Association between penicillin allergy documentation and antibiotic use
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that legalization of recreational marijuana is associated with increased traffic fatality rates.Applying these results to national driving statistics, nationwide legalization would be associated with 6800 (95% CI, 4200-9700) excess roadway deaths each year.Despite certain methodological differences, we found an increase similar to that reported by Aydelotte et al. 4 They reported an increase of 1.8 fatal crashes (equivalent to 2.0 fatalities) per BVMT.We concur with their opinion that changes may not be detected immediately after legalization but only after a longer time period or after commercial sales begin.We chose a control group consisting of all states with neither legal recreational nor medical marijuana to isolate the effects of marijuana.We did not require that control states have baseline attributes similar to the experimental states because the difference-in-difference technique removes biases in comparisons between experimental and control groups that result from permanent differences between those groups.Our conclusions, nonetheless, are limited by adjusting for only 3 state-specific factors that may have changed during the study period.It is possible that another confounder, rather than marijuana legalization and commercialization, caused the observed increase in roadway deaths.
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More recent drug allergy updates by the American Academy of Allergy, Asthma & Immunology/American College of Asthma Allergy and Immunology Joint Task Force emphasize that patients with a history of PCN allergy are often treated with less effective antibiotics associated with increased cost and risk of resistance.
“However, more recent drug allergy updates by the American Academy of Allergy, Asthma & Immunology/American College of Asthma Allergy and Immunology Joint Task Force emphasize that patients with a history of PCN allergy are often treated with less effective antibiotics associated with increased cost and risk of resistance.39”
From An updated review of pediatric autoimmune neuropsychiatric disorders associated with Streptococcus/pediatric acute-onset neuropsychiatric syndrome, also known as idiopathic autoimmune encephalitis: What the allergist should know (2023) · cites this paper as [39]
The Results and Discussion (pages not provided) report that inpatients with documented penicillin allergy received β-lactam alternatives more often and that these alternatives may be inferior. The cited paper is a cross-sectional study, not a Joint Task Force drug-allergy update, and our copy does not address increased cost or antibiotic resistance. (LLM, conf=0.88)
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- Authors
- Blumenthal, K. G., Kuper, K., Schulz, L. T., Bhowmick, T., Postelnick, M., Lee, F., & Walensky, R. P.
- Affiliations
- Harvard University (US)
- Vizient Inc, Irving, Texas
- University of Wisconsin–Madison (US)
- Rutgers, The State University of New Jersey (US)
- Northwestern Memorial Hospital (US)
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Blumenthal, Kimberly G.
- ORCID
- Venue
- JAMA Internal Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 2020-08-01
- Volume
- 180
- Issue
- 8
- Pages
- 1120
- ISSN
- 2168-6106 (ISSN-L)
- PMC
- PMC7325068
- OpenAlex
- W3037661986
- Cited by
- 69
- References
- 6
- Citations by year
- 2026: 20 · 2025: 12 · 2024: 8 · 2023: 8 · 2022: 10 · 2021: 6 · 2020: 5
- FWCI
- 4.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JAMA Internal Medicine (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Rutgers University Community Repository (Rutgers University) (submittedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (K01AI125631)
- Topics
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antibiotic Use and Resistance
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Health Sciences › Medicine › Pharmacology › Drug-Induced Adverse Reactions
- Keywords
- penicillin allergy, allergy documentation, antibiotic use, antibiotic prescribing, drug allergy labeling
- MeSH terms
- Adult, Aged, Anti-Bacterial Agents, Cross-Sectional Studies, Documentation, Drug Hypersensitivity, Female, Humans, Male, Middle Aged, Penicillins, Texas
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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