Persistent opioid use after wisdom tooth extraction
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This pharmacoepidemiology study uses commercial claims database data to describe the rate of persistent opioid use among patients aged 13 to 30 years prescribed perioperative opioids for wisdom tooth extraction.
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Adolescents and young adults (aged 13-30 years) undergoing third-molar extraction and filling a perioperative opioid prescription had a 1.6% increased risk of receiving a diagnosis of a substance use disorder compared with those not filling an opioid prescription.
“and a 1.6% increased risk of receiving a diagnosis of a substance use disorder than patients undergoing a third-molar extraction but not filling an opioid prescription.”
From Evidence-based clinical practice guideline for the pharmacologic management of acute dental pain in adolescents, adults, and older adults (2024) · cites this paper as [9]
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Experimental — accuracy not yet measuredRelying on opioids to manage acute dental pain can have unintended negative consequences.
“Relying on opioids to manage acute dental pain can have unintended negative consequences.”
From Evidence-based clinical practice guideline for the pharmacologic management of acute dental pain in adolescents, adults, and older adults (2024) · cites this paper as [9]
Adolescents and young adults (aged 13-30 years) undergoing third-molar extraction and filling a perioperative opioid prescription had a 0.8% increased risk of persistent opioid use compared with those not filling an opioid prescription.
“adolescents and young adults (aged 13–30 years) undergoing third-molar extraction and filling a perioperative opioid prescription (≥1 opioid prescriptions filled 7 days before-3 days after the procedure) was associated with a 0.8% increased risk of persistent opioid use”
From Evidence-based clinical practice guideline for the pharmacologic management of acute dental pain in adolescents, adults, and older adults (2024) · cites this paper as [9]
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- American Dental Association. Statement on the use of opioids in the treatment of dental pain. https://www.ada.org/en/press-room/news-releases /2018-archives/february/american-dental-association-statement-on-opioids. Accessed June 15, 2018.
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- Authors
- Harbaugh, C. M., Nalliah, R. P., Hu, H. M., Englesbe, M. J., Waljee, J. F., & Brummett, C. M.
- Affiliations
- University of Michigan (US)
- Michigan Opioid Prescribing Engagement Network, Ann Arbor
- Corresponding author
- Brummett, Chad M.
- ORCID
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2018-08-07
- Volume
- 320
- Issue
- 5
- Pages
- 504
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- PMC
- PMC6142986
- OpenAlex
- W2885232486
- Cited by
- 153
- References
- 5
- Citations by year
- 2026: 8 · 2025: 16 · 2024: 14 · 2023: 10 · 2022: 22 · 2021: 27 · 2020: 27 · 2019: 23 · 2018: 5
- FWCI
- 19.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JAMA (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Health and Human Services
- Eli Lilly and Company
- University of Michigan
- Michigan Department of Health and Human Services
- National Institutes of Health
- Substance Abuse and Mental Health Services Administration
- National Institute on Aging (K08AG055670)
- National Institute of Mental Health (K01MH099141)
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K08HD075831)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Health Sciences › Medicine › Surgery › Anesthesia and Pain Management
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
- Keywords
- persistent opioid use, third molar extraction, perioperative opioids, opioid prescribing, young adults, dental treatment
- MeSH terms
- Adolescent, Adult, Age Factors, Analgesics, Opioid, Female, Humans, Male, Opioid-Related Disorders, Pain, Postoperative, Postoperative Pain, Postoperative Period, Tooth Extraction, Logistic Models, Young Adult
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