The DOI matches its OpenAlex record; 1 of the 1 references it cites were found in a registry or an index.
The relative risk of incident coronary heart disease associated with recently stopping the use of beta-blockers
Abstract
We conducted a population-based, case-control study of risk factors for first events of coronary heart disease in patients with high blood pressure. All subjects had hypertension treated with medication. The 248 cases presented with new coronary heart disease from 1982 through 1984, and the 737 controls were a probability sample of health maintenance organization patients free of coronary heart disease. The health maintenance organization's computerized pharmacy database identified recent stoppers--patients who did not fill their prescriptions regularly enough to be at least 80% compliant. After adjustment for potential confounding factors, subjects who had recently stopped using beta-blockers had a transient fourfold increase in the relative risk of coronary heart disease (relative risk, 4.5; 95% confidence interval, 1.1 to 18.5). The association was specific to beta-blockers but not diuretics. A withdrawal syndrome immediately following the cessation of beta-blocker use may be an acute precipitant of angina and myocardial infarction in hypertensive patients who have no prior history of coronary heart disease.
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Citations
Cites
Beta blockade during and after myocardial infarction: An overview of the randomized trials
Yusuf, S., Peto, R., Lewis, J., Collins, R., & Sleight, P. (1985) · Progress in Cardiovascular Diseases · doi:10.1016/s0033-0620(85)80003-7 · Cited by 3,205
Cited by
Viswanathan, M., Golin, C. E., Jones, C. D., Ashok, M., Blalock, S. J., Wines, R. C. M., Coker-Schwimmer, E. J. L., Rosen, D. L., Sista, P., & Lohr, K. N. (2012) · Annals of Internal Medicine · doi:10.7326/0003-4819-157-11-201212040-00538 · Cited by 754
(2004) · European Heart Journal · doi:10.1016/j.ehj.2004.06.002 · Cited by 557
Anaphylaxis—a practice parameter update 2015
Lieberman, P., Nicklas, R. A., Randolph, C., Oppenheimer, J., Bernstein, D., Bernstein, J., Ellis, A., Golden, D. B. K., Greenberger, P., Kemp, S., et al. (2015) · Annals of Allergy, Asthma & Immunology · doi:10.1016/j.anai.2015.07.019 · Cited by 474
Bramley, T. J., Nightengale, B. S., Frech-Tamas, F., & Gerbino, P. P. (2006) · Journal of Managed Care Pharmacy · doi:10.18553/jmcp.2006.12.3.239 · Cited by 380
Compliance with cardiovascular disease prevention strategies: A review of the research
Burke, L. E., Dunbar-Jacob, J. M., & Hill, M. N. (1997) · Annals of Behavioral Medicine · doi:10.1007/bf02892289 · Cited by 286
Metadata
- Authors
- Psaty, B. M.
- Venue
- JAMA
- Publisher
- American Medical Association
- Published
- 1990-03-23
- Volume
- 263
- Issue
- 12
- Pages
- 1653-1657
- ISSN
- 0002-9955 (ISSN-L)
- OpenAlex
- W4255783390
- Cited by
- 268
- References
- 1
- FWCI
- 8.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The relative risk of incident coronary heart disease associated with recently stopping the use of beta-blockers. https://app.cochat.ai/papers/10.1001/jama.263.12.1653
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- Psaty, B. M. (1990). The relative risk of incident coronary heart disease associated with recently stopping the use of beta-blockers. JAMA. https://doi.org/10.1001/jama.263.12.1653
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
