The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Association of Age and Sex With Myocardial Infarction Symptom Presentation and In-Hospital Mortality
Open accessAbstract
CONTEXT: Women are generally older than men at hospitalization for myocardial infarction (MI) and also present less frequently with chest pain/discomfort. However, few studies have taken age into account when examining sex differences in clinical presentation and mortality. OBJECTIVE: To examine the relationship between sex and symptom presentation and between sex, symptom presentation, and hospital mortality, before and after accounting for age in patients hospitalized with MI. DESIGN, SETTING, AND PATIENTS: Observational study from the National Registry of Myocardial Infarction, 1994-2006, of 1,143,513 registry patients (481,581 women and 661,932 men). MAIN OUTCOME MEASURES: We examined predictors of MI presentation without chest pain and the relationship between age, sex, and hospital mortality. RESULTS: The proportion of MI patients who presented without chest pain was significantly higher for women than men (42.0% [95% CI, 41.8%-42.1%] vs 30.7% [95% CI, 30.6%-30.8%]; P < .001). There was a significant interaction between age and sex with chest pain at presentation, with a larger sex difference in younger than older patients, which became attenuated with advancing age. Multivariable adjusted age-specific odds ratios (ORs) for lack of chest pain for women (referent, men) were younger than 45 years, 1.30 (95% CI, 1.23-1.36); 45 to 54 years, 1.26 (95% CI, 1.22-1.30); 55 to 64 years, 1.24 (95% CI, 1.21-1.27); 65 to 74 years, 1.13 (95% CI, 1.11-1.15); and 75 years or older, 1.03 (95% CI, 1.02-1.04). Two-way interaction (sex and age) on MI presentation without chest pain was significant (P < .001). The in-hospital mortality rate was 14.6% for women and 10.3% for men. Younger women presenting without chest pain had greater hospital mortality than younger men without chest pain, and these sex differences decreased or even reversed with advancing age, with adjusted OR for age younger than 45 years, 1.18 (95% CI, 1.00-1.39); 45 to 54 years, 1.13 (95% CI, 1.02-1.26); 55 to 64 years, 1.02 (95% CI, 0.96-1.09); 65 to 74 years, 0.91 (95% CI, 0.88-0.95); and 75 years or older, 0.81 (95% CI, 0.79-0.83). The 3-way interaction (sex, age, and chest pain) on mortality was significant (P < .001). CONCLUSION: In this registry of patients hospitalized with MI, women were more likely than men to present without chest pain and had higher mortality than men within the same age group, but sex differences in clinical presentation without chest pain and in mortality were attenuated with increasing age.
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Cites
Universal Definition of Myocardial Infarction
Thygesen, K., Alpert, J. S., White, H. D., TASK FORCE MEMBERS: Chairpersons: Kristian Thygesen (Denmark), J. S. A. (., Biomarker Group: Allan S. Jaffe, C. (., ECG Group: Bernard Chaitman, C.-O. (., Imaging Group: Richard Underwood, C. (., Intervention Group: Jean-Pierre Bassand, C.-O. (., Clinical Investigation Group: Paul W. Armstrong, C. (., Global Perspective Group: Philip A. Poole-Wilson, C. (., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.187397 · Cited by 4,230
Thygesen, K. A. (2007) · Circulation · Cited by 3,126
Task Force Members, Thygesen, K., Alpert, J. S., White, H. D., Biomarker Group, Jaffe, A. S., Apple, F. S., Galvani, M., Katus, H. A., Newby, L. K., et al. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm355 · Cited by 2,541
Pathology of the Vulnerable Plaque
Virmani, R., Burke, A. P., Farb, A., & Kolodgie, F. D. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.10.065 · Cited by 2,315
Lerner, D. J., & Kannel, W. B. (1986) · American Heart Journal · doi:10.1016/0002-8703(86)90155-9 · Cited by 1,725
Sex-Based Differences in Early Mortality after Myocardial Infarction
Vaccarino, V., Parsons, L., Every, N. R., Barron, H. V., & Krumholz, H. M. (1999) · New England Journal of Medicine · doi:10.1056/nejm199907223410401 · Cited by 1,298
Self-citationSex, Clinical Presentation, and Outcome in Patients with Acute Coronary Syndromes
Hochman, J. S., Tamis, J. E., Thompson, T. D., Weaver, W. D., White, H. D., Van de Werf, F., Aylward, P., Topol, E. J., & Califf, R. M. (1999) · New England Journal of Medicine · doi:10.1056/nejm199907223410402 · Cited by 903
Canto, J. G. (2000) · JAMA · doi:10.1001/jama.283.24.3223 · Cited by 798
Self-citationBlomkalns, A. L., Chen, A. Y., Hochman, J. S., Peterson, E. D., Trynosky, K., Diercks, D. B., Brogan, G. X., Boden, W. E., Roe, M. T., Ohman, E. M., et al. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.11.055 · Cited by 653
Self-citationEffect of Risk Factors on the Mechanism of Acute Thrombosis and Sudden Coronary Death in Women
Burke, A. P., Farb, A., Malcom, G. T., Liang, Y.-H., Smialek, J., & Virmani, R. (1998) · Circulation · doi:10.1161/01.cir.97.21.2110 · Cited by 436
Cited by
Roffi, M., Patrono, C., Collet, J.-P., Mueller, C., Valgimigli, M., Andreotti, F., Bax, J. J., Borger, M. A., Brotons, C., Chew, D. P., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehv320 · Cited by 8,261
2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes
Amsterdam, E. A., Wenger, N. K., Brindis, R. G., Casey, D. E., Ganiats, T. G., Holmes, D. R., Jaffe, A. S., Jneid, H., Kelly, R. F., Kontos, M. C., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.09.017 · Cited by 3,595
Self-citationGulati, M., Levy, P. D., Mukherjee, D., Amsterdam, E., Bhatt, D. L., Birtcher, K. K., Blankstein, R., Boyd, J., Bullock-Palmer, R. P., Conejo, T., et al. (2021) · Circulation · doi:10.1161/cir.0000000000001029 · Cited by 1,611
Acute Myocardial Infarction in Women: A Scientific Statement From the American Heart Association
Mehta, L. S., Beckie, T. M., DeVon, H. A., Grines, C. L., Krumholz, H. M., Johnson, M. N., Lindley, K. J., Vaccarino, V., Wang, T. Y., Watson, K. E., et al. (2016) · Circulation · doi:10.1161/cir.0000000000000351 · Cited by 1,244
Cardiovascular Disease in Women: Clinical Perspectives
Garcia, M., Mulvagh, S. L., Bairey Merz, C. N., Buring, J. E., & Manson, J. E. (2016) · Circulation Research · doi:10.1161/circresaha.116.307547 · Cited by 1,080
Metadata
- Authors
- Canto, J. G., Rogers, W. J., Goldberg, R. J., Peterson, E. D., Wenger, N. K., Vaccarino, V., Kiefe, C. I., Frederick, P. D., Sopko, G., Zheng, Z.-J., & NRMI Investigators, F. T.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2012-02-22
- Volume
- 307
- Issue
- 8
- Pages
- 813-22
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2082793300
- Cited by
- 716
- References
- 21
- FWCI
- 32.99
- Type
- journal article
- Language
- en
- Open access
- green
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- Canto, J. G., Rogers, W. J., Goldberg, R. J., Peterson, E. D., Wenger, N. K., Vaccarino, V., Kiefe, C. I., Frederick, P. D., Sopko, G., Zheng, Z.-J., & NRMI Investigators, F. T. (2012). Association of Age and Sex With Myocardial Infarction Symptom Presentation and In-Hospital Mortality. JAMA. https://doi.org/10.1001/jama.2012.199
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