Accelerometer-derived "weekend warrior" physical activity and incident cardiovascular disease
Open accessAbstract
Importance: Guidelines recommend 150 minutes or more of moderate to vigorous physical activity (MVPA) per week for overall health benefit, but the relative effects of concentrated vs more evenly distributed activity are unclear. Objective: To examine associations between an accelerometer-derived "weekend warrior" pattern (ie, most MVPA achieved over 1-2 days) vs MVPA spread more evenly with risk of incident cardiovascular events. Design, Setting, and Participants: Retrospective analysis of UK Biobank cohort study participants providing a full week of accelerometer-based physical activity data between June 8, 2013, and December 30, 2015. Exposures: Three MVPA patterns were compared: active weekend warrior (active WW, ≥150 minutes with ≥50% of total MVPA achieved in 1-2 days), active regular (≥150 minutes and not meeting active WW status), and inactive (<150 minutes). The same patterns were assessed using the sample median threshold of 230.4 minutes or more of MVPA per week. Main Outcomes and Measures: Associations between activity pattern and incident atrial fibrillation, myocardial infarction, heart failure, and stroke were assessed using Cox proportional hazards regression, adjusted for age, sex, racial and ethnic background, tobacco use, alcohol intake, Townsend Deprivation Index, employment status, self-reported health, and diet quality. Results: A total of 89 573 individuals (mean [SD] age, 62 [7.8] years; 56% women) who underwent accelerometry were included. When stratified at the threshold of 150 minutes or more of MVPA per week, a total of 37 872 were in the active WW group (42.2%), 21 473 were in the active regular group (24.0%), and 30 228 were in the inactive group (33.7%). In multivariable-adjusted models, both activity patterns were associated with similarly lower risks of incident atrial fibrillation (active WW: hazard ratio [HR], 0.78 [95% CI, 0.74-0.83]; active regular: 0.81 [95% CI, 0.74-0.88; inactive: HR, 1.00 [95% CI, 0.94-1.07]), myocardial infarction (active WW: 0.73 [95% CI, 0.67-0.80]; active regular: 0.65 [95% CI, 0.57-0.74]; and inactive: 1.00 [95% CI, 0.91-1.10]), heart failure (active WW: 0.62 [95% CI, 0.56-0.68]; active regular: 0.64 [95% CI, 0.56-0.73]; and inactive: 1.00 [95% CI, 0.92-1.09]), and stroke (active WW: 0.79 [95% CI, 0.71-0.88]; active regular: 0.83 [95% CI, 0.72-0.97]; and inactive: 1.00 [95% CI, 0.90-1.11]). Findings were consistent at the median threshold of 230.4 minutes or more of MVPA per week, although associations with stroke were no longer significant (active WW: 0.89 [95% CI, 0.79-1.02]; active regular: 0.87 [95% CI, 0.74-1.02]; and inactive: 1.00 [95% CI, 0.90-1.11]). Conclusions and Relevance: Physical activity concentrated within 1 to 2 days was associated with similarly lower risk of cardiovascular outcomes to more evenly distributed activity.
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Physical activity concentrated within 1 to 2 days of the week, termed the 'weekend warrior' pattern, was also associated with a lower risk of cardiovascular outcomes.
“Physical activity concentrated within 1 to 2 days of the week, termed the ' weekend warrior ' pattern, was also associated with a lower risk of cardiovascular outcomes. 328”
From EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). (2024) · cites this paper as [328]
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- Authors
- Khurshid, S., Al-Alusi, M. A., Churchill, T. W., Guseh, J. S., & Ellinor, P. T.
- Affiliations
- Broad Institute (US)
- Cardiovascular Research Center, Massachusetts General Hospital, Boston
- Massachusetts General Hospital (US)
- Corresponding author
- Ellinor, Patrick T.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2023-07-18
- Volume
- 330
- Issue
- 3
- Pages
- 247
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- PMC
- PMC10354673
- OpenAlex
- W4384626708
- Cited by
- 204
- References
- 13
- Citations by year
- 2026: 61 · 2025: 81 · 2024: 49 · 2023: 13
- FWCI
- 36.23
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- JAMA (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (KL2TR002542)
- National Heart, Lung, and Blood Institute (K23HL159262, R01HL092577, R01HL157635, T32HL007208, R01HL139731)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
- Keywords
- moderate-to-vigorous physical activity, cardiovascular disease, atrial fibrillation, myocardial infarction, heart failure, stroke, accelerometer-measured activity, incident cardiovascular events, UK Biobank, older adults, middle-aged adults, sex differences, socioeconomic deprivation, alcohol consumption, diet quality, Townsend deprivation index
- MeSH terms
- Aged, Atrial Fibrillation, Cardiovascular Diseases, Female, Heart Failure, Humans, Male, Middle Aged, Myocardial Infarction, Retrospective Studies, Cohort Studies, Exercise, Accelerometry
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