Ethical Obligations to Inform Patients About Use of AI Tools
Abstract
This Perspective discusses the use of artificial intelligence (AI) tools in health care and offers a framework for deciding what patients should be told about AI tools.
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Guidance from the Stanford HEAL AI framework suggests that patient disclosure and consent to AI should depend on both the risk of physical harm and the degree of patient agency afforded by the tool.
“Guidance from the Stanford HEAL AI framework suggests that patient disclosure and consent to AI should depend on both the risk of physical harm and the degree of patient agency afforded by the tool.61”
From Prognostication and clinical opportunities with AI for coronary artery calcium: a scoping review (2026) · cites this paper as [61]
Cites
Understanding Liability Risk from Using Health Care Artificial Intelligence Tools
Mello, M. M., & Guha, N. (2024) · New England Journal of Medicine · doi:10.1056/nejmhle2308901 · Cited by 155 · see citing works
Self-citationPatients’ Trust in Health Systems to Use Artificial Intelligence
Nong, P., & Platt, J. E. (2025) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.60628 · Cited by 101 · see citing works
Patient Consent and The Right to Notice and Explanation of AI Systems Used in Health Care
Hurley, M. E., Lang, B. H., Kostick, K. M., Smith, J. N., & Blumenthal‐Barby, J. (2024) · The American Journal of Bioethics · doi:10.1080/15265161.2024.2399828 · Cited by 74 · see citing works
Callahan, A., McElfresh, D., Banda, J. M., Bunney, G., Char, D., Chen, J., Corbin, C. K., Dash, D., Downing, N. L., Jain, S. S., et al. (2024) · NEJM Catalyst · doi:10.1056/cat.24.0131 · Cited by 61 · see citing works
Self-citationEthics in Patient Preferences for Artificial Intelligence–Drafted Responses to Electronic Messages
Cavalier, J. S., Goldstein, B. A., Ravitsky, V., Bélisle‐Pipon, J., Bedoya, A., Maddocks, J., Klotman, S., Roman, M., Sperling, J. B., Xu, C. D., et al. (2025) · JAMA Network Open · doi:10.1001/jamanetworkopen.2025.0449 · Cited by 55 · see citing works
Rose, S. L., & Shapiro, D. (2024) · CHEST Journal · doi:10.1016/j.chest.2024.04.014 · Cited by 47 · see citing works
Public Attitudes Toward Notification of Use of Artificial Intelligence in Health Care
Platt, J. E., Nong, P., Carmona, G., & Kardia, S. L. R. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.50102 · Cited by 42 · see citing works
Nong, P., & Ji, M. (2025) · Journal of the American Medical Informatics Association · doi:10.1093/jamia/ocaf031 · Cited by 40 · see citing works
Opportunities and risks of artificial intelligence in patient portal messaging in primary care
Biro, J. M., Handley, J. L., Malcolm McCurry, J., Visconti, A., Weinfeld, J., Gregory Trafton, J., & Ratwani, R. M. (2025) · npj Digital Medicine · doi:10.1038/s41746-025-01586-2 · Cited by 35 · see citing works
Calibrating AI Reliance—A Physician’s Superhuman Dilemma
Patil, S. V., Myers, C. G., & Lu‐Myers, Y. (2025) · JAMA Health Forum · doi:10.1001/jamahealthforum.2025.0106 · Cited by 24 · see citing works
Binkley, C. E., & Pilkington, B. (2023) · The American Journal of Bioethics · doi:10.1080/15265161.2023.2250289 · Cited by 15 · see citing works
A Call for Disclosure When Using AI for Patient Communications
Millen, M. M., Tai‐Seale, M., & Longhurst, C. (2025) · NEJM AI · doi:10.1056/aip2401167 · Cited by 14 · see citing works
Co-creating Consent for Data Use — AI-Powered Ethics for Biomedical AI
Evans, B. J., & Bihorac, A. (2024) · NEJM AI · doi:10.1056/aipc2400237 · Cited by 10 · see citing works
Integrating Artificial Intelligence Support in Patient Care While Respecting Ethical Principles
Sharko, M., & Cole, C. L. (2025) · JAMA Network Open · doi:10.1001/jamanetworkopen.2025.0462 · Cited by 9 · see citing works
Spector‐Bagdady, K., & London, A. J. (2025) · The American Journal of Bioethics · doi:10.1080/15265161.2025.2458424 · Cited by 5 · see citing works
A Heuristic for Notifying Patients About AI: From Institutional Declarations to Informed Consent
Elmore, M., Economou-Zavlanos, N., & Pencina, M. J. (2025) · The American Journal of Bioethics · doi:10.1080/15265161.2025.2458422 · Cited by 4 · see citing works
Consenting to and Contesting AI Use – Different Functions but Both Are Necessary
Ploug, T., & Holm, S. (2025) · The American Journal of Bioethics · doi:10.1080/15265161.2025.2457721 · Cited by 4 · see citing works
Stroud, A. M., Miller, J. E., & Barry, B. A. (2025) · The American Journal of Bioethics · doi:10.1080/15265161.2025.2457775 · Cited by 4 · see citing works
Balancing Transparency and Trust: Reevaluating AI Disclosure in Healthcare
Pflanzer, M. (2025) · The American Journal of Bioethics · doi:10.1080/15265161.2025.2457700 · Cited by 3 · see citing works
Beyond Disclosure: Rethinking Patient Consent and AI Accountability in Healthcare
Yang, Y. T. (2025) · The American Journal of Bioethics · doi:10.1080/15265161.2025.2457688 · Cited by 2 · see citing works
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Navarro, D. F., Lewis, M., Blease, C. R., Shah, R., Riggare, S. S., Delacroix, S., & Lehman, R. (2025) · BMJ · doi:10.1136/bmj-2025-085325 · Cited by 15 · see citing works
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Weightman, A. L., Clayton, P. A., & Coghlan, S. (2025) · Kidney360 · doi:10.34067/kid.0000001074 · Cited by 5 · see citing works
Duffourc, M., & Cahill, R. A. (2025) · npj Digital Medicine · doi:10.1038/s41746-025-02157-1 · Cited by 6 · see citing works
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Perlis, R. H. (2025) · JAMA · doi:10.1001/jama.2025.14026 · Cited by 4 · see citing works
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Mello, M. M., Childs, P. B., & Roberts, J. L. (2025) · JAMA Health Forum · doi:10.1001/jamahealthforum.2025.5020 · Cited by 4 · see citing works
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Sakr, J. (2026) · npj Digital Medicine · doi:10.1038/s41746-026-02621-6 · Cited by 3 · see citing works
Trust is all you Need: Reinforcing the Patient-physician Bond in Times of AI
Reis, F., Reis, M., Drzeniek, N. M., & Balzer, F. (2025) · Journal of Medical Systems · doi:10.1007/s10916-025-02296-8 · Cited by 2 · see citing works
Wiefels, C., Juárez‐Orozco, L. E., Craviolatti, P. S., Diahiliev, O., Eskander, A. M., Giubbini, R., Milan, E., Zhou, W., Karthikeyan, G., Jiménez‐Heffernan, A., et al. (2025) · Seminars in Nuclear Medicine · doi:10.1053/j.semnuclmed.2025.11.011 · Cited by 2 · see citing works
Zhang, W., Qi, S., Hu, Y., Zhai, X., Zhai, W., Liu, S., Li, Z., Su, W., Liu, S., Liu, W., et al. (2026) · npj Health Systems · doi:10.1038/s44401-026-00101-3 · Cited by 2 · see citing works
Informed consent and ethical considerations in AI for dentistry and medicine: a scoping review
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Barrison, P., Platt, J. E., Ackerman, M. S., Friedman, C. P., & Vinson, A. H. (2026) · International Journal of Medical Informatics · doi:10.1016/j.ijmedinf.2026.106507 · Cited by 1 · see citing works
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Changaris, M., & Niameh, F. V. (2026) · Frontiers in Digital Health · doi:10.3389/fdgth.2026.1761009 · Cited by 1 · see citing works
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Lorello, G. R., & Murali, M. (2025) · Anaesthesia · doi:10.1111/anae.70089 · Cited by 1 · see citing works
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Advancing AI in healthcare: three strategic roles for quality and safety leaders
Rakover, J., Renton, M., Barker, P., & Kantor, G. S. A. (2025) · BMJ Quality & Safety · doi:10.1136/bmjqs-2025-019050
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Mello, M. M., Char, D. S., & Xu, S. H. (2025) · JAMA · doi:10.1001/jama.2025.18506
Self-citationGlobal perspectives on artificial intelligence-augmented health care
Bhatia, R., Jaisani, Z., Dey, A. K., Muralidharan, J., Khan, R., Bhatia, M., & Gangadharan, A. (2025) · The Journal of Clinical and Scientific Research · doi:10.4103/jcsr.jcsr_130_25
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Verma, R., Bains, S. S., Muthani, S. H. R., Arunachalam, A., Mohan, V., & Gold, J. A. (2026) · JMIR Medical Informatics · doi:10.2196/85015
Mesquita, C. T., da Silva, F. S., & do Couto, A. B. C. (2026) · Arquivos Brasileiros de Cardiologia · doi:10.36660/abc.20260254i
Zhang, M., Wei, Y., Feng, F., Tian, H., Yang, Y., Yan, L., Cai, Y., Wang, D., Zhu, C., & Yu, C. (2026) · BMC Nursing · doi:10.1186/s12912-026-05036-6
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Shen, C., & Lipoff, J. B. (2026) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2026.07.091
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Alasmar, A. Y., Gunn-Sandell, L. B., Fischer, S. M., Fink, R. M., Juarez-Colunga, E., Campbell, E. G., & DeCamp, M. (2026) · BMJ Supportive & Palliative Care · doi:10.1136/spcare-2026-006358
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Binkley, C. E., Moran, B., Zier, L. S., Beauchamp, L., & Lloyd, R. C. (2026) · American Journal of Medical Quality · doi:10.1097/jmq.0000000000000344
Lei, Q.-K., Wu, T.-X., Zhang, C.-L., & Zheng, Y. (2026) · Liver Research · doi:10.1016/j.livres.2026.08.001
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Lai, S., Guan, Z., Zhang, Y., Hong, J., Zeng, D., Echouffo-Tcheugui, J. B., Qin, Y., Shen, J., Li, H., Jiang, Z., et al. (2026) · Nature Health · doi:10.1038/s44360-026-00190-2
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Sohrabniya, F., Naveed, K., Mohammad‐Rahimi, H., Woolley, J., Haghighat, S., Stoustrup, P. B., & Pauwels, R. (2026) · Orthodontics and Craniofacial Research · doi:10.1111/ocr.70179
Chai, E. S., Abraham, K., Hanes, R., Williams, A., Wolinsky, H., Kryvenko, O. N., Stoyanova, R. S., Penedo, F. J., Khandekar, A., Nahar, B., et al. (2026) · BJUI Compass · doi:10.1002/bco2.70262
Runde, A. P., Fahey, J. L., Pelit, W. S., Ortiz, C. E., Koo, S. M., Jordan, S., Chrulski, K. E., Kleberg, J. A., Buckner, H. D., Brown, N. M., et al. (2026) · Life · doi:10.3390/life16111785
Lenze, N. R., & Goldstein, C. A. (2026) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2026.08.020
Reis, M., Choi, J., Kim, Y. J., Luan, Y. L., Lyu, P., & Reis, F. (2026) · npj Digital Medicine · doi:10.1038/s41746-026-03361-3
Waeiss, Q., Chang, L. J., Lutley, K., & Magnus, D. C. (2026) · doi:10.2196/preprints.114409
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Keamy-Minor, E., Dudum, R., Bragdon, C. L., Ngo, S., Xu, S., Asch, S. M., Maron, D. J., Brown-Johnson, C., Sandhu, A. T., & Rodriguez, F. (2026) · American Heart Journal Plus Cardiology Research and Practice · doi:10.1016/j.ahjo.2026.100989
Self-citationCunningham, J. M., Velasquez, S. A. T., Jin, L., Morrow, J. D., Botros-Brey, S., & Rodríguez, R. (2026) · MedEdPORTAL · doi:10.15766/mep_2374-8265.11645
- Authors
- Mello, M. M., Char, D., & Xu, S. H.
- Affiliations
- Stanford Medicine (US)
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2025-09-02
- Volume
- 334
- Issue
- 9
- Pages
- 767
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W4412528223
- Cited by
- 57
- References
- 20
- Citations by year
- 2026: 40 · 2025: 17
- FWCI
- 13.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Health Informatics › Artificial Intelligence in Healthcare and Education
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ethics and bioethics in healthcare
- Social Sciences › Safety Research › Ethics and Social Impacts of AI
- Keywords
- artificial intelligence in healthcare, patient information, informed consent, moral obligation, AI disclosure, patient autonomy
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