The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Frequent Recovery of HIV-1 From Genital Herpes Simplex Virus Lesions in HIV-1–Infected Men
Abstract
CONTEXT: Genital ulcer disease has been epidemiologically linked as a risk factor in the transmission of the human immunodeficiency virus 1 (HIV-1). While herpes simplex virus 2 (HSV-2) is the most common cause of genital ulcers, no study has systematically evaluated the frequency or titer of HIV-1 virus in HSV-2 lesions. OBJECTIVE: To compare lesional HIV-1 RNA levels during and after genital HSV-2 reactivation and to evaluate the frequency, titer, and duration of HIV-1 RNA shedding in lesions due to HSV-2. DESIGN: Convenience sample. SETTING: Sexually transmitted disease research clinic at the University of Washington, Seattle. PATIENTS: Twelve HIV-infected men with a history of symptomatic HSV-2 infection who underwent daily sampling of genital lesions for HIV-1 RNA by polymerase chain reaction assay and HSV-2 by culture. MAIN OUTCOME MEASURE: Detection of lesional HIV RNA and HSV-2. RESULTS: HIV-1 RNA was detected from lesional swabs in 25 of 26 consecutively studied HSV-2 episodes and on 67% of days in which genital lesions were noted. The HIV-1 RNA titers in lesional swabs exceeded 10000 copies/mL of swab sample in 75% of samples (range, 2.2-3.2 x 10(5) copies/mL of swab sample). HIV-1 RNA in genital lesion swabs was seen in persons with high and low titers of plasma HIV-1 RNA and was not associated with plasma HIV-1 RNA levels. CONCLUSIONS: HIV-1 virions can consistently be detected in genital ulcers caused by HSV-2, which suggests that genital herpes infection likely increases the efficiency of the sexual transmission of HIV-1.
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Citations
Cites
Quantitation of HIV-1 RNA in Plasma Predicts Outcome after Seroconversion
Mellors, J. W., Kingsley, L. A., Rinaldo, C. R., Todd, J. A., Hoo, B. S., Kokka, R. P., & Gupta, P. (1995) · Annals of Internal Medicine · doi:10.7326/0003-4819-122-8-199504150-00003 · Cited by 917
Genetic relationships determined by a DNA heteroduplex mobility assay: analysis of HIV-1 env genes
Delwart, E., Shpaer, E., Louwagie, J., McCutchan, F., Grez, M., Rubsamen-Waigmann, H., & Mullins, J. (1993) · Science · doi:10.1126/science.8235655 · Cited by 757
Cameron, D. W., D'Costa, L., Maitha, G., Cheang, M., Piot, P., Simonsen, J. N., Ronald, A., Gakinya, M., Ndinya-Achola, J. O., Brunham, R., et al. (1989) · The Lancet · doi:10.1016/s0140-6736(89)90589-8 · Cited by 753
Changes in Plasma HIV-1 RNA and CD4+ Lymphocyte Counts and the Risk of Progression to AIDS
O'Brien, W. A., Hartigan, P. M., Martin, D., Esinhart, J., Hill, A., Benoit, S., Rubin, M., Simberkoff, M. S., & Hamilton, J. D. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602153340703 · Cited by 720
Virologic Characteristics of Subclinical and Symptomatic Genital Herpes Infections
Wald, A., Zeh, J., Selke, S., Ashley, R. L., & Corey, L. (1995) · New England Journal of Medicine · doi:10.1056/nejm199509213331205 · Cited by 507
Wald, A., Corey, L., Cone, R., Hobson, A., Davis, G., & Zeh, J. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119237 · Cited by 388
Peterman, T. A. (1988) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1988.03720010033036 · Cited by 369
O'Brien, W., Grovit-Ferbas, K., Namazi, A., Ovcak-Derzic, S., Wang, H., Park, J., Yeramian, C., Mao, S., & Zack, J. (1995) · Blood · doi:10.1182/blood.v86.3.1082.1082 · Cited by 304
Human immunodeficiency virus type 1 evolution in vivo tracked by DNA heteroduplex mobility assays
Delwart, E. L., Sheppard, H. W., Walker, B. D., Goudsmit, J., & Mullins, J. I. (1994) · Journal of Virology · doi:10.1128/jvi.68.10.6672-6683.1994 · Cited by 296
Underdiagnosis of Genital Herpes by Current Clinical and Viral-Isolation Procedures
Koutsky, L. A., Stevens, C. E., Holmes, K. K., Ashley, R. L., Kiviat, N. B., Critchlow, C. W., & Corey, L. (1992) · New England Journal of Medicine · doi:10.1056/nejm199206043262305 · Cited by 286
Cited by
Fleming, D. T., & Wasserheit, J. N. (1999) · Sexually Transmitted Infections · doi:10.1136/sti.75.1.3 · Cited by 2,271
Acyclovir and transmission of HIV-1 from persons infected with HIV-1 and HSV-2.
Celum, C., Wald, A., Lingappa, J. R., Magaret, A. S., Wang, R. S., Mugo, N., Mujugira, A., Baeten, J. M., Mullins, J. I., Hughes, J. P., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0904849 · Cited by 524
Corey, L., Langenberg, A. G. M., Ashley, R., Sekulovich, R. E., Izu, A. E., Douglas, Jr., Handsfield, H. H., Warren, T., Marr, L., Tyring, S., et al. (1999) · JAMA · doi:10.1001/jama.282.4.331 · Cited by 490
Lawn, S. D., Butera, S. T., & Folks, T. M. (2001) · Clinical Microbiology Reviews · doi:10.1128/cmr.14.4.753-777.2001 · Cited by 313
High rates of syphilis among STI patients are contributing to the spread of HIV-1 in India.
Reynolds, S. J., Risbud, A. R., Shepherd, M. E., Rompalo, A. M., Ghate, M. V., Godbole, S. V., Joshi, S. N., Divekar, A. D., Gangakhedkar, R. R., Bollinger, R. C., et al. (2006) · Sexually Transmitted Infections · doi:10.1136/sti.2005.015040 · Cited by 95
Metadata
- Authors
- Schacker, T.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 1998-07-01
- Volume
- 280
- Issue
- 1
- Pages
- 61
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2075323628
- Cited by
- 309
- References
- 30
- FWCI
- 18.09
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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