The DOI matches its Crossref record, with a small difference in title or year; 16 of the 16 references it cites were found in a registry or an index.
The Aging Thyroid: The Use of Thyroid Hormone in Older Persons
Abstract
The overall prevalence of thyroid hormone use in an unselected population of older adults (n = 2575; average age, 68.6 years) was 6.9% (10.0% in women and 2.3% in men). Eighty-one percent of women taking it were doing so for appropriate indications, eg, hypothyroidism, while 12% were not, eg, for obesity or high serum cholesterol; more men (29%) were taking it inappropriately. Inappropriate use was associated with desiccated thyroid more than with thyroxine. After follow-up averaging 6.9 years, 58% of inappropriate users were still taking it. Underuse also occurred. Thirty-seven percent of those definitely hypothyroid had a clearly elevated serum thyrotropin level (greater than 10 mU/L) despite thyroid therapy. Thyroid therapy is common in the elderly; most is appropriate. When inappropriate use occurs, it is more common in men and more often associated with desiccated thyroid, still commonly used in this age group. In chronic users of thyroid hormone, it is important to review currently appropriate indications and to measure serum thyrotropin levels to assess the adequacy of treatment of primary hypothyroidism.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“As levothyroxine requirements decrease with age, iatrogenic hyperthyroidism is more common in older people.3 5”
From Levothyroxine dose and risk of fractures in older adults: nested case-control study (2011) · cites this paper as [5]
Citations
Cites
Jh, M. (1964) · Annals of Internal Medicine · doi:10.7326/0003-4819-60-4-742_2 · Cited by 690
A Radioimmunoassay for Measurement of Thyroxine in Unextracted Serum*
CHOPRA, I. J. (1972) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-34-6-938 · Cited by 539
Sawin, C. T. (1985) · Archives of Internal Medicine · doi:10.1001/archinte.145.8.1386 · Cited by 439
Self-citationMurray, G. R. (1891) · BMJ · doi:10.1136/bmj.2.1606.796 · Cited by 233
A Sensitive and Precise Radioimmunoassay for Human Thyroid-Stimulating Hormone
PEKARY, A. E., Hershman, J. M., & Parlow, A. F. (1975) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-41-4-676 · Cited by 154
Leaverton, P. E., Sorlie, P. D., Kleinman, J. C., Dannenberg, A. L., Ingster, L. M., Kannel, W. B., & Cornoni‐Huntley, J. C. (1987) · Journal of Chronic Diseases · doi:10.1016/0021-9681(87)90129-9 · Cited by 146
Thyroid-Hormone Enhancement of Imipramine in Nonretarded Depressions
Wilson, I. C., Prange, A. J., McClane, T. K., Rabon, A. M., & Lipton, M. A. (1970) · New England Journal of Medicine · doi:10.1056/nejm197005072821903 · Cited by 135
Breast cancer. Relationship to thyroid supplements for hypothyroidism
Kapdi, C. C. (1976) · JAMA · doi:10.1001/jama.236.10.1124 · Cited by 100
Krugman, L. G., Hershman, J. M., CHOPRA, I. J., Levine, G. A., Pekary, A. E., Geffner, D. L., & TECO, G. N. C. (1975) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-41-1-70 · Cited by 68
Value of postirradiation screening for thyroid nodules. A controlled study of recalled patients
Royce, P. C. (1979) · JAMA · doi:10.1001/jama.242.24.2675 · Cited by 36
Cited by
Sorted by citations
Hollowell, J. G., Staehling, N. W., Flanders, W. D., Hannon, W. H., Gunter, E. W., Spencer, C. A., & Braverman, L. E. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.87.2.489 · Cited by 4,279
Fade, J. V., Franklyn, J. A., Cross, K. W., Jones, S. C., & Sheppard, M. C. (1991) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1991.tb01739.x · Cited by 567
Roberts, C. G., & Ladenson, P. W. (2004) · The Lancet · doi:10.1016/s0140-6736(04)15696-1 · Cited by 567
Risk for fracture in women with low serum levels of thyroid-stimulating hormone
Bauer, D. C., Ettinger, B., Nevitt, M. C., Stone, K. L., & for the Study of Osteoporotic Fractures Research Group (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-134-7-200104030-00009 · Cited by 467
Bodai, B. I., & Tuso, P. (2015) · The Permanente Journal · doi:10.7812/tpp/14-241 · Cited by 397
Metadata
- Authors
- Sawin, C. T.
- Affiliations
- United States Department of Veterans Affairs (US)
- Corresponding author
- Sawin, Clark T.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 1989-05-12
- Volume
- 261
- Issue
- 18
- Pages
- 2653
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2043303113
- Cited by
- 94
- References
- 16
- Citations by year
- 2023: 2 · 2021: 1 · 2019: 2 · 2017: 2 · 2016: 5 · 2015: 5 · 2014: 2 · 2013: 3 · 2012: 4
- FWCI
- 3.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Keywords
- thyroid hormone replacement, older adults, hypothyroidism, inappropriate prescribing, desiccated thyroid, levothyroxine, serum thyrotropin, sex differences in prescribing
- MeSH terms
- Age Factors, Aged, Drug Utilization, Female, Follow-Up Studies, Goiter, Humans, Hypercholesterolemia, Hypothyroidism, Male, Sex Factors, Thyroid Diseases, Thyroid Hormones, Cohort Studies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
