The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Association of Leisure-Time Physical Activity With Risk of 26 Types of Cancer in 1.44 Million Adults
Open accessAbstract
IMPORTANCE: Leisure-time physical activity has been associated with lower risk of heart-disease and all-cause mortality, but its association with risk of cancer is not well understood. OBJECTIVE: To determine the association of leisure-time physical activity with incidence of common types of cancer and whether associations vary by body size and/or smoking. DESIGN, SETTING, AND PARTICIPANTS: We pooled data from 12 prospective US and European cohorts with self-reported physical activity (baseline, 1987-2004). We used multivariable Cox regression to estimate hazard ratios (HRs) and 95% confidence intervals for associations of leisure-time physical activity with incidence of 26 types of cancer. Leisure-time physical activity levels were modeled as cohort-specific percentiles on a continuous basis and cohort-specific results were synthesized by random-effects meta-analysis. Hazard ratios for high vs low levels of activity are based on a comparison of risk at the 90th vs 10th percentiles of activity. The data analysis was performed from January 1, 2014, to June 1, 2015. EXPOSURES: Leisure-time physical activity of a moderate to vigorous intensity. MAIN OUTCOMES AND MEASURES: Incident cancer during follow-up. RESULTS: A total of 1.44 million participants (median [range] age, 59 [19-98] years; 57% female) and 186 932 cancers were included. High vs low levels of leisure-time physical activity were associated with lower risks of 13 cancers: esophageal adenocarcinoma (HR, 0.58; 95% CI, 0.37-0.89), liver (HR, 0.73; 95% CI, 0.55-0.98), lung (HR, 0.74; 95% CI, 0.71-0.77), kidney (HR, 0.77; 95% CI, 0.70-0.85), gastric cardia (HR, 0.78; 95% CI, 0.64-0.95), endometrial (HR, 0.79; 95% CI, 0.68-0.92), myeloid leukemia (HR, 0.80; 95% CI, 0.70-0.92), myeloma (HR, 0.83; 95% CI, 0.72-0.95), colon (HR, 0.84; 95% CI, 0.77-0.91), head and neck (HR, 0.85; 95% CI, 0.78-0.93), rectal (HR, 0.87; 95% CI, 0.80-0.95), bladder (HR, 0.87; 95% CI, 0.82-0.92), and breast (HR, 0.90; 95% CI, 0.87-0.93). Body mass index adjustment modestly attenuated associations for several cancers, but 10 of 13 inverse associations remained statistically significant after this adjustment. Leisure-time physical activity was associated with higher risks of malignant melanoma (HR, 1.27; 95% CI, 1.16-1.40) and prostate cancer (HR, 1.05; 95% CI, 1.03-1.08). Associations were generally similar between overweight/obese and normal-weight individuals. Smoking status modified the association for lung cancer but not other smoking-related cancers. CONCLUSIONS AND RELEVANCE: Leisure-time physical activity was associated with lower risks of many cancer types. Health care professionals counseling inactive adults should emphasize that most of these associations were evident regardless of body size or smoking history, supporting broad generalizability of findings.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“data from 1.44 million participants across several prospective cohort studies revealed that, as compared to individuals exhibiting high levels of leisure-time physical activity (≥90th percentile), those who were physically inactive (≤10th percentile) had a greater risk (>20%) of developing several cancers, including esophageal adenocarcinoma; liver, lung, kidney, gastric cardia and endometrial”
From Chronic inflammation in the etiology of disease across the life span (2019) · cites this paper as [102]
In the citing paper
“Physical activity and exercise benefits apply to conditions characterized by very distinct pathophysiology, such as Alzheimer’s disease [629], cancer [628], heart disease [630], and pneumonia/other infections [631,632].”
From Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR) (2025) · cites this paper as [628]
In the citing paper
“Physical activity and exercise benefits apply to conditions characterized by very distinct pathophysiology, such as Alzheimer’s disease [629], cancer [628], heart disease [630], and pneumonia/other infections [631,632].”
From Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR) (2025) · cites this paper as [628]
In the citing paper
“Indeed, observational evidence shows that PA levels lower than recommended threshold are already associated with reduced mortality [65,628,668], and benefits exhibit a curvilinear dose-dependency [628,668].”
From Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR) (2025) · cites this paper as [628]
In the citing paper
“Physical activity is associated with reduced mortality risk1, and reduced risk of CVD1 and certain cancers2–4.”
From Association of wearable device-measured vigorous intermittent lifestyle physical activity with mortality (2022) · cites this paper as [3]
In the citing paper
“Epidemiological studies suggest that physical activity in leisure time reduces the risk of at least 13 different cancer types (41, 42, 222, 223).”
From Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020) · cites this paper as [222]
In the citing paper
“The effects of exercise on cancer growth were mediated via a direct regulation of natural killer cells by a mechanism that involved epinephrine-dependent mobilization of natural killer cells to the circulation and an IL-6-dependent redistribution to tumors.”
From Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020) · cites this paper as [222]
In the citing paper
“Running mice demonstrated a marked reduction in tumor volume and incidence across 6 different tumor models.”
From Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020) · cites this paper as [222]
In the citing paper
“Blocking IL-6 signaling during exercise abolished the exercise-induced inhibition of tumor growth.”
From Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020) · cites this paper as [222]
In the citing paper
“A meta-analysis pooled data from 12 prospective cohorts with self-reported physical activity and found that increased physical activity levels are associated with decreased risk of incident cancer across multiple types; many of these associations remained even after adjusting for BMI129.”
From Exerkines in health, resilience and disease (2022) · cites this paper as [129]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482
Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552
The Physical Activity Guidelines for Americans
Piercy, K. L., Troiano, R. P., Ballard, R. M., Carlson, S. A., Fulton, J. E., Galuska, D. A., George, S. M., & Olson, R. D. (2018) · JAMA · doi:10.1001/jama.2018.14854 · Cited by 9,755
Analysis of Incomplete Multivariate Data
Schafer, J. L. (1997) · doi:10.1201/9781439821862 · Cited by 6,012
Global physical activity levels: surveillance progress, pitfalls, and prospects
Hallal, P. C., Andersen, L. B., Bull, F. C., Guthold, R., Haskell, W., & Ekelund, U. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60646-1 · Cited by 5,711
Analysis of Incomplete Multivariate Data
Booth, D. E., & Schafer, J. L. (2000) · Technometrics · doi:10.2307/1271466 · Cited by 5,627
Food, nutrition, physical activity, and the prevention of cancer: a global perspective
Marmot, M. G., Atinmo, T., Byers, T., Chen, J., Hirohata, T., Jackson, A., James, W., Kolonel, L. N., Kumanyika, S., Leitzmann, C., et al. (2008) · Choice Reviews Online · doi:10.5860/choice.45-5024 · Cited by 5,368
Renehan, A. G., Tyson, M., Egger, M., Heller, R. F., & Zwahlen, M. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60269-x · Cited by 5,219
International Classification of Diseases for Oncology
National Cancer Institute (2020) · Definitions · doi:10.32388/1bjeus · Cited by 3,810
International Classification of Diseases for Oncology
Trott, P. A. (1977) · Journal of Clinical Pathology · doi:10.1136/jcp.30.8.782-c · Cited by 1,688
Flagged first, then by citations
Cited by
Sorted by citations
Items 601–700 of 999
Pahwa, M., Harris, M. A., MacLeod, J. S., Tjepkema, M., Peters, P. A., & Demers, P. A. (2017) · Cancer Epidemiology · doi:10.1016/j.canep.2017.06.004 · Cited by 12
Gressel, O., Samuels, N., Levy, M., Leviov, M., Lavie, O., & Ben‐Arye, E. (2020) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2019.0437 · Cited by 11
Cuthbertson, C. C., Nichols, H. B., Tan, X. M., Kucharska‐Newton, A., HEISS, G. M., Joshu, C. E., Platz, E. A., & Evenson, K. R. (2020) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-20-0870 · Cited by 11
Contribution of physical education classes to daily physical activity levels of adolescents
Sanz-Martín, D., Tendero, G. R., & García, E. F. (2021) · Physical Activity Review · doi:10.16926/par.2021.09.18 · Cited by 21
Temur, A. A., & Rashid, F. A. (2022) · Asian Pacific Journal of Cancer Prevention · doi:10.31557/apjcp.2022.23.8.2649 · Cited by 11
Wu, M., Pang, Y., Chen, M., Li, L., Yan, L., Ning, J., Liu, Q., Zhang, Y., Jiang, T., Kang, A., et al. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.158598 · Cited by 11
Single-cell sequencing of immune cells after marathon and symptom-limited cardiopulmonary exercise
Yu, Y., Zhang, X., Chen, Y., Li, Y., Bian, S., Yang, Y., Song, H., Zhang, C., Dong, Z., Li, G., et al. (2023) · iScience · doi:10.1016/j.isci.2023.106532 · Cited by 11
Görig, T., Apfelbacher, C., Drewitz, K. P., Reimers, A. K., Breitbart, E. W., & Diehl, K. (2023) · Photodermatology Photoimmunology & Photomedicine · doi:10.1111/phpp.12898 · Cited by 11
Haddad, K. E., Rolland, Y., Gérard, S., Mourey, L., Sourdet, S., Vellas, B. J., Stephan, E., van Kan, G. A., Barreto, P. D. S., & Balardy, L. (2019) · The journal of nutrition health & aging · doi:10.1007/s12603-019-1293-8 · Cited by 11
Bock, B. C., Palitsky, R., DUNSIGER, S. I., Williams, D. M., & Serber, E. R. (2020) · Psychology of sport and exercise · doi:10.1016/j.psychsport.2020.101802 · Cited by 12
Xian, W., Shen, J., Zhou, H., Liu, J., Zhang, Y., Zhang, Z., Zhou, T., Hong, S., Yang, Y., Fang, W., et al. (2020) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-020-03409-1 · Cited by 11
Echarri, A. A., Beresford, M. J., Campbell, J. P., Jones, R. H., Butler, R., Gollob, K. J., Brum, P. C., Thompson, D., & Turner, J. E. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.616188 · Cited by 11
Parke, S. C., Ng, A., Martone, P., Gerber, L. H., Zucker, D. S., Engle, J. P., Gupta, E., Power, K., Sokolof, J., Shahpar, S., et al. (2021) · PM&R · doi:10.1002/pmrj.12664 · Cited by 11
Effect of exercise on peritoneal microenvironment and progression of ovarian cancer.
Morrisson, M. J., Bi, F., Yang, K. B., Cady, S. L., Hartwich, T. M. P., Cerchia, A. P., Li, Z., Kim, J., Irwin, M. L., & Yang‐Hartwich, Y. (2021) · Europe PMC (PubMed Central) · Cited by 12
Chan, J. E., Caesar, M. A., Mann, A. K., Koh‐Bell, A., Richardson, M. T., Johnson, C. A., Kapp, D. S., & Chan, J. K. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2022.853636 · Cited by 11
Leisure-Time Physical Activity and Cancer Mortality Among Cancer Survivors
Rees‐Punia, E., Teras, L. R., Newton, C. C., Moore, S. C., Lee, I.-M. M., Bates‐Fraser, L. C., Chiang, K. E., Bloodworth, D. E., Eliassen, A. H., Mucci, L. A., et al. (2026) · JAMA Network Open · doi:10.1001/jamanetworkopen.2025.56971 · Cited by 10
Self-citationDie Muskulatur – das „signalstoffgestützte periphere Zentrum“ adaptiver Wirkungen
Laube, W. (2022) · Manuelle Medizin · doi:10.1007/s00337-022-00868-0 · Cited by 10
Paul, D., & Nedelcu, A. M. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1040034 · Cited by 11
Cho, Y., Jang, H., Kwon, S., & Oh, H. (2023) · BMC Public Health · doi:10.1186/s12889-023-15969-1 · Cited by 12
Mechanisms Underlying the Rarity of Skeletal Muscle Cancers
Kump, D. S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126480 · Cited by 10
Du, X. L., & Song, L. (2021) · Cancer Epidemiology · doi:10.1016/j.canep.2021.102076 · Cited by 10
Højman, P., Stagaard, R., Adachi-Fernandez, E., Deshmukh, A. S., Mund, A., Olsen, C. H., Keller, L., Pedersen, B. K., & Gehl, J. (2022) · Scientific Reports · doi:10.1038/s41598-022-08850-5 · Cited by 12
Ge, Z., Wu, S., Qi, Z., & Ding, S. (2022) · Journal of Cancer · doi:10.7150/jca.66245 · Cited by 10
Physical Exercise and Tumor Energy Metabolism
Vulczak, A., & Alberici, L. C. (2022) · Cancer Treatment and Research Communications · doi:10.1016/j.ctarc.2022.100600 · Cited by 21
Lee, J., & Kim, S. Y. (2023) · Korean Journal of Gastroenterology · doi:10.4166/kjg.2023.083 · Cited by 11
John, J. C., Ho, J., Raber, M., Basen-Engquist, K. M., Jacobson, L. T., & Strong, L. L. (2023) · Journal of Behavioral Medicine · doi:10.1007/s10865-023-00457-z · Cited by 10
Li, C., Zhang, J., Pan, P., Zhang, J., Hou, X., Wang, Y., Chen, G., Muhammad, P., Reis, R. L., Ding, L., et al. (2024) · Advanced Science · doi:10.1002/advs.202400665 · Cited by 9
Does active commuting help Czech adolescents meet health recommendations for physical activity?
Vorlíček, M., & Mitáš, L. R. J. D. J. (2018) · Tělesná kultura · doi:10.5507/tk.2017.005 · Cited by 10
An Apoptotic and Endosymbiotic Explanation of the Warburg and the Inverse Warburg Hypotheses
Kaczanowski, S., Klim, J., & Zielenkiewicz, U. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103100 · Cited by 9
New Roles for Vitamin D Superagonists: From COVID to Cancer
Easty, D. J., Farr, C. J., & Hennessy, B. T. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.644298 · Cited by 11
Mediterranean Diet and Physical Activity: Two Imperative Components in Breast Cancer Prevention
Dilnaz, F., Zafar, F., Afroze, T., Zakia, U. B., Chowdhury, T., Swarna, S. S., Fathma, S., Tasmin, R., Sakibuzzaman, M., Fariza, T. T., et al. (2021) · Cureus · doi:10.7759/cureus.17306 · Cited by 10
Liu, Z., Zhang, L., Shi, S., & Xia, W. (2017) · PLoS ONE · doi:10.1371/journal.pone.0169375 · Cited by 10
Feng, Y., Powell, L., Vassallo, A. J., Hamer, M., & Stamatakis, E. (2020) · International Journal of Cancer · doi:10.1002/ijc.33052 · Cited by 11
Maliniak, M. L., Gapstur, S. M., McCullough, L. E., Rees‐Punia, E., Gaudet, M. M., Um, C. Y., Guinter, M. A., Flanders, W. D., & Patel, A. V. (2020) · Cancer Causes & Control · doi:10.1007/s10552-020-01365-2 · Cited by 13
Self-citationPhillips, S. M., & Joyner, M. J. (2018) · British Journal of Sports Medicine · doi:10.1136/bjsports-2018-100226 · Cited by 10
Lactate Potentiates Differentiation and Expansion of Cytotoxic T CellsPreprint
Rundqvist, H., Veliça, P., Barbieri, L., Gameiro, P. A., Cunha, P. P., Gojković, M., Bargiela, D., Mijwel, S., Ahlstedt, E., Foskolou, I. P., et al. (2019) · SSRN Electronic Journal · doi:10.2139/ssrn.3411249 · Cited by 10
The mitochondrial multi-omic response to exercise training across tissuesPreprint
Amar, D., Gay, N. R., Jimenez‐Morales, D., Beltran, P. M. J., Ramaker, M. E., Raja, A. N., Zhao, B., Sun, Y., Marwaha, S., Gaul, D. A., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.13.523698 · Cited by 10
Chen, W., Lin, G.-L., Lin, Y.-J., Su, T.-Y., Wang, C., & Wu, W. (2023) · Scandinavian Journal of Work Environment & Health · doi:10.5271/sjweh.4106 · Cited by 9
Ning, Y., Dong, Z. X., Jia, Z., Zhao, W., Ding, Y., Wang, Q., Zhu, R., & Han, S. (2023) · Frontiers in Public Health · doi:10.3389/fpubh.2023.1260804 · Cited by 9
Joseph, J. M., Hillengaß, M., Cannioto, R. A., Tario, J. D., Wallace, P. K., Attwood, K. M., Groman, A. E., Jacobson, H., Wittmeyer, B., Mohammadpour, H., et al. (2024) · Clinical Lymphoma Myeloma & Leukemia · doi:10.1016/j.clml.2024.04.006 · Cited by 9
Zhao, K., Li, X., & Li, J. (2024) · Journal of Medical Internet Research · doi:10.2196/55937 · Cited by 9
Dyslipidemia progression and increased lung cancer risk: a prospective cohort study
Shao, Y., Li, W., Wen, C., Yang, M., Ning, X., Hu, K., & Wu, X. (2024) · European Journal of Epidemiology · doi:10.1007/s10654-024-01175-9 · Cited by 9
Exerkines: Potential regulators of ferroptosis
Jia, M., Li, F., Wu, T., & Chen, N. (2025) · Journal of sport and health science/Journal of Sport and Health Science · doi:10.1016/j.jshs.2025.101032 · Cited by 10
Exercise boost after surgery improves survival in model of metastatic breast cancer
Stagaard, R., Jensen, A. R. D., Schauer, T., Bay, M. L., Tavanez, A. R., Wielsøe, S., Peletier, M. C., Strøbech, J. E., Oria, V. O., Zornhagen, K. W., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1533798 · Cited by 9
He, X., Jing, W., Zhu, R., Wang, Q., Yang, J., Tang, X., Yang, Y., Che, K., Deng, J., Yin, M., et al. (2025) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2025.105527 · Cited by 10
Comorbidity in Midlife and Cancer Outcomes
Lavery, J. A., Boutros, P. C., Moskowitz, C. S., & Jones, L. W. (2025) · JAMA Network Open · doi:10.1001/jamanetworkopen.2025.3469 · Cited by 9
miR-126: a bridge between cancer and exercise
Liu, Z., Ke, S., & Wan, Y. (2025) · Cancer Cell International · doi:10.1186/s12935-025-03784-0 · Cited by 9
Life Factors and Melanoma: From the Macroscopic State to the Molecular Mechanism
Wang, H., Zhang, H., Zhou, Y., Li, C., & Guo, W. (2025) · Advanced Science · doi:10.1002/advs.202501388 · Cited by 10
Practical guidelines for exercise prescription in different clinical populations
Komici, K., Bianco, A., Cuomo, A., Bianco, R., Illario, M., Guerra, G., Paoli, A., Schena, F., & Iaccarino, G. (2026) · Frontiers in Sports and Active Living · doi:10.3389/fspor.2026.1649549 · Cited by 12
Assessment and monitoring practices of Australian fitness professionals
Bennie, J. A., Wiesner, G., van Uffelen, J. G. Z., Harvey, J. T., Craike, M. J., & Biddle, S. (2017) · Journal of science and medicine in sport · doi:10.1016/j.jsams.2017.07.010 · Cited by 9
Exercise as a Candidate Antitumor Strategy: A Window into the Future
Koelwyn, G. J., & Jones, L. W. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-1318 · Cited by 9
Courtney, J. B., Handley, E., Pagoto, S., Russell, M., & Conroy, D. E. (2021) · Nutrients · doi:10.3390/nu13061856 · Cited by 9
Soldos, P., Besenyi, Z., Hidéghety, K., Pávics, L., Hegedűs, Á., Rácz, L., & Kopper, B. (2021) · Pathology & Oncology Research · doi:10.3389/pore.2021.1609798 · Cited by 10
Behavioral factors to modulate immunotherapy efficacy in cancer
Jongerius, C., Vermeulen, L., van Egmond, M., Evers, A., Buffart, L. M., & Lenos, K. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1066359 · Cited by 7
The effect of single bout and prolonged aerobic exercise on tumor hypoxia in mice
Elming, P. B., Busk, M., Wittenborn, T. R., Bussink, J., Horsman, M. R., & Lønbro, S. (2023) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00561.2022 · Cited by 9
Evolving field of cardio-oncology
Li, G., Zhang, L., & Liu, M. (2023) · Cancer Pathogenesis and Therapy · doi:10.1016/j.cpt.2023.02.002 · Cited by 9
Active and Happy? Physical Activity and Life Satisfaction among Young Educated Women
Wypych-Ślusarska, A., Majer, N., Krupa-Kotara, K. H., & Niewiadomska, E. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20043145 · Cited by 18
Matsuo, R., Ikeda, A., Tomooka, K., Naito, Y., Uesugi, Y., Maruyama, K., Kawamura, R., Takata, Y., Osawa, H., Saito, I., et al. (2023) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.64173 · Cited by 9
Seppä, K., Heikkinen, S. M. M., Ryynänen, H., Albanes, D., Eriksson, J. G., Härkänen, T., Jousilahti, P., Knekt, P., Koskinen, S. V. P., Männistö, S., et al. (2023) · European Journal of Cancer · doi:10.1016/j.ejca.2023.113502 · Cited by 9
Xin, X., Huang, L., Pan, Q., Zhang, J., & Hu, W. (2024) · Cancer Medicine · doi:10.1002/cam4.7085 · Cited by 8
Platek, A. J., Cannioto, R. A., Etter, J. L., Kim, J. H., Joseph, J. M., Gulati, N. R., Schmitt, K. L., Callahan, E. H., Khachatryan, E., Nagy, R. D., et al. (2017) · European Archives of Oto-Rhino-Laryngology · doi:10.1007/s00405-017-4688-3 · Cited by 9
Barberio, A. M., Friedenreich, C. M., Lynch, B. M., Campbell, K. L., Arora, P., & Brenner, D. R. (2018) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-17-1124 · Cited by 9
Lee, S., Lee, E., Natipagon‐Shah, B., & Toyama, J. (2018) · Asian Pacific Journal of Cancer Prevention · doi:10.31557/apjcp.2018.19.11.3271 · Cited by 9
Heckman, C. J., & Manning, M. (2018) · Journal of Behavioral Medicine · doi:10.1007/s10865-018-9991-y · Cited by 9
Thai, C. L., Taber, J. M., Oh, A., Segar, M., Blake, K. D., & Patrick, H. (2019) · American Journal of Health Promotion · doi:10.1177/0890117119826870 · Cited by 9
Cancers in France in 2015 attributable to insufficient physical activity
Touillaud, M. S., Arnold, M., Dossus, L., Freisling, H., Bray, F., Margaritis, I., Deschamps, V., & Soerjomataram, I. (2019) · Cancer Epidemiology · doi:10.1016/j.canep.2019.02.009 · Cited by 9
Walking and Sun Protective Behaviors: Cross-Sectional Associations of Beneficial Health Factors
Tribby, C. P., Perna, F. M., & Berrigan, D. A. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16132361 · Cited by 9
Huerta, J. M., Molina, A. J., Chirlaque, M. D., Yepes, P., Moratalla-Navarro, F., Moreno, V. R., Amiano, P., Guevara, M., Moreno‐Iribas, C., Llorca, J., et al. (2019) · Breast Cancer Research and Treatment · doi:10.1007/s10549-019-05358-x · Cited by 9
Lamkin, D. M., Bradshaw, K. P., Chang, J. Y., Epstein, M., Gomberg, J., Prajapati, K. P., Soliman, V. H., Sylviana, T., Wong, Y., Morizono, K., et al. (2021) · PeerJ · doi:10.7717/peerj.10725 · Cited by 9
Renman, D., Gylling, B., Vidman, L., Bodén, S., Strigård, K., Palmqvist, R., Harlid, S., Gunnarsson, U., & Guelpen, B. R. V. (2021) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-21-0508 · Cited by 9
Buss, L. A., Hock, B. D., Merry, T. L., Ang, A. D., Robinson, B. A., Currie, M. J., & Dachs, G. U. (2021) · PLoS ONE · doi:10.1371/journal.pone.0258831 · Cited by 9
Alrashdi, N. Z., Motl, R. W., Aguiar, E. J., Ryan, M. K., Perumean‐Chaney, S. E., & Ithurburn, M. P. (2021) · Journal of Hip Preservation Surgery · doi:10.1093/jhps/hnab086 · Cited by 9
Pereira, M. G., Voltarelli, V. A., Tobias, G. C., de Souza, L., Borges, G. S., da Paixão, A. O., de Almeida, N. R., Bowen, T. S., Demasi, M., Miyabara, E. H., et al. (2021) · Cancers · doi:10.3390/cancers14010028 · Cited by 12
Proportion and number of cancer cases and deaths attributable to behavioral risk factors in Vietnam
Ha, L. D., Tran, A., Bui, L., Giovannucci, E. L., Mucci, L. A., Song, M., Le, P. D., Minh, H. V., Trần, H. T., Giang, K. B., et al. (2023) · International Journal of Cancer · doi:10.1002/ijc.34549 · Cited by 9
Exercise Professionals in the Cancer Center: Experiences, Recommendations, and Future Research
Cheema, B. S., Fairman, C. M., & Marthick, M. (2019) · Translational Journal of the American College of Sports Medicine · doi:10.1249/tjx.0000000000000088 · Cited by 9
Watts, E. L., Gonzales, T. I., Strain, T., Saint‐Maurice, P. F., Bishop, D. T., Chanock, S. J., Johansson, M., Keku, T. O., Marchand, L. L., Moreno, V. R., et al. (2023) · British Journal of Cancer · doi:10.1038/s41416-023-02489-3 · Cited by 8
Self-citationEnergy oversupply to tissues: a single mechanism possibly underlying multiple cancer risk factors
Wu, D. J., Aktipis, A., & Pepper, J. W. (2019) · Evolution Medicine and Public Health · doi:10.1093/emph/eoz004 · Cited by 9
Mangra, G. I., Mangra, M. G., Bocean, C. G., & Vărzaru, A. A. (2024) · Healthcare · doi:10.3390/healthcare12191941 · Cited by 8
Mabena, N., Rugbeer, N., Lehmann, S., Torres, G., Patel, D., Mabunda, M., Greyling, M., Thornton, J. S., Choi, Y., Stranges, S., et al. (2025) · British Journal of Sports Medicine · doi:10.1136/bjsports-2024-108813 · Cited by 8
Michou, V., Zervoudis, S., Eskitzis, P., Tsamos, G., Vasdeki, D., Vouxinou, A., Markja, A., & Iatrakis, G. M. (2025) · Medicina · doi:10.3390/medicina61071167 · Cited by 11
Guo, L., Jiang, L., & Huang, H. (2025) · PLoS ONE · doi:10.1371/journal.pone.0334088 · Cited by 8
Associations Between Physical Activity and Alcohol Consumption in Rural Cancer Survivors
Mama, S. K., Heredia, N. I., Johnston, H., & Conroy, D. E. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.871192 · Cited by 8
Ortolan, S., Neunhäeuserer, D., Quinto, G., Barra, B., Centanini, A., Battista, F., Vecchiato, M., Marchi, V. D., Celidoni, M., Rebba, V. S., et al. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19127375 · Cited by 8
Physical activity and the risk of non‐Hodgkin lymphoma subtypes: A pooled analysis
Boyle, T., Kleinstern, G., Bracci, P. M., Cerhan, J. R., Benavente, Y., Casabonne, D., Chiu, B. C. ‐., Habermann, T. M., Holly, E. A., Liebow, M., et al. (2022) · International Journal of Cancer · doi:10.1002/ijc.34266 · Cited by 8
Ceci, C., García‐Chico, C., Atzori, M. G., Lacal, P. M., Lista, S., Santos‐Lozano, A., Graziani, G., & Pinto-Fraga, J. (2023) · Journal of Cancer · doi:10.7150/jca.88559 · Cited by 9
Integrative Oncology Approaches to Reduce Recurrence of Disease and Improve Survival
Powers-James, C. R., Morse, M., Narayanan, S., Ramondetta, L. M., Lopez, G., Wagner, R., & Cohen, L. G. (2024) · Current Oncology Reports · doi:10.1007/s11912-023-01467-5 · Cited by 10
Emery, A., Moore, S. E., Crowe, J., Murray, J., Peacock, O., Thompson, D., Betts, F., Rapps, S., Ross, L., Rothschild-Rodriguez, D., et al. (2024) · BMC Cancer · doi:10.1186/s12885-024-11817-6 · Cited by 9
Self-citationBay, M. L., Gehl, J., Pedersen, B. K., & Højman, P. (2017) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-17-0075 · Cited by 7
The Benefits of Exercise Effect on Cancer: A Review
Lee, N. (2020) · Exercise Science · doi:10.15857/ksep.2020.29.1.4 · Cited by 8
Lee, J., Min, J., Lee, D. H., Kang, D., & Jeon, J. Y. (2020) · Supportive Care in Cancer · doi:10.1007/s00520-020-05514-w · Cited by 8
Martín-Doménech, A., Peiró, R., Esplugues, A., Cameo, S. C., Legaz-Sánchez, E., & Pérez‐Sanz, E. (2020) · Gaceta Sanitaria · doi:10.1016/j.gaceta.2020.04.021 · Cited by 8
Paudel, S., Subedi, N., McLachlan, C. S., Smith, B. J., Kallestrup, P., & Neupane, D. (2021) · BMJ Open · doi:10.1136/bmjopen-2021-051846 · Cited by 8
Beyond colonoscopy: Physical activity as a viable adjunct to prevent colorectal cancer
Chang, W., & Chiu, H. (2022) · Digestive Endoscopy · doi:10.1111/den.14377 · Cited by 8
Bigman, G., Adebamowo, S. N., Yawe, K.-D. T., Yilkudi, M., Olaomi, O. O., Badejo, O., Famooto, A., Ezeome, E., Salu, I. K., Miner, E., et al. (2022) · Cancer Epidemiology · doi:10.1016/j.canep.2022.102195 · Cited by 8
Wang, W., Xu, Y., Wang, X., Chu, Y., Zhang, H., Zhou, L., Zhu, H., Ji, L., Kuai, R., Zhou, F., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.929092 · Cited by 8
Dietary Intake of Anthocyanidins and Renal Cancer Risk: A Prospective Study
Xu, X., Zhu, Y., Li, S., & Xia, D. (2023) · Cancers · doi:10.3390/cancers15051406 · Cited by 8
Gale, R. P., Bennett, J. M., & Hoffman, F. O. (2017) · Mediterranean Journal of Hematology and Infectious Diseases · doi:10.4084/mjhid.2017.025 · Cited by 8
Rezende, L. F. M., García, L., Mielke, G. I., Lee, D. H., Wu, K., Giovannucci, E. L., & Eluf‐Neto, J. (2018) · Cancer Epidemiology · doi:10.1016/j.canep.2018.07.006 · Cited by 9
Sydó, N., Merkely, B. P., Carta, K. A. G., Becker, D. J., Hussain, N., Murphy, J. G., Sydó, T., López-Jiménez, F. A., & Allison, T. G. (2018) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2018.08.012 · Cited by 9
Mediators of physical activity between standard exercise and exercise video games.
Bock, B. C., DUNSIGER, S. I., Ciccolo, J. T., Serber, E. R., Wu, W., Sillice, M. A., & Marcus, B. H. (2019) · Health Psychology · doi:10.1037/hea0000791 · Cited by 8
Metadata
- Authors
- Moore, S. C., Lee, I.-M., Weiderpass, E., Campbell, P. T., Sampson, J. N., Kitahara, C. M., Keadle, S. K., Arem, H., Berrington de Gonzalez, A., Hartge, P., Adami, H.-O., Blair, C. K., Borch, K. B., Boyd, E., Check, D. P., Fournier, A., Freedman, N. D., Gunter, M., Johannson, M., Khaw, K.-T., Linet, M. S., Orsini, N., Park, Y., Riboli, E., Robien, K., Schairer, C., Sesso, H., Spriggs, M., Van Dusen, R., Wolk, A., Matthews, C. E., & Patel, A. V.
- Affiliations
- National Cancer Institute (US)
- Brigham and Women's Hospital (US)
- Karolinska Institutet (SE)
- American Cancer Society (US)
- United States Agency for International Development (US)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland
- Harvard University (US)
- University of New Mexico (US)
- UiT The Arctic University of Norway (NO)
- Information Management Services (US)
- Centre for Research in Epidemiology and Population Health, Institut Gustave Roussy, Villejuif, France
- Centre international de recherche sur le cancer (FR)
- University of Cambridge (GB)
- Washington University in St. Louis (US)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, England
- George Washington University (US)
- Information Management Services, Inc, Rockville, Maryland
- Corresponding author
- Moore, Steven C.
- ORCID
- Moore, Steven C.
- Lee, I-Min
- Weiderpass, Elisabete
- Campbell, Peter T.
- Sampson, Joshua N.
- Kitahara, Cari M.
- Keadle, Sarah K.
- Arem, Hannah
- Adami, Hans-Olov
- Blair, Cindy K.
- Borch, Kristin B.
- Check, David P.
- Freedman, Neal D.
- Gunter, Marc
- Khaw, Kay-Tee
- Linet, Martha S.
- Orsini, Nicola
- Park, Yikyung
- Robien, Kim
- Schairer, Catherine
- Sesso, Howard
- Wolk, Alicja
- Matthews, Charles E.
- Patel, Alpa V.
- Venue
- JAMA Internal Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 2016-06-01
- Volume
- 176
- Issue
- 6
- Pages
- 816
- ISSN
- 2168-6106 (ISSN-L)
- PMC
- PMC5812009
- OpenAlex
- W2402756356
- Cited by
- 1,487
- References
- 48
- Citations by year
- 2026: 113 · 2025: 139 · 2024: 144 · 2023: 163 · 2022: 154 · 2021: 155 · 2020: 175 · 2019: 184 · 2018: 134 · 2017: 107 · 2016: 18
- FWCI
- 79.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JAMA Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Spiral (Imperial College London) (submittedVersion)
- Funders
- World Health Organization
- Cancer Research UK (14136)
- National Institute for Health and Care Research (NF-SI-0512-10114)
- National Institutes of Health (Z99 CA999999)
- Medical Research Council (MR/N003284/1)
- National Cancer Institute (R01CA039742)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Health Sciences › Medicine › Oncology › Global Cancer Incidence and Screening
- Keywords
- leisure-time physical activity, cancer incidence, cancer risk, moderate-to-vigorous physical activity, body size, smoking, esophageal adenocarcinoma, liver cancer, lung cancer, kidney cancer, gastric cardia cancer, endometrial cancer, myeloid leukemia, breast cancer, colorectal cancer, colorectal adenoma, colorectal polyps, recurrent colorectal cancer, colorectal cancer mortality
- MeSH terms
- Adult, European Union, Female, Follow-Up Studies, Humans, Leisure Activities, Male, Middle Aged, Neoplasms, Retrospective Studies, Risk Factors, United States, Meta-Analysis as Topic, Exercise, Body Mass Index, Incidence, Risk Assessment, Evidence-Based Medicine
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
