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Antiretroviral Therapy in Adults: Updated Recommendations of the International AIDS Society–USA Panel

Carpenter, Charles C. J., Cooper, David A., Fischl, Margaret A., Gatell, Jose M., Gazzard, Brian G., Hammer, Scott M., Hirsch, Martin S., Jacobsen, Donna M., Katzenstein, David A., Montaner, Julio S. G., Richman, Douglas D., Saag, Michael S., Schechter, Mauro, Schooley, Robert T., Thompson, Melanie A., Vella, Stefano, Yeni, Patrick G., Volberding, Paul A.·2000·JAMA

Abstract

OBJECTIVE: To update recommendations for antiretroviral therapy for adult human immunodeficiency virus type 1 (HIV-1) infection, based on new information and drugs that are available. PARTICIPANTS: A 17-member international physician panel with antiretroviral research and HIV patient care experience initially convened by the International AIDS Society-USA in December 1995. EVIDENCE: Available clinical and basic science data including phase 3 controlled trials; data on clinical, virologic, and immunologic end points; research conference reports; HIV pathogenesis data; and panel expert opinion. Recommendations were limited to therapies available (US Food and Drug Administration approved) in 1999. CONSENSUS PROCESS: The panel assesses new research reports and interim results and regularly meets to consider how the new data affect therapy recommendations. Recommendations are updated via full-panel consensus. Guidelines are presented as recommendations if the supporting evidence warrants routine use in the particular situation and as considerations if data are preliminary or incomplete but suggestive. CONCLUSIONS: The availability of new antiretroviral drugs has expanded treatment choices. The importance of adherence, emerging long-term complications of therapy, recognition and management of antiretroviral failure, and new monitoring tools are addressed. Optimal care requires individualized management and ongoing attention to relevant scientific and clinical information in the field.

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Metadata

Authors
Carpenter, C. C. J., Cooper, D. A., Fischl, M. A., Gatell, J. M., Gazzard, B. G., Hammer, S. M., Hirsch, M. S., Jacobsen, D. M., Katzenstein, D. A., Montaner, J. S. G., Richman, D. D., Saag, M. S., Schechter, M., Schooley, R. T., Thompson, M. A., Vella, S., Yeni, P. G., & Volberding, P. A.
Venue
JAMA
Published
2000-01-19
Volume
283
Issue
3
Pages
381
ISSN
  • 0002-9955 (ISSN-L)
  • 0098-7484
OpenAlex
W2133315239
Cited by
1,012
References
1
FWCI
156.85
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Antiretroviral Therapy in Adults: Updated Recommendations of the International AIDS Society–USA Panel. https://app.cochat.ai/papers/10.1001/jama.283.3.381
The paper
Carpenter, C. C. J., Cooper, D. A., Fischl, M. A., Gatell, J. M., Gazzard, B. G., Hammer, S. M., Hirsch, M. S., Jacobsen, D. M., Katzenstein, D. A., Montaner, J. S. G., Richman, D. D., Saag, M. S., Schechter, M., Schooley, R. T., Thompson, M. A., Vella, S., Yeni, P. G., & Volberding, P. A. (2000). Antiretroviral Therapy in Adults: Updated Recommendations of the International AIDS Society–USA Panel. JAMA. https://doi.org/10.1001/jama.283.3.381

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.