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Stem Cell Therapy for Heart Failure: An Unfulfilled Promise?
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valve replacement in an unselected population: a report from the STS/ACC Transcatheter Valve Therapy Registry.
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“Unfortunately, the weight of evidence so far indicates no clinically meaningful benefit resulting from injection therapies, owing to the limited engraftment capacity of the injected CMs and the lack of control over the cells' survival, arrangement, and electromechanical coupling 48 .”
From Leaf-venation-directed cellular alignment for macroscale cardiac constructs with tissue-like functionalities (2023) · cites this paper as [48]
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Yancy, C. W., Jessup, M. L., Bozkurt, B., Butler, J., Casey, D. E., Colvin, M. M., Drazner, M. H., Filippatos, G. S., Fonarow, G. C., Givertz, M. M., et al. (2016) · Circulation · doi:10.1161/cir.0000000000000435 · Cited by 906
Halliday, B. P., Wassall, R., Lota, A. S., Khalique, Z., Gregson, J., Newsome, S., Jackson, R. W., Rahneva, T., Wage, R., Smith, G. C., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)32484-x · Cited by 657
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Cell-Based Therapy in Cardiac Regeneration
Braunwald, E. (2018) · Circulation Research · doi:10.1161/circresaha.118.313484 · Cited by 84
Heart Failure with Myocardial Recovery - The Patient Whose Heart Failure Has Improved: What Next?
Nijst, P., Martens, P., & Müllens, W. (2017) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2017.05.009 · Cited by 33
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Research works printed but not linked: 1
- Yau, Effect of intramyocardial injection of mesenchymal precursor cells on successful temporary weaning from left ventricular assist device support among patients with advanced heart failure: a randomized clinical trial, JAMA
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Coffey, S., Dixit, P., Saw, E. L., Babakr, A. A., van Hout, I., Galvin, I. F., Saxena, P., Bunton, R. W., Davis, P. J., Lamberts, R. R., et al. (2021) · International Journal of Cardiology · doi:10.1016/j.ijcard.2021.08.039 · Cited by 2
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Hébert, J. M., & Loring, J. F. (2021) · Springer eBooks · doi:10.1007/978-3-030-22009-9_1031
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Metadata
- Authors
- Curfman, G.
- Affiliations
- Deputy Editor, JAMA
- Corresponding author
- Curfman, Gregory
- ORCID
- Curfman, Gregory
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2019-03-26
- Volume
- 321
- Issue
- 12
- Pages
- 1186
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2922678205
- Cited by
- 30
- References
- 7
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 4 · 2022: 4 · 2021: 11 · 2020: 3 · 2019: 5
- FWCI
- 3.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Valve Diseases and Treatments
- Keywords
- stem cell therapy, heart failure, cell therapy, regenerative medicine
- MeSH terms
- Heart Failure, Heart-Assist Devices, Humans, Injections, Weaning, Stem Cell Transplantation
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