Cited by 2,119HIV Research and TreatmentHIV/AIDS drug development and treatmentHIV/AIDS Research and Interventions

Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy

Finzi, Diana, Blankson, Joel, Siliciano, Janet D., Margolick, Joseph B., Chadwick, Karen, Pierson, Theodore, Smith, Kendall, Lisziewicz, Julianna +9 more·1999·Nature Medicine

Abstract

Combination therapy for HIV-1 infection can reduce plasma virus to undetectable levels, indicating that prolonged treatment might eradicate the infection. However, HIV-1 can persist in a latent form in resting CD4+ T cells. We measured the decay rate of this latent reservoir in 34 treated adults whose plasma virus levels were undetectable. The mean half-life of the latent reservoir was very long (43.9 months). If the latent reservoir consists of only 1 x 10(5) cells, eradication could take as long as 60 years. Thus, latent infection of resting CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective anti-retroviral therapy.

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Crossref · 10.1038/8394

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  • HAART does not offer a permanent cure because interruption of therapy leads to rapid rebound of viremia from latent reservoirs.

    “Moreover, although HARRT extends the lives of HIV-1 infected patients, it does not offer a permanent cure, since interruption of therapy leads to rapid rebound of viremia from latent reservoirs [3,4].”

    From Newer Gene Editing Technologies toward HIV Gene Therapy (2013) · cites this paper as [3]

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Authors
Finzi, D., Blankson, J., Siliciano, J. D., Margolick, J. B., Chadwick, K., Pierson, T., Smith, K., Lisziewicz, J., Lori, F., Flexner, C., Quinn, T. C., Chaisson, R. E., Rosenberg, E., Walker, B., Gange, S., Gallant, J., & Siliciano, R. F.
Affiliations
  • Johns Hopkins University (US)
  • Cornell University (US)
  • Georgetown University (US)
  • National Institutes of Health (US)
  • Harvard University (US)
Venue
Nature Medicine
Published
1999-05
Volume
5
Issue
5
Pages
512-517
ISSN
  • 1078-8956 (ISSN-L)
  • 1546-170X
OpenAlex
W1497870368
Cited by
2,119
References
42
Citations by year
2026: 39 · 2025: 45 · 2024: 55 · 2023: 56 · 2022: 62 · 2021: 77 · 2020: 112 · 2019: 90 · 2018: 112 · 2017: 88 · 2016: 96 · 2015: 67 · 2014: 82 · 2013: 83 · 2012: 60
FWCI
39.88
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Allergy and Infectious Diseases (AI 43222, R01AI043222)
Topics
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
  • Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
  • Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
Keywords
HIV-1, latent viral reservoir, CD4+ T cells, viral persistence, antiretroviral therapy, viral eradication
MeSH terms
Adult, Cells, Cultured, Cross-Sectional Studies, Drug Therapy, Combination, Female, Half-Life, Humans, Longitudinal Studies, Male, Middle Aged, RNA, Viral, Virus Replication, CD4-Positive T-Lymphocytes, HIV-1, HIV Infections, Virus Latency, Viral Load

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