infection
Writing Committee of the WHO Consultation on Clinical Aspects of Pandemic (H1N1) 2009 Influenza (2010) · New England Journal of Medicine · doi:10.1056/nejmra1000449 · Cited by 1,056 · see citing works
Pandemic 2009 Influenza A(H1N1) Virus Illness Among Pregnant Women in the United States
Siston, A. M. (2010) · JAMA · doi:10.1001/jama.2010.479 · Cited by 1,031 · see citing works
Noah, M. A., Peek, G. J., Finney, S. J., Griffiths, M., Harrison, D. A., Grieve, R., Sadique, Z., Sekhon, J. S., McAuley, D. F., Firmin, R. K., et al. (2011) · JAMA · doi:10.1001/jama.2011.1471 · Cited by 832 · see citing works
Andes, D. R., Safdar, N., Baddley, J. W., Playford, G., Reboli, A. C., Rex, J. H., Sobel, J. D., Pappas, P. G., Kullberg, B. J., & for the Mycoses Study Group (2012) · Clinical Infectious Diseases · doi:10.1093/cid/cis021 · Cited by 793 · see citing works
The co-pathogenesis of influenza viruses with bacteria in the lung.
McCullers, J. A. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3231 · Cited by 722 · see citing works
Kerkhove, M. D. V., Vandemaele, K., Shinde, V., Jaramillo-Gutierrez, G., Koukounari, A., Donnelly, C. A., Carlino, L. O., Owen, R., Paterson, B., Pelletier, L., et al. (2011) · PLoS Medicine · doi:10.1371/journal.pmed.1001053 · Cited by 707 · see citing works
Severe 2009 H1N1 Influenza in Pregnant and Postpartum Women in California
Louie, J. K., Acosta, M., Jamieson, D. J., & Honein, M. A. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0910444 · Cited by 646 · see citing works
Critical care crisis and some recommendations during the COVID-19 epidemic in China
Xie, J., Tong, Z., Guan, X., Du, B., Qiu, H., & Slutsky, A. S. (2020) · Intensive Care Medicine · doi:10.1007/s00134-020-05979-7 · Cited by 612 · see citing works
Prevention and Control of Seasonal Influenza with Vaccines
Grohskopf, L. A., Sokolow, L. Z., Broder, K. R., Olsen, S. J., Karron, R. A., Jernigan, D. B., & Bresee, J. (2016) · MMWR Recommendations and Reports · doi:10.15585/mmwr.rr6505a1 · Cited by 597 · see citing works
Pandemic Preparedness and Response — Lessons from the H1N1 Influenza of 2009
Fineberg, H. V. (2014) · New England Journal of Medicine · doi:10.1056/nejmra1208802 · Cited by 562 · see citing works
Influenza virus-related critical illness: pathophysiology and epidemiology
Kalil, A. C., & Thomas, P. G. (2019) · Critical Care · doi:10.1186/s13054-019-2539-x · Cited by 524 · see citing works
Projecting hospital utilization during the COVID-19 outbreaks in the United States
Moghadas, S. M., Shoukat, A., Fitzpatrick, M. C., Wells, C. R., Sah, P., Pandey, A., Sachs, J. D., Wang, Z., Meyers, L. A., Singer, B. H., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2004064117 · Cited by 480 · see citing works
Respiratory viral infection-induced microbiome alterations and secondary bacterial pneumonia.
Hanada, S., Pirzadeh, M., Carver, K. Y., & Deng, J. C. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02640 · Cited by 495 · see citing works
Morgan, O. W., Bramley, A. M., Fowlkes, A. L., Freedman, D. S., Taylor, T. H., Gargiullo, P. M., Belay, B., Jain, S., Cox, C. L., Kamimoto, L., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009694 · Cited by 445 · see citing works
Jenne, C. N., Wong, C. H. Y., Zemp, F. J., McDonald, B., Rahman, M. M., Forsyth, P. A., McFadden, G., & Kubes, P. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.01.005 · Cited by 443 · see citing works
COVID-19 and multiorgan failure: A narrative review on potential mechanisms
Mokhtari, T., Hassani, F., Ghaffari, N., Ebrahimi, B., Yarahmadi, A., & Hassanzadeh, G. (2020) · Journal of Molecular Histology · doi:10.1007/s10735-020-09915-3 · Cited by 440 · see citing works
2009 Pandemic Influenza A (H1N1)
Shieh, W.-J., Blau, D. M., Denison, A. M., DeLeon-Carnes, M., Adem, P., Bhatnagar, J., Sumner, J., Liu, L., Patel, M., Batten, B., et al. (2010) · The American Journal of Pathology · doi:10.2353/ajpath.2010.100115 · Cited by 429 · see citing works
A Novel Risk Factor for a Novel Virus: Obesity and 2009 Pandemic Influenza A (H1N1)
Louie, J. K., Acosta, M. Y., Samuel, M., Schechter, R., Vugia, D. J., Harriman, K. H., Matyas, B. T., & the California Pandemic (H1N1) Working Group (2011) · Clinical Infectious Diseases · doi:10.1093/cid/ciq152 · Cited by 425 · see citing works
Mortality from pandemic A/H1N1 2009 influenza in England: public health surveillance study
Donaldson, L. J., Rutter, P. D., Ellis, B. M., Greaves, F., Mytton, O. T., Pebody, R. G., & Yardley, I. E. (2009) · BMJ · doi:10.1136/bmj.b5213 · Cited by 421 · see citing works
Grohskopf, L. A., Shay, D. K., Shimabukuro, T. T., Sokolow, L. Z., Keitel, W. A., Bresee, J., & Cox, N. J. (2013) · Cited by 403 · see citing works
Rice, T. W., Rubinson, L., Uyeki, T. M., Vaughn, F. L., John, B. B., Miller, R. R., Higgs, E., Randolph, A. G., Smoot, B. E., & Thompson, B. T. (2012) · Critical Care Medicine · doi:10.1097/ccm.0b013e3182416f23 · Cited by 391 · see citing works
Bacterial Coinfection in Influenza: A Grand Rounds Review
Chertow, D. S., & Memoli, M. J. (2013) · JAMA · doi:10.1001/jama.2012.194139 · Cited by 390 · see citing works
Managing ICU surge during the COVID-19 crisis: Rapid guidelines.
Aziz, S., Arabi, Y. M., Alhazzani, W., Evans, L., Citerio, G., Fischkoff, K., Salluh, J., Meyfroidt, G., Alshamsi, F., Oczkowski, S., et al. (2020) · Intensive Care Medicine · doi:10.1007/s00134-020-06092-5 · Cited by 380 · see citing works
Th1 and Th17 hypercytokinemia as early host response signature in severe pandemic influenza
Bermejo-Martín, J. F., de Lejarazu, R. O., Pumarola, T., Rello, J., Almansa, R., Ramírez, P., Martín‐Loeches, I., Varillas‐Delgado, D., Gallegos, M. C., Arbeloa, C. S., et al. (2009) · Critical Care · doi:10.1186/cc8208 · Cited by 373 · see citing works
Patroniti, N. A., Zangrillo, A., Pappalardo, F., Peris, A., Cianchi, G., Braschi, A., Iotti, G. A., Arcadipane, A. F., Panarello, G., Ranieri, V. M., et al. (2011) · Intensive Care Medicine · doi:10.1007/s00134-011-2301-6 · Cited by 359 · see citing works
Kumar, D., Michaels, M. G., Morris, M. I., Green, M., Avery, R. K., Liu, C., Danziger‐Isakov, L. A., Stosor, V., Estabrook, M., Gantt, S. M., et al. (2010) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(10)70133-x · Cited by 361 · see citing works
Diabetes and the Severity of Pandemic Influenza A (H1N1) Infection
Allard, R., Leclerc, P., Tremblay, C. G., & Tannenbaum, T.-N. (2010) · Diabetes Care · doi:10.2337/dc09-2215 · Cited by 340 · see citing works
Comparison of Hospitalized Patients With ARDS Caused by COVID-19 and H1N1
Tang, X., Du, R.-H., Wang, R., Cao, T., Guan, L., Yang, C.-Q., Zhu, Q., Hu, M., Li, X.-Y., Li, Y., et al. (2020) · CHEST Journal · doi:10.1016/j.chest.2020.03.032 · Cited by 339 · see citing works
2009 pandemic influenza A (H1N1) in pregnancy: a systematic review of the literature
Mosby, L. G., Rasmussen, S. A., & Jamieson, D. J. (2011) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2010.12.033 · Cited by 335 · see citing works
Early Corticosteroids in Severe Influenza A/H1N1 Pneumonia and Acute Respiratory Distress Syndrome
Brun‐Buisson, C., Richard, J.-C., Mercat, A., Thiébaut, A. C. M., & Brochard, L. J. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201101-0135oc · Cited by 335 · see citing works
MacIntyre, C. R., Chughtai, A. A., Barnes, M., Ridda, I., Seale, H., Toms, R., & Heywood, A. (2018) · BMC Infectious Diseases · doi:10.1186/s12879-018-3548-0 · Cited by 323 · see citing works
Severity of 2009 Pandemic Influenza A (H1N1) Virus Infection in Pregnant Women
Creanga, A. A., Johnson, T. F., Graitcer, S. B., Hartman, L. K., Al‐Samarrai, T., Schwarz, A. G., Chu, S. Y., Sackoff, J. E., Jamieson, D. J., Fine, A. D., et al. (2010) · Obstetrics and Gynecology · doi:10.1097/aog.0b013e3181d57947 · Cited by 322 · see citing works
International Journal of Collaborative Research on Internal Medicine & Public Health
Valdivia, J. R. M. (2021) · Journal of Womens Health Issues and Care · Cited by 300 · see citing works
Metersky, M. L., Masterton, R. G., Lode, H., File, T. M., & Babinchak, T. (2012) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2012.01.003 · Cited by 293 · see citing works
Platelets in inflammation and infection
Jenne, C. N., & Kubes, P. (2015) · Platelets · doi:10.3109/09537104.2015.1010441 · Cited by 271 · see citing works
Correlates of severe disease in patients with 2009 pandemic influenza (H1N1) virus infection
Zarychanski, R., Stuart, T. L., Kumar, A., Doucette, S. P., Elliott, L. J., Kettner, J., & Plummer, F. A. (2010) · Canadian Medical Association Journal · doi:10.1503/cmaj.091884 · Cited by 270 · see citing works
Self-citationCorticosteroids as adjunctive therapy in the treatment of influenza
Rodrigo, C., Leonardi‐Bee, J., Nguyen‐Van‐Tam, J. S., & Lim, W. S. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010406.pub2 · Cited by 265 · see citing works
Wauters, J., Baar, I., Meersseman, P., Meersseman, W., Dams, K., Paep, R. D., Lagrou, K., Wilmer, A. P., Jorens, P. G., & Hermans, G. (2012) · Intensive Care Medicine · doi:10.1007/s00134-012-2673-2 · Cited by 264 · see citing works
Critical care management of adults with community-acquired severe respiratory viral infection
Arabi, Y. M., Fowler, R., & Hayden, F. G. (2020) · Intensive Care Medicine · doi:10.1007/s00134-020-05943-5 · Cited by 260 · see citing works
Robinson, D. P., Lorenzo, M. E., Jian, W., & Klein, S. L. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002149 · Cited by 257 · see citing works
Nguyen‐Van‐Tam, J. S., Openshaw, P., Hashim, A., Gadd, E. M., Lim, W. S., Semple, M. G., Read, R. C., Taylor, B. L., Brett, S. J., McMenamin, J., et al. (2010) · Thorax · doi:10.1136/thx.2010.135210 · Cited by 248 · see citing works
Sud, S., Sud, M. K., Friedrich, J. O., Meade, M., Ferguson, N. D., Wunsch, H., & Adhikari, N. K. J. (2010) · BMJ · doi:10.1136/bmj.c2327 · Cited by 245 · see citing works
Xu, J., Yang, X., Yang, L., Zou, X., Wang, Y., Wu, Y., Zhou, T., Yuan, Y., Qi, H., Fu, S., et al. (2020) · Critical Care · doi:10.1186/s13054-020-03098-9 · Cited by 236 · see citing works
Complications of seasonal and pandemic influenza
Rothberg, M. B., & Haessler, S. (2010) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181c92eeb · Cited by 237 · see citing works
Fezeu, L., Julia, C., Henegar, A., Bitu, J., Hu, F. B., Grobbee, D. E., Kengne, A. P., Herçberg, S., & Czernichow, S. (2011) · Obesity Reviews · doi:10.1111/j.1467-789x.2011.00864.x · Cited by 236 · see citing works
Iwasaki, M., Saito, J., Zhao, H., Sakamoto, A., Hirota, K., & Ma, D. (2020) · Inflammation · doi:10.1007/s10753-020-01337-3 · Cited by 229 · see citing works
Pandemic 2009 Influenza A in Argentina: A Study of 337 Patients on Mechanical Ventilation
Estenssoro, E., Ríos, F. G., Apezteguía, C., Reina, R., Neira, J., Ceraso, D. H., Orlandi, C., Valentini, R., Tiribelli, N., Brizuela, M., et al. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/201001-0037oc · Cited by 230 · see citing works
Acute respiratory distress syndrome: new definition, current and future therapeutic options.
Fanelli, V., Vlachou, A., Ghannadian, S., Simonetti, U., Slutsky, A. S., & Zhang, H. (2013) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2072-1439.2013.04.05 · Cited by 229 · see citing works
Clinical aspects and cytokine response in severe H1N1 influenza A virus infection
Hagău, N., Slavcovici, A., Gonganau, D. N., Oltean, S., Dîrzu, D. S., Brezoszki, E. S., Maxim, M., Ciuce, C., Mleșnițe, M., Gavrus, R. L., et al. (2010) · Critical Care · doi:10.1186/cc9324 · Cited by 227 · see citing works
Sullivan, S. J., Jacobson, R. M., Dowdle, W. R., & Poland, G. A. (2009) · Mayo Clinic Proceedings · doi:10.4065/mcp.2009.0588 · Cited by 228 · see citing works
Critically Ill Children During the 2009–2010 Influenza Pandemic in the United States
Randolph, A. G., Vaughn, F., Sullivan, R., Rubinson, L., Thompson, B. T., Yoon, G., Smoot, E., Rice, T. W., Loftis, L. L., Helfaer, M., et al. (2011) · Pediatrics · doi:10.1542/peds.2011-0774 · Cited by 222 · see citing works
Mechanisms of sex disparities in influenza pathogenesis
Klein, S. L., Hodgson, A., & Robinson, D. P. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.0811427 · Cited by 219 · see citing works
Kim, S.-H., Hong, S., Yun, S.-C., Choi, W.-I., Ahn, J.-J., Lee, Y. J., Lee, H.-B., Lim, C., & Koh, Y. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201101-0110oc · Cited by 219 · see citing works
The conneXion between sex and immune responses
Forsyth, K. S., Jiwrajka, N., Lovell, C. D., Toothacre, N. E., & Anguera, M. C. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-00996-9 · Cited by 226 · see citing works
Martín‐Loeches, I., Lisboa, T. C., Rhodes, A., Moreno, R. P., Silva, E., Sprung, C. L., Chiche, J., Barahona, D., Villabon, M., Balasini, C., et al. (2010) · Intensive Care Medicine · doi:10.1007/s00134-010-2078-z · Cited by 211 · see citing works
Outcomes of adults hospitalised with severe influenza
Lee, N. L. S., Choi, K. W. Y., Chan, P. K. S., Hui, D. S. C., Lui, G. C.-Y., Wong, B. C. K., Wong, R. Y. K., Sin, W. Y., Hui, W. M., Ngai, K. L. K., et al. (2010) · Thorax · doi:10.1136/thx.2009.130799 · Cited by 209 · see citing works
Influenza virus-related critical illness: prevention, diagnosis, treatment
Chow, E. J., Doyle, J., & Uyeki, T. M. (2019) · Critical Care · doi:10.1186/s13054-019-2491-9 · Cited by 208 · see citing works
Lansbury, L. E., Rodrigo, C., Leonardi-Bee, J., Nguyen-Van-Tam, J., & Shen Lim, W. (2020) · Critical Care Medicine · doi:10.1097/ccm.0000000000004093 · Cited by 207 · see citing works
Martín-Loeches, I., Sanchez-Corral, A., Diaz, E., Granada, R. M., Zaragoza, R., Villavicencio, C., Albaya, A., Cerdá, E., Catalán, R. M., Luque, P., et al. (2011) · Chest · doi:10.1378/chest.10-1396 · Cited by 203 · see citing works
The weight of obesity on the human immune response to vaccination
Painter, S. D., Ovsyannikova, I. G., & Poland, G. A. (2015) · Vaccine · doi:10.1016/j.vaccine.2015.06.101 · Cited by 203 · see citing works
Noninvasive Ventilation for Acute Respiratory Failure
HESS, D. R. (2013) · Respiratory Care · doi:10.4187/respcare.02319 · Cited by 201 · see citing works
Hospitalization and Critical Care of 109 Decedents with COVID-19 Pneumonia in Wuhan, China
Du, R., Liu, L., Yin, W., Wang, W., Guan, L., Yuan, M.-L., Li, Y.-L., Hu, Y., Li, X., Sun, B., et al. (2020) · Annals of the American Thoracic Society · doi:10.1513/annalsats.202003-225oc · Cited by 198 · see citing works
Obesity and Respiratory Hospitalizations During Influenza Seasons in Ontario, Canada: A Cohort Study
Kwong, J. C., Campitelli, M. A., & Rosella, L. C. (2011) · Clinical Infectious Diseases · doi:10.1093/cid/cir442 · Cited by 196 · see citing works
Sun, X., Shi, Y., Zeng, Q., Wang, Y., Du, W., Wei, N., Xie, R., & Chang, C. J. (2013) · BMC Public Health · doi:10.1186/1471-2458-13-261 · Cited by 194 · see citing works
Muthuri, S. G., Myles, P. R., Venkatesan, S., Leonardi‐Bee, J., & Nguyen‐Van‐Tam, J. S. (2012) · The Journal of Infectious Diseases · doi:10.1093/infdis/jis726 · Cited by 193 · see citing works
Corticosteroids as adjunctive therapy in the treatment of influenza
Lansbury, L., Rodrigo, C., Leonardi‐Bee, J., Nguyen‐Van‐Tam, J. S., & Lim, W. S. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010406.pub3 · Cited by 195 · see citing works
Adhikari, N. K. J., Dellinger, R. P., Lundin, S., Payen, D. M., Vallet, B., Gerlach, H., Park, K. J., Mehta, S., Slutsky, A. S., & Friedrich, J. O. (2013) · Critical Care Medicine · doi:10.1097/ccm.0b013e3182a27909 · Cited by 189 · see citing works
Immortal time bias in observational studies of time-to-event outcomes
Jones, M., & Fowler, R. (2016) · Journal of Critical Care · doi:10.1016/j.jcrc.2016.07.017 · Cited by 190 · see citing works
Platelets in Immune Response to Virus and Immunopathology of Viral Infections
Hottz, E. D., Bozza, F. A., & Bozza, P. T. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00121 · Cited by 188 · see citing works
Epidemiology of 2009 Pandemic Influenza A (H1N1) in the United States
Jhung, M. A., Swerdlow, D. L., Olsen, S. J., Jernigan, D. B., Biggerstaff, M., Kamimoto, L., Kniss, K. L., Reed, C., Fry, A. M., Brammer, L., et al. (2010) · Clinical Infectious Diseases · doi:10.1093/cid/ciq008 · Cited by 187 · see citing works
Xie, J., Wu, W., Li, S., Hu, Y., Hu, M., Li, J., Yang, Y., Huang, T., Zheng, K. C., Wang, Y., et al. (2020) · Intensive Care Medicine · doi:10.1007/s00134-020-06211-2 · Cited by 187 · see citing works
Distinct phenotypes require distinct respiratory management strategies in severe COVID-19
Robba, C., Battaglini, D., Ball, L., Patroniti, N. A., Loconte, M., Brunetti, I., Vena, A., Giacobbe, D. R., Bassetti, M., Rocco, P. R. M., et al. (2020) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2020.103455 · Cited by 185 · see citing works
Risk of severe outcomes among patients admitted to hospital with pandemic (H1N1) influenza
Campbell, A., Rodin, R., Kropp, R., Mao, Y., Hong, Z., Vachon, J., Spika, J. S., & Pelletier, L. (2010) · Canadian Medical Association Journal · doi:10.1503/cmaj.091823 · Cited by 183 · see citing works
Sex Hormones Regulate Innate Immune Cells and Promote Sex Differences in Respiratory Virus Infection
Kadel, S., & Kovats, S. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01653 · Cited by 181 · see citing works
Coronavirus Disease 2019 as Cause of Viral Sepsis: A Systematic Review and Meta-Analysis*
Karakike, E., Giamarellos‐Bourboulis, E. J., Kyprianou, M., Fleischmann-Struzek, C., Pletz, M. W., Netea, M. G., Reinhart, K., & Kyriazopoulou, E. (2021) · Critical Care Medicine · doi:10.1097/ccm.0000000000005195 · Cited by 182 · see citing works
F ifty Y ears of R esearch in ARDS. Is Acute Respiratory Distress Syndrome a Preventable Disease?
Yadav, H., Thompson, B., & Gajic, O. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201609-1767ci · Cited by 179 · see citing works
Impact of Seasonal and Pandemic Influenza on Emergency Department Visits, 2003–2010, Ontario, Canada
Schanzer, D. L., & Schwartz, B. (2013) · Academic Emergency Medicine · doi:10.1111/acem.12111 · Cited by 175 · see citing works
Risk Factors for Severe Illness with 2009 Pandemic Influenza A (H1N1) Virus Infection in China
Yu, H., Feng, Z., Uyeki, T. M., Liao, Q., Zhou, L., Feng, S., Ye, M., Xiang, N., Huai, Y., Yuan, Y., et al. (2011) · Clinical Infectious Diseases · doi:10.1093/cid/ciq144 · Cited by 175 · see citing works
Host adaptive immunity deficiency in severe pandemic influenza
Bermejo-Martín, J. F., Martín‐Loeches, I., Rello, J., Antón, A., Almansa, R., Xu, L., López–Campos, G., Pumarola, T., Ran, L., Ramírez, P., et al. (2010) · Critical Care · doi:10.1186/cc9259 · Cited by 174 · see citing works
Shekar, K., Mullany, D. V., Thomson, B., Ziegenfuss, M. D., Platts, D. G., & Fraser, J. F. (2014) · Critical Care · doi:10.1186/cc13865 · Cited by 168 · see citing works
Moser, J. S., Galindo‐Fraga, A., Ortiz-Hernández, A. A., Gu, W., Hunsberger, S., Galán‐Herrera, J., Guerrero, M. L., Ruiz-Palacios, G. M., Beigel, J. H., & The La Red ILI 002 Study Group (2018) · Influenza and Other Respiratory Viruses · doi:10.1111/irv.12618 · Cited by 169 · see citing works
Einav, S., Hick, J. L., Hanfling, D., Erstad, B. L., Toner, E. S., Branson, R. D., Kanter, R. K., Kissoon, N. “., Dichter, J. R., Devereaux, A. V., et al. (2014) · CHEST Journal · doi:10.1378/chest.14-0734 · Cited by 167 · see citing works
Obesity predisposes to the risk of higher mortality in young COVID‐19 patients
Zhang, F., Xiong, Y., Wei, Y., Hu, Y., Wang, F., Li, G., Liu, K., Du, R., Wang, C., & Zhu, W. (2020) · Journal of Medical Virology · doi:10.1002/jmv.26039 · Cited by 165 · see citing works
Sprung, C. L., Zimmerman, J. L., Christian, M. D., Joynt, G. M., Hick, J. L., Taylor, B., Richards, G. A., Sandrock, C., Cohen, R., & Adini, B. B. (2010) · Intensive Care Medicine · doi:10.1007/s00134-010-1759-y · Cited by 167 · see citing works
Projecting demand for critical care beds during COVID-19 outbreaks in Canada
Shoukat, A., Wells, C. R., Langley, J. M., Singer, B. H., Galvani, A. P., & Moghadas, S. M. (2020) · Canadian Medical Association Journal · doi:10.1503/cmaj.200457 · Cited by 163 · see citing works
Miller, R. R., Markewitz, B. A., Rolfs, R. T., Brown, S. M., Dascomb, K. K., Grissom, C. K., Friedrichs, M. D., Mayer, J., Hirshberg, E. L., Conklin, J., et al. (2009) · CHEST Journal · doi:10.1378/chest.09-2517 · Cited by 157 · see citing works
Quispe-Laime, A. M., Bracco, J. D., Barberio, P. A., Campagne, C. G., Rolfo, V. E., Umberger, R. A., & Meduri, G. U. (2009) · Intensive Care Medicine · doi:10.1007/s00134-009-1727-6 · Cited by 156 · see citing works
Winck, J. C., & Ambrosino, N. (2020) · Pulmonology · doi:10.1016/j.pulmoe.2020.04.013 · Cited by 157 · see citing works
Biomarkers of inflammation and the etiology of sepsis
Grondman, I., Pîrvu, A., Riza, A. L., Ioana, M. I., & Netea, M. G. (2020) · Biochemical Society Transactions · doi:10.1042/bst20190029 · Cited by 149 · see citing works
Treatment and Prevention of Pandemic H1N1 Influenza
Rewar, S., Mirdha, D., & Rewar, P. (2016) · Annals of Global Health · doi:10.1016/j.aogh.2015.08.014 · Cited by 148 · see citing works
Belongia, E. A. (2010) · JAMA · doi:10.1001/jama.2010.1277 · Cited by 146 · see citing works
Interleukin-6 Is a Potential Biomarker for Severe Pandemic H1N1 Influenza A Infection
Paquette, S. G., Banner, D., Zhao, Z., Yuan, F., Huang, S. S. H., Leon, A. J., Ng, D. C. K., Almansa, R., Martín‐Loeches, I., Ramírez, P., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038214 · Cited by 144 · see citing works
- Authors
- Kumar, A.
- Affiliations
- Health Sciences Centre (CA)
- Corresponding author
- Kumar, Anand
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2009-11-04
- Volume
- 302
- Issue
- 17
- Pages
- 1872
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2148958087
- Cited by
- 1,425
- References
- 47
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 16 · 2023: 23 · 2022: 28 · 2021: 55 · 2020: 89 · 2019: 38 · 2018: 33 · 2017: 35 · 2016: 53 · 2015: 63 · 2014: 74 · 2013: 128 · 2012: 156
- FWCI
- 171.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Thoracic Society
- Alberta Health Services
- Hamilton Health Sciences
- McGill University
- London Health Sciences Centre
- McMaster University
- BC Children's Hospital
- McGill University Health Centre
- University of Alberta
- University of Toronto
- Jewish General Hospital
- Hospital for Sick Children
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Keywords
- pandemic influenza, critically ill patients, intensive care, mortality, mechanical ventilation, hypoxemia, neuraminidase inhibitors, organ dysfunction, shock, Aboriginal Canadians, pediatric patients, treatment outcomes, Canada, influenza A (H1N1) 2009
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Hypoxia, Canada, Child, Child, Preschool, Disease Outbreaks, Female, Humans, Infant, Influenza, Human, Intensive Care Units, Length of Stay, Male, Middle Aged, Multiple Organ Failure, Prospective Studies, Respiration, Artificial, Respiratory Distress Syndrome, Comorbidity, Critical Illness, Age Distribution, Influenza A Virus, H1N1 Subtype, Kaplan-Meier Estimate, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
