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Case-Fatality Rate and Characteristics of Patients Dying in Relation to COVID-19 in Italy
Abstract
This Viewpoint from physicians with the Italian National Institute of Health confirms a higher case-fatality rate from coronavirus disease 2019 (COVID-19) in Italy compared with China and explains possible reasons, including age, cause of death definitions, and testing strategy.
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“the current state of hospitals and other healthcare settings is becoming more “deliriogenic” as they restrict visitors, require all staff members to wear personal protective equipment (PPE), and minimize patient interaction to avoid exposure [24].”
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“Leading authorities on delirium have found that altered mental status may be one of the first signs of COVID-19 infection among vulnerable older adults”
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Sex differences and similarities in the neuroimmune response to central administration of poly I:C
Posillico, C. K., Garcia-Hernandez, R. E., & Tronson, N. C. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02235-7 · Cited by 42
Challenges posed by COVID‐19 in cancer patients: A narrative review
Afshar, Z. M., Hosseinzadeh, R., Barary, M., Ebrahimpour, S., Alijanpour, A., Sayad, B., Hosseinzadeh, D., Miri, S. R., Sio, T. T. W., Sullman, M. J. M., et al. (2021) · Cancer Medicine · doi:10.1002/cam4.4519 · Cited by 36
Clinical Characteristics of Children with COVID-19
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Mortality risk assessment in Spain and Italy, insights of the HOPE COVID-19 registry
Nuñez-Gil, I. J., Fernández, C., Estrada, V., Becerra‐Muñoz, V. M., El‐Battrawy, I., Uribarri, A., Fernández‐Rozas, I., Feltes, G. I., Viana-Llamas, M. C., Trabattoni, D., et al. (2020) · Internal and Emergency Medicine · doi:10.1007/s11739-020-02543-5 · Cited by 35
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Dying in the face of the COVID-19 pandemic: Contextual considerations and clinical recommendations.
LeRoy, A. S., Robles, B., Kilpela, L. S., & Garcini, L. M. (2020) · Psychological Trauma Theory Research Practice and Policy · doi:10.1037/tra0000818 · Cited by 35
Cancer and SARS-CoV-2 Infection: Diagnostic and Therapeutic Challenges
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Citation Network Analysis of the Novel Coronavirus Disease 2019 (COVID-19)
Martínez-Pérez, C., Alvarez-Peregrina, C. C., Villa-Collar, C. C., & Sánchez‐Tena, M. Á. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17207690 · Cited by 35
Metadata
- Authors
- Onder, G., Rezza, G., & Brusaferro, S.
- Affiliations
- Istituto Superiore di Sanità (IT)
- Corresponding author
- Onder, Graziano
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2020-03-23
- Volume
- 323
- Issue
- 18
- Pages
- 1775-1776
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W3012925204
- Cited by
- 4,171
- References
- 10
- Citations by year
- 2026: 13 · 2025: 77 · 2024: 163 · 2023: 316 · 2022: 643 · 2021: 1139 · 2020: 1814
- FWCI
- 127.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System (University of Udine) (submittedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Physical Sciences › Mathematics › Modeling and Simulation › COVID-19 epidemiological studies
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Keywords
- COVID-19 pandemic, case fatality rate, mortality, Italy, age as risk factor, diagnostic testing strategy
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, COVID-19 Testing, Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Child, Child, Preschool, China, Data Collection, Female, Humans, Infant, Infant, Newborn, Italy, Male, Middle Aged, Pneumonia, Viral, Population Surveillance, Sex Factors, Comorbidity, Cluster Analysis, Age Distribution, Coronavirus Infections, Clinical Laboratory Techniques, Young Adult, Pandemics, Real-Time Polymerase Chain Reaction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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