Cited by 667Atrial Fibrillation Management and OutcomesCardiac Arrhythmias and TreatmentsCardiac pacing and defibrillation studies

The DOI matches its Crossref record; 29 of the 31 references it cites were found in a registry or an index.

Radiofrequency Ablation vs Antiarrhythmic Drugs as First-Line Treatment of Paroxysmal Atrial Fibrillation (RAAFT-2): A Randomized Trial

Open access

Morillo, Carlos A., Verma, Atul, Connolly, Stuart J., Kuck, Karl H., Nair, Girish M., Champagne, Jean, Sterns, Laurence D., Beresh, Heather, Healey, Jeffrey S., Natale, Andrea, RAAFT-2 Investigators·2014·JAMA

DOI 10.1001/jama.2014.467

Open this paper in CoChat — free account Open PDF

Abstract

IMPORTANCE: Atrial fibrillation (AF) is the most common rhythm disorder seen in clinical practice. Antiarrhythmic drugs are effective for reduction of recurrence in patients with symptomatic paroxysmal AF. Radiofrequency ablation is an accepted therapy in patients for whom antiarrhythmic drugs have failed; however, its role as a first-line therapy needs further investigation. OBJECTIVE: To compare radiofrequency ablation with antiarrhythmic drugs (standard therapy) in treating patients with paroxysmal AF as a first-line therapy. DESIGN, SETTING, AND PATIENTS: A randomized clinical trial involving 127 treatment-naive patients with paroxysmal AF were randomized at 16 centers in Europe and North America to received either antiarrhythmic therapy or ablation. The first patient was enrolled July 27, 2006; the last patient, January 29, 2010. The last follow-up was February 16, 2012. INTERVENTIONS: Sixty-one patients in the antiarrhythmic drug group and 66 in the radiofrequency ablation group were followed up for 24 months. MAIN OUTCOMES AND MEASURES: The time to the first documented atrial tachyarrhythmia of more than 30 seconds (symptomatic or asymptomatic AF, atrial flutter, or atrial tachycardia), detected by either scheduled or unscheduled electrocardiogram, Holter, transtelephonic monitor, or rhythm strip, was the primary outcome. Secondary outcomes included symptomatic recurrences of atrial tachyarrhythmias and quality of life measures assessed by the EQ-5D tool. RESULTS: Forty-four patients (72.1%) in the antiarrhythmic group and in 36 patients (54.5%) in the ablation group experienced the primary efficacy outcome (hazard ratio [HR], 0.56 [95% CI, 0.35-0.90]; P = .02). For the secondary outcomes, 59% in the drug group and 47% in the ablation group experienced the first recurrence of symptomatic AF, atrial flutter, atrial tachycardia (HR, 0.56 [95% CI, 0.33-0.95]; P = .03). No deaths or strokes were reported in either group; 4 cases of cardiac tamponade were reported in the ablation group. In the standard treatment group, 26 patients (43%) underwent ablation after 1-year. Quality of life was moderately impaired at baseline in both groups and improved at the 1 year follow-up. However, improvement was not significantly different among groups. CONCLUSIONS AND RELEVANCE: Among patients with paroxysmal AF without previous antiarrhythmic drug treatment, radiofrequency ablation compared with antiarrhythmic drugs resulted in a lower rate of recurrent atrial tachyarrhythmias at 2 years. However, recurrence was frequent in both groups. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00392054.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1001/jama.2014.467

Cites

29 of 29 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

EuroQol: a new facility for the measurement of health-related quality of life
(1990) · Health Policy · doi:10.1016/0168-8510(90)90421-9 · Cited by 15,736
Impact of Atrial Fibrillation on the Risk of Death: The Framingham Heart Study
Benjamin, E. J., Wolf, P. A., D’Agostino, R. B., Silbershatz, H., Kannel, W. B., & Levy, D. (1998) · Circulation · doi:10.1161/01.cir.98.10.946 · Cited by 4,575
Cox’s regression model for counting processes: A large sample study
Andersen, P. K., & Gill, R. D. (1982) · The Annals of Statistics · doi:10.1214/aos/1176345976 · Cited by 4,419
2012 focused update of the ESC Guidelines for the management of atrial fibrillation
Authors Task Force Members, Camm, A. J., Lip, G. Y. H., Caterina, R. D., Savelieva, I., Atar, D., Hohnloser, S. H., Hindricks, G., Kirchhof, P. F., Bax, J. J., et al. (2012) · EP Europace · doi:10.1093/europace/eus305 · Cited by 3,823
2012 focused update of the ESC Guidelines for the management of atrial fibrillation
Authors Task Force Members, Camm, A. J., Lip, G. Y. H., Caterina, R. D., Savelieva, I., Atar, D., Hohnloser, S. H., Hindricks, G., Kirchhof, P. F., Bax, J. J., et al. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs253 · Cited by 2,929
Updated worldwide survey on the methods, efficacy, and safety of catheter ablation for human atrial fibrillation
Cappato, R., Calkins, H., Chen, S.-A., Davies, W., Iesaka, Y., Kalman, J., Kim, Y.-H., Klein, G., Natale, A., Packer, D., et al. (2010) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.109.859116 · Cited by 2,852
Self-citation
Temporal Relations of Atrial Fibrillation and Congestive Heart Failure and Their Joint Influence on Mortality: The Framingham Heart Study
Wang, T. J., Larson, M. G., Levy, D., Vasan, R. S., Leip, E. P., Wolf, P. A., D’Agostino, R. B., Murabito, J. M., Kannel, W. B., & Benjamin, E. J. (2003) · Circulation · doi:10.1161/01.cir.0000072767.89944.6e · Cited by 1,970
HRS/EHRA/ECAS Expert Consensus Statement on Catheter and Surgical Ablation of Atrial Fibrillation: Recommendations for Personnel, Policy, Procedures and Follow-Up
Calkins, H. G., Brugada, J., Packer, D. L., Cappato, R., Chen, S., Crijns, H. J. G. M., Damiano, R. J., Davies, D. W., Haines, D. E., Haı̈ssaguerre, M., et al. (2007) · Heart Rhythm · doi:10.1016/j.hrthm.2007.04.005 · Cited by 1,690
Self-citation
HRS/EHRA/ECAS Expert Consensus Statement on Catheter and Surgical Ablation of Atrial Fibrillation: Recommendations for Personnel, Policy, Procedures and Follow-Up
Calkins, H. G., Brugada, J., Packer, D. L., Cappato, R., Chen, S.-A., Crijns, H. J. G. M., Damiano, R. J., Davies, D. W., Haines, D. E., Haïssaguerre, M., et al. (2007) · EP Europace · doi:10.1093/europace/eum120 · Cited by 1,289
Self-citation
Comparison of Antiarrhythmic Drug Therapy and Radiofrequency Catheter Ablation in Patients With Paroxysmal Atrial Fibrillation: A Randomized Controlled Trial
Wilber, D. J., Pappone, C., Neuzil, P., De Paola, A., Marchlinski, F., Natale, A., Macle, L., Daoud, E. G., Calkins, H., Hall, B., et al. (2010) · JAMA · doi:10.1001/jama.2009.2029 · Cited by 1,170
Self-citation

Flagged first, then by citations

Show all 31 references

2 of the 31 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

EuroQol Group, 2007, EQ-5D Value Sets: Inventory, Comparative Eview and User Guide

Sorted by citations

Items 101–200 of 667

Catheter ablation of atrial fibrillation in the young: insights from the German Ablation Registry
Chun, K. R. J., Schmidt, B., Kück, K., Andresen, D., Willems, S., Spitzer, S. G., Hoffmann, E., Schumacher, B., Eckardt, L., Seidl, K., et al. (2013) · Clinical Research in Cardiology · doi:10.1007/s00392-013-0553-6 · Cited by 54
Atrial Fibrillation and Heart Failure: Update 2015
Thihalolipavan, S., & Morin, D. P. (2015) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2015.07.004 · Cited by 54
The Clinical Benefits and Mortality Reduction Associated With Catheter Ablation in Subjects With Atrial Fibrillation
Khan, S. U., Rahman, H., Talluri, S., & Kaluski, E. (2018) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2018.03.003 · Cited by 53
Atrial Fibrillation Catheter Ablation Increases the Left Atrial Pressure
Park, J., Yu, H. T., Kim, T., Uhm, J., Joung, B., Lee, M., Hwang, C., & Pak, H. (2019) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.118.007073 · Cited by 52
Atrial fibrillation ablation in heart failure
Richter, S., Biase, L. D., & Hindricks, G. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy778 · Cited by 51
II Diretrizes Brasileiras de Fibrilação Atrial
Magalhães, L., Figueiredo, M., Cintra, F., Eb, S., Kuniyoshi, R. R., Teixeira, R., Filho, A. L., d’Ávila, A., de Paola, A., Kalil, C., et al. (2016) · Arquivos Brasileiros de Cardiologia · doi:10.5935/abc.20160055 · Cited by 51
Efficacy and safety of the second generation cryoballoon ablation for the treatment of paroxysmal atrial fibrillation in patients over 75 years: a comparison with a younger cohort
Abugattás-Torres, J. P., Iacopino, S., Moran, D., Regibus, V. D., Takarada, K., Mugnai, G., Ströker, E., Coutiño-Moreno, H. E., Choudhury, R., Storti, C., et al. (2017) · EP Europace · doi:10.1093/europace/eux023 · Cited by 49
Clinical and Echocardiographic Risk Factors Predict Late Recurrence after Radiofrequency Catheter Ablation of Atrial Fibrillation
Kim, Y. G., Choi, J., Boo, K. Y., Kim, D. Y., Oh, S., Park, H.-S., Lee, K., Shim, J., Kim, J. S., Park, S. W., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-43283-7 · Cited by 49
Focal impulse and rotor modulation as a stand-alone procedure for the treatment of paroxysmal atrial fibrillation: A within-patient controlled study with implanted cardiac monitoring
Berntsen, R. F., Haland, T. F., Skårdal, R., & Holm, T. (2016) · Heart Rhythm · doi:10.1016/j.hrthm.2016.04.016 · Cited by 48
The Impact of First Procedure Success Rate on the Economics of Atrial Fibrillation Ablation
MANSOUR, M. C., Karst, E., Heist, E. K., Dalal, N., Wasfy, J. H., Packer, D. L., Calkins, H. G., Ruskin, J. N., & Mahapatra, S. (2016) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2016.06.002 · Cited by 47
Association of catheter ablation for atrial fibrillation with mortality and stroke: A systematic review and meta-analysis
Barra, S., Baran, J. M., Narayanan, K., Bovéda, S., Fynn, S. P., Heck, P. M., Grace, A. A., Agarwal, S., Primo, J. J., Marijon, É., et al. (2018) · International Journal of Cardiology · doi:10.1016/j.ijcard.2018.03.068 · Cited by 47
Patient selection, peri-procedural management, and ablation techniques for catheter ablation of atrial fibrillation: an EHRA survey
Iliodromitis, K. E., Lenarczyk, R., Scherr, D., Conte, G., Farkowski, M. M., Marín, F. R., García‐Seara, J., Simovic, S. M., & Potpara, T. (2022) · EP Europace · doi:10.1093/europace/euac236 · Cited by 46
The Short and Long-Term Efficacy of Pulmonary Vein Isolation as a Sole Treatment Strategy for Paroxysmal Atrial Fibrillation: A Systematic Review and Meta-Analysis
Kis, Z., Muka, T., Franco, O. H., Bramer, W. M., de Vries, L. J., Kardos, A., & Szili‐Törok, T. (2017) · Current Cardiology Reviews · doi:10.2174/1573403x13666170117125124 · Cited by 45
Safety and efficacy of cryoballoon ablation for the treatment of atrial fibrillation in elderly patients
Abdin, A., Yalın, K., Lyan, E., Sawan, N., Liosis, S., Meyer‐Saraei, R., Elsner, C., Lange, S. A., Heeger, C.-H. H., Eitel, C., et al. (2018) · Clinical Research in Cardiology · doi:10.1007/s00392-018-1336-x · Cited by 45
Catheter ablation vs. antiarrhythmic drugs as ‘first-line’ initial therapy for atrial fibrillation: a pooled analysis of randomized data
Chen, S., Pürerfellner, H., Ouyang, F. O., Kiuchi, M. G., Meyer, C. G., Martinek, M., Futyma, P., Zhu, L., Schratter, A., Wang, J., et al. (2021) · EP Europace · doi:10.1093/europace/euab185 · Cited by 45
Catheter ablation for atrial fibrillation: indications and future perspective
Natale, A., Mohanty, S., Sanders, P., Anter, E., Shah, A. J., Al-Mohani, G., & Haı̈ssaguerre, M. (2024) · European Heart Journal · doi:10.1093/eurheartj/ehae618 · Cited by 44
Self-citation
Radiofrequency Catheter Ablation Improves the Quality of Life Measured with a Short Form-36 Questionnaire in Atrial Fibrillation Patients: A Systematic Review and Meta-Analysis
Kim, Y. G., Shim, J., Choi, J., & Kim, Y. (2016) · PLoS ONE · doi:10.1371/journal.pone.0163755 · Cited by 43
Catheter Ablation Improves Mortality and Other Outcomes in Real‐World Patients With Atrial Fibrillation
Yang, P., Sung, J., Jang, E., Yu, H. T., Kim, T., Uhm, J., Kim, J., Pak, H., Lee, M., & Joung, B. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.119.015740 · Cited by 43
The burden of proof: The current state of atrial fibrillation prevention and treatment trials
Zakeri, R., Wagoner, D. R. V., Calkins, H. G., Wong, T., Ross, H., Heist, E. K., Meyer, T. E., Kowey, P. R., Mentz, R. J., Cleland, J. G. F., et al. (2017) · Heart Rhythm · doi:10.1016/j.hrthm.2017.01.032 · Cited by 42
Treatment of atrial fibrillation: a comprehensive review and practice guide
Li, J., Gao, M., Zhang, M., Liu, D., Li, Z., Du, J., & Hou, Y. (2020) · Cardiovascular journal of South Africa/Cardiovascular journal of Southern Africa · doi:10.5830/cvja-2019-064 · Cited by 42
Patient-Reported Outcomes in Atrial Fibrillation Research
Steinberg, B. A., Dorian, P., Anstrom, K. J., Hess, R., Mark, D. B., Noseworthy, P. A., Spertus, J. A., & Piccini, J. P. (2019) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2019.03.008 · Cited by 41
JCS / JHRS 2020 Guideline on Pharmacotherapy of Cardiac Arrhythmias
Ono, K., Iwasaki, Y., Akao, M., Ikeda, T., Ishii, K., Inden, Y., Kusano, K., Kobayashi, Y., Koretsune, Y., Sasano, T., et al. (2022) · Journal of Arrhythmia · doi:10.1002/joa3.12714 · Cited by 41
A computational comparison of radiofrequency and pulsed field ablation in terms of lesion morphology in the cardiac chamber
Gómez-Barea, M., García-Sánchez, T., & Ivorra, A. (2022) · Scientific Reports · doi:10.1038/s41598-022-20212-9 · Cited by 40
The role of rotors in atrial fibrillation.
Krummen, D. E., Swarup, V., & Narayan, S. M. (2015) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2072-1439.2014.11.15 · Cited by 40
Efficacy of Short-Term Antiarrhythmic Drugs Use after Catheter Ablation of Atrial Fibrillation—A Systematic Review with Meta-Analyses and Trial Sequential Analyses of Randomized Controlled Trials
Chen, W., Liu, H., Ling, Z., Xu, Y., Fan, J., Du, H., Xiao, P., Su, L., Liu, Z., Lan, X., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0156121 · Cited by 40
Obesity is associated with impaired long-term success of pulmonary vein isolation: a plea for risk factor management before ablation
Maat, G. E. D., Mulder, B. A., Berretty, W. L., Al-Jazairi, M. I. H., Tan, Y. E. S., Wiesfeld, A. C. P., Mariani, M. A., Gelder, I. C. V., Rienstra, M., & Blaauw, Y. (2018) · Open Heart · doi:10.1136/openhrt-2017-000771 · Cited by 40
Stroke and Cardiovascular Events After Ablation or Antiarrhythmic Drugs for Treatment of Patients With Atrial Fibrillation
MANSOUR, M. C., Heist, E. K., Agarwal, R., Bunch, T. J., Karst, E., Ruskin, J. N., & Mahapatra, S. (2018) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2018.01.043 · Cited by 39
CircRNAs expression profile of persistant atrial fibrillation in patient with rheumatic heart disease
Hu, M. (2018) · The Anatolian Journal of Cardiology · doi:10.14744/anatoljcardiol.2018.35902 · Cited by 39
Influence of atrial fibrillation type on outcomes of ablation vs. drug therapy: results from CABANA
Monahan, K. H., Bunch, T. J., Mark, D. B., Poole, J. E., Bahnson, T. D., Al‐Khalidi, H. R., Silverstein, A. P., Daniels, M. R., Lee, K. L., Packer, D. L., et al. (2022) · EP Europace · doi:10.1093/europace/euac055 · Cited by 39
Atrial Ectopy Predicts Late Recurrence of Atrial Fibrillation After Pulmonary Vein Isolation
Gang, U. J. O., Nalliah, C. J., Lim, T. W., Thiagalingam, A., Kovoor, P., Ross, D. L., & Thomas, S. P. (2015) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.114.002052 · Cited by 36
Radiofrequency catheter ablation maintains its efficacy better than antiarrhythmic medication in patients with paroxysmal atrial fibrillation: On-treatment analysis of the randomized controlled MANTRA-PAF trial
Raatikainen, M. J. P., Hakalahti, A., Uusimaa, P., Nielsen, J. C., Johannessen, A. C., Hindricks, G., Walfridsson, H., Pehrson, S. M., Englund, A., Hartikainen, J. E. K., et al. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.06.160 · Cited by 35
A randomized clinical trial of early invasive intervention for atrial fibrillation (EARLY-AF) - methods and rationale
Andrade, J. G., Champagne, J., Deyell, M. W., Essebag, V., Lauck, S., Morillo, C. A., Sapp, J. L., Skanes, A. C., Theoret-Patrick, P., Wells, G. A., et al. (2018) · American Heart Journal · doi:10.1016/j.ahj.2018.05.020 · Cited by 34
Self-citation
Catheter Ablation vs. Anti-Arrhythmic Drugs as First-Line Treatment in Symptomatic Paroxysmal Atrial Fibrillation: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
Saglietto, A., Gaïta, F., Ponti, R. D., Ferrari, G. M. D., & Anselmino, M. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.664647 · Cited by 33
Predicting Values of Neutrophil-to-Lymphocyte Ratio (NLR), High-Sensitivity C-Reactive Protein (hs-CRP), and Left Atrial Diameter (LAD) in Patients with Nonvalvular Atrial Fibrillation Recurrence After Radiofrequency Ablation
Ding, B., Liu, P., Zhang, F., Hui, J., & He, L. (2021) · Medical Science Monitor · doi:10.12659/msm.934569 · Cited by 33
Efficacy and Safety of Catheter Ablation vs Antiarrhythmic Drugs as Initial Therapy for Management of Symptomatic Paroxysmal Atrial Fibrillation: A Meta-Analysis
Razzack, A. A., Lak, H. M., Pothuru, S., Rahman, S., Hassan, S. A., Hussain, N., Najeeb, H., Reddy, K. T., Syeda, H., Yasmin, F., et al. (2022) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2303112 · Cited by 33
Cryoablation or Drug Therapy for Initial Treatment of Atrial Fibrillation
Andrade, J. G., Turgeon, R. D., Macle, L., & Deyell, M. W. (2022) · European Cardiology Review · doi:10.15420/ecr.2021.38 · Cited by 33
Is pulmonary vein isolation still the cornerstone in atrial fibrillation ablation?
Bunch, T. J., & Cutler, M. J. (2015) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2072-1439.2014.12.46 · Cited by 33
Atrial Fibrillation Ablation and Reduction of Stroke Events
Barra, S., Narayanan, K., Bovéda, S., Primo, J. J., Gonçalves, H., Baran, J. M., Agarwal, S., Marijon, É., & Providencia, R. A. (2019) · Stroke · doi:10.1161/strokeaha.119.026890 · Cited by 33
Predictors for Progression of Atrial Fibrillation in Patients Awaiting Atrial Fibrillation Ablation
Kochhäuser, S., Dechering, D. G., Trought, K., Hache, P., Haig-Carter, T., Khaykin, Y., Wulffhart, Z. A., Pantano, A. A., Tsang, B., Eckardt, L., et al. (2016) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2016.02.031 · Cited by 32
Self-citation
Antiarrhythmic Drug Therapy for Rhythm Control in Atrial Fibrillation
Waks, J. W., & ZIMETBAUM, P. J. (2016) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248416651722 · Cited by 34
Catheter ablation and healthcare utilization and cost among patients with paroxysmal versus persistent atrial fibrillation
Friedman, D. J., Field, M. E., Rahman, M., Goldstein, L. J., Sha, Q., Sidharth, M., Khanna, R., & Piccini, J. P. (2020) · Heart Rhythm O2 · doi:10.1016/j.hroo.2020.12.017 · Cited by 32
Combined atrial fibrillation ablation and left atrial appendage occlusion procedure in the United States: a propensity score matched analysis from 2016–2019 national readmission database
Pasupula, D. K., Malleshappa, S. K. S., Munir, M. B., Bhat, A. G., Anandaraj, A., Jakkoju, A., Spooner, M., Koranne, K., Hsu, J. C., Olshansky, B., et al. (2022) · EP Europace · doi:10.1093/europace/euac181 · Cited by 31
Ablation of atrial fibrillation and risk of stroke: A meta-analysis
Providencia, R. A., Ali, H., Barra, S., Creta, A., Kukendrarajah, K., Kanagaratnam, P., Farkowski, M. M., & Cappato, R. (2025) · Heart Rhythm · doi:10.1016/j.hrthm.2025.05.021 · Cited by 31
Comparison of the Different Anesthesia Strategies for Atrial Fibrillation Catheter Ablation: A Systematic Review and Meta-Analysis
Pang, N., Gao, J. L., Zhang, N., Zhang, B., & Wang, R. (2022) · Cardiology Research and Practice · doi:10.1155/2022/1124372 · Cited by 32
Silent cerebral events as a result of left atrial catheter ablation do not cause neuropsychological sequelae—a MRI-controlled multicenter study
von Bary, C., Deneke, T., Arentz, T., Schade, A., Lehrmann, H., Eissnert, C., Schwab‐Malek, S., Fredersdorf, S., Üçer, E., Baldaranov, D., et al. (2015) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-015-0004-6 · Cited by 31
Real-world data of radiofrequency catheter ablation in paroxysmal atrial fibrillation: Short- and long-term clinical outcomes from the prospective multicenter REAL-AF Registry
Osorio, J., Miranda‐Arboleda, A. F., Velasco, A., Varley, A. L., Rajendra, A. B., MORALES, G. X., Hoyos, C., Matos, C. D., Thorne, C., D'Souza, B. A., et al. (2024) · Heart Rhythm · doi:10.1016/j.hrthm.2024.04.090 · Cited by 30
Safety of Same Day Discharge after Atrial Fibrillation Ablation
Lakkireddy, D. (2020) · Journal of Atrial Fibrillation · doi:10.4022/jafib.2150 · Cited by 30
Pulsed Field Ablation of Atrial Fibrillation: A Comprehensive Review
Matos, C. D., Hoyos, C., Miranda‐Arboleda, A. F., Díaz, J. C., Hincapie, D., Patiño, C., Hernadez, R. H., Zei, P. C., Romero, J. E., & Osorio, J. (2023) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2411337 · Cited by 29
Catheter ablation of atrial fibrillation using ablation index‐guided high‐power technique: Frankfurt AI high‐power 15‐month follow‐up
Chen, S., Schmidt, B., Bordignon, S., Tohoku, S., URBAN, V., Schulte‐Hahn, B., & Chun, K. R. J. (2021) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.14912 · Cited by 29
Outcomes of Early Rhythm Control Therapy in Patients With Atrial Fibrillation and a High Comorbidity Burden in Large Real-World Cohorts
Dickow, J., Kany, S., Cardoso, V. R., Ellinor, P. T., Gkoutos, G. V., Houten, H. K. V., Kirchhof, P. F., Metzner, A., Noseworthy, P. A., Yao, X., et al. (2023) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.122.011585 · Cited by 29
Exposure-Based Therapy for Symptom Preoccupation in Atrial Fibrillation: An Uncontrolled Pilot Study
Särnholm, J., Skúladóttir, H., Rück, C., Pedersen, S. S., Braunschweig, F., & Ljótsson, B. (2017) · Behavior Therapy · doi:10.1016/j.beth.2017.06.001 · Cited by 30
Impact of atrial fibrillation phenotype and left atrial volume on outcome after pulmonary vein isolation
Chollet, L., Iqbal, S. U. R., Wittmer, S., Thalmann, G., Madaffari, A., Kozhuharov, N., Galuszka, O., Küffer, T., Gräni, C., Brugger, N., et al. (2024) · EP Europace · doi:10.1093/europace/euae071 · Cited by 28
Atrio-Esophageal Fistula: A Case Series and Literature Review
Schuring, C. A., Mountjoy, L. J., Priaulx, A. B., Schneider, R. J., Smith, H. L., Wall, G. C., Kadaria, D., & Sodhi, A. (2017) · American Journal of Case Reports · doi:10.12659/ajcr.903966 · Cited by 28
Guía ESC 2020 sobre el diagnóstico y tratamiento de la fibrilación auricular, desarrollada en colaboración de la European Association of Cardio-Thoracic Surgery (EACTS)
Hindricks, G., Potpara, T., Dagres, N., Arbelo, E., Bax, J. J., Blomström‐Lundqvist, C., Boriani, G., Castellà, M., Dan, G., Dilaveris, P., et al. (2021) · Revista Española de Cardiología · doi:10.1016/j.recesp.2020.10.022 · Cited by 34
Association between leucocyte telomere length and the risk of atrial fibrillation: An updated systematic review and meta-analysis
Zheng, Y., Zhang, N., Wang, Y., Wang, F., Li, G., Tse, G., & Liu, T. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101707 · Cited by 28
Visualizable vs. standard, non-visualizable steerable sheath for pulmonary vein isolation procedures: Randomized, single-centre trial
Janosi, K.-F., Debreceni, D., Janosa, B., Bocz, B., Símor, T., & Kupó, P. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.1033755 · Cited by 28
Effects of Inflammatory Cell Death Caused by Catheter Ablation on Atrial Fibrillation
Liu, D., Li, Y., & Zhao, Q. (2023) · Journal of Inflammation Research · doi:10.2147/jir.s422002 · Cited by 27
Randomized trial comparing robotic to manual ablation for atrial fibrillation
Ullah, W., McLean, A., Hunter, R. J., Baker, V., Richmond, L., Cantor, E. J., Dhinoja, M., Sporton, S. C., Earley, M. J., & SCHILLING, R. J. (2014) · Heart Rhythm · doi:10.1016/j.hrthm.2014.06.026 · Cited by 27
The impact of atrial fibrillation type on the risks of thromboembolic recurrence, mortality and major haemorrhage in patients with previous stroke: A systematic review and meta-analysis of observational studies
Mentel, A., Quinn, T. J., Cameron, A. C., Lees, K. R., & Abdul‐Rahim, A. H. (2020) · European Stroke Journal · doi:10.1177/2396987319896674 · Cited by 27
Five-year clinical outcomes of visually guided laser balloon pulmonary vein isolation for the treatment of paroxysmal atrial fibrillation
Reißmann, B., Budelmann, T., Wißner, E., Schlüter, M., Heeger, C.-H. H., Mathew, S., Maurer, T., Lemeš, C., Fink, T., Rillig, A., et al. (2017) · Clinical Research in Cardiology · doi:10.1007/s00392-017-1199-6 · Cited by 26
Screening and management of atrial fibrillation in primary care
Ponamgi, S., Siontis, K. C., Rushlow, D. R., Graff‐Radford, J., Montori, V. M., & Noseworthy, P. A. (2021) · BMJ · doi:10.1136/bmj.n379 · Cited by 27
Benefits of early rhythm control of atrial fibrillation
Eckardt, L., Wolfes, J., & Frommeyer, G. (2023) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2023.04.001 · Cited by 27
Efficacy and safety of high-power short-duration ablation for atrial fibrillation: a systematic review and meta-analysis of randomized controlled trials
Amin, A. M., Ghaly, R., Ibrahim, A. A. A., Ali, M. A., Almaadawy, O., Elzahaby, A., Abuelazm, M. T., Abdelazeem, B., & Munir, M. B. (2024) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-024-01782-2 · Cited by 26
Revealing the Influences of Sex Hormones and Sex Differences in Atrial Fibrillation and Vascular Cognitive Impairment
Chang, Y., Chen, Y., & Kang, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168776 · Cited by 27
Low incidence of major complications after the first six hours post atrial fibrillation ablation: Is same‐day discharge safe and feasible in most patients?
Paul‐Nordin, A., Drca, N., Insulander, P., Bastani, H., Bourke, T., Braunschweig, F., Kennebäck, G., von Olshausen, G., Sadigh, B., Saluveer, O., et al. (2021) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.15243 · Cited by 25
Mortality benefit of catheter ablation versus medical therapy in atrial fibrillation: An RCT only meta‐analysis
Ravi, V., Poudyal, A., Li, L., Larsen, T. R., Wasserlauf, J., Trohman, R. G., Krishnan, K., Sharma, P. S., & Huang, H. D. (2021) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.15330 · Cited by 25
The effects of cognitive behavioral therapy on health-related quality of life, anxiety, depression, illness perception, and in atrial fibrillation patients: a six-month longitudinal study
Minjie, Z., Zhijuan, X., Xinxin, S., Bai, X., & Qu, S. (2023) · BMC Psychology · doi:10.1186/s40359-023-01457-z · Cited by 25
Internet-Delivered Exposure-Based Therapy for Symptom Preoccupation in Atrial Fibrillation: Uncontrolled Pilot Trial
Särnholm, J., Skúladóttir, H., Rück, C., Klavebäck, S., Ólafsdóttir, E., Pedersen, S. S., Braunschweig, F., & Ljótsson, B. (2021) · JMIR Cardio · doi:10.2196/24524 · Cited by 25
Ablation Versus Antiarrhythmic Drugs as First-Line Treatment of Paroxysmal Atrial Fibrillation: A Meta-Analysis of Randomized Trials
Kheiri, B., Simpson, T. F., Przybylowicz, R., Merrill, M. E., Alhamoud, H., Osman, M., Dalouk, K. A., Stecker, E. C., Henrikson, C. A., & Nazer, B. (2021) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.120.009692 · Cited by 25
Catheter and Surgical Ablation for Atrial Fibrillation
Montané, B., Zhang, S., Wolfe, J. D., Prime, S., Luo, C., Cooper, D. H., Doering, M. M., Blomström‐Lundqvist, C., Nashef, S. A. M., Osmancik, P. P., et al. (2025) · Annals of Internal Medicine · doi:10.7326/annals-25-00253 · Cited by 24
Clinical outcome of 2nd generation cryoballoon pulmonary vein isolation in patients over 75 years of age
Pott, A., Messemer, M., Petscher, K., Iturbe-Orbe, M., Bothner, C., Rottbauer, W., & Dahme, T. (2016) · Journal of Cardiology · doi:10.1016/j.jjcc.2016.07.020 · Cited by 24
Outcomes and Safety of Fluoroless Catheter Ablation for Atrial Fibrillation
Lurie, A., Amit, G., Divakaramenon, S., Acosta, J. G., Healey, J. S., & Wong, J. A. (2020) · CJC Open · doi:10.1016/j.cjco.2020.11.002 · Cited by 24
Self-citation
Contemporary approaches to treating arrhythmias
Zipes, D. P. (2014) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2014.211 · Cited by 24
Impact of catheter ablation timing according to duration of atrial fibrillation history on arrhythmia recurrences and clinical outcomes: a meta-analysis
Karakasis, P., Tzeis, S. E., Pamporis, K., Schuermans, A., Theofilis, P., Milaras, N., Tsiachris, D., Efremidis, M., Antoniadis, A. P., & Fragakis, N. (2025) · EP Europace · doi:10.1093/europace/euaf110 · Cited by 26
Anesthetic Choice for Atrial Fibrillation Ablation: A National Anesthesia Clinical Outcomes Registry Analysis
Dada, R. S., Hayanga, J. W. A., Woods, K. E., SCHWARTZMAN, D. S., Thibault, D. P., Ellison, M. B., Schmidt, S. B., Siddoway, D., Badhwar, V., & Hayanga, H. K. (2021) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2020.12.046 · Cited by 23
Effectiveness of a Mindfulness Meditation App Based on an Electroencephalography-Based Brain-Computer Interface in Radiofrequency Catheter Ablation for Patients With Atrial Fibrillation: Pilot Randomized Controlled Trial
He, Y., Tang, Z., Sun, G., Cai, C., Wang, Y., Yang, G., & Bao, Z. (2023) · JMIR mhealth and uhealth · doi:10.2196/44855 · Cited by 24
Second-generation cryoballoon ablation as a first-line treatment of symptomatic atrial fibrillation: Two-year outcome and predictors of recurrence after a single procedure
Akkaya, E., Berkowitsch, A., Zaltsberg, S., Greiß, H., Hamm, C. W., Sperzel, J., Neumann, T., & Kuniss, M. (2018) · International Journal of Cardiology · doi:10.1016/j.ijcard.2017.11.011 · Cited by 23
Action potential shortening rescues atrial calcium alternans
Kanaporis, G., Kalik, Z. M., & Blatter, L. A. (2018) · The Journal of Physiology · doi:10.1113/jp277188 · Cited by 23
PREvention of recurrent arrhythmias with Mediterranean diet (PREDIMAR) study in patients with atrial fibrillation: Rationale, design and methods
Barrio-López, M. T., Ruiz‐Canela, M., Ramos, P., Tercedor, L., Ibáñez, J. L., Ortiz, M., Goñi, L., Ibáñez-Críado, A., Ruiz, R. M., García‐Bolao, I., et al. (2019) · American Heart Journal · doi:10.1016/j.ahj.2019.10.009 · Cited by 23
Voltage-guided ablation in persistent atrial fibrillation—favorable 1-year outcome and predictors
Schade, A., Costello‐Boerrigter, L. C., Steinborn, F., Bayri, A. H., Chapran, M., Surber, R., Schulze, P. C., & Mattea, V. (2020) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-020-00882-z · Cited by 23
Impact of left atrial posterior wall isolation on arrhythmia outcomes in patients with atrial fibrillation undergoing repeat ablation
Pothineni, N. V. K., Lin, A., Frankel, D. S., Supple, G. E., Garcia, F. C., Lin, D., Hyman, M. C., Kumareswaran, R., Arkles, J., Riley, M., et al. (2021) · Heart Rhythm O2 · doi:10.1016/j.hroo.2021.07.004 · Cited by 23
Modelling the lifetime cost-effectiveness of catheter ablation for atrial fibrillation with heart failure
Gao, L., & Moodie, M. (2019) · BMJ Open · doi:10.1136/bmjopen-2019-031033 · Cited by 22
Ablation versus anti-arrhythmic therapy for reducing all hospital episodes from recurrent atrial fibrillation: a prospective, randomized, multi-centre, open label trial
Kanagaratnam, P., McCready, J. W., Tayebjee, M. H., Shepherd, E., Sasikaran, T., TODD, D. M., Johnson, N. A., Kyriacou, A. L., Hayat, S. A., Hobson, N. A., et al. (2022) · EP Europace · doi:10.1093/europace/euac253 · Cited by 22
Cryoballoon ablation versus radiofrequency ablation for atrial fibrillation
Reißmann, B., Metzner, A., & Kück, K. (2016) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2016.12.002 · Cited by 22
Hybrid atrial fibrillation ablation in patients with persistent atrial fibrillation or failed catheter ablation
Al-Jazairi, M. I. H., Rienstra, M., Klinkenberg, T. J., Mariani, M. A., Gelder, I. C. V., & Blaauw, Y. (2019) · Netherlands Heart Journal · doi:10.1007/s12471-019-1228-3 · Cited by 22
Health-Related Quality of Life in Patients With Atrial Fibrillation Treated With Catheter Ablation or Antiarrhythmic Drug Therapy: A Systematic Review and Meta-analysis
Allan, K. S., Aves, T., Henry, S., Banfield, L. E., Victor, J. C., Dorian, P., Healey, J. S., Andrade, J. G., Carroll, S. L., & McGillion, M. H. (2020) · CJC Open · doi:10.1016/j.cjco.2020.03.013 · Cited by 22
Self-citation
Combination of ablation and left atrial appendage closure as “One‐stop” procedure in the treatment of atrial fibrillation: Current status and future perspective
He, B., Jiang, L., Hao, Z., Wang, H., & Miao, Y. (2021) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.14201 · Cited by 21
Second-generation cryoballoon versus contact force radiofrequency ablation for atrial fibrillation: an updated meta-analysis of evidence from randomized controlled trials
Wu, C., Li, X., Lv, Z., Chen, Q., Lou, Y., Mao, W., & Zhou, X. (2021) · Scientific Reports · doi:10.1038/s41598-021-96820-8 · Cited by 21
Quality of life after the initial treatment of atrial fibrillation with cryoablation versus drug therapy
Wazni, O. M., Dandamudi, G., Sood, N. A., HOYT, R. H., Tyler, J. D., Durrani, S., Niebauer, M. J., Makati, K. J., Halperin, B. D., Gauri, A. J., et al. (2021) · Heart Rhythm · doi:10.1016/j.hrthm.2021.10.009 · Cited by 21
Rhythm-Monitoring Strategy and Arrhythmia Recurrence in Atrial Fibrillation Ablation Trials: A Systematic Review
Unni, R. R., Prager, R. T., Odabashian, R., Zhang, J. J., Hing, N. N. F., Nery, P. B., Pi, L., Aldawood, W., Sadek, M. M., Redpath, C. J., et al. (2022) · CJC Open · doi:10.1016/j.cjco.2022.02.001 · Cited by 21
Self-citation
Atrial Fibrillation and Risk of Dementia/Cognitive Decline.
SHAH, A. D., Merchant, F. M., & DeLurgio, D. B. (2016) · PubMed · doi:10.4022/jafib.1353 · Cited by 21
Significant reduction of radiation exposure in cryoballoon-based pulmonary vein isolation
Reißmann, B., Maurer, T., Wohlmuth, P., Krüger, M., Heeger, C.-H. H., Lemeš, C., Fink, T., Riedl, J., Santoro, F., Mathew, S., et al. (2017) · EP Europace · doi:10.1093/europace/eux066 · Cited by 21
Value of Interatrial Block for the Prediction of Silent Ischemic Brain Lesions
Çinier, G. (2018) · Journal of Atrial Fibrillation · doi:10.4022/jafib.2037 · Cited by 21
The effects of gender on electrical therapies for the heart: physiology, epidemiology, and access to therapies
Boriani, G., Lorenzetti, S., Cerbai, E., Oreto, G., Bronzetti, G., Malavasi, V. L., Biffi, A., Padeletti, L., Botto, G., & Diemberger, I. (2017) · EP Europace · doi:10.1093/europace/eux068 · Cited by 21
Organized Sources Are Spatially Conserved in Recurrent Compared to Pre‐Ablation Atrial Fibrillation: Further Evidence for Non‐Random Electrical Substrates
Lalani, G., Coysh, T., Baykaner, T., Zaman, J. A. B., HOPPER, K., Schricker, A. A., Trikha, R., Clopton, P., Krummen, D. E., & Narayan, S. M. (2016) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.12964 · Cited by 20
Chamber-specific transcriptional responses in atrial fibrillation
Lipovsky, C. E., Jiménez, J., Guo, Q., Li, G., Yin, T., Hicks, S. C., Bhatnagar, S., Takahashi, K., Zhang, D. M., Brumback, B. D., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.135319 · Cited by 20
Regional differences in referral, procedures, and outcome after ablation for atrial fibrillation in Europe: a report from the Atrial Fibrillation Ablation Pilot Registry of the European Society of Cardiology
Riahi, S., Arbelo, E., Brugada, J., Maggioni, A. P., Tavazzi, L., Vardas, P. E., Laroche, C., Efremidis, M., Xhaët, O., Woźniak, A., et al. (2015) · EP Europace · doi:10.1093/europace/euv386 · Cited by 20
Three‐year outcomes and reconnection patterns after initial contact force guided pulmonary vein isolation for paroxysmal atrial fibrillation
Nair, G. M., Yeo, C., MacDonald, Z., Ainslie, M., Alqarawi, W., Nery, P. B., Redpath, C. J., Sadek, M. M., Spence, S., Green, M. S., et al. (2017) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.13280 · Cited by 20
Self-citation
Comparison of treatment outcomes between convergent procedure and catheter ablation for paroxysmal atrial fibrillation evaluated with implantable loop recorder monitoring
Jan, M., Žižek, D., Geršak, Ž. M., & Geršak, B. (2018) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.13625 · Cited by 20
Surface ECG and intracardiac spectral measures predict atrial fibrillation recurrence after catheter ablation
Szilágyi, J., Walters, T. E., Marcus, G. M., Vedantham, V., Moss, J. D., Badhwar, N., Lee, B. K., Lee, R. J., Tseng, Z. H., & Gerstenfeld, E. P. (2018) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.13699 · Cited by 20

Authors: Morillo, C. A., Verma, A., Connolly, S. J., Kuck, K. H., Nair, G. M., Champagne, J., Sterns, L. D., Beresh, H., Healey, J. S., Natale, A., & RAAFT-2 Investigators
Affiliations: Population Health Research Institute (CA)
Southlake Regional Health Center (CA)
Asklepios Klinik St Georg, Hamburg, Germany
Ottawa Heart Institute (CA)
Université Laval (CA)
Victoria Cardiac Arrhythmia Trials Inc, Victoria, Canada
McMaster University, Population Health Research Institute, Hamilton Health Sciences, Hamilton, Canada
St David's Medical Center (US)
Corresponding author: Morillo, Carlos A.
ORCID: Morillo, Carlos A.
Verma, Atul
Connolly, Stuart J.
Nair, Girish M.
Champagne, Jean
Sterns, Laurence D.
Natale, Andrea
Venue: JAMA
Publisher: American Medical Association (AMA)
Published: 2014-02-19
Volume: 311
Issue: 7
Pages: 692
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.2014.467
OpenAlex: W2125891322
Cited by: 667
References: 31
Citations by year: 2026: 23 · 2025: 50 · 2024: 58 · 2023: 44 · 2022: 60 · 2021: 68 · 2020: 63 · 2019: 47 · 2018: 45 · 2017: 56 · 2016: 63 · 2015: 48 · 2014: 37
FWCI: 46.73
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: JAMA (publishedVersion)
PubMed (publishedVersion)
Funders: Biosense Webster
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
Keywords: paroxysmal atrial fibrillation, radiofrequency catheter ablation, antiarrhythmic drugs, first-line therapy, atrial tachyarrhythmia recurrence, atrial flutter, atrial tachycardia, quality of life, treatment-naive patients, bleeding risk
MeSH terms: Adult, Aged, Anti-Arrhythmia Agents, Atrial Fibrillation, Atrial Flutter, Female, Heart Atria, Humans, Male, Middle Aged, Recurrence, Tachycardia, Treatment Outcome, Catheter Ablation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Radiofrequency Ablation vs Antiarrhythmic Drugs as First-Line Treatment of Paroxysmal Atrial Fibrillation (RAAFT-2): A Randomized Trial

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks