The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Effects of Diet and Physical Activity Interventions on Weight Loss and Cardiometabolic Risk Factors in Severely Obese Adults: A Randomized Trial
Open accessAbstract
CONTEXT: The prevalence of severe obesity is increasing markedly, as is prevalence of comorbid conditions such as hypertension and type 2 diabetes mellitus; however, apart from bariatric surgery and pharmacotherapy, few clinical trials have evaluated the treatment of severe obesity. OBJECTIVE: To determine the efficacy of a weight loss and physical activity intervention on the adverse health risks of severe obesity. DESIGN, SETTING, AND PARTICIPANTS: Single-blind randomized trial conducted from February 2007 through April 2010 at the University of Pittsburgh. Participants were 130 (37% African American) severely obese (class II or III) adult participants without diabetes recruited from the community. INTERVENTIONS: One-year intensive lifestyle intervention consisting of diet and physical activity. One group (initial physical activity) was randomized to diet and physical activity for the entire 12 months; the other group (delayed physical activity) had the identical dietary intervention but with physical activity delayed for 6 months. MAIN OUTCOME MEASURES: Changes in weight. Secondary outcomes were additional components comprising cardiometabolic risk, including waist circumference, abdominal adipose tissue, and hepatic fat content. RESULTS: Of 130 participants randomized, 101 (78%) completed the 12-month follow-up assessments. Although both intervention groups lost a significant amount of weight at 6 months, the initial-activity group lost significantly more weight in the first 6 months compared with the delayed-activity group (10.9 kg [95% confidence interval {CI}, 9.1-12.7] vs 8.2 kg [95% CI, 6.4-9.9], P = .02 for group × time interaction). Weight loss at 12 months, however, was similar in the 2 groups (12.1 kg [95% CI, 10.0-14.2] vs 9.9 kg [95% CI, 8.0-11.7], P = .25 for group × time interaction). Waist circumference, visceral abdominal fat, hepatic fat content, blood pressure, and insulin resistance were all reduced in both groups. The addition of physical activity promoted greater reductions in waist circumference and hepatic fat content. CONCLUSION: Among patients with severe obesity, a lifestyle intervention involving diet combined with initial or delayed initiation of physical activity resulted in clinically significant weight loss and favorable changes in cardiometabolic risk factors. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00712127.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Several exercise trials combined with weight loss reported larger improvements in CVD risk factors.21,40,41”
From Aerobic, resistance, or combined exercise training and cardiovascular risk profile in overweight or obese adults: the CardioRACE trial (2024) · cites this paper as [21]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502
Prevalence and Trends in Obesity Among US Adults, 1999-2008
Flegal, K. M. (2010) · JAMA · doi:10.1001/jama.2009.2014 · Cited by 7,580
Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery
Sjöström, L., Lindroos, A.-K., Peltonen, M., Torgerson, J., Bouchard, C., Carlsson, B., Dahlgren, S., Larsson, B., Narbro, K., Sjöström, C. D., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa035622 · Cited by 4,457
DONNELLY, J. E., BLAIR, S. N., JAKICIC, J. M., MANORE, M. M., RANKIN, J. W., & SMITH, B. K. (2009) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181949333 · Cited by 2,658
Self-citationPark, Y.-W., Zhu, S., Palaniappan, L., Heshka, S., Carnethon, M. R., & Heymsfield, S. B. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.4.427 · Cited by 2,074
A Randomized Trial of a Low-Carbohydrate Diet for Obesity
Foster, G. D., Wyatt, H. R., Hill, J. O., McGuckin, B. G., Brill, C., Mohammed, B. S., Szapary, P. O., Rader, D. J., Edman, J. S., & Klein, S. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022207 · Cited by 1,794
Reduction in Weight and Cardiovascular Disease Risk Factors in Individuals With Type 2 Diabetes
The Look AHEAD Research Group (2007) · Diabetes Care · doi:10.2337/dc07-0048 · Cited by 1,522
Dixon, J. B., O’Brien, P. E., Playfair, J., Chapman, L., Schachter, L. M., Skinner, S., Proietto, J., Bailey, M., & Anderson, M. (2008) · JAMA · doi:10.1001/jama.299.3.316 · Cited by 1,434
A Low-Carbohydrate as Compared with a Low-Fat Diet in Severe Obesity
Samaha, F. F., Iqbal, N., Seshadri, P., Chicano, K. L., Daily, D. A., McGrory, J., Williams, T., Williams, M., Gracely, E. J., & Stern, L. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022637 · Cited by 1,267
Effect of laparoscopic Roux-en Y gastric bypass on type 2 diabetes mellitus
Schauer, P. R., Burguera, B., Ikramuddin, S., Cottam, D., Gourash, W., Hamad, G., Eid, G. M., Mattar, S., Ramanathan, R., Barinas-Mitchel, E., et al. (2003) · Annals of Surgery · doi:10.1097/01.sla.0000089851.41115.1b · Cited by 1,183
Self-citation
Cited by
Sorted by citations
Items 501–556 of 556
Les inconvénients de perdre du poids
Bosomworth, N. J. (2012) · Canadian Family Physician
FACTORS ASSOCIATED WITH PHYSICAL ACTIVITY IN PATIENTS UNDERGOING BARIATRIC SURGERY
Kovacs, S. J. (2017) · D-Scholarship@Pitt (University of Pittsburgh)
Kubat, E., Giori, N. J., Hwa, K. J., & Eisenberg, D. (2016)
Obesity Treatment Alternatives: Foods to Surgery
Bayham, B. E. (2011) · doi:10.31390/gradschool_theses.3593
Prevalence of interstitial and other lung diseases on Aruba.
Deenstra, D. D., Niek, W., Kock, S., Stuart, W. J., Cobben, N. A. M., Wijnen, P. A. H. M., & Drent, M. (2017) · Sarcoidosis vasculitis and diffuse lung diseases · doi:10.36141/svdld.v34i3.6038
Noori, J. A. (2016) · Universiti Putra Malaysia Institutional Repository (Universiti Putra Malaysia)
Hicks, T. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/twc7-e248
MULTIDISCIPLINARY APPROACH TO TREATMENT OF PROTEIN MALNUTRITION SYNDROME (CLINICAL CASE)
Perekhrestenko, O. V., LISUN, Y. B., Калашніков, О. О., Зуб, Ю. М., Кішенко, Ю. І., & Бак, Р. П. (2019) · Pain anesthesia and intensive care · doi:10.25284/2519-2078.3(88).2019.177398
An Approach to Obesity Management for Gastroenterologists and Hepatologists
Briscoe, J., Saumoy, M., & Pickett‐Blakely, O. (2019) · Current Treatment Options in Gastroenterology · doi:10.1007/s11938-019-00250-5
Okechukwu, C. E. (2020) · International Journal of Health & Allied Sciences · doi:10.4103/ijhas.ijhas_116_19
Management of the High-Risk Bariatric Surgery Candidate
Benotti, P. N. (2014) · Springer eBooks · doi:10.1007/978-1-4939-0906-3_13
Maghroun, M., Mohammadifard, N., Sajjadi, F., Jafari-Dinani, N., Karimi, S., Rabiei, K., Masoudi, S., & Sarrafzadegan, N. (2021) · PubMed Central · doi:10.22122/arya.v17i0.1698
An android based fitness and nutritional plan application
Vaidya, S., Ladke, A., Satikosare, P., Barapatre, D., & Meshram, P. M. (2021) · International journal of advance research and innovative ideas in education
Suboc, G., & Oshman, L. D. (2021) · Evidence-Based Practice · doi:10.1097/ebp.0000000000001352
Hospital-affiliated Medical Fitness Center Usage: Findings from a 12-week Weight Management Program
Nichols, M., Alemagno, S. A., Stephens, P. C., & Jackson, C. (2018) · Journal of Public Health Issues and Practices · doi:10.33790/jphip1100108
McNeil, J. (2021) · NC Digital Online Collection of Knowledge and Scholarship (The University of North Carolina at Greensboro)
Physical Activity and Writing an Exercise Prescription
Peraino, A. (2015) · Endocrine updates · doi:10.1007/978-1-4939-2146-1_5
Assessment of Effect of Exercise on Body Composition in Obese and Overweight
Shireesha, R., & Obulesu, O. (2022) · Annals of International medical and Dental Research · doi:10.53339/aimdr.2022.8.1.1
Sympathetic Nervous System and Cardiovascular Alterations Due to Food Restrictions
Shah, A. K., & Dhalla, N. S. (2021) · Advances in biochemistry in health and disease · doi:10.1007/978-3-030-84763-0_15
Richard, S. M., DeBerard, S. C., & Murray, J. (2020) · Springer eBooks · doi:10.1007/978-3-030-39903-0_1616
Egan, B. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733721587.793550370
Ferro, I. D. S., Araújo, M. Y. C., Rocha, A. P. R., Queiroz, D. C., Juday, V., & Codogno, J. S. (2019) · journal of physical education · doi:10.4025/jphyseduc.v30i13058
Richard, S. M., & DeBerard, S. (2012) · Springer eBooks · doi:10.1007/978-1-4419-1005-9_1616
Alick, C., Braxton, D., Skinner, H. G., Alexander, R., Ammerman, A., Keyserling, T., & Samuel-Hodge, C. (2023) · American Journal of Health Promotion · doi:10.1177/08901171231190597
Castilho, M. M., de Souza, A. A., de Sousa, T. R., Faúndez-Casanova, C., Alexandrino, W. G. D. S., Moya-Mata, I., Pascoini, M. J. D. S., Franzini, P. C., Westphal, G., & Nardo, N. (2023) · Ciencias de la actividad física · doi:10.29035/rcaf.24.2.5
Tahir, A. R. M., Haw, V. J., Zaid, W. S. W., Nizaruddin, M. A., & Ludin, A. F. M. (2023) · Turkish Journal of Pharmaceutical Sciences · doi:10.4274/tjps.galenos.2023.23428
Obesity and Metabolic Syndrome in the United States
Osei, A. D., Ohene-Kyei, E. T., & Echouffo-Tcheugui, J. B. (2023) · Springer eBooks · doi:10.1007/978-3-319-12125-3_55-1
Javadi, L., Moradi, S., Amirpoor, M., Majidi, V., & Nikniaz, L. (2023) · Crescent Journal of Medical and Biological Sciences · doi:10.34172/cjmb.2023.4002
Erregungszustände, Symptome, Verhalten, Schlaf und Körpertemperatur
Brown, R. F., & Thorsteinsson, E. (2024) · Springer eBooks · doi:10.1007/978-3-031-55637-1_7
Makuch, R., Kucharski, A., Pilarski, K., Chrościcka, A., Gała, K., Czajka, A., Lenard, P., Michalska, S., Dewicka, M., & Wawrzyniak, A. M. (2024) · Quality in Sport · doi:10.12775/qs.2024.15.52231 · Cited by 1
Gesundheit – Ernährung in Prävention und Therapie typisch ernährungsassoziierter Erkrankungen
Kolm, M. (2024) · Springer eBooks · doi:10.1007/978-3-662-68301-9_5
Hu, N., Ai, B., Wang, Y., Ren, Y., Chen, H., Chen, Z., & Li, W. (2024) · BMC Infectious Diseases · doi:10.1186/s12879-024-10064-1
Intensive Lifestyle Interventions as a Measure to Reduce the Rising Obesity Cases
Limiri, D. M. (2024) · Premier journal of public health. · doi:10.70389/pjph.100013
Jia, C., Yi, Y., & Xu, Q. (2025) · Journal of Applied Gerontology · doi:10.1177/07334648251355051
Weight Management Through a Woman’s Life Stages: A Practical Evidence-Based Guide
Scholcoff, C., Yecies, E. B., Worthington, R. O., & Farkas, A. H. (2025) · Journal of Women s Health · doi:10.1177/15409996251405062
Physical Activity as a Weight Management Strategy
Jakicic, J. M., & Rogers, R. J. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1203-2_15
Self-citationOkube, O. T., Kimani, S. T., & Waithira, M. (2023) · Research Square · doi:10.21203/rs.3.rs-2353352/v1
Hei, Y., & Xie, Y. (2025) · Nutrition Reviews · doi:10.1093/nutrit/nuaf217
Zou, Y., Cao, Z., Chen, Y., Yuan, M., Zhang, Z., Gu, W., Wang, J., Zhao, S., & Hong, J. (2026) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s573217
Plasticité des muqueuses gastrique et instestinale après chirurgie bariatrique
Ribeiro‐Parenti, L. (2018) · theses.fr (ABES) · doi:10.70675/ebd178d7z525fz46c6z9ca5z6babd16dee1b
Cailleaux, P. (2022) · theses.fr (ABES) · doi:10.70675/c86911ecz3e22z449fzb988ze55d8c9e7ae8
Wallentowitz, L., García, M. G., Atorrasagasti, C., Harms, C., Huhn, E. A., Roser, P., Verlohren, S., Giesen, E. M., & Blois, S. M. (2026) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-026-10053-6 · Cited by 3
Zhang, R., Jin, A., Fan, X., Li, F., Feng, Y., Zeng, L., Wang, J., Fan, N., Niu, L., & Liu, D. (2026) · Translational Vision Science & Technology · doi:10.1167/tvst.15.6.24
Liu, Y., Zhao, M., & Qian, B. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1835096
张, 晓. (2026) · Advances in Clinical Medicine · doi:10.12677/acm.2026.1672703
Hu, P., Wang, Y., Zheng, G., Qian, Z. M., Chen, G., Tian, F., Wei, S., Zhuang, Z., Elliott, M., Kavuri, M., et al. (2026) · Acta Diabetologica · doi:10.1007/s00592-026-02764-8
Kovyanova, T. I., Nerush, M. O., Карагодин, В. П., Borodko, D. D., Rozhkova, U. V., Antonov, S. A., & Utkina, A. S. (2026) · Biomedicines · doi:10.3390/biomedicines14081868
Lee, J., Kim, T., Hwang, D., Kyun, S., Jang, I., Kim, N., Lim, K., Park, H., Kwon, I., Kim, S.-W., et al. (2026) · Metabolites · doi:10.3390/metabo16090618
Parashar, A., Negi, G. S., Marwaha, R., Lal, P., & Gupta, A. K. (2026) · International Journal of Preventive Medicine · doi:10.4103/ijpvm.ijpvm_326_25
Lin, T., Dakup, P., Schepmoes, A., Fillmore, T., Swensen, A., Kelly, S. S., Zhang, T., Pu, J., Jacobs, J., DeLany, J. P., et al. (2026) · Clinical Proteomics · doi:10.1186/s12014-026-09625-0
Self-citationLi, Q., Chen, Z., Xu, G., & Zhang, J. J. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1969222
Cardiovascular disease among diabetic women with bilateral oophorectomy.
Appiah, D. (2013) · ThinkIR: The University of Louisville's Institutional Repository (University of Louisville) · doi:10.18297/etd/43
Impact of diet induced obesity on mouse skeletal muscle health: metabolism, growth and regeneration.
Trajcevski, K. E. (2014) · MacSphere (McMaster University) · doi:10.71548/22585
Martinez, E. E. (2014) · DukeSpace (Duke University)
Metadata
- Authors
- Goodpaster, B. H., DeLany, J. P., Otto, A. D., Kuller, L., Vockley, J., South-Paul, J. E., Thomas, S. B., Brown, J., McTigue, K., Hames, K. C., Lang, W., & Jakicic, J. M.
- Affiliations
- University of Pittsburgh (US)
- ORCID
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2010-10-27
- Volume
- 304
- Issue
- 16
- Pages
- 1795
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- PMC
- PMC3082279
- OpenAlex
- W2093609715
- Cited by
- 558
- References
- 41
- Citations by year
- 2026: 15 · 2025: 16 · 2024: 14 · 2023: 22 · 2022: 24 · 2021: 32 · 2020: 20 · 2019: 28 · 2018: 27 · 2017: 33 · 2016: 46 · 2015: 59 · 2014: 60 · 2013: 53 · 2012: 56
- FWCI
- 51.02
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Pennsylvania Department of Health
- University of Pittsburgh
- National Institutes of Health (UL1TR000005)
- Medical Center, University of Pittsburgh
- National Institute on Aging (P30AG024827)
- National Institute of Diabetes and Digestive and Kidney Diseases (T32-DK07052, R01DK078775, T32DK007052)
- National Center for Research Resources (UL1RR024153)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- morbid obesity, weight loss, lifestyle intervention, dietary intervention, physical activity, cardiometabolic risk factors, hepatic fat content, visceral adipose tissue, waist circumference, insulin resistance, blood pressure, hypertension, type 2 diabetes prevention, African American adults, bariatric surgery alternatives, obesity-related comorbidities
- MeSH terms
- Adult, Blood Pressure, Cardiovascular Diseases, Diet, Exercise Therapy, Female, Humans, Insulin Resistance, Life Style, Liver, Male, Middle Aged, Obesity, Morbid, Risk Factors, Time Factors, Weight Loss, Single-Blind Method, Treatment Outcome, Intra-Abdominal Fat, Waist Circumference
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
