Neuromuscular Blockers in Early Acute Respiratory Distress Syndrome
Open accessAbstract
BACKGROUND: In patients undergoing mechanical ventilation for the acute respiratory distress syndrome (ARDS), neuromuscular blocking agents may improve oxygenation and decrease ventilator-induced lung injury but may also cause muscle weakness. We evaluated clinical outcomes after 2 days of therapy with neuromuscular blocking agents in patients with early, severe ARDS. METHODS: In this multicenter, double-blind trial, 340 patients presenting to the intensive care unit (ICU) with an onset of severe ARDS within the previous 48 hours were randomly assigned to receive, for 48 hours, either cisatracurium besylate (178 patients) or placebo (162 patients). Severe ARDS was defined as a ratio of the partial pressure of arterial oxygen (PaO2) to the fraction of inspired oxygen (FIO2) of less than 150, with a positive end-expiratory pressure of 5 cm or more of water and a tidal volume of 6 to 8 ml per kilogram of predicted body weight. The primary outcome was the proportion of patients who died either before hospital discharge or within 90 days after study enrollment (i.e., the 90-day in-hospital mortality rate), adjusted for predefined covariates and baseline differences between groups with the use of a Cox model. RESULTS: The hazard ratio for death at 90 days in the cisatracurium group, as compared with the placebo group, was 0.68 (95% confidence interval [CI], 0.48 to 0.98; P=0.04), after adjustment for both the baseline PaO2:FIO2 and plateau pressure and the Simplified Acute Physiology II score. The crude 90-day mortality was 31.6% (95% CI, 25.2 to 38.8) in the cisatracurium group and 40.7% (95% CI, 33.5 to 48.4) in the placebo group (P=0.08). Mortality at 28 days was 23.7% (95% CI, 18.1 to 30.5) with cisatracurium and 33.3% (95% CI, 26.5 to 40.9) with placebo (P=0.05). The rate of ICU-acquired paresis did not differ significantly between the two groups. CONCLUSIONS: In patients with severe ARDS, early administration of a neuromuscular blocking agent improved the adjusted 90-day survival and increased the time off the ventilator without increasing muscle weakness. (Funded by Assistance Publique-Hôpitaux de Marseille and the Programme Hospitalier de Recherche Clinique Régional 2004-26 of the French Ministry of Health; ClinicalTrials.gov number, NCT00299650.)
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
This recommendation was based on a meta-analysis of 3 trials that examined the role of NMBAs in ARDS, showing reduced risks of death (RR 0.72; 95% CI 0.58-0.91) and barotrauma (RR 0.43; 95% CI 0.20-0.90) with the use of cisatracurium infusion.
“This recommendation was based on a meta-analysis of 3 trials that examined the role of NMBAs in ARDS [465–467], showing reduced risks of death (RR 0.72; 95% CI 0.58–0.91) and barotrauma (RR 0.43; 95% CI 0.20–0.90) with the use of cisatracurium infusion [468].”
From Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 (2021) · cites this paper as [467]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
(2000) · New England Journal of Medicine · doi:10.1056/nejm200005043421801 · Cited by 12,941 · see citing works
The Acute Respiratory Distress Syndrome
Matthay, M. A. (1996) · New England Journal of Medicine · doi:10.1056/nejm199605303342209 · Cited by 4,924 · see citing works
The Acute Respiratory Distress Syndrome
Ware, L. B., & Matthay, M. A. (2000) · New England Journal of Medicine · doi:10.1056/nejm200005043421806 · Cited by 4,666 · see citing works
Incidence and Outcomes of Acute Lung Injury
Rubenfeld, G. D., Caldwell, E., Peabody, E., Weaver, J., Martin, D. P., Neff, M., Stern, E. J., & Hudson, L. D. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050333 · Cited by 3,684 · see citing works
Esteban, A. (2002) · JAMA · doi:10.1001/jama.287.3.345 · Cited by 1,768 · see citing works
Paresis Acquired in the Intensive Care Unit A Prospective Multicenter Study
Jonghe, B. D. (2002) · JAMA · doi:10.1001/jama.288.22.2859 · Cited by 1,518 · see citing works
Opioid analgesics and antagonists
Reisine, T. (1996) · Medical Entomology and Zoology · Cited by 1,205 · see citing works
Mechanical ventilation guided by esophageal pressure in acute lung injury.
Talmor, D., Sarge, T., Malhotra, A., O'Donnell, C. R., Ritz, R., Lisbon, A., Novack, V., & Loring, S. H. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0708638 · Cited by 1,149 · see citing works
Evolution of Mechanical Ventilation in Response to Clinical Research
Esteban, A., Ferguson, N. D., Meade, M. O., Frutos–Vivar, F., Apezteguía, C., Brochard, L. J., Raymondos, K., Nín, N., Hurtado, J., Vinko Tomicic, F., et al. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200706-893oc · Cited by 719 · see citing works
Epidemiology and outcome of acute lung injury in European intensive care units
for the ALIVE Study Group, Brun‐Buisson, C., Minelli, C., Bertolini, G., Brazzi, L., Pimentel, J., Lewandowski, K., Bion, J., Romand, J.-A., Villar, J., et al. (2004) · Intensive Care Medicine · doi:10.1007/s00134-003-2022-6 · Cited by 685 · see citing works
Schoenfeld, D., & Bernard, G. R. (2002) · Critical Care Medicine · doi:10.1097/00003246-200208000-00016 · Cited by 560 · see citing works
Murray, M. J., DeBlock, H. F., Erstad, B. L., Gray, A. W., Jacobi, J., Jordan, C. J., McGee, W. T., McManus, C., Meade, M. O., Nix, S. A., et al. (2016) · Critical Care Medicine · doi:10.1097/ccm.0000000000002027 · Cited by 514 · see citing works
Tidal Volume Reduction in Patients with Acute Lung Injury When Plateau Pressures Are Not High
Hager, D. N., Krishnan, J. A., Hayden, D. L., & Brower, R. G. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200501-048cp · Cited by 509 · see citing works
Persistent Paralysis in Critically Ill Patients after Long-Term Administration of Vecuronium
Segredo, V., Caldwell, J. E., Matthay, M. A., Sharma, M. L., Gruenke, L. D., & Miller, R. D. (1992) · New England Journal of Medicine · doi:10.1056/nejm199208203270804 · Cited by 484 · see citing works
Forel, J.-M., Roch, A., Marin, V., Michelet, P., Demory, D., Blache, J.-L., Perrin, G., Gainnier, M., Bongrand, P., & Papazian, L. (2006) · Critical Care Medicine · doi:10.1097/01.ccm.0000239435.87433.0d · Cited by 400 · see citing works
Self-citationGainnier, M., Roch, A., Forel, J.-M., Thirion, X., Arnal, J.-M., Donati, S., & Papazian, L. (2004) · Critical Care Medicine · doi:10.1097/01.ccm.0000104114.72614.bc · Cited by 349 · see citing works
Self-citationMehta, S., Burry, L. D., Fischer, S. E., Martinez-Motta, J. C., Hallett, D. C., Bowman, D., Wong, C., Meade, M. O., Stewart, T. E., & Cook, D. J. (2006) · Critical Care Medicine · doi:10.1097/01.ccm.0000196830.61965.f1 · Cited by 298 · see citing works
Murray, M. J., Cowen, J., DeBlock, H., Erstad, B., Gray, A. W., Tescher, A. N., McGee, W. T., Prielipp, R. C., Susla, G., Jacobi, J., et al. (2002) · Critical Care Medicine · doi:10.1097/00003246-200201000-00021 · Cited by 283 · see citing works
Hansen-Flaschen, J. H., Brazinsky, S. A., BASILE, C., & LANKIN, P. N. (1992) · Survey of Anesthesiology · doi:10.1097/00132586-199208000-00047 · Cited by 271 · see citing works
Epidemiology and outcome of acute lung injury in European intensive care units
Brun‐Buisson, C., Minelli, C., Bertolini, G., Brazzi, L., Pimentel, J., Lewandowski, K., Bion, J., Romand, J. A., Villar, J., Thorsteinsson, A., et al. (2004) · Intensive Care Medicine · doi:10.1007/s00134-003-2136-x · Cited by 258 · see citing works
Muscle Weakness in Mechanically Ventilated Patients With Severe Asthma
Leatherman, J. W., Fluegel, W. L., David, W. S., Davies, S. F., & Iber, C. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.153.5.8630621 · Cited by 257 · see citing works
Hansen-Flaschen, J. H. (1991) · JAMA · doi:10.1001/jama.1991.03470200082040 · Cited by 250 · see citing works
Low-Tidal-Volume Ventilation in the Acute Respiratory Distress Syndrome
Malhotra, A. (2007) · New England Journal of Medicine · doi:10.1056/nejmct074213 · Cited by 217 · see citing works
Acute Respiratory Distress Syndrome
Bernard, G. R. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200504-663oe · Cited by 178 · see citing works
Rocuronium exacerbates mechanical ventilation–induced diaphragm dysfunction in rats
Testelmans, D., Maes, K., Wouters, P. F., Gosselin, N., DeRuisseau, K. C., Powers, S. K., Sciot, R., Decramer, M., & Gayan‐Ramirez, G. (2006) · Critical Care Medicine · doi:10.1097/01.ccm.0000245783.28478.ad · Cited by 104 · see citing works
Sedation, analgesia, and neuromuscular blockade in sepsis: An evidence-based review
Vender, J. S., Szokol, J. W., Murphy, G. S., & Nitsun, M. (2004) · Critical Care Medicine · doi:10.1097/01.ccm.0000145907.86298.12 · Cited by 75 · see citing works
Intensive care sedation of mechanically ventilated patients: a national Swedish survey
Samuelson, K. A. M., Larsson, S., Lundberg, D., & Fridlund, B. (2003) · Intensive and Critical Care Nursing · doi:10.1016/s0964-3397(03)00065-x · Cited by 55 · see citing works
Murray, M. J., Coursin, D. B., Scuderi, P. E., Kamath, G. S., Prough, D. S., Howard, D. M., & Abou-Donia, M. A. (1995) · Critical Care Medicine · doi:10.1097/00003246-199503000-00007 · Cited by 49 · see citing works
Bredenberg, C. E. (1974) · Surgical Clinics of North America · doi:10.1016/s0039-6109(16)40436-6 · Cited by 48 · see citing works
Prolonged weakness after cisatracurium infusion
Davis, N. A., Rodgers, J. E., Gonzalez, E. R., & Fowler, A. A. (1998) · Critical Care Medicine · doi:10.1097/00003246-199807000-00038 · Cited by 45 · see citing works
Hansen-Flaschen, J. H. (1991) · JAMA · doi:10.1001/jama.266.20.2870 · Cited by 30 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Reisine T, Pasternak G. Opioid anal- 16. gesics and antagonists. In: Hardman J, Limbird L, eds. The pharmacological ba- sis of therapeutics. 9th ed. New York: McGraw-Hill, 1996:521-55.
Cited by
Sorted by citations
Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock
Dellinger, R. P., Levy, M. M., Rhodes, A., Annane, D., Gerlach, H., Opal, S. M., Sevransky, J. E., Sprung, C. L., Douglas, I. S., Jaeschke, R., et al. (2013) · Critical Care Medicine · doi:10.1097/ccm.0b013e31827e83af · Cited by 9,694 · see citing works
Dellinger, R. P., Levy, M. M., Rhodes, A., Annane, D., Gerlach, H., Opal, S. M., Sevransky, J., Sprung, C. L., Douglas, I. S., Jaeschke, R., et al. (2013) · Intensive Care Medicine · doi:10.1007/s00134-012-2769-8 · Cited by 7,282 · see citing works
Surviving Sepsis Campaign: International guidelines for management of sepsis and septic shock: 2016.
Rhodes, A., Evans, L. E., Alhazzani, W., Levy, M. M., Antonelli, M., Ferrer, R., Kumar, A., Sevransky, J. E., Sprung, C. L., Nunnally, M. E., et al. (2017) · Intensive Care Medicine · doi:10.1007/s00134-017-4683-6 · Cited by 6,621 · see citing works
Bellani, G., Laffey, J. G., Pham, T., Fan, E., Brochard, L., Esteban, A., Gattinoni, L., van Haren, F., Larsson, A., McAuley, D. F., et al. (2016) · JAMA · doi:10.1001/jama.2016.0291 · Cited by 5,766 · see citing works
Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021
Evans, L., Rhodes, A., Alhazzani, W., Antonelli, M., Coopersmith, C. M., French, C., Machado, F. R., Mcintyre, L., Ostermann, M., Prescott, H. C., et al. (2021) · Intensive Care Medicine · doi:10.1007/s00134-021-06506-y · Cited by 5,082 · see citing works
Prone positioning in severe acute respiratory distress syndrome.
Guérin, C., Reignier, J., Richard, J.-C., Beuret, P., Gacouin, A., Boulain, T., Mercier, E., Badet, M., Mercat, A., Baudin, O., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1214103 · Cited by 4,040 · see citing works
Self-citationSurviving Sepsis Campaign: International guidelines for management of sepsis and septic shock: 2016.
Rhodes, A., Evans, L. E., Alhazzani, W., Levy, M. M., Antonelli, M., Ferrer, R., Kumar, A., Sevransky, J. E., Sprung, C. L., Nunnally, M. E., et al. (2017) · Critical Care Medicine · doi:10.1097/ccm.0000000000002255 · Cited by 3,652 · see citing works
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.
Evans, L., Rhodes, A., Alhazzani, W., Antonelli, M., Coopersmith, C. M., French, C., Machado, F. R., Mcintyre, L., Ostermann, M., Prescott, H. C., et al. (2021) · Critical Care Medicine · doi:10.1097/ccm.0000000000005337 · Cited by 2,935 · see citing works
Functional Disability 5 Years after Acute Respiratory Distress Syndrome
Herridge, M. S., Tansey, C. M., Matte, A. L., TOMLINSON, G. A., Diaz-Granados, N., Cooper, A., Guest, C. B., Mazer, C. D., Mehta, S., Stewart, T. E., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1011802 · Cited by 2,829 · see citing works
Acute respiratory distress syndrome
Matthay, M. A., Zemans, R. L., Zimmerman, G. A., Arabi, Y. M., Beitler, J. R., Mercat, A., Herridge, M. S., Randolph, A. G., & Calfee, C. S. (2019) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0069-0 · Cited by 2,419 · see citing works
Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome
Combes, A., Hajage, D., Capellier, G., Demoule, A., Lavoué, S., Guervilly, C., Da Silva, D., Zafrani, L., Tirot, P., Veber, B., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1800385 · Cited by 2,380 · see citing works
Ventilator-Induced Lung Injury
Slutsky, A. S., & Ranieri, V. M. (2013) · New England Journal of Medicine · doi:10.1056/nejmra1208707 · Cited by 2,275 · see citing works
Acute respiratory distress syndrome
Thompson, B. T., Chambers, R. C., & Liu, K. D. (2017) · New England Journal of Medicine · doi:10.1056/nejmra1608077 · Cited by 1,807 · see citing works
The acute respiratory distress syndrome
Matthay, M. A., Ware, L. B., & Zimmerman, G. A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60331 · Cited by 1,706 · see citing works
Fan, E., Sorbo, L. D., Goligher, E. C., Hodgson, C. L., Munshi, L., Walkey, A. J., Adhikari, N. K. J., Amato, M. B. P., Branson, R. D., Brower, R. G., et al. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201703-0548st · Cited by 1,647 · see citing works
Acute Respiratory Distress Syndrome
Fan, E., Brodie, D., & Slutsky, A. S. (2018) · JAMA · doi:10.1001/jama.2017.21907 · Cited by 1,482 · see citing works
Mechanical Ventilation to Minimize Progression of Lung Injury in Acute Respiratory Failure
Brochard, L. J., Slutsky, A. S., & Pesenti, A. M. (2016) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201605-1081cp · Cited by 1,279 · see citing works
Weiss, S. L., Peters, M. J., Alhazzani, W. A., Agus, M. S. D., Flori, H. R., Inwald, D. P., Nadel, S., Schlapbach, L. J., Tasker, R. C., Argent, A. C., et al. (2020) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0000000000002198 · Cited by 1,268 · see citing works
Acute respiratory distress syndrome
Meyer, N. J., Gattinoni, L., & Calfee, C. S. (2021) · The Lancet · doi:10.1016/s0140-6736(21)00439-6 · Cited by 1,185 · see citing works
Grasselli, G., Calfee, C. S., Camporota, L., Poole, D., Amato, M. B. P., Antonelli, M. M., Arabi, Y. M., Baroncelli, F., Beitler, J. R., Bellani, G., et al. (2023) · Intensive Care Medicine · doi:10.1007/s00134-023-07050-7 · Cited by 995 · see citing works
Self-citationEarly Neuromuscular Blockade in the Acute Respiratory Distress Syndrome
The National Heart, L. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1901686 · Cited by 886 · see citing works
A New Global Definition of Acute Respiratory Distress Syndrome
Matthay, M. A., Arabi, Y. M., Arroliga, A. C., Bernard, G. R., Bersten, A. D., Brochard, L. J., Calfee, C. S., Combes, A., Daniel, B. M., Ferguson, N. D., et al. (2023) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202303-0558ws · Cited by 881 · see citing works
ICU-Acquired Weakness and Recovery from Critical Illness
Kress, J. P., & Hall, J. B. (2014) · New England Journal of Medicine · doi:10.1056/nejmra1209390 · Cited by 862 · see citing works
Extracorporeal Membrane Oxygenation for ARDS in Adults
Brodie, D., & Bacchetta, M. (2011) · New England Journal of Medicine · doi:10.1056/nejmct1103720 · Cited by 836 · see citing works
Schmidt, M., Bailey, M., Sheldrake, J., Hodgson, C. L., Aubron, C., Rycus, P. T., Scheinkestel, C. D., Cooper, D. J., Brodie, D., Pellegrino, V. A., et al. (2014) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201311-2023oc · Cited by 829 · see citing works
Clinical review: intensive care unit acquired weakness
Hermans, G., & Van den Berghe, G. (2015) · Critical Care · doi:10.1186/s13054-015-0993-7 · Cited by 792 · see citing works
Vanhorebeek, I., Latronico, N., & den Berghe, G. V. (2020) · Intensive Care Medicine · doi:10.1007/s00134-020-05944-4 · Cited by 768 · see citing works
Formal guidelines: Management of acute respiratory distress syndrome.
Papazian, L., Aubron, C., Brochard, L., Chiche, J.-D., Combes, A., Dreyfuss, D., Forel, J.-M., Guérin, C., Jaber, S., Mekontso-Dessap, A., et al. (2019) · Annals of Intensive Care · doi:10.1186/s13613-019-0540-9 · Cited by 761 · see citing works
Self-citationMesenchymal stem (stromal) cells for treatment of ARDS: a phase 1 clinical trial
Wilson, J. G., Liu, K. D., Zhuo, H., Caballero, L., McMillan, M., Fang, X., Cosgrove, K. M., Vojnik, R., Calfee, C. S., Lee, J. W., et al. (2014) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(14)70291-7 · Cited by 759 · see citing works
Grasselli, G., Tonetti, T., Protti, A., Länger, T., Girardis, M., Bellani, G., Laffey, J. G., Carrafiello, G., Carsana, L., Rizzuto, C., et al. (2020) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(20)30370-2 · Cited by 698 · see citing works
Critical illness polyneuropathy and myopathy: a major cause of muscle weakness and paralysis
Latronico, N., & Bolton, C. F. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(11)70178-8 · Cited by 690 · see citing works
Weiss, S. L., Peters, M. J., Alhazzani, W. A., Agus, M. S. D., Flori, H. R., Inwald, D. P., Nadel, S., Schlapbach, L. J., Tasker, R. C., Argent, A. C., et al. (2020) · Intensive Care Medicine · doi:10.1007/s00134-019-05878-6 · Cited by 638 · see citing works
The Application of Esophageal Pressure Measurement in Patients with Respiratory Failure
Akoumianaki, E., Maggiore, S. M., Valenza, F., Bellani, G., Jubran, A., Loring, S. H., Pelosi, P. P., Talmor, D. S., Grasso, S., Chiumello, D., et al. (2014) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201312-2193ci · Cited by 636 · see citing works
Self-citationSpontaneous Effort Causes Occult Pendelluft during Mechanical Ventilation
Yoshida, T., Torsani, V., Gomes, S., Santiago, R. R. D. S., Beraldo, M. A., Costa, E. L. V., Tucci, M. R., Zin, W. A., Kavanagh, B. P., & Amato, M. B. P. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201303-0539oc · Cited by 576 · see citing works
Schmidt, M., Zogheib, E. H., Rozé, H., Repessé, X., Lebreton, G., Luyt, C. E., Trouillet, J., Bréchot, N., Nieszkowska, A., Dupont, H., et al. (2013) · Intensive Care Medicine · doi:10.1007/s00134-013-3037-2 · Cited by 575 · see citing works
Arabi, Y. M., Arifi, A. A., Balkhy, H. H., Najm, H. K., Al‐Dawood, A., Ghabashi, A., Hawa, H., Alothman, A. F., Al-Khaldi, A., & Raiy, B. A. (2014) · Annals of Internal Medicine · doi:10.7326/m13-2486 · Cited by 573 · see citing works
Intubation and Ventilation amid the COVID-19 Outbreak
Meng, L., Qiu, H., Wan, L., Ai, Y., Xue, Z., Guo, Q., Deshpande, R. P., Zhang, L., Meng, J., Tong, C., et al. (2020) · Anesthesiology · doi:10.1097/aln.0000000000003296 · Cited by 566 · see citing works
Esophageal and transpulmonary pressure in the clinical setting: meaning, usefulness and perspectives
Mauri, T., Yoshida, T., Bellani, G., Goligher, E. C., Carteaux, G., Rittayamai, N., Mojoli, F., Chiumello, D., Piquilloud, L., Grasso, S., et al. (2016) · Intensive Care Medicine · doi:10.1007/s00134-016-4400-x · Cited by 559 · see citing works
Asynchronies during mechanical ventilation are associated with mortality
Blanch, L. L., Villagra, A. L. R., Sales, B., Montanyà, J., Lucangelo, U., Luján, M., García-Esquirol, Ó., Chacón, E., Estruga, A., Oliva, J. C., et al. (2015) · Intensive Care Medicine · doi:10.1007/s00134-015-3692-6 · Cited by 539 · see citing works
Murray, M. J., DeBlock, H. F., Erstad, B. L., Gray, A. W., Jacobi, J., Jordan, C. J., McGee, W. T., McManus, C., Meade, M. O., Nix, S. A., et al. (2016) · Critical Care Medicine · doi:10.1097/ccm.0000000000002027 · Cited by 514 · see citing works
Guidelines on the management of acute respiratory distress syndrome
Griffiths, M., McAuley, D. F., Perkins, G. D., Barrett, N. A., Blackwood, B., Boyle, A. J., Chee, N., Connolly, B. A., Dark, P. M., Finney, S. J., et al. (2019) · BMJ Open Respiratory Research · doi:10.1136/bmjresp-2019-000420 · Cited by 506 · see citing works
Prone Position in Acute Respiratory Distress Syndrome. Rationale, Indications, and Limits
Gattinoni, L., Taccone, P., Carlesso, E., & Marini, J. J. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201308-1532ci · Cited by 482 · see citing works
Qadir, N., Sahetya, S. K., Munshi, L., Summers, C., Abrams, D. C., Beitler, J. R., Bellani, G., Brower, R. G., Burry, L. D., Chen, J., et al. (2023) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202311-2011st · Cited by 476 · see citing works
Self-citationLiberal or Conservative Oxygen Therapy for Acute Respiratory Distress Syndrome
Barrot, L., Asfar, P., Mauny, F., Winiszewski, H., Montini, F., Badie, J., Quenot, J.-P., Pili-Floury, S., Bouhemad, B., Louis, G., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa1916431 · Cited by 467 · see citing works
Self-citationHerridge, M. S., Moss, M., Hough, C. L., Hopkins, R. O., Rice, T. W., Bienvenu, O. J., & Azoulay, E. (2016) · Intensive Care Medicine · doi:10.1007/s00134-016-4321-8 · Cited by 442 · see citing works
ECMO for severe ARDS: systematic review and individual patient data meta-analysis
Combes, A., Peek, G. J., Hajage, D., Hardy, P., Abrams, D. C., Schmidt, M., Dechartres, A., & Elbourne, D. R. (2020) · Intensive Care Medicine · doi:10.1007/s00134-020-06248-3 · Cited by 431 · see citing works
Critical illness-associated diaphragm weakness
Dres, M., Goligher, E. C., Heunks, L. M. A., & Brochard, L. J. (2017) · Intensive Care Medicine · doi:10.1007/s00134-017-4928-4 · Cited by 418 · see citing works
MacLaren, G., Combes, A., & Bartlett, R. H. (2011) · Intensive Care Medicine · doi:10.1007/s00134-011-2439-2 · Cited by 410 · see citing works
Acute respiratory distress syndrome
Sweeney, R. M., & McAuley, D. F. (2016) · The Lancet · doi:10.1016/s0140-6736(16)00578-x · Cited by 402 · see citing works
The Sick and the Weak: Neuropathies/Myopathies in the Critically Ill
Friedrich, O., Reid, M. B., den Berghe, G. V., Vanhorebeek, I., Hermans, G., Rich, M. M., & Larsson, L. (2015) · Physiological Reviews · doi:10.1152/physrev.00028.2014 · Cited by 394 · see citing works
Severity scoring of lung oedema on the chest radiograph is associated with clinical outcomes in ARDS
Warren, M. A., Zhao, Z., Koyama, T., Bastarache, J. A., Shaver, C. M., Semler, M. W., Rice, T. W., Matthay, M. A., Calfee, C. S., & Ware, L. B. (2018) · Thorax · doi:10.1136/thoraxjnl-2017-211280 · Cited by 392 · see citing works
The Acute Respiratory Distress Syndrome: From Mechanism to Translation
Han, S., & Mallampalli, R. K. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402513 · Cited by 391 · see citing works
Reappraisal of Ventilator-Free Days in Critical Care Research
Yehya, N., Harhay, M. O., Curley, M. A. Q., Schoenfeld, D., & Reeder, R. (2019) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201810-2050cp · Cited by 389 · see citing works
The impact of extended bed rest on the musculoskeletal system in the critical care environment
Parry, S. M., & Puthucheary, Z. A. (2015) · Extreme Physiology & Medicine · doi:10.1186/s13728-015-0036-7 · Cited by 383 · see citing works
Constantin, J., Jabaudon, M., Lefrant, J., Jaber, S., Quenot, J., Langeron, O., Ferrandière, M., Grelon, F., Séguin, P., Ichaï, C., et al. (2019) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(19)30138-9 · Cited by 381 · see citing works
Self-citationMechanical Ventilation: State of the Art
Pham, T. O., Brochard, L. J., & Slutsky, A. S. (2017) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2017.05.004 · Cited by 379 · see citing works
Laffey, J. G., Bellani, G., Pham, T., Fan, E., Madotto, F., Bajwa, E. K., Brochard, L., Clarkson, K., Esteban, A., Gattinoni, L., et al. (2016) · Intensive Care Medicine · doi:10.1007/s00134-016-4571-5 · Cited by 378 · see citing works
Lemiale, V., Mokart, D., Resche‐Rigon, M., Pène, F., Mayaux, J., Faucher, E., Nyunga, M., Girault, C., Perez, P., Guitton, C., et al. (2015) · JAMA · doi:10.1001/jama.2015.12402 · Cited by 376 · see citing works
Self-citationVentilator-induced Lung Injury
Beitler, J. R., Malhotra, A., & Thompson, B. (2016) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2016.07.004 · Cited by 360 · see citing works
on behalf of the section Respiratory Failure of the European Society for Paediatric and Neonatal Intensive Care, Kneyber, M. C. J., Luca, D. D., Calderini, E., Jarreau, P., Javouhey, É., López‐Herce, J., Hammer, J., Macrae, D. J., Markhorst, D. G., et al. (2017) · Intensive Care Medicine · doi:10.1007/s00134-017-4920-z · Cited by 360 · see citing works
Needham, D. M., Colantuoni, E., Méndez-Téllez, P. A., Dinglas, V. D., Sevransky, J., Himmelfarb, C. D., Desai, S. V., Shanholtz, C. B., Brower, R. G., & Pronovost, P. J. (2012) · BMJ · doi:10.1136/bmj.e2124 · Cited by 354 · see citing works
Jolley, S. E., Bunnell, A. E., & Hough, C. L. (2016) · CHEST Journal · doi:10.1016/j.chest.2016.03.045 · Cited by 348 · see citing works
Yoshida, T., Fujino, Y., Amato, M. B. P., & Kavanagh, B. P. (2016) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201604-0748cp · Cited by 346 · see citing works
Robba, C., Poole, D., McNett, M., Asehnoune, K., Bösel, J., Bruder, N. J., Chieregato, A., Cinotti, R., Duranteau, J., Einav, S., et al. (2020) · Intensive Care Medicine · doi:10.1007/s00134-020-06283-0 · Cited by 345 · see citing works
Self-citationEarly Neuromuscular Blockade in the Acute Respiratory Distress Syndrome
Moss, M., Ulysse, C. A., & Angus, D. C. (2019) · New England Journal of Medicine · doi:10.1056/nejmc1908874 · Cited by 341 · see citing works
Schmidt, M., Pham, T. O., Arcadipane, A. F., Agerstrand, C. L., Ohshimo, S., Pellegrino, V. A., Vuylsteke, A., Guervilly, C., McGuinness, S., Piérard, S., et al. (2019) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201806-1094oc · Cited by 328 · see citing works
Prescott, H. C., Calfee, C. S., Thompson, B., Angus, D. C., & Liu, V. X. (2016) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201512-2544cp · Cited by 323 · see citing works
Mowery, N. T., Terzian, W. T. H., & Nelson, A. C. (2020) · Current Problems in Surgery · doi:10.1016/j.cpsurg.2020.100777 · Cited by 323 · see citing works
Smith, F. G., Perkins, G. D., Gates, S., Young, D., McAuley, D. F., Tunnicliffe, W. S., Khan, Z., & Lamb, S. E. (2011) · The Lancet · doi:10.1016/s0140-6736(11)61623-1 · Cited by 322 · see citing works
Analgesia and sedation in patients with ARDS
Chanques, G., Constantin, J., Devlin, J. W., Ely, E. W., Fraser, G. L., Gélinas, C., Girard, T. D., Guérin, C., Jabaudon, M., Jaber, S., et al. (2020) · Intensive Care Medicine · doi:10.1007/s00134-020-06307-9 · Cited by 316 · see citing works
Self-citationSpontaneous breathing during lung-protective ventilation in an experimental acute lung injury model
Yoshida, T., Uchiyama, A., Matsuura∥, N., Mashimo, T., & Fujino, Y. (2012) · Critical Care Medicine · doi:10.1097/ccm.0b013e3182451c40 · Cited by 315 · see citing works
The "baby lung" became an adult
Gattinoni, L., Marini, J. J., Pesenti, A. M., Quintel, M., Mancebo, J., & Brochard, L. J. (2016) · Intensive Care Medicine · doi:10.1007/s00134-015-4200-8 · Cited by 305 · see citing works
Bos, L. D. J., Schouten, L. R. A., van Vught, L. A., Wiewel, M. A., Ong, D. S. Y., Cremer, O. L., Artigas, A., Martín‐Loeches, I., Hoogendijk, A. J., van der Poll, T., et al. (2017) · Thorax · doi:10.1136/thoraxjnl-2016-209719 · Cited by 298 · see citing works
Guérin, C., Beuret, P., Constantin, J.-M., Bellani, G., García-Olivares, P., Roca, O., Meertens, J. H. J. M., Maia, P., Becher, T., Peterson, J., et al. (2017) · Intensive Care Medicine · doi:10.1007/s00134-017-4996-5 · Cited by 296 · see citing works
Self-citationIncreased Incidence of Barotrauma in Patients with COVID-19 on Invasive Mechanical Ventilation
McGuinness, G., Zhan, C., Rosenberg, N., Azour, L., Wickstrom, M. L., Mason, D. M., Thomas, K. M., & Moore, W. H. (2020) · Radiology · doi:10.1148/radiol.2020202352 · Cited by 293 · see citing works
Mechanical Ventilation-Induced Reverse-Triggered Breaths
Akoumianaki, E., Lyazidi, A., Rey, N., Matamis, D., Perez-Martinez, N., Giraud, R., Mancebo, J., Brochard, L. J., & Richard, J.-C. (2013) · CHEST Journal · doi:10.1378/chest.12-1817 · Cited by 289 · see citing works
Acute respiratory distress syndrome and acute lung injury
Dushianthan, A., Grocott, M. P. W., Postle, A. D., & Cusack, R. (2011) · Postgraduate Medical Journal · doi:10.1136/pgmj.2011.118398 · Cited by 288 · see citing works
Grosse-Sundrup, M., Henneman, J. P., Sandberg, W. S., Bateman, B. T., Uribe, J. V., Nguyen, N. T., Ehrenfeld, J. M., Martinez, E. A., Kurth, T., & Eikermann, M. (2012) · BMJ · doi:10.1136/bmj.e6329 · Cited by 285 · see citing works
Clinical trials in acute respiratory distress syndrome: challenges and opportunities
Matthay, M. A., McAuley, D. F., & Ware, L. B. (2017) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(17)30188-1 · Cited by 283 · see citing works
Interventions for preventing critical illness polyneuropathy and critical illness myopathy
Hermans, G., Jonghe, B. D., Bruyninckx, F., & den Berghe, G. V. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006832.pub3 · Cited by 280 · see citing works
Frantzeskaki, F. G., Armaganidis, A., & Orfanos, S. E. (2016) · Respiration · doi:10.1159/000453002 · Cited by 276 · see citing works
Respiratory Drive in Critically Ill Patients. Pathophysiology and Clinical Implications
Vaporidi, K., Akoumianaki, E., Telías, I., Goligher, E. C., Brochard, L. J., & Georgopoulos, D. (2019) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201903-0596so · Cited by 273 · see citing works
Joannidis, M., Forni, L. G., Klein, S., Honoré, P. M., KASHANI, K. B., Ostermann, M., Prowle, J. R., Bagshaw, S. M., Cantaluppi, V., Darmon, M., et al. (2019) · Intensive Care Medicine · doi:10.1007/s00134-019-05869-7 · Cited by 271 · see citing works
Positive pressure ventilation in the cardiac intensive care unit
Alviar, C. L., Miller, P. E., McAreavey, D., Katz, J. N., Lee, B., Moriyama, B., Soble, J., van Diepen, S., Solomon, M. A., & Morrow, D. A. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.06.074 · Cited by 271 · see citing works
on behalf of the investigators of the Acurasys and Proseva trials, Guérin, C., Papazian, L., Reignier, J., Ayzac, L., Loundou, A., & Forel, J.-M. (2016) · Critical Care · doi:10.1186/s13054-016-1556-2 · Cited by 268 · see citing works
Self-citationBiomarkers for Acute Respiratory Distress syndrome and prospects for personalised medicine
Spadaro, S., Park, M., Turrini, C., Tunstall, T., Thwaites, R. S., Mauri, T., Ragazzi, R., Ruggeri, P., Hansel, T. T., Caramori, G., et al. (2019) · Journal of Inflammation · doi:10.1186/s12950-018-0202-y · Cited by 268 · see citing works
Meduri, G. U., Bridges, L., Shih, M., Marik, P. E., Siemieniuk, R. A. C., & Koçak, M. (2015) · Intensive Care Medicine · doi:10.1007/s00134-015-4095-4 · Cited by 264 · see citing works
Pham, T. O., & Rubenfeld, G. D. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201609-1773cp · Cited by 264 · see citing works
Yoshida, T., Uchiyama, A., Matsuura∥, N., Mashimo, T., & Fujino, Y. (2012) · Critical Care Medicine · doi:10.1097/ccm.0b013e3182711972 · Cited by 263 · see citing works
Bertoni, M., Telías, I., Urner, M., Long, M., Sorbo, L. D., Fan, E., Sinderby, C. A., Beck, J. C., Liu, L., Qiu, H., et al. (2019) · Critical Care · doi:10.1186/s13054-019-2617-0 · Cited by 263 · see citing works
Critical care management of adults with community-acquired severe respiratory viral infection
Arabi, Y. M., Fowler, R., & Hayden, F. G. (2020) · Intensive Care Medicine · doi:10.1007/s00134-020-05943-5 · Cited by 260 · see citing works
Biotrauma and Ventilator-Induced Lung Injury
Curley, G. F., Laffey, J. G., Zhang, H., & Slutsky, A. S. (2016) · CHEST Journal · doi:10.1016/j.chest.2016.07.019 · Cited by 257 · see citing works
Alhazzani, W., Alshahrani, M., Jaeschke, R., Forel, J. M., Papazian, L., Sevransky, J., & Meade, M. O. (2013) · Critical Care · doi:10.1186/cc12557 · Cited by 250 · see citing works
Self-citationHistory of Mechanical Ventilation. From Vesalius to Ventilator-induced Lung Injury
Slutsky, A. S. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201503-0421pp · Cited by 248 · see citing works
Schmidt, M., Stewart, C. E., Bailey, M., Nieszkowska, A., Kelly, J., Murphy, L., Pilcher, D. V., Cooper, D. J., Scheinkestel, C. D., Pellegrino, V. A., et al. (2015) · Critical Care Medicine · doi:10.1097/ccm.0000000000000753 · Cited by 244 · see citing works
Extracorporeal Membrane Oxygenation for Adult Respiratory Failure
Peek, G. J., Moore, H. M., Moore, N., Sosnowski, A. W., & Firmin, R. K. (1997) · CHEST Journal · doi:10.1378/chest.112.3.759 · Cited by 242 · see citing works
High Positive End-Expiratory Pressure Renders Spontaneous Effort Noninjurious
Morais, C. C. A., Koyama, Y., Yoshida, T., Plens, G. M., Gomes, S., Lima, C. A. S., Ramos, O., Pereira, S. M., Kawaguchi, N., Yamamoto, H., et al. (2018) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201706-1244oc · Cited by 240 · see citing works
Monitoring of the Respiratory Muscles in the Critically Ill
Doorduin, J., van Hees, H. W. H., van der Hoeven, J. G., & Heunks, L. M. A. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201206-1117cp · Cited by 238 · see citing works
The Pathophysiology of Sepsis-Associated AKI
Kuwabara, S., Goggins, E. S., & Okusa, M. D. (2022) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.00850122 · Cited by 232 · see citing works
Acute respiratory distress syndrome: new definition, current and future therapeutic options.
Fanelli, V., Vlachou, A., Ghannadian, S., Simonetti, U., Slutsky, A. S., & Zhang, H. (2013) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2072-1439.2013.04.05 · Cited by 229 · see citing works
- Authors
- Papazian, L., Forel, J.-M., Gacouin, A., Penot-Ragon, C., Perrin, G., Loundou, A., Jaber, S., Arnal, J.-M., Perez, D., Seghboyan, J.-M., Constantin, J.-M., Courant, P., Lefrant, J.-Y., Guérin, C., Prat, G., Morange, S., & Roch, A.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Université de la Méditerranée Aix-Marseille II (FR)
- Hôpital Pontchaillou (FR)
- Hôpital Sainte-Marguerite (FR)
- Assistance Publique Hôpitaux de Marseille (FR)
- Hôpital Saint Eloi (FR)
- Centre Hospitalier Universitaire de Besançon (FR)
- CHU Ambroise Paré (BE)
- Centre Hospitalier Universitaire de Clermont-Ferrand (FR)
- Centre Hospitalier Universitaire de Nîmes (FR)
- Hôpital de la Croix-Rousse (FR)
- Inserm (FR)
- ORCID
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2010-09-16
- Volume
- 363
- Issue
- 12
- Pages
- 1107-1116
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2115186092
- Cited by
- 2,432
- References
- 29
- Citations by year
- 2026: 86 · 2025: 114 · 2024: 111 · 2023: 130 · 2022: 166 · 2021: 181 · 2020: 268 · 2019: 185 · 2018: 186 · 2017: 190 · 2016: 201 · 2015: 134 · 2014: 151 · 2013: 131 · 2012: 107
- FWCI
- 85.76
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
- Keywords
- cisatracurium, acute respiratory distress syndrome, mechanical ventilation, 90-day mortality, ventilator-induced lung injury, muscle weakness, oxygenation, intensive care unit patients, mortality risk factors, PaO2/FiO2 ratio, plateau pressure
- MeSH terms
- Atracurium, Combined Modality Therapy, Double-Blind Method, Humans, Infusions, Intravenous, Middle Aged, Multiple Organ Failure, Neuromuscular Blocking Agents, Pneumothorax, Respiration, Artificial, Respiratory Distress Syndrome, Ventilator Weaning, Survival Rate, Proportional Hazards Models, Treatment Outcome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
