The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Effect of Noninvasive Ventilation vs Oxygen Therapy on Mortality Among Immunocompromised Patients With Acute Respiratory Failure: A Randomized Clinical Trial
Abstract
IMPORTANCE: Noninvasive ventilation has been recommended to decrease mortality among immunocompromised patients with hypoxemic acute respiratory failure. However, its effectiveness for this indication remains unclear. OBJECTIVE: To determine whether early noninvasive ventilation improved survival in immunocompromised patients with nonhypercapnic acute hypoxemic respiratory failure. DESIGN, SETTING, AND PARTICIPANTS: Multicenter randomized trial conducted among 374 critically ill immunocompromised patients, of whom 317 (84.7%) were receiving treatment for hematologic malignancies or solid tumors, at 28 intensive care units (ICUs) in France and Belgium between August 12, 2013, and January 2, 2015. INTERVENTIONS: Patients were randomly assigned to early noninvasive ventilation (n = 191) or oxygen therapy alone (n = 183). MAIN OUTCOMES AND MEASURES: The primary outcome was day-28 mortality. Secondary outcomes were intubation, Sequential Organ Failure Assessment score on day 3, ICU-acquired infections, duration of mechanical ventilation, and ICU length of stay. RESULTS: At randomization, median oxygen flow was 9 L/min (interquartile range, 5-15) in the noninvasive ventilation group and 9 L/min (interquartile range, 6-15) in the oxygen group. All patients in the noninvasive ventilation group received the first noninvasive ventilation session immediately after randomization. On day 28 after randomization, 46 deaths (24.1%) had occurred in the noninvasive ventilation group vs 50 (27.3%) in the oxygen group (absolute difference, -3.2 [95% CI, -12.1 to 5.6]; P = .47). Oxygenation failure occurred in 155 patients overall (41.4%), 73 (38.2%) in the noninvasive ventilation group and 82 (44.8%) in the oxygen group (absolute difference, -6.6 [95% CI, -16.6 to 3.4]; P = .20). There were no significant differences in ICU-acquired infections, duration of mechanical ventilation, or lengths of ICU or hospital stays. CONCLUSIONS AND RELEVANCE: Among immunocompromised patients admitted to the ICU with hypoxemic acute respiratory failure, early noninvasive ventilation compared with oxygen therapy alone did not reduce 28-day mortality. However, study power was limited. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT01915719.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Vincent, J. L., Moreno, R., Takala, J., Willatts, S., De Mendonça, A., Bruining, H., Reinhart, C. K., Suter, P. M., & Thijs, L. G. (1996) · Intensive Care Medicine · doi:10.1007/bf01709751 · Cited by 11,674
Neuromuscular Blockers in Early Acute Respiratory Distress Syndrome
Papazian, L., Forel, J.-M., Gacouin, A., Penot-Ragon, C., Perrin, G., Loundou, A., Jaber, S., Arnal, J.-M., Perez, D., Seghboyan, J.-M., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1005372 · Cited by 2,432
Self-citation
Cited by
Official ERS/ATS clinical practice guidelines: noninvasive ventilation for acute respiratory failure
Rochwerg, B., Brochard, L., Elliott, M. W., Hess, D., Hill, N. S., Nava, S., Navalesi, P., Antonelli, M., Brozek, J., Conti, G., et al. (2017) · European Respiratory Journal · doi:10.1183/13993003.02426-2016 · Cited by 1,668
Diagnosis of severe respiratory infections in immunocompromised patients
Azoulay, E., Russell, L., Van de Louw, A., Metaxa, V., Bauer, P., Povoa, P., Montero, J. G., Loeches, I. M., Mehta, S., Puxty, K., et al. (2020) · Intensive Care Medicine · doi:10.1007/s00134-019-05906-5 · Cited by 346
Self-citationExhaled air dispersion during high-flow nasal cannula therapy versus CPAP via different masks
Hui, D. S., Chow, B. K., Lo, T., Tsang, O. T. Y., Ko, F. W., Ng, S. S., Gin, T., & Chan, M. T. V. (2019) · European Respiratory Journal · doi:10.1183/13993003.02339-2018 · Cited by 328
Use of high-flow nasal cannula oxygenation in ICU adults: a narrative review
Papazian, L., Corley, A., Hess, D., Fraser, J. F., Frat, J.-P., Guitton, C., Jaber, S., Maggiore, S. M., Nava, S., Rello, J., et al. (2016) · Intensive Care Medicine · doi:10.1007/s00134-016-4277-8 · Cited by 304
Self-citationClinical Significance of Upper Airway Virus Detection in Critically Ill Hematology Patients
Legoff, J., Zucman, N., Lemiale, V., Mokart, D., Pène, F., Lambert, J., Kouatchet, A., Demoule, A., Vincent, F., Nyunga, M., et al. (2019) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201804-0681oc · Cited by 80
Self-citation
Metadata
- Authors
- Lemiale, V., Mokart, D., Resche-Rigon, M., Pène, F., Mayaux, J., Faucher, E., Nyunga, M., Girault, C., Perez, P., Guitton, C., Ekpe, K., Kouatchet, A., Théodose, I., Benoit, D., Canet, E., Barbier, F., Rabbat, A., Bruneel, F., Vincent, F., Klouche, K., Loay, K., Mariotte, E., Bouadma, L., Moreau, A.-S., Seguin, A., Meert, A.-P., Reignier, J., Papazian, L., Mehzari, I., Cohen, Y., Schenck, M., Hamidfar, R., Darmon, M., Demoule, A., Chevret, S., & Azoulay, E.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2015-10-27
- Volume
- 314
- Issue
- 16
- Pages
- 1711
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W1922120322
- Cited by
- 378
- References
- 2
- FWCI
- 31.16
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Effect of Noninvasive Ventilation vs Oxygen Therapy on Mortality Among Immunocompromised Patients With Acute Respiratory Failure: A Randomized Clinical Trial. https://app.cochat.ai/papers/10.1001/jama.2015.12402
- The paper
- Lemiale, V., Mokart, D., Resche-Rigon, M., Pène, F., Mayaux, J., Faucher, E., Nyunga, M., Girault, C., Perez, P., Guitton, C., Ekpe, K., Kouatchet, A., Théodose, I., Benoit, D., Canet, E., Barbier, F., Rabbat, A., Bruneel, F., Vincent, F., . . . Azoulay, E. (2015). Effect of Noninvasive Ventilation vs Oxygen Therapy on Mortality Among Immunocompromised Patients With Acute Respiratory Failure: A Randomized Clinical Trial. JAMA. https://doi.org/10.1001/jama.2015.12402
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
