The DOI matches its Crossref record, with a small difference in title or year.
Long-term Outcome of Episodes of Major Depression: Clinical and Public Health Significance
Abstract
Twenty-one percent (20/97) of patients with an episode of major depressive disorder and no history of chronic minor depression who sought treatment at five university medical centers had not recovered after two years of prospective follow-up. The rate of recovery was highest in the three months after entry into the study, with a notable decrease in rate after one year. Most patients who did not recover had severe depressive symptoms throughout the two years of follow-up. Long duration of episode before entry into the study, inpatient hospitalization status at entry, intact marriage, low family income, admitting research center, and a history of nonaffective psychiatric disorders (including alcoholism) predicted a chronic course. The implications of these findings for clinicians, researchers, and public health planners are discussed.
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“Relapse rates after a first episode of depression in those with no depression history are 20% to 30% compared with 70% to 80% for those who have experienced two or more episodes (Keller 1984).”
From Interventions for preventing relapse and recurrence of a depressive disorder in children and adolescents (2012) · cites this paper as Keller 1984
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Trivedi, M. H., Rush, A. J., Wisniewski, S. R., Nierenberg, A. A., Warden, D., Ritz, L., Norquist, G., Howland, R. H., Lebowitz, B., McGrath, P. J., et al. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.1.28 · Cited by 3,879
Keller, M. B. (1987) · Archives of General Psychiatry · doi:10.1001/archpsyc.1987.01800180050009 · Cited by 1,643
Self-citationThe Netherlands Study of Depression and Anxiety (NESDA): rationale, objectives and methods
Penninx, B. W. J. H., Beekman, A. T. F., Smit, J. H., Zitman, F. G., Nolen, W. A., Spinhoven, P., Cuijpers, P. J., de Jong, P. J., van Marwijk, H., Assendelft, W. J., et al. (2008) · International Journal of Methods in Psychiatric Research · doi:10.1002/mpr.256 · Cited by 930
Hirschfeld, R. M. A. (1997) · JAMA · doi:10.1001/jama.277.4.333 · Cited by 896
Keller, M. B. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820100053010 · Cited by 864
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Metadata
- Authors
- Keller, M. B.
- Corresponding author
- Keller, Martin B.
- ORCID
- Keller, Martin B.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 1984-08-10
- Volume
- 252
- Issue
- 6
- Pages
- 788
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W4253268125
- Cited by
- 295
- References
- 0
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 7 · 2013: 6 · 2012: 6
- FWCI
- 12.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R01MH025478, U01MH025478)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- major depressive disorder, long-term outcomes, recovery from depression, chronic depression, episode duration, hospitalization, marital status, household income, alcoholism, public health implications
- MeSH terms
- Adult, Depressive Disorder, Humans, Middle Aged, Outcome and Process Assessment, Health Care, Probability
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