Cited by 1,003Hormonal and reproductive studiesMenopause: Health Impacts and TreatmentsLipoproteins and Cardiovascular Health

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Association of Testosterone Therapy With Mortality, Myocardial Infarction, and Stroke in Men With Low Testosterone Levels

Vigen, Rebecca·2013·JAMA

DOI 10.1001/jama.2013.280386

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Abstract

IMPORTANCE: Rates of testosterone therapy are increasing and the effects of testosterone therapy on cardiovascular outcomes and mortality are unknown. A recent randomized clinical trial of testosterone therapy in men with a high prevalence of cardiovascular diseases was stopped prematurely due to adverse cardiovascular events raising concerns about testosterone therapy safety. OBJECTIVES: To assess the association between testosterone therapy and all-cause mortality, myocardial infarction (MI), or stroke among male veterans and to determine whether this association is modified by underlying coronary artery disease. DESIGN, SETTING, AND PATIENTS: A retrospective national cohort study of men with low testosterone levels (<300 ng/dL) who underwent coronary angiography in the Veterans Affairs (VA) system between 2005 and 2011. MAIN OUTCOMES AND MEASURES: Primary outcome was a composite of all-cause mortality, MI, and ischemic stroke. RESULTS: Of the 8709 men with a total testosterone level lower than 300 ng/dL, 1223 patients started testosterone therapy after a median of 531 days following coronary angiography. Of the 1710 outcome events, 748 men died, 443 had MIs, and 519 had strokes. Of 7486 patients not receiving testosterone therapy, 681 died, 420 had MIs, and 486 had strokes. Among 1223 patients receiving testosterone therapy, 67 died, 23 had MIs, and 33 had strokes. At 3 years after coronary angiography, the Kaplan-Meier estimated cumulative percentages with events were 19.9%in the no testosterone therapy group vs 25.7%in the testosterone therapy group,with an absolute risk difference of 5.8%(95%CI, -1.4%to 13.1%) [corrected].The Kaplan-Meier estimated cumulative percentages with events among the no testosterone therapy group vs testosterone therapy group at 1 year after coronary angiography were 10.1% vs 11.3%; at 2 years, 15.4% vs 18.5%; and at 3 years, 19.9% vs 25.7 [corrected].There was no significant difference in the effect size of testosterone therapy among those with and without coronary artery disease (test for interaction, P = .41). CONCLUSIONS AND RELEVANCE: Among a cohort of men in the VA health care system who underwent coronary angiography and had a low serum testosterone level, the use of testosterone therapy was associated with increased risk of adverse outcomes. These findings may inform the discussion about the potential risks of testosterone therapy.

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Authors: Vigen, R.
Affiliations: The University of Texas Southwestern Medical Center (US)
Corresponding author: Vigen, Rebecca
ORCID: Vigen, Rebecca
Venue: JAMA
Publisher: American Medical Association (AMA)
Published: 2013-11-06
Volume: 310
Issue: 17
Pages: 1829
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.2013.280386
OpenAlex: W2132123717
Cited by: 1,003
References: 39
Citations by year: 2026: 25 · 2025: 45 · 2024: 48 · 2023: 62 · 2022: 52 · 2021: 52 · 2020: 60 · 2019: 70 · 2018: 87 · 2017: 101 · 2016: 96 · 2015: 136 · 2014: 162 · 2013: 5
FWCI: 104.22
Type: journal article
Language: en
Open access: closed
Locations: JAMA (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Keywords: testosterone replacement therapy, androgen deficiency, hypogonadism, all-cause mortality, myocardial infarction, ischemic stroke, cardiovascular outcomes, coronary artery disease, male veterans, coronary angiography, men's health, hormone replacement therapy, early trial termination, sex differences in cardiovascular risk
MeSH terms: Aged, Coronary Artery Disease, Humans, Male, Middle Aged, Mortality, Myocardial Infarction, Retrospective Studies, Risk, Testosterone, Veterans, Cohort Studies, Coronary Angiography, Stroke, Andropause

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Association of Testosterone Therapy With Mortality, Myocardial Infarction, and Stroke in Men With Low Testosterone Levels

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