New “21st Century Cures” Legislation: Speed and Ease vs Science
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The most popular DNN architecture used for EHR data analysis is RNN.
“Even though, various DL architectures have been used, the most popular DNN architecture used for EHR data analysis is RNN [52], [53].”
From Secondary Use of Electronic Health Record: Opportunities and Challenges (2020) · cites this paper as [52]
Cites
Real-World Evidence — What Is It and What Can It Tell Us?
Sherman, R. E., Anderson, S. A., Pan, G. J. D., Gray, G. W., Gross, T. P., Hunter, N. L., LaVange, L. M., Marinac‐Dabic, D., Marks, P. W., Robb, M. A., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmsb1609216 · Cited by 2,134 · see citing works
The Anatomy of Medical Research: US and International Comparisons
Moses, H., Matheson, D. H. M., Cairns-Smith, S., George, B. P., Palisch, C., & Dorsey, E. R. (2015) · JAMA · doi:10.1001/jama.2014.15939 · Cited by 446 · see citing works
Clinical Trial Evidence Supporting FDA Approval of Novel Therapeutic Agents, 2005-2012
Downing, N. S., Aminawung, J. A., Shah, N. D., Krumholz, H. M., & Ross, J. S. (2014) · JAMA · doi:10.1001/jama.2013.282034 · Cited by 408 · see citing works
Kesselheim, A. S., Tan, Y. T., & Avorn, J. (2015) · Health Affairs · doi:10.1377/hlthaff.2014.1038 · Cited by 144 · see citing works
Self-citationSurrogate Outcomes in Clinical Trials
Svensson, S. A., Menkes, D. B., & Lexchin, J. (2013) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2013.3037 · Cited by 121 · see citing works
The 21st Century Cures Act — Will It Take Us Back in Time?
Avorn, J., & Kesselheim, A. S. (2015) · New England Journal of Medicine · doi:10.1056/nejmp1506964 · Cited by 102 · see citing works
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Secondary Use of Electronic Health Record: Opportunities and Challenges
Shah, S. M., & Khan, R. A. (2020) · IEEE Access · doi:10.1109/access.2020.3011099 · Cited by 158 · see citing works
- Authors
- Kesselheim, A. S., & Avorn, J.
- Affiliations
- Brigham and Women's Hospital (US)
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2017-02-14
- Volume
- 317
- Issue
- 6
- Pages
- 581
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2569503431
- Cited by
- 93
- References
- 6
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 5 · 2023: 2 · 2022: 8 · 2021: 11 · 2020: 9 · 2019: 14 · 2018: 15 · 2017: 22 · 2016: 1 · 2012: 1
- FWCI
- 29.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Pharmaceutical Economics and Policy
- Health Sciences › Medicine › Physiology › Biomedical Ethics and Regulation
- Health Sciences › Health Professions › Health Information Management › Healthcare Regulation
- Keywords
- 21st Century Cures Act, drug approval, drug development, regulatory policy, pharmaceutical law
- MeSH terms
- Budgets, Drug Industry, Financing, Government, National Institutes of Health (U.S.), Politics, Research Support as Topic, Science, United States, United States Food and Drug Administration, Drug Approval
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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