Adverse Reactions to Allogeneic Whole Blood Donation by 16- and 17-Year-Olds
Abstract
Context Donations by minors (16- and 17-year-olds) now account for approximately 8% of the whole blood collected by the American Red Cross, but young age and first-time donation status are known to be independent risk factors for donation-related complications. Objective To evaluate adverse reactions to allogeneic whole blood donation by 16- and 17-year-olds compared with older donors in American Red Cross blood centers. Design, setting, and participants Prospective documentation of adverse events among 16- and 17-year-old donors using standardized collection protocols, definitions, and reporting methods in 2006. Data were from 9 American Red Cross blood centers that routinely collect from 16- and 17-year-olds, a population that provides 80% of its donations at high school blood drives. Main outcome measures Rate of systemic (syncopal-type) and phlebotomy-related donor complications per 10,000 collections. Results In 2006, 9 American Red Cross regions collected 145,678 whole blood donations from 16- and 17-year-olds, 113,307 from 18- and 19-year-olds, and 1,517,460 from donors aged 20 years or older. Complications were recorded in 15,632 (10.7%), 9359 (8.3%), and 42,987 (2.8%) donations in each corresponding age group. In a multivariate logistic regression model, young age had the strongest association with complications (odds ratio [OR], 3.05; 95% confidence interval [CI], 2.52-3.69; P Conclusions A higher incidence of donation-related complications and injury occurs among 1…
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Any adverse event, even a minor one, will definitely reduce the likelihood of repeat donation.
“Their significance lies in the fact that any adverse event, even a minor one will definitely reduce the likelihood of repeat donation (11,12).”
From ADVERSE EVENTS IN BLOOD DONORS: SPECTRUM AND REMEDY (2023) · cites this paper as [11]
Criteria for selection of whole blood donors and the donor questionnaire & consent form were in accordance with the Drugs and Cosmetics Act, Ministry of Health and Family Welfare, Government of India.
“Criteria for the selection of whole blood donors and the donor questionnaire & consent form were in accordance with the rules laid down in the Drugs and Cosmetics Act, Ministry of Health and Family Welfare, Government of India (11).”
From ADVERSE EVENTS IN BLOOD DONORS: SPECTRUM AND REMEDY (2023) · cites this paper as [11]
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References 28 · Cited by 183
- Authors
- Eder, A. F.
- Affiliations
- American Red Cross (US)
- Corresponding author
- Eder, Anne F.
- ORCID
- Eder, Anne F.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2008-05-21
- Volume
- 299
- Issue
- 19
- Pages
- 2279
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2142465643
- Cited by
- 183
- References
- 28
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 2 · 2023: 7 · 2022: 7 · 2021: 6 · 2020: 6 · 2019: 8 · 2018: 5 · 2017: 13 · 2016: 12 · 2015: 7 · 2014: 9 · 2013: 7 · 2012: 18
- FWCI
- 37.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Business, Management and Accounting › Management of Technology and Innovation › Blood donation and transfusion practices
- Health Sciences › Medicine › Biochemistry › Blood transfusion and management
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ethics in Clinical Research
- Keywords
- whole blood donation, phlebotomy complications, first-time donors, donor safety, American Red Cross, blood centers, female sex as risk factor, age as risk factor
- MeSH terms
- Adolescent, Adult, Blood Donors, Female, Humans, Male, Red Cross, Risk Factors, Safety, Syncope, United States, Phlebotomy
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