The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Human immunodeficiency virus type 1 evolution in vivo tracked by DNA heteroduplex mobility assays
Open accessAbstract
High mutation rates and strong selective pressures imposed on human immunodeficiency viruses in vivo result in the formation of pools of genetic variants known as quasispecies. DNA heteroduplex mobility and tracking analyses were used to monitor the generation of HIV sequence diversity, to estimate quasispecies complexity, and to assess the turnover of genetic variants to approach an understanding of the relationship between viral quasispecies evolution in vivo and disease progression. Proviral DNA pools were nearly homogeneous soon after sexual transmission. The emergence and clearance of individual variants then occurred at different rates in different individuals. High quasispecies complexity was found in long-term-infected, asymptomatic individuals, while rapid CD4+ cell decline and AIDS were often, but not always, associated with lower quasispecies complexity. Proviral genetic variation was often low following in vitro culture, because of the outgrowth of one or a few variants that often became more abundant only later as proviruses in peripheral blood mononuclear cells. These studies provide insight into the dynamics of human immunodeficiency virus sequence changes in vivo and illustrate the utility of heteroduplex analysis for the study of phenomena associated with rapid genetic changes.
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Cited by
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Self-citationAdaptive Evolution of Human Immunodeficiency Virus-Type 1 During the Natural Course of Infection
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Frequent Recovery of HIV-1 From Genital Herpes Simplex Virus Lesions in HIV-1–Infected Men
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Metadata
- Authors
- Delwart, E. L., Sheppard, H. W., Walker, B. D., Goudsmit, J., & Mullins, J. I.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1994-10
- Volume
- 68
- Issue
- 10
- Pages
- 6672-6683
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W1977279184
- Cited by
- 296
- References
- 56
- FWCI
- 8.25
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Delwart, E. L., Sheppard, H. W., Walker, B. D., Goudsmit, J., & Mullins, J. I. (1994). Human immunodeficiency virus type 1 evolution in vivo tracked by DNA heteroduplex mobility assays. Journal of Virology. https://doi.org/10.1128/jvi.68.10.6672-6683.1994
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