Cited by 309Diabetes Treatment and ManagementPharmaceutical Practices and Patient OutcomesDiabetes Management and Research

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Polypharmacy in the Aging Patient: A Review of Glycemic Control in Older Adults With Type 2 Diabetes

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Lipska, Kasia J., Krumholz, Harlan, Soones, Tacara, Lee, Sei J.·2016·JAMA

DOI 10.1001/jama.2016.0299PMC PMC4823136

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Abstract

IMPORTANCE: There is substantial uncertainty about optimal glycemic control in older adults with type 2 diabetes mellitus. OBSERVATIONS: Four large randomized clinical trials (RCTs), ranging in size from 1791 to 11,440 patients, provide the majority of the evidence used to guide diabetes therapy. Most RCTs of intensive vs standard glycemic control excluded adults older than 80 years, used surrogate end points to evaluate microvascular outcomes and provided limited data on which subgroups are most likely to benefit or be harmed by specific therapies. Available data from randomized clinical trials suggest that intensive glycemic control does not reduce major macrovascular events in older adults for at least 10 years. Furthermore, intensive glycemic control does not lead to improved patient-centered microvascular outcomes for at least 8 years. Data from randomized clinical trials consistently suggest that intensive glycemic control immediately increases the risk of severe hypoglycemia 1.5- to 3-fold. Based on these data and observational studies, for the majority of adults older than 65 years, the harms associated with a hemoglobin A1c (HbA1c) target lower than 7.5% or higher than 9% are likely to outweigh the benefits. However, the optimal target depends on patient factors, medications used to reach the target, life expectancy, and patient preferences about treatment. If only medications with low treatment burden and hypoglycemia risk (such as metformin) are required, a lower HbA1c target may be appropriate. If patients strongly prefer to avoid injections or frequent fingerstick monitoring, a higher HbA1c target that obviates the need for insulin may be appropriate. CONCLUSIONS AND RELEVANCE: High-quality evidence about glycemic treatment in older adults is lacking. Optimal decisions need to be made collaboratively with patients, incorporating the likelihood of benefits and harms and patient preferences about treatment and treatment burden. For the majority of older adults, an HbA1c target between 7.5% and 9% will maximize benefits and minimize harms.

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Targeting intensive glycaemic control versus targeting conventional glycaemic control for type 2 diabetes mellitus
Hemmingsen, B., Lund, S. S., Gluud, C. N., Vaag, A. A., Almdal, T., & Wetterslev, J. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008143.pub4 · Cited by 287
Retracted
Targeting intensive glycaemic control versus targeting conventional glycaemic control for type 2 diabetes mellitus
Hemmingsen, B., Lund, S. S., Gluud, C. N., Vaag, A. A., Almdal, T., Hemmingsen, C., & Wetterslev, J. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008143.pub2 · Cited by 69
Retracted
Magnesium Replacement Improves the Metabolic Profile in Obese and Pre-Diabetic Patients with Mild-to-Moderate Chronic Kidney Disease: A 3-Month, Randomised, Double-Blind, Placebo-Controlled Study
Toprak, Ö., Kurt, H., Sarı, Y., Şarkış, C., Us, H., & Kırık, A. (2017) · Kidney & Blood Pressure Research · doi:10.1159/000468530 · Cited by 29,770
The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus
(1993) · New England Journal of Medicine · doi:10.1056/nejm199309303291401 · Cited by 24,667
Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
(1998) · The Lancet · doi:10.1016/s0140-6736(98)07019-6 · Cited by 20,023
Diagnosis and Classification of Diabetes Mellitus
American Diabetes Association (2010) · Diabetes Care · doi:10.2337/dc11-s062 · Cited by 14,075
2013 ESH/ESC Guidelines for the management of arterial hypertension
Authors Task Force Members, Mancia, G., Fagard, R., Narkiewicz, K., Redon, J., Zanchetti, A., Böhm, M., Christiaens, T., Cífková, R., Backer, G. D., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht151 · Cited by 13,728
Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes
Zinman, B., Wanner, C., Lachin, J. M., Fitchett, D., Bluhmki, E., Hantel, S., Mattheus, M., Devins, T., Johansen, O. E., Woerle, H. J., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1504720 · Cited by 12,315
Standards of Medical Care in Diabetes
Power, D. V. (2006) · Diabetes Care · doi:10.2337/diacare.29.02.06.dc05-1593 · Cited by 8,675
Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group.
Turner, R. C., Fox, C., Matthews, McElroy, H. H., Cull, C. A., Holman, R. R., Neil, P., Hadden, D. R., Wright, D., Manley, E., et al. (1998) · The Lancet · Cited by 8,419

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[68]Bloomfield HE Greer N Newman D Predictors and consequences of severe hypoglycemia in adults with diabetes—a systematic review of the evidence VA-ESP Project #09-009 2012 Accessed October 1, 2015 http://www.hsrd.research.va.gov/publications/esp/hypoglycemia-2012.pdf 23256228

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Prescription medication use among patients with type 2 diabetes in the United States: 1999–2020
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Overtreatment and undertreatment in a sample of elderly people with diabetes
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Font, C. C., Francia, C. C., Vinagre, I., Jansà, M., & Donlo, I. C. (2021) · Endocrinología Diabetes y Nutrición · doi:10.1016/j.endinu.2020.10.015 · Cited by 6
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McCreedy, E. M., Kane, R. L., Gollust, S. E., Shippee, N. D., & Clark, K. (2018) · The Journal of the American Board of Family Medicine · doi:10.3122/jabfm.2018.02.170141 · Cited by 6
Glycemic control and use of glucose-lowering medications in hospital-admitted type 2 diabetes patients over 80 years
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Lee, A. K., Steinman, M. A., & Lee, S. J. (2020) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2020-001624 · Cited by 5
Self-citation
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Baseline treatments and metabolic control of 288,913 type 2 diabetes patients in a 10-year retrospective cohort in Malaysia
Wan, K. S., Mustapha, F. I., Chandran, A., Ganapathy, S. S., Zakariah, N., Ramasamy, S., Subbarao, G. R., & Yusoff, M. F. M. (2023) · Scientific Reports · doi:10.1038/s41598-023-44564-y · Cited by 5
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Sun, B., He, F., Sun, L., Zhou, J., Shen, J., Xu, J., Wu, B. Y., Liu, R., Wang, X., Xu, H. Y., et al. (2018) · Endocrine · doi:10.1007/s12020-018-1715-0 · Cited by 5
Acute diabetes complications
Piro, S., & Purrello, F. (2021) · Journal of Gerontology and Geriatrics · doi:10.36150/2499-6564-n457 · Cited by 5

Authors: Lipska, K. J., Krumholz, H., Soones, T., & Lee, S. J.
Affiliations: Yale University (US)
Yale New Haven Hospital (US)
Icahn School of Medicine at Mount Sinai (US)
San Francisco VA Medical Center (US)
ORCID: Lipska, Kasia J.
Krumholz, Harlan
Soones, Tacara
Lee, Sei J.
Venue: JAMA
Publisher: American Medical Association (AMA)
Published: 2016-03-08
Volume: 315
Issue: 10
Pages: 1034
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.2016.0299
PMC: PMC4823136
OpenAlex: W2295084748
Cited by: 309
References: 167
Citations by year: 2026: 15 · 2025: 15 · 2024: 11 · 2023: 15 · 2022: 22 · 2021: 42 · 2020: 31 · 2019: 39 · 2018: 37 · 2017: 42 · 2016: 34
FWCI: 50.88
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: JAMA (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (K23AG048359, K23AG040779, P30AG021342, P30AG044281)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords: polypharmacy, older adults, type 2 diabetes, glycemic control, tight glycemic control, HbA1c targets, hypoglycemia risk, metformin, patient preferences, shared decision-making, treatment burden, microvascular outcomes, macrovascular events
MeSH terms: Aged, Aged, 80 and over, Diabetes Mellitus, Type 2, Female, Glycated Hemoglobin, Humans, Hyperglycemia, Hypoglycemia, Hypoglycemic Agents, Life Expectancy, Male, Time Factors, Blood Glucose Self-Monitoring, Randomized Controlled Trials as Topic, Polypharmacy, Patient Preference, Observational Studies as Topic

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Polypharmacy in the Aging Patient: A Review of Glycemic Control in Older Adults With Type 2 Diabetes

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