Cited by 515Opioid Use Disorder TreatmentPain Management and Opioid UseSubstance Abuse Treatment and Outcomes

The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.

Association of Mental Health Disorders With Prescription Opioids and High-Risk Opioid Use in US Veterans of Iraq and Afghanistan

Seal, Karen H., Shi, Ying, Cohen, Gregory, Cohen, Beth E., Maguen, Shira, Krebs, Erin E., Neylan, Thomas C.·2012·JAMA

DOI 10.1001/jama.2012.234

Open this paper in CoChat — free account

Abstract

CONTEXT: Record numbers of Iraq and Afghanistan veterans survive their war injuries and yet continue to experience pain and mental health problems, particularly posttraumatic stress disorder (PTSD). Little is known about the association of mental health disorders and prescription opioid use. OBJECTIVE: To investigate the effect of mental health disorders, particularly PTSD, on risks and adverse clinical outcomes associated with prescription opioid use. DESIGN: Retrospective cohort study involving 141,029 Iraq and Afghanistan veterans who received at least 1 non-cancer-related pain diagnosis within 1 year of entering the Department of Veterans Affairs (VA) health care system from October 1, 2005, through December 31, 2010. MAIN OUTCOME MEASURES: Independent association of mental health disorders and the prescription of opioids, higher risk opioid use, and adverse clinical outcomes (eg, accidents and overdose) within 1 year of receiving a pain-related diagnosis. RESULTS: A total of 15,676 veterans were prescribed opioids within 1 year of their initial pain diagnosis. Compared with 6.5% of veterans without mental health disorders, 17.8% (adjusted relative risk [RR], 2.58; 95% CI, 2.49-2.67) of veterans with PTSD and 11.7% (adjusted RR, 1.74; 95% CI, 1.67-1.82) with other mental health diagnoses but without PTSD were significantly more likely to receive opioids for pain diagnoses. Of those who were prescribed pain medication, veterans with PTSD were more likely than those without mental health disorders to receive higher-dose opioids (22.7% vs 15.9%, adjusted RR, 1.42; 95% CI, 1.31-1.54), receive 2 or more opioids concurrently (19.8% vs 10.7%, adjusted RR, 1.87; 95% CI, 1.70-2.06), receive sedative hypnotics concurrently (40.7% vs 7.6%, adjusted RR, 5.46; 95% CI, 4.91-6.07), or obtain early opioid refills (33.8% vs 20.4%; adjusted RR, 1.64; 95% CI, 1.53-1.75). Receiving prescription opioids (vs not) was associated with an increased risk of adverse clinical outcomes for all veterans (9.5% vs 4.1%; RR, 2.33; 95% CI, 2.20-2.46), which was most pronounced in veterans with PTSD. CONCLUSION: Among US veterans of Iraq and Afghanistan, mental health diagnoses, especially PTSD, were associated with an increased risk of receiving opioids for pain, high-risk opioid use, and adverse clinical outcomes.

Integrity signals

Registry

Crossref · 10.1001/jama.2012.234

Cites

49 of 49 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
Lifetime Prevalence and Age-of-Onset Distributions of DSM-IV Disorders in the National Comorbidity Survey Replication
Kessler, R. C., Berglund, P., Demler, O., Jin, R., Merikangas, K. R., & Walters, E. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.593 · Cited by 20,391
Combat Duty in Iraq and Afghanistan, Mental Health Problems, and Barriers to Care
Hoge, C. W., Castro, C. A., Messer, S. C., McGurk, D., Cotting, D. I., & Koffman, R. L. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040603 · Cited by 4,778
Longitudinal Assessment of Mental Health Problems Among Active and Reserve Component Soldiers Returning From the Iraq War
Milliken, C. S., Auchterlonie, J. L., & Hoge, C. W. (2007) · JAMA · doi:10.1001/jama.298.18.2141 · Cited by 1,640
Opioid Prescriptions for Chronic Pain and Overdose
Dunn, K. M., Saunders, K. W., Rutter, C. M., Banta‐Green, C. J., Merrill, J. O., Sullivan, M. D., Weisner, C. M., Silverberg, M. J., Campbell, C. I., Psaty, B. M., et al. (2010) · Annals of Internal Medicine · doi:10.7326/0003-4819-152-2-201001190-00006 · Cited by 1,265
Opioids in chronic non-cancer pain: systematic review of efficacy and safety
Kalso, E., Edwards, J. E., Moore, A. R., & McQuay, H. J. (2004) · Pain · doi:10.1016/j.pain.2004.09.019 · Cited by 1,216
Untitled work
Seal (2007) · doi:10.1001/archinte.167.5.476 · Cited by 936
Self-citation
Opioids for chronic noncancer pain: A meta-analysis of effectiveness and side effects
Furlan, A. D. (2006) · Canadian Medical Association Journal · doi:10.1503/cmaj.051528 · Cited by 873
Trends and Risk Factors for Mental Health Diagnoses Among Iraq and Afghanistan Veterans Using Department of Veterans Affairs Health Care, 2002–2008
Seal, K. H., Metzler, T. J., Gima, K. S., Bertenthal, D., Maguen, S., & Marmar, C. R. (2009) · American Journal of Public Health · doi:10.2105/ajph.2008.150284 · Cited by 859
Self-citation
A Flood of Opioids, a Rising Tide of Deaths
Okie, S. (2010) · New England Journal of Medicine · doi:10.1056/nejmp1011512 · Cited by 832

Flagged first, then by citations

Show all 49 references

Sorted by citations

Items 301–400 of 514

Effectiveness of a substance use treatment program for veterans with chronic pain and opioid use disorder
Ward, R. C., Tang, Y., Axon, R. N., Casarella, J., Whitfield, N., & Rauch, S. A. M. (2021) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2021.108635 · Cited by 9
Cultivating Change Door to Door: Educational Outreach to Improve Prescribing Practices in Rural Veterans with Posttraumatic Stress Disorder
Montaño, M., Bernardy, N. C., & Sherrieb, K. (2017) · Substance Abuse · doi:10.1080/08897077.2017.1303423 · Cited by 9
Long-term Mental Health Trajectories of Injured Military Servicemembers
Dalton, M. K., Manful, A., Jarman, M. P., Koehlmoos, T. P., Weissman, J. S., Cooper, Z. R., & Schoenfeld, A. J. (2021) · Annals of Surgery · doi:10.1097/sla.0000000000005165 · Cited by 8
Yoga Plus Mantram Repetition to Reduce Chronic Pain in Veterans With Post-Traumatic Stress Disorder: A Feasibility Trial
Groessl, E. J., Hafey, C., McCarthy, A., Hernandez, R. M., Prado-Nava, M., Casteel, D., McKinnon, S., Chang, D. G., Ayers, C. R., Rutledge, T. R., et al. (2023) · Global Advances in Integrative Medicine and Health · doi:10.1177/27536130231220623 · Cited by 8
The Impact of Chronic Opioid Use on Colonoscopy Outcomes
Nusrat, S., Mahmood, S., Bitar, H., Tierney, W. M., Bielefeldt, K., & Madhoun, M. F. (2015) · Digestive Diseases and Sciences · doi:10.1007/s10620-015-3639-3 · Cited by 8
Combined effect of posttraumatic stress disorder and prescription opioid use on risk of cardiovascular disease
Scherrer, J. F., Salas, J., Lustman, P. J., Tuerk, P. W., Gebauer, S., Norman, S. B., Schneider, D., Chard, K. M., van den Berk‐Clark, C., Cohen, B. E., et al. (2019) · European Journal of Preventive Cardiology · doi:10.1177/2047487319850717 · Cited by 8
Self-citation
Opioid Medications Prescribing and the Pain-Depression Dyad in Primary Care: Analysis of 2014–2015 National Ambulatory Medical Care Survey (NAMCS) Data
Lin, S. X., Patel, K., & Younge, R. G. (2019) · The Journal of the American Board of Family Medicine · doi:10.3122/jabfm.2019.04.180311 · Cited by 7
Patterns of prescription opioid utilization among adolescents and adults with comorbid chronic pain and mental health diagnosis
Olopoenia, A., Onukwugha, E., Simoni, J. M., Camelo-Castillo, W., Villalonga-Olives, E., Gandhi, A. B., & Slejko, J. F. (2020) · Pain · doi:10.1097/j.pain.0000000000001934 · Cited by 8
Association between discontinuing chronic opioid therapy and newly diagnosed substance use disorders, accidents, self‐inflicted injuries and drug overdoses within the prescribers' health care system: a retrospective cohort study
Hayes, C. J., Krebs, E. E., Li, C., Brown, J. D., Hudson, T. J., & Martin, B. C. (2021) · Addiction · doi:10.1111/add.15689 · Cited by 8
Self-citation
Clinical monitoring and high-risk conditions among patients with SUD newly prescribed opioids and benzodiazepines
Grossbard, J. R., Malte, C. A., Saxon, A. J., & Hawkins, E. J. (2014) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2014.03.020 · Cited by 9
A Mobile and Web-Based Self-Directed Complementary and Integrative Health Program for Veterans and Their Partners (Mission Reconnect): Protocol for a Mixed-Methods Randomized Controlled Trial
Haun, J. N., Ballistrea, L. M., Melillo, C., Standifer, M. K., Kip, K. E., Paykel, J. M., Murphy, J. L., Fletcher, C. E., Mitchinson, A., Kozak, L. E., et al. (2019) · JMIR Research Protocols · doi:10.2196/13666 · Cited by 8
Identifying Opioid-Related Electronic Health Record Phenotypes for Emergency Care Research and Surveillance: An Expert Consensus Driven Concept Mapping Process
Taylor, R. A., Fiellin, D. A., D’Onofrio, G., & Venkatesh, A. K. (2022) · Substance Abuse · doi:10.1080/08897077.2021.1975864 · Cited by 7
Association between opioid therapy trajectories and potential opioid‐related adverse health events
Hayes, C. J., Koonce, R. M., Gressler, L. E., Hu, B., Williams, J. S., & Martin, B. C. (2022) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.5495 · Cited by 7
(RE-)AIMing for Rapid Uptake
Heavey, S. C., Beehler, G. P., & Funderburk, J. S. (2023) · Medical Care · doi:10.1097/mlr.0000000000001934 · Cited by 7
VA Patients With High Numbers of Opioid Prescriptions
Petrakis, I. L., Sofuoglu, M., & Rosenheck, R. A. (2014) · Addictive Disorders & Their Treatment · doi:10.1097/adt.0000000000000058 · Cited by 7
A retrospective chart review of opioid represcribing following nonfatal overdose at a Veterans Affairs hospital
Boyle, J., Clement, C., Atherton, A. S., & Stock, C. J. (2017) · Mental Health Clinician · doi:10.9740/mhc.2017.11.276 · Cited by 7
Medical-encounter mental health diagnoses, non-fatal injury and polypharmacy indicators of risk for accident death in the US Army enlisted soldiers, 2004–2009
Lewandowski-Romps, L. M., Schroeder, H. M., Berglund, P. A., Colpe, L. J., Cox, K., Hauret, K. G., Hay, J. D., Jones, B. H., Little, R. J. A., Mitchell, C. M., et al. (2017) · Preventive Medicine · doi:10.1016/j.ypmed.2017.11.016 · Cited by 7
Caring for Military Veterans in the Community: An Interprofessional Approach
Crytzer, M. (2019) · Journal of Community Health Nursing · doi:10.1080/07370016.2019.1583839 · Cited by 7
Center Predictors of Long-Term Benzodiazepine Use in Chronic Obstructive Pulmonary Disease and Post-traumatic Stress Disorder
Donovan, L. M., Malte, C. A., Spece, L. J., Griffith, M. F., Feemster, L. C., Zeliadt, S. B., Au, D. H., & Hawkins, E. J. (2019) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201901-048oc · Cited by 7
Psychiatric Comorbidity and Co-Occurring Opioid Misuse: Depression Mediates the Relationship between Post-Traumatic Stress Disorder and Opioid Misuse in Community Pharmacy Settings
Hruschak, V., Hildenbrand, A. K., & Cochran, G. (2019) · Substance Abuse · doi:10.1080/08897077.2019.1621238 · Cited by 7
The acceptability and feasibility of screening, brief intervention, and referral to treatment for pain management among new England veterans with chronic pain: A pilot study
Sellinger, J. J., Martino, S., Lazar, C. M., Mattocks, K. M., Rando, K., Serowik, K. L., Ablondi, K. M., Fenton, B. T., Gilstad‐Hayden, K., Brummett, B. R., et al. (2021) · Pain Practice · doi:10.1111/papr.13023 · Cited by 7
Understanding Pain and Trauma Symptoms in Veterans From Resting-State Connectivity: Unsupervised Modeling
Strigo, I. A., Spadoni, A. D., & Simmons, A. N. (2022) · Frontiers in Pain Research · doi:10.3389/fpain.2022.871961 · Cited by 7
Prescription stimulant use during long-term opioid therapy and risk for opioid use disorder
Scherrer, J. F., Salas, J., Grucza, R., Wilens, T., Quinn, P. D., Sullivan, M. D., Rossom, R., Wright, E. A., Piper, B., Sanchez, K., et al. (2022) · Drug and Alcohol Dependence Reports · doi:10.1016/j.dadr.2022.100122 · Cited by 7
Initial treatment approaches and healthcare utilization among veterans with low back pain: a propensity score analysis
Schmidt, C. T., Borgia, M. L., Zhang, T., Gochyyev, P., Shireman, T. I., & Resnik, L. J. (2023) · BMC Health Services Research · doi:10.1186/s12913-023-09207-y · Cited by 7
Risks and Responsibilities in Prescribing Opioids for Chronic Noncancer Pain, Part 2: Best Practices
Cone, E. J., DePriest, A. Z., GORDON, A. S., & Passik, S. D. (2014) · Postgraduate Medicine · doi:10.3810/pgm.2014.11.2841 · Cited by 7
Development and preliminary validation of the Opioid Abuse Risk Screener
Henrie-Barrus, P., Averill, L. A., Sudweeks, R. R., Averill, C. L., & Mota, N. P. (2016) · Health Psychology Open · doi:10.1177/2055102916648995 · Cited by 7
Healthcare system-wide implementation of opioid-safety guideline recommendations: the case of urine drug screening and opioid-patient suicide- and overdose-related events in the Veterans Health Administration
Brennan, P. L., Re, A. C. D., Henderson, P. T., & Trafton, J. A. (2016) · Translational Behavioral Medicine · doi:10.1007/s13142-016-0423-7 · Cited by 7
Pinnipeds and PTSD: An Analysis of a Human-Animal Interaction Case Study Program for a Veteran
Wortman, R. A., Vallone, T., Karnes, M., Walawander, C., Daly, D. D., & Garrity, B. K. F. (2018) · Occupational Therapy International · doi:10.1155/2018/2686728 · Cited by 9
Patterns of opioid use (codeine, morphine or meperidine) in the Canadian population over time: analysis of the Longitudinal National Population Health Survey 1994–2011
Cañizares, M., Power, J. D., Rampersaud, Y. R., & Badley, E. M. (2019) · BMJ Open · doi:10.1136/bmjopen-2019-029613 · Cited by 7
Mental health conditions and the risk of chronic opioid therapy among patients with rheumatoid arthritis: a retrospective veterans affairs cohort study
Liberman, J. S., McGowan, L. D., Greevy, R. A., Morrow, J. A., Griffin, M. R., Roumie, C. L., & Grijalva, C. G. (2020) · Clinical Rheumatology · doi:10.1007/s10067-020-04955-2 · Cited by 7
Outpatient Pharmacy Prescriptions During the First Year Following Serious Combat Injury: A Retrospective Analysis
Melcer, T., Walker, J., Sazon, J., Domasing, R., Perez, K. G., Bhatnagar, V., & Galarneau, M. R. (2020) · Military Medicine · doi:10.1093/milmed/usaa038 · Cited by 7
Risk Factors Associated With the Prescription of Opioids Among Service Members Following a First Mild Traumatic Brain Injury
Hoover, P. J., Johnson, D., Wu, T., French, L. M., & Caban, J. J. (2021) · Journal of Head Trauma Rehabilitation · doi:10.1097/htr.0000000000000711 · Cited by 7
Opioids and chronic pain
Stannard, C. (2016) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0000000000000203 · Cited by 7
Social support and the association between post-traumatic stress disorder and risk for long-term prescription opioid use
Sullivan, M. D., Wilson, L., Amick, M., Miller-Matero, L. R., Chrusciel, T., Salas, J., Zabel, C., Lustman, P. J., Ahmedani, B. K., Carpenter, R. W., et al. (2024) · Pain · doi:10.1097/j.pain.0000000000003286 · Cited by 6
Opioid Use Initiation, Progression, and Motivations Among OEF/OIF/OND-Era Veterans in New York City: An Age-Period-Cohort Analysis
Elliott, L. C., Golub, A. L., & Bennett, A. S. (2017) · Military Behavioral Health · doi:10.1080/21635781.2017.1343163 · Cited by 6
Advancing Research and Theory on Aging Military Veterans in a Relational Context
Monk, J. K., Proulx, C. M., Marini, C. M., & Fiori, K. L. (2020) · Journal of Family Theory & Review · doi:10.1111/jftr.12378 · Cited by 7
Using actor-partner interdependence modeling to understand recent illicit opioid use and injection drug use among men in community supervision and their female partners in New York City
Davis, A., Pala, A. N., Gilbert, L., Marotta, P. L., Goddard‐Eckrich, D., & El‐Bassel, N. (2020) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2020.102843 · Cited by 6
Concurrent and proximal associations among PTSD symptoms, prescription opioid use, and co-use of other substances: Results from a daily monitoring study.
Badour, C. L., Flores, J., Hood, C. O., Jones, A. C., Brake, C. A., Tipsword, J. M., Penn, C. J., & McCann, J. P. (2022) · Psychological Trauma Theory Research Practice and Policy · doi:10.1037/tra0001303 · Cited by 6
Morphine administration during low ovarian hormone stage results in transient over expression of fear memories in females
Pérez-Torres, E. M., Ramos‐Ortolaza, D. L., Silva, R. J. M., Santini, E., Ríos-Ruiz, E. J., & Torres-Reverón, A. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00129 · Cited by 7
Posttraumatic stress disorder and correlates of disease activity among veterans with ankylosing spondylitis
Liew, J. W., Williams, J. L., Dobscha, S. K., & Barton, J. L. (2017) · Rheumatology International · doi:10.1007/s00296-017-3801-7 · Cited by 6
The impact of co-occurring opioid misuse and PTSD on response inhibition
Price, M., Brier, Z. M. F., Mirhashem, R., & Allen, H. C. (2018) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2018.05.011 · Cited by 6
High-Dose Opioid Use Among Veterans with Unexplained Gastrointestinal Symptoms Versus Structural Gastrointestinal Diagnoses
Balbale, S. N., Cao, L., Trivedi, I., Stulberg, J. J., Suda, K. J., Gellad, W. F., Evans, C. T., Lambert, B. L., Jordan, N., & Keefer, L. (2021) · Digestive Diseases and Sciences · doi:10.1007/s10620-020-06742-0 · Cited by 6
Mental health and substance use disorder comorbidities among Medicaid beneficiaries: Associations with opioid use disorder and prescription opioid misuse
Swartz, J. A., Franceschini, D., & Scamperle, K. (2023) · AIMS Public Health · doi:10.3934/publichealth.2023046 · Cited by 5
A Health Assessment Survey of Veteran Students: Utilizing a Community College-Veterans Affairs Medical Center Partnership
Misra‐Hebert, A. D., Santurri, L. E., DeChant, R., Watts, B., Sehgal, A. R., & Aron, D. C. (2015) · Military Medicine · doi:10.7205/milmed-d-14-00711 · Cited by 5
Pain and pain prescribing: what is in a number?
Stannard, C. F. (2018) · British Journal of Anaesthesia · doi:10.1016/j.bja.2018.03.002 · Cited by 5
Advanced models for improved prediction of opioid-related overdose and suicide events among Veterans using administrative healthcare data
Ward, R. C., Weeda, E. R., Taber, D. J., Axon, R. N., & Gebregziabher, M. (2021) · Health Services and Outcomes Research Methodology · doi:10.1007/s10742-021-00263-7 · Cited by 5
Healthcare costs and utilization associated with pain among breast cancer survivors: a propensity score matched cohort study using SEER-Medicare data
Lakkad, M., Martin, B. C., Li, C., Harrington, S. E., Dayer, L. E., & Painter, J. T. (2022) · Journal of Cancer Survivorship · doi:10.1007/s11764-022-01282-0 · Cited by 5
An updated view on the influence of initial opioid prescription characteristics on long-term opioid use among opioid naïve patients
Smith, A. M., Shah, A., & Martin, B. C. (2024) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2024.112463 · Cited by 5
Treatment of a Large Cohort of Veterans Experiencing Musculoskeletal Disorders with Spinal Cord Stimulation in the Veterans Health Administration: Veteran Characteristics and Outcomes
Wandner, L. D., Fenton, B. T., Goulet, J. L., Carroll, C. M., Heapy, A. A., Higgins, D. M., Bair, M. J., Sandbrink, F., & Kerns, R. D. (2020) · Journal of Pain Research · doi:10.2147/jpr.s241567 · Cited by 5
Impact of transitioning from long-term to intermittent opioid therapy on the development of opioid-related adverse outcomes: A retrospective cohort study
Hayes, C. J., Krebs, E. E., Brown, J. D., Li, C., Hudson, T. J., & Martin, B. C. (2021) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2021.109236 · Cited by 5
Self-citation
Risky alcohol use among patients dispensed opioid medications: A clinical community pharmacy study
Cochran, G., Charron, E. M., Brown, J. L., Cernasev, A., Hohmeier, K. C., & Winhusen, T. M. (2022) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2022.109406 · Cited by 5
Randomised, pragmatic, waitlist controlled trial of cannabis added to prescription opioid support on opioid dose reduction and pain in adults with chronic non-cancer pain: study protocol
Jashinski, J., Grossman, E., Quaye, A., Cather, C., Potter, K. W., Schoenfeld, D., Evins, A. E., & Gilman, J. M. (2022) · BMJ Open · doi:10.1136/bmjopen-2022-064457 · Cited by 8
Prescription Opioid Misuse and Suicidal Behaviors Among US Veterans: A Cross-Sectional Study from the 2015–2019 National Survey on Drug Use and Health
Betancourt, C. A., Kitsantas, P., Goldberg, D. G., & Hawks, B. A. (2022) · The Journal of Behavioral Health Services & Research · doi:10.1007/s11414-022-09820-5 · Cited by 5
Managing Opioid Use Disorder and Co-Occurring Posttraumatic Stress Disorder Among Veterans
Snow, R. D., & Wynn, S. T. (2018) · Journal of Psychosocial Nursing and Mental Health Services · doi:10.3928/02793695-20180212-03 · Cited by 5
Prescription Opioid Use Among Seriously Mentally Ill Veterans Nationally in the Veterans Health Administration
Mathew, N., & Rosenheck, R. (2016) · Community mental health journal · doi:10.1007/s10597-015-9939-4 · Cited by 5
Utilizing Implementation Science to Identify Barriers and Facilitators to Implementing Harm Reduction Services in the Veterans Health Administration (VHA)Preprint
Harvey, L. H., Sliwinski, S. K., Flike, K., Boudreau, J., Gifford, A. L., Branch‐Elliman, W., & Hyde, J. K. (2022) · Research Square · doi:10.21203/rs.3.rs-1720487/v1 · Cited by 5
Machine Learning for Analyzing Drug Safety in Electronic Health Records
Guan, M. (2023) · Computational methods in engineering & the sciences · doi:10.1007/978-3-031-20730-3_26 · Cited by 5
Counseling Veterans with Chronic Pain During the COVID-19 Pandemic: A Secondary Analysis of a Randomized Controlled Trial
Lazar, C. M., Rosen, M. I., Sellinger, J. J., Mattocks, K. M., Navarra, L., Ross, K. A., & Martino, S. (2021) · Pain Medicine · doi:10.1093/pm/pnab349 · Cited by 4
Comparative effectiveness of pain control between opioids and gabapentinoids in older patients with chronic pain
Kim, E. M., Raji, M. A., Westra, J. R., Wilkes, D. M., & Kuo, Y. (2023) · Pain · doi:10.1097/j.pain.0000000000003006 · Cited by 5
Colorectal Cancer Screening Among Individuals With a Substance Use Disorder: A Retrospective Cohort Study
Sonoda, K., Sales, J., Bello, J. K., Grucza, R. A., & Scherrer, J. F. (2024) · AJPM Focus · doi:10.1016/j.focus.2024.100218 · Cited by 4
Preoperative Mental Health Disorders Affect Opioid Consumption and Perioperative Complications After Total Shoulder Arthroplasty
Mayfield, C. K., Abu-Zahra, M., Bolia, I. K., Kotlier, J. L., Lin, E. H., Gamradt, S. C., Weber, A. E., Liu, J. N., & Petrigliano, F. A. (2024) · Orthopedics · doi:10.3928/01477447-20240918-01 · Cited by 4
Transforming Pain Care in the United States Department of Veterans Affairs
Kerns, R. D. (2012) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e31826b6ce8 · Cited by 4
Suicidal Behavior and Prescription Opioid Medication
Searles, V. B., & Davis, J. M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800634-4.00056-1 · Cited by 4
Outpatient prescribing of opioids to adults diagnosed with mental disorders in the United States
Taylor, M. T., Horton, D. B., Juliano, T., Olfson, M., & Gerhard, T. (2020) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2020.108414 · Cited by 4
Association of Potential for Deaths of Despair With Age and Military Service Era
Fairman, K. A., & Buckley, K. D. (2021) · Military Medicine · doi:10.1093/milmed/usab249 · Cited by 4
Risk of an Opioid-Related Emergency Department Visit or Hospitalization Among Older Breast, Colorectal, Lung, and Prostate Cancer Survivors
Gibson, D. C., Raji, M. A., Holmes, H. M., Baillargeon, J., & Kuo, Y. (2022) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2021.08.030 · Cited by 4
A qualitative exploration of dentists' opioid prescribing decisions within U.S. veterans affairs facilities
Sharp, L. K., Solanki, P. A., Boyer, T. L., Vivo, A., Kale, I. O., Hughes, A. M., Gibson, G., Jurasic, M. M., Evans, C. T., & Suda, K. J. (2022) · Pain · doi:10.1097/j.pain.0000000000002759 · Cited by 4
Posttraumatic stress and pain-related anxiety among trauma-exposed adults with chronic pain in terms of opioid misuse and dependence
Rogers, A. H., Garey, L., Viana, A. G., Williams, M., & Zvolensky, M. J. (2023) · Addictive Behaviors · doi:10.1016/j.addbeh.2023.107668 · Cited by 4
Attitudes and Access Patterns of Michigan Veterans Ineligible for Oral Healthcare Benefits: A cross-sectional study.
Nieto, V., Arnett, M., & Furgeson, D. (2019) · PubMed · Cited by 4
Using Explainable Deep Learning and Logistic Regression to Evaluate Complementary and Integrative Health Treatments in Patients with Musculoskeletal Disorders
Redd, D., Goulet, J. L., & Zeng‐Treitler, Q. (2020) · Hawaii International Conference on System Sciences (HICSS) · doi:10.24251/hicss.2020.398 · Cited by 4
Opiate Action on Sleep and Breathing
Lydic, R., Keifer, J. C., Baghdoyan, H. A., Craft, R. M., & Angel, C. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-24288-2.00024-6 · Cited by 4
Commentary on Higgins et al . (2020): How are chronic pain, psychological distress and opioid dependence related?
Sullivan, M. D. (2019) · Addiction · doi:10.1111/add.14850 · Cited by 4
Post-traumatic stress disorder and risk of first-time and repeated opioid-related hospitalizations among World Trade Center Health Registry enrollees
Garrey, S. K., Locke, S. H., Pollari, C. D., Li, J., & Takemoto, E. E. (2023) · Psychiatry Research · doi:10.1016/j.psychres.2023.115462 · Cited by 3
Early High-Risk Opioid Prescribing and Persistent Opioid Use in Australian Workers with Workers’ Compensation Claims for Back and Neck Musculoskeletal Disorders or Injuries: A Retrospective Cohort Study
Tefera, Y. G., Gray, S., Nielsen, S., Donato, M. F. D., & Collie, A. (2025) · CNS Drugs · doi:10.1007/s40263-025-01169-5 · Cited by 3
Promoting Adherence to a Yoga Intervention for Veterans With Chronic Low Back Pain
Gonzalez, C., Chang, D. G., Rutledge, T., & Groessl, E. J. (2025) · Global Advances in Integrative Medicine and Health · doi:10.1177/27536130251323247 · Cited by 3
Natural Product Use for Chronic Pain: A New Survey of Patterns of Use, Beliefs, Concerns, and Disclosure to Providers
Seal, K. H., Feinberg, T., Moore, L. C., Woodruff, N. A., Purcell, N., Bertenthal, D., McCamish, N., & Becker, W. R. (2025) · Global Advances in Integrative Medicine and Health · doi:10.1177/27536130251320101 · Cited by 3
Self-citation
Sex and race-ethnicity influences on opioid overdose deaths among veterans diagnosed with opioid use disorder between 2016 and 2021
Mandavia, A. D., Fonda, J. R., Banducci, A. N., Ameral, V., Sistad, R. E., Loeffel, L. B., Roth, C. E., Simpson, T. L., Stein, M. D., Marx, B. P., et al. (2025) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2025.112764 · Cited by 3
Characteristics of Opioid Prescriptions to Veterans With Chronic Gastrointestinal Symptoms and Disorders Dually Enrolled in the Department of Veterans Affairs and Medicare Part D
Balbale, S. N., Cao, L., Trivedi, I., Stulberg, J. J., Suda, K. J., Gellad, W. F., Evans, C. T., Lambert, B. L., Keefer, L., & Jordan, N. (2021) · Military Medicine · doi:10.1093/milmed/usab095 · Cited by 3
Root Cause Analysis of Adverse Events Involving Opioid Overdoses in the Veterans Health Administration
Norris, B., Soncrant, C., Mills, P. D., & Gunnar, W. (2021) · The Joint Commission Journal on Quality and Patient Safety · doi:10.1016/j.jcjq.2021.04.010 · Cited by 3
Opioid Prescriptions in Chronic Pain Rehabilitation. A Prospective Study on the Prevalence and Association between Individual Patient Characteristics and Opioids
Svanberg, M., Stålnacke, B., Quinn, P. D., & Boersma, K. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10102130 · Cited by 3
Medication-assisted treatment and self-help group participation among military veterans with opioid or alcohol use disorder
Albright, D. L., McDaniel, J. T., Suntai, Z., Laha-Walsh, M. K., Frick, K. D., Weatherly, T., & McIntosh, S. (2021) · BMJ Military Health · doi:10.1136/bmjmilitary-2021-001845 · Cited by 3
Impact of an opioid prescribing alert system on patients with posttraumatic stress disorder
Bestha, D. P., Tomatsu, S., Hutcheson, B., Blankenship, K. M., Yu, Z., Wally, M. K., Wyatt, S. A., Seymour, R. B., Hsu, J. R., Rachal, J., et al. (2022) · American Journal on Addictions · doi:10.1111/ajad.13261 · Cited by 3
Survival Outcomes Associated With the Size of Opioid Prescriptions in the Management of Chronic Pain Related to Advanced Nasopharyngeal Carcinoma
Li, K., Zhang, S., Sun, W. T., Zhang, Y., Yu, M., Zhang, G., & Yu, W. (2022) · Ear Nose & Throat Journal · doi:10.1177/01455613221145093 · Cited by 3
Phoenix On Fire: A Phenomenological Study Of A Psychiatric Hospital Fire In Iran.
Nouri, M., Ostadtaghizadeh, A., Aliabadi, S. F., Pashaei-Asl, Y., AlJasem, M., & Aghdash, S. A. (2022) · PubMed Central · Cited by 3
Opioid Dependence Risk Factors and Risk Assessment
McAnally, H. B. (2017) · Springer eBooks · doi:10.1007/978-3-319-47497-7_10 · Cited by 3
Opioid prescribing and risks among commercially insured women undergoing pelvic organ prolapse repair
Gressler, L. E., dosReis, S., & Chughtai, B. I. (2021) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.5239 · Cited by 3
Preventing the Pain of PTSD
Seal, K. H., & Stein, M. B. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3006635 · Cited by 3
Self-citation
Pain in the Civilian and Military Workplace
Gossett, E. W., & Harms, P. D. (2018) · Emerald Group Publishing Limited eBooks · doi:10.1108/s1479-355520180000016012 · Cited by 4
Opioid prescribing trends in a Veterans Affairs emergency department and dental clinic before and after implementation of opioid-prescribing guidelines
Lavasani, R., Chung, M. H., Beatty, A., Lawrence, P. T., & Unni, E. (2020) · Mental Health Clinician · doi:10.9740/mhc.2020.09.270 · Cited by 3
Maternal prepregnancy surgery and risk of neonatal abstinence syndrome in future newborns: a longitudinal cohort study
Auger, N., Low, N. C. P., Carrier, F. M., Ayoub, A., & Luu, T. M. (2019) · Canadian Medical Association Journal · doi:10.1503/cmaj.181519 · Cited by 3
Statistical Analysis of County-Level Contributing Factors to Opioid-Related Overdose Deaths in the United States
Kim, H., & Yang, H. Y. (2020) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc44109.2020.9176465 · Cited by 3
Psychology’s role in addressing the dual crises of chronic pain and opioid-related harms: Introduction to the special issue.
Palermo, T. M., & Kerns, R. D. (2020) · American Psychologist · doi:10.1037/amp0000711 · Cited by 3
Candidate Genes from an FDA-Approved Algorithm Fail to Predict Opioid Use Disorder Risk in Over 450,000 VeteransPreprint
Davis, C. N., Jinwala, Z., Hatoum, A. S., Toikumo, S., Arpana Agrawal, A., Rentsch, C. T., Edenberg, H. J., Baurley, J. W., Hartwell, E. E., Crist, R. C., et al. (2024) · medRxiv · doi:10.1101/2024.05.16.24307486 · Cited by 3
The Prevalence of Non-Cancer Pain Diagnoses in Adults with Attention-Deficit Hyperactivity Disorder
Chruciel, T., Quinn, P. D., Salas, J., & Scherrer, J. F. (2022) · Pain Medicine · doi:10.1093/pm/pnac159 · Cited by 2
MMPI-2-RF Profiles of Treatment-Seeking Veterans in a VA Pain Clinic and Associations with Markers of Physical Performance
Wolf, E. J., Higgins, D. M., Zhao, X., Hawn, S. E., Sanborn, V. E., Todd, C. A., Fein‐Schaffer, D., Houranieh, A. M., & Miller, M. W. (2023) · Journal of Clinical Psychology in Medical Settings · doi:10.1007/s10880-023-09967-z · Cited by 2
Is post-traumatic stress disorder a risk factor for development of opioid use disorder among individuals with chronic non-cancer pain? A systematic review
Kendurkar, A., Wilson, J., Sunderland, M., Dunlop, A. J., Hayes, C., Marel, C., & Mills, K. L. (2023) · British Journal of Pain · doi:10.1177/20494637231202078 · Cited by 2
A Risk-Structured Model of the Influence of Mental Health on Opioid Addiction
Newton, K. R., Luttrell, L. M., Blackwood, J. C., Montovan, K. J., & Goldwyn, E. E. (2025) · Bulletin of Mathematical Biology · doi:10.1007/s11538-025-01431-3 · Cited by 2
Prescribed opioid analgesic use in pregnancy and risk of neurodevelopmental disorders in children: A retrospective study in Sweden
Cleary, E. N., Sujan, A. C., Rickert, M. E., Fischer, F., Lagerberg, T., Chang, Z., Lichtenstein, P., Quinn, P. D., Öberg, A. S., & D'Onofrio, B. M. (2025) · PLoS Medicine · doi:10.1371/journal.pmed.1004721 · Cited by 2
US Department of Defense consensus guidelines on neuromodulation for pain management in an active-duty military population from a tri-service, multispecialty working group
McLean, B. C., Phillips, C. R., Wilson, S. M., Merrell, J. D., Gelfand, H., Reece, D. E., Riegleman, D., Rodriguez, S. E., & Cohen, S. P. (2026) · Regional Anesthesia & Pain Medicine · doi:10.1136/rapm-2026-107787 · Cited by 2
When two drugs are not better than one: Treating mood symptoms in patients with chronic opioid use
Kronenberg, G., Desai, D., & Anghelescu, I. G. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.08.028 · Cited by 2

Authors: Seal, K. H., Shi, Y., Cohen, G., Cohen, B. E., Maguen, S., Krebs, E. E., & Neylan, T. C.
Affiliations: San Francisco VA Medical Center (US)
University of California, San Francisco (US)
Indiana University (US)
Corresponding author: Seal, Karen H.
ORCID: Seal, Karen H.
Shi, Ying
Cohen, Gregory
Cohen, Beth E.
Maguen, Shira
Krebs, Erin E.
Neylan, Thomas C.
Venue: JAMA
Publisher: American Medical Association (AMA)
Published: 2012-03-07
Volume: 307
Issue: 9
Pages: 940-7
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.2012.234
OpenAlex: W1972850166
Cited by: 515
References: 49
Citations by year: 2026: 7 · 2025: 17 · 2024: 19 · 2023: 33 · 2022: 31 · 2021: 36 · 2020: 42 · 2019: 52 · 2018: 59 · 2017: 47 · 2016: 44 · 2015: 37 · 2014: 34 · 2013: 38 · 2012: 16
FWCI: 38.64
Type: journal article
Language: en
Open access: closed
Locations: JAMA (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (K23HL094765)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords: opioid use, post-traumatic stress disorder, mental illness, Iraq and Afghanistan veterans, opioid overdose, opioid refills, sedative-hypnotic drugs, adverse clinical outcomes, veterans' health care, pain management, opioid prescribing practices, opioid-related deaths, opioid-related hospitalizations, opioid-related emergency department visits
MeSH terms: Adult, Analgesics, Opioid, Mental Disorders, Female, Humans, Male, Opioid-Related Disorders, Pain, Retrospective Studies, Risk, Stress Disorders, Post-Traumatic, United States, Veterans, Cohort Studies, Iraq War, 2003-2011, Prescription Drugs, Afghan Campaign 2001-, Drug Overdose

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Association of Mental Health Disorders With Prescription Opioids and High-Risk Opioid Use in US Veterans of Iraq and Afghanistan

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks