The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Association of Pembrolizumab With Tumor Response and Survival Among Patients With Advanced Melanoma
Open accessAbstract
IMPORTANCE: The programmed death 1 (PD-1) pathway limits immune responses to melanoma and can be blocked with the humanized anti-PD-1 monoclonal antibody pembrolizumab. OBJECTIVE: To characterize the association of pembrolizumab with tumor response and overall survival among patients with advanced melanoma. DESIGN, SETTINGS, AND PARTICIPANTS: Open-label, multicohort, phase 1b clinical trials (enrollment, December 2011-September 2013). Median duration of follow-up was 21 months. The study was performed in academic medical centers in Australia, Canada, France, and the United States. Eligible patients were aged 18 years and older and had advanced or metastatic melanoma. Data were pooled from 655 enrolled patients (135 from a nonrandomized cohort [n = 87 ipilimumab naive; n = 48 ipilimumab treated] and 520 from randomized cohorts [n = 226 ipilimumab naive; n = 294 ipilimumab treated]). Cutoff dates were April 18, 2014, for safety analyses and October 18, 2014, for efficacy analyses. EXPOSURES: Pembrolizumab 10 mg/kg every 2 weeks, 10 mg/kg every 3 weeks, or 2 mg/kg every 3 weeks continued until disease progression, intolerable toxicity, or investigator decision. MAIN OUTCOMES AND MEASURES: The primary end point was confirmed objective response rate (best overall response of complete response or partial response) in patients with measurable disease at baseline per independent central review. Secondary end points included toxicity, duration of response, progression-free survival, and overall survival. RESULTS: Among the 655 patients (median [range] age, 61 [18-94] years; 405 [62%] men), 581 had measurable disease at baseline. An objective response was reported in 194 of 581 patients (33% [95% CI, 30%-37%]) and in 60 of 133 treatment-naive patients (45% [95% CI, 36% to 54%]). Overall, 74% (152/205) of responses were ongoing at the time of data cutoff; 44% (90/205) of patients had response duration for at least 1 year and 79% (162/205) had response duration for at least 6 months. Twelve-month progression-free survival rates were 35% (95% CI, 31%-39%) in the total population and 52% (95% CI, 43%-60%) among treatment-naive patients. Median overall survival in the total population was 23 months (95% CI, 20-29) with a 12-month survival rate of 66% (95% CI, 62%-69%) and a 24-month survival rate of 49% (95% CI, 44%-53%). In treatment-naive patients, median overall survival was 31 months (95% CI, 24 to not reached) with a 12-month survival rate of 73% (95% CI, 65%-79%) and a 24-month survival rate of 60% (95% CI, 51%-68%). Ninety-two of 655 patients (14%) experienced at least 1 treatment-related grade 3 or 4 adverse event (AE) and 27 of 655 (4%) patients discontinued treatment because of a treatment-related AE. Treatment-related serious AEs were reported in 59 patients (9%). There were no drug-related deaths. CONCLUSIONS AND RELEVANCE: Among patients with advanced melanoma, pembrolizumab administration was associated with an overall objective response rate of 33%, 12-month progression-free survival rate of 35%, and median overall survival of 23 months; grade 3 or 4 treatment-related AEs occurred in 14%. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT01295827.
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In the citing paper
“Immune checkpoint blockade with monoclonal antibodies (mAbs) targeting programmed cell death protein 1 (PD-1) provides long-term clinical benefits to nearly 40% of patients with advanced melanoma (1–5).”
From Fecal microbiota transplant overcomes resistance to anti–PD-1 therapy in melanoma patients (2021) · cites this paper as [2]
In the citing paper
“Both CTLA-4 and PD-1 act independently as brakes on CD3/CD28-dependent signaling, suggesting that underlying immune responses are required for checkpoint inhibitor treatment to take effect (66).”
From Anti-PD-1 and Anti-CTLA-4 Therapies in Cancer: Mechanisms of Action, Efficacy, and Limitations (2018) · cites this paper as [66]
In the citing paper
“In melanoma, anti-PD-1 treatment was more effective in patients with smaller tumors (66).”
From Anti-PD-1 and Anti-CTLA-4 Therapies in Cancer: Mechanisms of Action, Efficacy, and Limitations (2018) · cites this paper as [66]
In the citing paper
“Both CTLA-4 and PD-1 act independently as brakes on CD3/CD28-dependent signaling, suggesting that underlying immune responses are required for checkpoint inhibitor treatment to take effect (66).”
From Anti-PD-1 and Anti-CTLA-4 Therapies in Cancer: Mechanisms of Action, Efficacy, and Limitations (2018) · cites this paper as [66]
In the citing paper
“For example, patients with smaller tumors or low serum lactate dehydrogenase (LDH) levels at baseline have a better prognosis and are also more likely to respond to anti-PD-1 treatment (66).”
From Anti-PD-1 and Anti-CTLA-4 Therapies in Cancer: Mechanisms of Action, Efficacy, and Limitations (2018) · cites this paper as [66]
In the citing paper
“Patients more likely to benefit from checkpoint immunotherapy include those with tumors demonstrating a high density of somatic mutations, elevated PD-L1 expression and/or are enriched with IFNγ transcriptional profiles (8–13).”
From Reimagining IDO Pathway Inhibition in Cancer Immunotherapy via Downstream Focus on the Tryptophan–Kynurenine–Aryl Hydrocarbon Axis (2019) · cites this paper as [11]
In the citing paper
“The degree of tumor inflammation, as assessed by the presence of type I/II IFN signaling and infiltrating effector T cells, is associated with an improved response to checkpoint immunotherapy (8–11,13).”
From Reimagining IDO Pathway Inhibition in Cancer Immunotherapy via Downstream Focus on the Tryptophan–Kynurenine–Aryl Hydrocarbon Axis (2019) · cites this paper as [11]
In the citing paper
“Anti-PD-1 immunotherapy has shown efficacy in melanoma, but fewer than half of all melanoma patients treated with anti-PD-1 immunotherapy have a prolonged response5.”
From Mechanisms and prevention of UV‐induced melanoma (2018) · cites this paper as [5]
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Citations
Cites
New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)
Eisenhauer, E. A., Therasse, P., Bogaerts, J., Schwartz, L. H., Sargent, D., Ford, R., Dancey, J., Arbuck, S., Gwyther, S., Mooney, M., et al. (2009) · European Journal of Cancer · doi:10.1016/j.ejca.2008.10.026 · Cited by 29,534
The blockade of immune checkpoints in cancer immunotherapy
Pardoll, D. M. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3239 · Cited by 13,838
Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma
Larkin, J., Chiarion-Sileni, V., Gonzalez, R., Grob, J. J., Cowey, C. L., Lao, C. D., Schadendorf, D., Dummer, R., Smylie, M., Rutkowski, P., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1504030 · Cited by 8,157
Self-citationPembrolizumab for the Treatment of Non–Small-Cell Lung Cancer
Garon, E. B., Rizvi, N. A., Hui, R., Leighl, N., Balmanoukian, A. S., Eder, J. P., Patnaik, A., Aggarwal, C., Gubens, M., Horn, L., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1501824 · Cited by 6,198
Self-citationPembrolizumab versus Ipilimumab in Advanced Melanoma
Robert, C., Schachter, J., Long, G. V., Arance, A., Grob, J. J., Mortier, L., Daud, A., Carlino, M. S., McNeil, C., Lotem, M., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1503093 · Cited by 5,887
Self-citationTHE USE OF CONFIDENCE OR FIDUCIAL LIMITS ILLUSTRATED IN THE CASE OF THE BINOMIAL
Clopper, C. J., & Pearson, E. S. (1934) · Biometrika · doi:10.1093/biomet/26.4.404 · Cited by 5,327
Restoring function in exhausted CD8 T cells during chronic viral infection
Barber, D. L., Wherry, E. J., Masopust, D., Zhu, B., Allison, J. P., Sharpe, A. H., Freeman, G. J., & Ahmed, R. (2005) · Nature · doi:10.1038/nature04444 · Cited by 4,057
Safety and Tumor Responses with Lambrolizumab (Anti–PD-1) in Melanoma
Hamid, O., Robert, C., DAUD, A. I., Hodi, F. S., Hwu, W., Kefford, R. F., Wolchok, J. D., Hersey, P., Joseph, R. W., Weber, J. S., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1305133 · Cited by 3,427
Self-citationWolchok, J. D., Hoos, A., O'Day, S. J., Weber, J. S., Hamid, O., Lebbé, C., Maio, M., Binder, M., Bohnsack, O., Nichol, G. M., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-1624 · Cited by 3,214
Self-citationTopalian, S. L., Sznol, M., McDermott, D. F., Kluger, H. M., Carvajal, R. D., Sharfman, W. H., Brahmer, J. R., Lawrence, D. P., Atkins, M. B., Powderly, J. D., et al. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2013.53.0105 · Cited by 2,222
Self-citation
Research works printed but not linked: 4
- Robert C, Ribas A, Wolchok JD, et al. Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma. Lancet. 2014;384(9948):1109-1117.
- Ribas A, Puzanov I, Dummer R, et al. Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002). Lancet Oncol. 2015;16(8):908-918.
- Joseph RW, Elassaiss-Schaap J, Wolchok JD, et al. Baseline tumor size (BTS) and PD-L1 expression are independently associated with clinical outcomes in patients (pts) with metastatic melanoma (MM) treated with pembrolizumab (pembro; MK-3475). Abstract presented at: Society for Melanoma Research 2014 Congress; November 13-16, 2014; Zurich, Switzerland. Pigment Cell Melanoma Res. 2014;27:1188.
- Kluger HM, Sznol M, Callahan MK et al. Survival, response duration and activity by BRAF mutation status in a phase 1 trial of nivolumab (anti-PD-1; BMS-936558,ONO-4538) and ipilimumab concurrent therapy in advanced melanoma (MEL). Abstract presented at: Society for Melanoma Research 2014 Congress; November 13-16, 2014; Zurich, Switzerland. Pigment Cell Melanoma Res. 2014;27:1203.
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Shen, Y., Gong, Y., & Su, L. (2023) · Ocular Immunology and Inflammation · doi:10.1080/09273948.2023.2233015 · Cited by 4
Zager, J. S., & Hyams, D. M. (2023) · Clinical & Experimental Metastasis · doi:10.1007/s10585-023-10241-7 · Cited by 4
Wu, C., Ke, Y., Wan, L., & Xie, X. (2024) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-024-03663-z · Cited by 4
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Quresh, Q., & Quinet, R. (2017) · JCR Journal of Clinical Rheumatology · doi:10.1097/rhu.0000000000000525 · Cited by 4
Khushalani, N. I. (2018) · Journal of Clinical Oncology · doi:10.1200/jco.2017.76.8275 · Cited by 4
Erstine, E. M., Tetzlaff, M. T., Jia, X., Aung, P. P., Prieto, V. G., Funchain, P., Gastman, B., Billings, S. D., & Ko, J. S. (2019) · The American Journal of Surgical Pathology · doi:10.1097/pas.0000000000001277 · Cited by 4
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Lamos, C., & Hunger, R. E. (2020) · Zeitschrift für Rheumatologie · doi:10.1007/s00393-020-00870-8 · Cited by 4
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Xu, Z., Zhu, B., & Park, Y. (2020) · Statistics in Medicine · doi:10.1002/sim.8694 · Cited by 4
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Db, K. (2017) · Voprosy Onkologii · doi:10.37469/0507-3758-2017-63-3-358-367 · Cited by 4
Guadagni, S., Zoras, O., Fiorentini, G., Masedu, F., Lasithiotakis, K. G., Sarti, D., Farina, A. R., Mackay, A. R., & Clementi, M. (2021) · Journal of Surgical Research · doi:10.1016/j.jss.2021.05.054 · Cited by 4
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Ridge, N. A., Rajkumar-Calkins, A., Dudzinski, S. O., Kirschner, A. N., & Newman, N. B. (2022) · Advances in Radiation Oncology · doi:10.1016/j.adro.2022.100936 · Cited by 4
Zhang, Q., Zhang, Y., Zhu, H., Liu, K., Lou, P., Kong, P., Su, L., & Wang, S. (2023) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530323666230821102730 · Cited by 4
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Creasy, C. A., Forget, M., Singh, G., Tapia, C., Xu, M., Stephen, B., Sabir, S. H., Meric‐Bernstam, F., Haymaker, C., Bernatchez, C., et al. (2019) · European Journal of Immunology · doi:10.1002/eji.201948217 · Cited by 4
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Xu, H., & Wang, H. (2019) · IEEE International Conference on Bioinformatics and Biomedicine (BIBM) · doi:10.1109/bibm47256.2019.8983295 · Cited by 4
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Mandalà, M., & Massi, D. (2017) · Handbook of experimental pharmacology · doi:10.1007/164_2017_5 · Cited by 4
Saman, H. T., Saman, H. T., Shahab Uddin, M. S., Raza, S. S., Shrimali, R. K., & Rasul, K. I. (2020) · Clinical Oncology and Research · doi:10.31487/j.cor.2020.09.08 · Cited by 3
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Cao, M., Xu, M. Y., Bairmani, Z. A., Bashir, B., Waldman, S. A., & Snook, A. E. (2025) · Expert Review of Precision Medicine and Drug Development · doi:10.1080/23808993.2025.2560303 · Cited by 3
Wu, C., Li, Q., Yuan, Y., Liu, J., Wan, L., & Wang, R. (2025) · Discover Oncology · doi:10.1007/s12672-025-03883-4 · Cited by 3
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Guardamagna, M., Lochrin, S. E., Smithy, J. W., Postow, M. A., Gaudy‐Marqueste, C., Malissen, N., Monestier, S., Sullivan, R. J., Czapla, J., Lawless, A. R., et al. (2025) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2025-012225 · Cited by 3
Self-citationThe Immune Landscape of Acral Melanoma: From Basic to Clinical
Jiang, L., & Zhang, Z. Y. (2026) · Cancer Medicine · doi:10.1002/cam4.71615 · Cited by 3
Immunoplasticity in cutaneous melanoma: beyond pure morphology
Bosisio, F. M., & van den Oord, J. J. (2017) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-016-2058-y · Cited by 3
Update in Immunotherapies for Melanoma
Martin, S., & Lo, R. S. (2018) · Springer eBooks · doi:10.1007/978-3-319-66884-0_48 · Cited by 3
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Li, J., & Dong, C. (2018) · Science China Life Sciences · doi:10.1007/s11427-018-9409-7 · Cited by 3
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Wong, W. G., Holguin, R. A. P., Stahl, K. A., Olecki, E. J., Pameijer, C., & Shen, C. (2022) · Surgery in Practice and Science · doi:10.1016/j.sipas.2022.100056 · Cited by 3
Jin, T., Ge, L., Wang, W., Li, X., Ge, M., & Chen, L. (2023) · Endocrine · doi:10.1007/s12020-023-03452-1 · Cited by 3
Self-citationHuang, R., Yao, Y., Tong, X., Wang, L., Qian, W., Lu, J., Zhang, W., Liu, Y., Wang, S., Xian, S., et al. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.00135-23 · Cited by 3
Design Strategy and Consideration for Oncology Dose-Optimization: An Industry Perspective
Liu, R., Yuan, Y., Sen, S., Marchenko, O., Jiang, Q., Tian, H., Li, X. N., Lin, R., Lu, C., & Zhou, H. (2024) · Statistics in Biopharmaceutical Research · doi:10.1080/19466315.2024.2332650 · Cited by 4
Self-citationKoh, Y. W., Han, J.-H., Haam, S., & Lee, H. W. (2024) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2024.111999 · Cited by 3
Hegyi, B., Csikó, K. G., Balatoni, T., Fröhlich, G., Bőcs, K., Tóth, E., Mohos, A., Neumark, A. R., Menyhárt, C. D., Ferrone, S., et al. (2024) · Biomolecules · doi:10.3390/biom14121609 · Cited by 2
Ali, M. S., Ahn, J.-M., Espat, N. J., Calvino, A. S., Koness, J., Somasundar, P. S., & Kwon, S. (2025) · Immunotherapy · doi:10.1080/1750743x.2025.2452836 · Cited by 3
Trimboli, M., Marino, L., Iusi, I. C., Cucè, M., Tozza, S., Tagliaferri, P., Tassone, P., Gambardella, A., Manganelli, F., & Liguori, R. (2025) · Neurological Sciences · doi:10.1007/s10072-025-08422-1 · Cited by 3
Ryu, J. I., Han, M. H., Cheong, J. H., Kim, J. M., & Kim, C. H. (2017) · Immunotherapy · doi:10.2217/imt-2017-0003 · Cited by 3
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Sweis, R. F., & Luke, J. J. (2017) · Clinical skin cancer · doi:10.1016/j.clsc.2017.09.001 · Cited by 3
Adams, A. C., Macy, A. M., Kang, P. T., Castro-Ochoa, K. F., Wijeratne, E. M. K., Xu, Y.-M., Liu, M. X., Charos, A. E., Bosenberg, M., Gunatilaka, A. A. L., et al. (2021) · Translational Oncology · doi:10.1016/j.tranon.2021.101259 · Cited by 3
Trappen, P. O. V., Lebbe, I., Cuypere, E., & Claes, N. (2023) · Frontiers in Surgery · doi:10.3389/fsurg.2023.1189196 · Cited by 3
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Suarez, Z. K., Finke, A. C., Hospedales, E., Pérez, E., Sharifzadeh, A., Foster, J. G., & Ferris, A. H. (2023) · Journal of Oncology Pharmacy Practice · doi:10.1177/10781552231179369 · Cited by 3
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Géorgescu, M., Trifanescu, O. G., Serbanescu, L. G., Mitrica, R. I., Georgescu, D. E., Mihăilă, R. I., Neagu, A., Gaube, A., Botezatu, C., & Mastalier, B. S. M. (2023) · Cosmetics · doi:10.3390/cosmetics10060165 · Cited by 3
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Yokota, K., Takenouchi, T., Fujisawa, Y., Fukushima, S., Uchi, H., Inozume, T., Kiyohara, Y., Uhara, H., Nakagawa, K., Furukawa, H., et al. (2024) · The Journal of Dermatology · doi:10.1111/1346-8138.17002 · Cited by 3
Wang, Y., Tao, R., Li, Y., Tian, L., Yang, L., Liu, Z., & Yao, B. (2024) · Aging · doi:10.18632/aging.205932 · Cited by 3
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Corica, D. A., Bell, S. D., Miller, P. J., Kasperbauer, D. T., Lawler, N. J., Wakefield, M. R., & Fang, Y. (2024) · Cancers · doi:10.3390/cancers16234002 · Cited by 3
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Song, J., Ding, X.-L., Sun, X., Safi, M., & Tian, J. (2017) · Medicine · doi:10.1097/md.0000000000009278 · Cited by 2
Impact of genomics on the surgical management of melanoma
Ferguson, P. M., Long, G. V., Scolyer, R. A., & Thompson, J. F. (2018) · British journal of surgery · doi:10.1002/bjs.10751 · Cited by 3
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Beyersdorf, N., & Kerkau, T. (2020) · Der Internist · doi:10.1007/s00108-020-00813-0 · Cited by 3
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Amaral, T. M. S., & Garbe, C. (2016) · Annals of Translational Medicine · doi:10.21037/atm.2016.12.21 · Cited by 3
Melanoma: Immunotherapy in Advanced Melanoma and in the Adjuvant Setting
Eggermont, A. M. M., & Robert, C. (2017) · Springer eBooks · doi:10.1007/978-3-319-62431-0_34 · Cited by 3
Self-citationImmunotherapy for Basal Cell Carcinoma
Chen, L. L., Silapunt, S., & Migden, M. R. (2019) · Springer eBooks · doi:10.1007/978-3-030-26887-9_14 · Cited by 3
Balch, C. M. (2018) · Annals of Surgical Oncology · doi:10.1245/s10434-018-6516-4 · Cited by 3
2016: advances in medical oncology
Chubenko, V. A. (2017) · Practical oncology · doi:10.31917/1801115 · Cited by 3
Gray, M. A., Stanczak, M. A., Xiao, H., Pijnenborg, J. F. A., Mantuano, N. R., Malaker, S. A., Weidenbacher, P. A. B., Miller, C. L., Tanzo, J. T., Ahn, G., et al. (2019) · ChemRxiv · doi:10.26434/chemrxiv.8187146 · Cited by 3
Tumor Cell–Intrinsic Decr2 Regulates Ferroptosis and Immunotherapy Efficacy
Li, S., Shapiro, J. W., Shah, H., Higgs, E. F., Xie, L., Li, Y., Zha, Y., Trujillo, J., Cabanov, A., Jones, T. A., et al. (2025) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-24-0519 · Cited by 2
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Vile, R. G. (2025) · Journal of Clinical Oncology · doi:10.1200/jco-25-01890 · Cited by 2
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Noma, T., Wada, Y., Nishi, M., Teraoku, H., Yamada, S., Saito, Y., Ikemoto, T., Morine, Y., & Shimada, M. (2025) · The Journal of Medical Investigation · doi:10.2152/jmi.72.354 · Cited by 2
Li, Z., Wei, C., Wu, H., Wu, Z., Feng, X., Bian, F., Zeng, L., Zhang, P., Liao, Q., & Tang, R. (2025) · International Journal of Surgery · doi:10.1097/js9.0000000000004424 · Cited by 2
Legakis, L. P., Naagendran, M. S., Matthews, A. J., Morris, J. C., Davies, M. J., Prsic, E. H., & Price, C. C. (2026) · Supportive Care in Cancer · doi:10.1007/s00520-026-10448-w · Cited by 2
Integration of donor microbiota following FMT correlates with anti-PD-1 response in melanoma
Fessler, J. L., Olm, M. R., Engleman, E. G., & Sonnenburg, J. L. (2026) · Nature Communications · doi:10.1038/s41467-026-73465-7 · Cited by 5
Pharmacological interventions for melanoma: Comparative analysis using bayesian meta-analysis
Yang, Y., Pei, J., Gao, G., Yang, Z., Guo, S., Yue, B., & Qiu, J. (2016) · Oncotarget · doi:10.18632/oncotarget.12644 · Cited by 2
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Inoue, S., Kono, M., Fukuda, H., Shimamoto, Y., Nakagawa, K., Ohmori, M., Iwagami, H., Matsuno, K., Iwatsubo, T., Nakahira, H., et al. (2020) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.15246 · Cited by 2
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Martínez, J. A. (1995) · Studia Academica: Revista de Investigación Universitaria · Cited by 2
Jia, D., Xu, Y., Li, T., Yang, J., Chen, Y., & Li, T. (2024) · Dermatologic Therapy · doi:10.1155/2024/9952950 · Cited by 2
Gupta, M., Stukalin, I., Meyers, D. E., Heng, D. Y. C., Monzon, J. G., Cheng, T., & Navani, V. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1385425 · Cited by 2
Liang, L., Ye, Z., Wu, J., Lu, H., Liu, W., Meng, L., Li, Y., & Huang, H. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.153977 · Cited by 2
Chen, Y.-C., Zheng, W.-Z., Liu, C., Zhao, Y.-Q., Li, J., Du, Z.-S., Zhai, T., Lin, H., Shi, W., Cai, S.-Q., et al. (2024) · Cancer Cell International · doi:10.1186/s12935-024-03496-x · Cited by 3
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Khan, M., Dong, Y., Ullah, R., Li, M., Huang, Q., Hu, Y., Li, Y., & Luo, Z. Y. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202401076 · Cited by 2
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Greene, L. R., Srinivas, S. M., Park, S. Y., Hatami, N., Nobashi, T. W., Baratto, L., Toriihara, A., & Gambhir, S. S. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812512-0.00010-5 · Cited by 2
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Johnson, D. B., Chon, J., Johnson, M. R., & Balko, J. M. (2018) · Seminars in Cutaneous Medicine and Surgery · doi:10.12788/j.sder.2018.019 · Cited by 2
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Scherrer, E., Rau, R., Lorenzi, M. F., Shui, I. M., Townson, S. M., & Larkin, J. (2021) · Future Oncology · doi:10.2217/fon-2021-0154 · Cited by 2
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Moy, J. D., & Ferris, R. L. (2018) · Current cancer research · doi:10.1007/978-3-319-78762-6_14 · Cited by 2
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Lee, S. S., Loecher, M., & Puzanov, I. J. (2018) · Elsevier eBooks · doi:10.1016/b978-0-323-54948-6.00011-1 · Cited by 2
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Galluzzi, L., & Rudqvist, N.-P. (2020) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(20)30020-3 · Cited by 2
Bosisio, F. M., Antoranz, A., Herck, Y. V., Bolognesi, M. M., Marcelis, L., Chinello, C., Wouters, J., Magni, F., Alexopoulos, L. G., Stas, M., et al. (2020) · eLife · doi:10.7554/elife.53008.sa2 · Cited by 3
Doepner, M., Natale, C. A., Lee, I. Y., Venkat, S., Kim, S. H., Katzenellenbogen, J. A., Katzenellenbogen, B. S., Feigin, M. E., & Ridky, T. W. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.03.03.433757 · Cited by 2
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Sperber, J. E., Yoo, S., Owolo, E. S., Dalton, T., Zachem, T. J., Johnson, E., Herndon, J. E., Nguyen, A. D., Hockenberry, H., Bishop, B., et al. (2024) · Neuro-Oncology Practice · doi:10.1093/nop/npae057 · Cited by 1
Liu, Q., Xing, H., Xiong, M., & Zhang, X. (2024) · Angewandte Chemie · doi:10.1002/ange.202414327 · Cited by 1
Metadata
- Authors
- Ribas, A., Hamid, O., Daud, A., Hodi, F. S., Wolchok, J. D., Kefford, R., Joshua, A. M., Patnaik, A., Hwu, W.-J., Weber, J. S., Gangadhar, T. C., Hersey, P., Dronca, R., Joseph, R. W., Zarour, H., Chmielowski, B., Lawrence, D. P., Algazi, A., Rizvi, N. A., Hoffner, B., Mateus, C., Gergich, K., Lindia, J. A., Giannotti, M., Li, X. N., Ebbinghaus, S., Kang, S. P., & Robert, C.
- Affiliations
- University of California, Los Angeles (US)
- Angeles Clinic and Research Institute (US)
- University of California, San Francisco (US)
- Dana-Farber Cancer Institute (US)
- Memorial Sloan Kettering Cancer Center (US)
- Westmead Hospital (AU)
- Princess Margaret Cancer Centre (CA)
- South Texas Accelerated Research Therapeutics (US)
- The University of Texas MD Anderson Cancer Center (US)
- Moffitt Cancer Center (US)
- Abramson Cancer Center (US)
- The University of Sydney (AU)
- Mayo Clinic (US)
- Mayo Clinic in Florida (US)
- University of Pittsburgh (US)
- Massachusetts General Hospital (US)
- Institut Gustave Roussy (FR)
- Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
- Corresponding author
- Ribas, Antoni
- ORCID
- Ribas, Antoni
- Hamid, Omid
- Daud, Adil
- Hodi, F. Stephen
- Wolchok, Jedd D.
- Kefford, Richard
- Joshua, Anthony M.
- Patnaik, Amita
- Hwu, Wen-Jen
- Weber, Jeffrey S.
- Hersey, Peter
- Dronca, Roxana
- Joseph, Richard W.
- Zarour, Hassane
- Chmielowski, Bartosz
- Lawrence, Donald P.
- Algazi, Alain
- Rizvi, Naiyer A.
- Mateus, Christine
- Li, Xiaoyun Nicole
- Robert, Caroline
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2016-04-19
- Volume
- 315
- Issue
- 15
- Pages
- 1600
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2338494814
- Cited by
- 1,069
- References
- 22
- Citations by year
- 2026: 33 · 2025: 66 · 2024: 67 · 2023: 99 · 2022: 63 · 2021: 123 · 2020: 139 · 2019: 139 · 2018: 145 · 2017: 153 · 2016: 39
- FWCI
- 85.72
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- NOVA (University of Newcastle Australia) (submittedVersion)
- Funders
- National Cancer Institute (P30CA008748)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Health Sciences › Medicine › Oncology › Cutaneous Melanoma Detection and Management
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
- Keywords
- pembrolizumab, advanced melanoma, metastatic melanoma, anti-PD-1 therapy, anti-PD-1 monoclonal antibody, objective response rate, overall survival, progression-free survival, duration of response, ipilimumab, immune checkpoint inhibitors, treatment-naive patients, treatment-emergent adverse events, immune-related adverse events, immune-related pneumonitis, immune-related colitis
- MeSH terms
- Ipilimumab, Adult, Aged, Aged, 80 and over, Algorithms, Antibodies, Monoclonal, Antineoplastic Agents, Drug Administration Schedule, Female, Humans, Male, Melanoma, Middle Aged, Skin Neoplasms, Survival Rate, Treatment Outcome, Disease Progression, Disease-Free Survival, Young Adult, Programmed Cell Death 1 Receptor, Antibodies, Monoclonal, Humanized
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