The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Persistent Human Papillomavirus Infection as a Predictor of Cervical Intraepithelial Neoplasia
Abstract
Context Human papillomavirus (HPV) infection is believed to be the central cause of cervical cancer, although most of the epidemiological evidence has come from retrospective, case-control studies, which do not provide information on the dynamics of cumulative or persistent exposure to HPV infection. Objective To assess the risks of cervical neoplasia related to prior persistent HPV infections. Design and setting Longitudinal study of the natural history of HPV infection and cervical neoplasia in women residing in the city of São Paulo, Brazil, which was conducted between November 1993 and March 1997 and involved repeated measurements of HPV and lesions with follow-up until June 2000. Participants A total of 1611 women with no cytological lesions at enrollment and HPV test results available from the first 2 visits. Main outcome measure Cervical specimens taken for Papanicolaou cytology and HPV testing every 4 months in the first year and twice yearly thereafter. Incident cervical cancer precursor lesions ascertained by expert review of all cytology smears. Results The incidence rate of squamous intraepithelial lesions (SILs) was 0.73 per 1000 women-months (95% confidence interval [CI], 0.5-0.9) among women free of HPV at the 2 initial visits and 8.68 (95% CI, 2.3-15.1) among women with HPV type 16 or 18 infections persisting over both visits. Relative to those negative for HPV oncogenic types at both initial visits, the relative risk (RR) of incident SIL was 10.19 (95% CI, 5.…
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Full HPV genotyping is also useful clinically to identify patients with persisting, type-specific high-risk HPV infections which are known to confer a higher risk of cancer progression than incident infections by the same high-risk type (11).”
From Comparison of Seegene Anyplex II HPV28 with the PGMY-CHUV Assay for Human Papillomavirus Genotyping (2014) · cites this paper as [11]
Citations
Cites
IARC Monographs on the Evaluation of Carcinogenic Risks to Humans
Zuckerman, A. J. (1995) · Journal of Clinical Pathology · doi:10.1136/jcp.48.7.691-a · Cited by 8,766
NATURAL HISTORY OF CERVICOVAGINAL PAPILLOMAVIRUS INFECTION IN YOUNG WOMEN
Loria, G. R., Ierman, R. O. B., Eardsley, L. E. B., & Hang, H. J. C. (1998) · Cited by 1,890
Bauer, H. M. (1991) · JAMA · doi:10.1001/jama.1991.03460040048027 · Cited by 968
Koutsky, L. A., Holmes, K. K., Critchlow, C. W., Stevens, C. E., Paavonen, J. A., Beckmann, A. M., DeRouen, T. A., Galloway, D. A., Vernon, D., & Kiviat, N. B. (1992) · New England Journal of Medicine · doi:10.1056/nejm199210293271804 · Cited by 940
Woodman, C. B. J., Collins, S. I., Winter, H., Bailey, A. C., Ellis, J. R., Prior, P., Yates, M., Rollason, T. P., & Young, L. S. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04956-4 · Cited by 828
Persistent Genital Human Papillomavirus Infection as a Risk Factor for Persistent Cervical Dysplasia
Ho, G. Y. F., Burk, R. D., Klein, S., Kadish, A. S., Chang, C., PALAN, P., Basu, J., Tachezy, R., Lewis, R., & Romney, S. L. (1995) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/87.18.1365 · Cited by 804
Persistence of Type-Specific Human Papillomavirus Infection among Cytologically Normal Women
Hildesheim, A., SCHIFFMAN, M. H., Gravitt, P. E., Glass, A. G., Greer, C. E., Zhang, T., Scott, D. R., Rush, B. B., Lawler, P., Sherman, M. E., et al. (1994) · The Journal of Infectious Diseases · doi:10.1093/infdis/169.2.235 · Cited by 682
Moscicki, A., Shiboski, S. C., Broering, J. M., Powell, K., Clayton, L., Jay, N., Darragh, T. M., Brescia, R. J., Kanowitz, S., Miller, S., et al. (1998) · The Journal of Pediatrics · doi:10.1016/s0022-3476(98)70445-7 · Cited by 562
Moscicki, A. (2001) · JAMA · doi:10.1001/jama.285.23.2995 · Cited by 555
Epidemiologic Evidence and Human Papillomavirus Infection as a Necessary Cause of Cervical Cancer
Franco, E. L., Rohan, T. E., & VILLA, L. L. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.6.506 · Cited by 538
Cited by
Sorted by citations
Papillomaviruses and cancer: from basic studies to clinical application
Hausen, H. Z. (2002) · Nature reviews. Cancer · doi:10.1038/nrc798 · Cited by 4,031
The causal relation between human papillomavirus and cervical cancer
Bosch, F. X., Lorincz, A. T., Munoz, N., Meijer, C. J. L. M., & Shah, K. V. (2002) · Journal of Clinical Pathology · doi:10.1136/jcp.55.4.244 · Cited by 3,587
Gynecologists (2009) · Cited by 1,035
The epidemiology of human papillomavirus infections
Baseman, J. G., & Koutsky, L. A. (2005) · Journal of Clinical Virology · doi:10.1016/j.jcv.2004.12.008 · Cited by 957
2006 consensus guidelines for the management of women with abnormal cervical cancer screening tests
Wright, T. C., Massad, L. S., Dunton, C. J., Spitzer, M., Wilkinson, E. J., & Solomon, D. (2007) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2007.07.047 · Cited by 829
Metadata
- Authors
- Schlecht, N. F.
- Affiliations
- McGill University (CA)
- Corresponding author
- Schlecht, Nicolas F.
- ORCID
- Schlecht, Nicolas F.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2001-12-26
- Volume
- 286
- Issue
- 24
- Pages
- 3106
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2161489192
- Cited by
- 590
- References
- 22
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 15 · 2023: 12 · 2022: 10 · 2021: 10 · 2020: 15 · 2019: 16 · 2018: 12 · 2017: 13 · 2016: 21 · 2015: 28 · 2014: 28 · 2013: 18 · 2012: 27
- FWCI
- 20.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service (MA13647)
- National Cancer Institute (CA70269, R01CA070269)
- Topics
- Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Women's cancer prevention and management
- Keywords
- human papillomavirus, persistent HPV infection, cervical intraepithelial neoplasia, squamous intraepithelial lesions, HPV 16/18, cervical precancerous lesions, natural history of HPV infection, high-risk HPV genotypes, cervical cancer risk
- MeSH terms
- Adult, Uterine Cervical Dysplasia, Uterine Cervical Neoplasms, DNA, Viral, Female, Humans, Longitudinal Studies, Middle Aged, Risk Factors, Tumor Virus Infections, Vaginal Smears, Multivariate Analysis, Papillomaviridae, Papillomavirus Infections, Papanicolaou Test
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
