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Genome-wide Pleiotropy Between Parkinson Disease and Autoimmune Diseases
Open accessAbstract
Importance: Recent genome-wide association studies (GWAS) and pathway analyses supported long-standing observations of an association between immune-mediated diseases and Parkinson disease (PD). The post-GWAS era provides an opportunity for cross-phenotype analyses between different complex phenotypes. Objectives: To test the hypothesis that there are common genetic risk variants conveying risk of both PD and autoimmune diseases (ie, pleiotropy) and to identify new shared genetic variants and their pathways by applying a novel statistical framework in a genome-wide approach. Design, Setting, and Participants: Using the conjunction false discovery rate method, this study analyzed GWAS data from a selection of archetypal autoimmune diseases among 138 511 individuals of European ancestry and systemically investigated pleiotropy between PD and type 1 diabetes, Crohn disease, ulcerative colitis, rheumatoid arthritis, celiac disease, psoriasis, and multiple sclerosis. NeuroX data (6927 PD cases and 6108 controls) were used for replication. The study investigated the biological correlation between the top loci through protein-protein interaction and changes in the gene expression and methylation levels. The dates of the analysis were June 10, 2015, to March 4, 2017. Main Outcomes and Measures: The primary outcome was a list of novel loci and their pathways involved in PD and autoimmune diseases. Results: Genome-wide conjunctional analysis identified 17 novel loci at false discovery rate less than 0.05 with overlap between PD and autoimmune diseases, including known PD loci adjacent to GAK, HLA-DRB5, LRRK2, and MAPT for rheumatoid arthritis, ulcerative colitis and Crohn disease. Replication confirmed the involvement of HLA, LRRK2, MAPT, TRIM10, and SETD1A in PD. Among the novel genes discovered, WNT3, KANSL1, CRHR1, BOLA2, and GUCY1A3 are within a protein-protein interaction network with known PD genes. A subset of novel loci was significantly associated with changes in methylation or expression levels of adjacent genes. Conclusions and Relevance: The study findings provide novel mechanistic insights into PD and autoimmune diseases and identify a common genetic pathway between these phenotypes. The results may have implications for future therapeutic trials involving anti-inflammatory agents.
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“Multiple common genetic variants between PD patients and other inflammatory diseases have been identified.249,250”
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“Genomewide association studies have alluded to a significant genetic overlap between Parkinson's disease and autoimmune diseases.97”
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Cites
STRING v10: protein–protein interaction networks, integrated over the tree of life
Szklarczyk, D., Franceschini, A., Wyder, S., Forslund, K., Heller, D., Huerta-Cepas, J., Simonovic, M., Roth, A., Santos, A., Tsafou, K. P., et al. (2015) · Nucleic Acids Research · doi:10.1093/nar/gku1003 · Cited by 10,436
Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359
Inflammation and Alzheimer’s disease
Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514
Biological, clinical and population relevance of 95 loci for blood lipids
Teslovich, T. M., Musunuru, K., Smith, A. V., Edmondson, A. C., Stylianou, I. M., Koseki, M., Pirruccello, J. P., Ripatti, S., Chasman, D. I., Willer, C. J., et al. (2010) · Nature · doi:10.1038/nature09270 · Cited by 3,487
Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology
Zimprich, A. A., Biskup, S., Leitner, P., Lichtner, P., Farrer, M. J., Lincoln, S., Kachergus, J. M., Hulihan, M., Uitti, R. J., Calne, D. B., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.11.005 · Cited by 3,088
Self-citationGenome-wide association studies for complex traits: consensus, uncertainty and challenges
McCarthy, M. I., Abecasis, G. R., Cardon, L. R., Goldstein, D. B., Little, J., Ioannidis, J. P. A., & Hirschhorn, J. N. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2344 · Cited by 2,891
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
The International Multiple Sclerosis Genetics Consortium & The Wellcome Trust Case Control Consortium 2 (2011) · Nature · doi:10.1038/nature10251 · Cited by 2,697
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
the NIDDK IBD Genetics Consortium, Barrett, J. C., the Belgian-French IBD Consortium, the Wellcome Trust Case Control Consortium, Hansoul, S., Nicolae, D. L., Cho, J. H., Duerr, R. H., Rioux, J. D., Brant, S. R., et al. (2008) · Nature Genetics · doi:10.1038/ng.175 · Cited by 2,593
Franke, A., McGovern, D. P. B., Barrett, J. C., Wang, K., Radford-Smith, G. L., Ahmad, T., Lees, C. W., Balschun, T., Lee, J., Roberts, R., et al. (2010) · Nature Genetics · doi:10.1038/ng.717 · Cited by 2,520
Self-citationInternational Parkinson's Disease Genomics Consortium (IPDGC), Nalls, M. A., Parkinson's Study Group (PSG) Parkinson's Research: The Organized GENetics Initiative (PROGENI), 23andMe, GenePD, NeuroGenetics Research Consortium (NGRC), Hussman Institute of Human Genomics (HIHG), Investigator, T. A. J. D., (CHARGE), C. F. H. A. A. R. I. G. E., North American Brain Expression Consortium (NABEC), et al. (2014) · Nature Genetics · doi:10.1038/ng.3043 · Cited by 1,895
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- [16]16. Nielsen NM, Pasternak B, Stenager E, Koch-Henriksen N, Frisch M. Multiple sclerosis and risk of Parkinson's disease: a Danish nationwide cohort study. Eur J Neurol. 2014;21(1):107-111. Medline:24053187
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Sorted by citations
Items 101–200 of 356
Wallin, J., & Svenningsson, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115606 · Cited by 29
Wiström, E. D., O’Connell, K. S., Karadag, N., Bahrami, S., Hindley, G., Lin, A., Cheng, W., Steen, N. E., Shadrin, A. A., Frei, O., et al. (2021) · Addiction · doi:10.1111/add.15680 · Cited by 30
Self-citationWatad, ., McGonagle, D., Anis, S., Carmeli, R., Cohen, A. D., Tsur, A. M., Ben‐Shabat, N., Bragazzi, N. L., Lidar, M., & Amital, H. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106325 · Cited by 29
Yang, C., Farias, F. G., Ibáñez, L., Sadler, B. E., Fernández, M. V., Wang, F., Bradley, J. L., Eiffert, B., Bahena, J. A., Budde, J., et al. (2020) · medRxiv · doi:10.1101/2020.06.25.20140277 · Cited by 29
Fominykh, V., Shadrin, A. A., Jaholkowski, P. P., Bahrami, S., Athanasiu, L., Wightman, D. P., Uffelmann, E., Posthuma, D., Selbæk, G., Dale, A. M., et al. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106174 · Cited by 28
Self-citationDiabetes and Parkinson’s Disease: Understanding Shared Molecular Mechanisms
König, A., & Outeiro, T. F. (2024) · Journal of Parkinson s Disease · doi:10.3233/jpd-230104 · Cited by 29
The gut microbiome, systemic inflammation, and autoimmunity in Parkinson's disease
Fonseca, M. D. C., Zanetti, L., Fanourakis, S., Sulzer, D., & Mazmanian, S. K. (2025) · The Lancet Neurology · doi:10.1016/s1474-4422(25)00382-5 · Cited by 29
Labandeira, C. M., Bau, A. F., Ron, D. A., Muñoz, A., Losada, G. A., Koukoulis, A., Romero-López, J., & Rodriguez-Perez, A. I. (2021) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2021.100914 · Cited by 28
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Kurnik‐Łucka, M., Pasieka, P. M., Łączak, P., Wojnarski, M., Jurczyk, M., & Gil, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312932 · Cited by 28
Li, H., Zhang, C., Zhang, K., Liu, Y.-Z., Peng, X., & Zong, Q. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1137366 · Cited by 28
Tang, B., Lo, H. H., Lei, C., Ka In, U., Hsiao, W. L. W., Guo, X., Bai, J., Wong, V. K. W., & Law, B. Y. K. (2020) · Phytomedicine · doi:10.1016/j.phymed.2020.153208 · Cited by 28
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Paakinaho, A., Koponen, M., Tiihonen, M., Kauppi, M. J., Hartikainen, S. A., & Tolppanen, A. (2022) · Neurology · doi:10.1212/wnl.0000000000013303 · Cited by 27
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Li, C., Pang, D., Lin, J., Yang, T., & Shang, H. (2022) · BMC Medicine · doi:10.1186/s12916-022-02335-y · Cited by 28
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Pandey, R., Bakay, M. A., & Hakonarson, H. H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24098224 · Cited by 30
Torshizi, A. D., Truong, D. T., Hou, L., Smets, B., Whelan, C. D., & Li, S. (2024) · Nature Communications · doi:10.1038/s41467-024-50718-x · Cited by 27
Nataf, S., Guillen, M., & Pays, L. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02704 · Cited by 25
T cells in the brain inflammation
Yoshimura, A., Ohyagi, M., & Ito, M. (2022) · Advances in immunology · doi:10.1016/bs.ai.2022.10.001 · Cited by 29
Lee, J. H., Han, K., & Gee, H. Y. (2019) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2019.07.012 · Cited by 25
Dantas, R. L., Freff, J., Ambrée, O., Beins, E. C., Forstner, A. J., Dannlowski, U., Baune, B. T., Scheu, S., & Alferink, J. (2021) · Cells · doi:10.3390/cells10040941 · Cited by 29
Pini, L., Salvalaggio, A., Wennberg, A. M. V., Dimakou, A., Matteoli, M., & Corbetta, M. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101867 · Cited by 26
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Mosley, R. L., & Gendelman, H. E. (2017) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30276-4 · Cited by 26
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Gibson, L. L., McKeever, A., Cullen, A. E., Nicholson, T. R., Aarsland, D., Zandi, M. S., & Pollak, T. A. (2020) · Journal of Neurology · doi:10.1007/s00415-020-09825-0 · Cited by 24
Li, T., Ning, B., Kong, L., Dai, B., He, X., Thomas, J. M., Sawa, A., Ross, C. A., & Smith, W. W. (2021) · Cells · doi:10.3390/cells10020480 · Cited by 25
Lerche, S., Zimmermann, M., Röeben, B., Wurster, I., Fries, F. L., Deuschle, C., Waniek, K., Lachmann, I., Jakobi, M., Joos, T. O., et al. (2023) · npj Parkinson s Disease · doi:10.1038/s41531-023-00476-2 · Cited by 29
Kars, M. E., Wu, Y., Stenson, P. D., Cooper, D. N., Burisch, J. M., Peter, I., & Itan, Y. (2024) · Genome Medicine · doi:10.1186/s13073-024-01335-2 · Cited by 23
Zheng, C., Liu, S., Zhang, X., Hu, Y., Shang, X., Zhu, Z., Huang, Y., Wu, G., Xiao, Y., Du, Z., et al. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.880576 · Cited by 24
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Huang, Q., Zhu, X., & Xu, M. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.08.041 · Cited by 23
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Lutz, M. W., Luo, S., Williamson, D. E., & Chiba‐Falek, O. (2020) · Alzheimer s & Dementia · doi:10.1002/alz.12128 · Cited by 25
Menozzi, E., Mulroy, E., Akbarian‐Tefaghi, L., Bhatia, K. P., & Balint, B. (2021) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2021.05.026 · Cited by 24
Mitochondrial antigen presentation: a mechanism linking Parkinson’s disease to autoimmunity
Fahmy, A. M., Boulais, J., Desjardins, M., & Matheoud, D. (2019) · Current Opinion in Immunology · doi:10.1016/j.coi.2019.02.004 · Cited by 22
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Karami, M., Sanaye, P. M., Ghorbani, A., Amirian, R., Goleij, P., Babamohamadi, M., & Izadi, Z. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06354-0 · Cited by 23
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Shadrin, A. A., Mucha, S., Ellinghaus, D., Makarious, M. B., Blauwendraat, C., Sreelatha, A. A. K., Heras‐Garvin, A., Ding, J., Hammer, M. B., Foubert‐Samier, A., et al. (2020) · Movement Disorders · doi:10.1002/mds.28338 · Cited by 22
Self-citationImmune system and new avenues in Parkinson’s disease research and treatment
Nasrolahi, A., Safari, F., Farhoudi, M., Khosravi, A., Farajdokht, F., Bastaminejad, S., Shotorbani, S. S., & Mahmoudi, J. (2019) · Reviews in the Neurosciences · doi:10.1515/revneuro-2018-0105 · Cited by 21
McCaffrey, T. A., Laurent, G. S., Shtokalo, D. N., Антонец, Д., Vyatkin, Y. V., Jones, D. R., Battison, E., & Nigg, J. T. (2020) · BMC Medical Genomics · doi:10.1186/s12920-020-00808-8 · Cited by 21
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Pan, M., Li, X., Xu, G., Tian, X., Li, Y., & Fang, W. (2023) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-023-01337-5 · Cited by 19
Ehtewish, H., Mesleh, A. G., Ponirakis, G., Lennard, K. S., Hamad, H. K. A., Chandran, M., Parray, A., Abdesselem, H., Wijten, P., Decock, J. V., et al. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1256745 · Cited by 20
Li, C., Ke, B., Chen, J., Xiao, Y., Wang, S., Jiang, R., Zheng, X., Lin, J., Huang, J., & Shang, H. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.02.013 · Cited by 20
Satapathy, T., & Kumar, D. (2024) · Pharmacological Research - Modern Chinese Medicine · doi:10.1016/j.prmcm.2024.100499 · Cited by 20
Kritzinger, A., Ferger, B., Gillardon, F., Stierstorfer, B., Birk, G., Kochanek, S., & Ciossek, T. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.02.008 · Cited by 20
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Nenasheva, V. V., & Tarantul, V. Z. (2019) · Stem Cells and Development · doi:10.1089/scd.2019.0152 · Cited by 20
Li, C., Ou, R., Gu, X., Wei, Q., & Shang, H. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.01.023 · Cited by 20
Liley, J., & Wallace, C. (2021) · Biometrical Journal · doi:10.1002/bimj.201900254 · Cited by 20
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Kung, P., Elsayed, I., Reyes‐Pérez, P., & Bandrés‐Ciga, S. (2022) · Journal of Parkinson s Disease · doi:10.3233/jpd-223176 · Cited by 22
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Wetzel, A., Lei, S. H., Liu, T., Hughes, M. P., Peng, Y., McKay, T. R., Waddington, S. N., Grannò, S., Rahim, A. A., & Harvey, K. (2024) · Scientific Reports · doi:10.1038/s41598-024-63130-8 · Cited by 19
Lutz, M. W., Casanova, R., Saldana, S. J., Kuchibhatla, M. N., Plassman, B. L., & Hayden, K. M. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.10.028 · Cited by 19
Wallings, R. L., McFarland, K. N., Staley, H. A., Neighbarger, N. K., Schaake, S., Brüggemann, N., Zittel, S., Usnich, T., Klein, C., Sammler, E. M., et al. (2024) · Science Translational Medicine · doi:10.1126/scitranslmed.adl1535 · Cited by 19
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Jankovic, J. J. (2017) · Immunotherapy · doi:10.2217/imt-2017-0146 · Cited by 19
Chen, L., Hou, J., Zeng, X., Guo, Q., Deng, M., Kloeber, J. A., Tu, X., Zhao, F., Wu, Z., Huang, J., et al. (2021) · Clinical and Translational Medicine · doi:10.1002/ctm2.341 · Cited by 17
Kar, S. P., Considine, D. P. C., Tyrer, J. P., Plummer, J. T., Chen, S., Dezem, F. S., Barbeira, A. N., Rajagopal, P. S., Rosenow, W. T., Moreno, F., et al. (2021) · Human Genetics and Genomics Advances · doi:10.1016/j.xhgg.2021.100042 · Cited by 18
Zhang, X., Liang, Y., Huang, Y. S., Liu, S., Li, Q., Wang, S., Wu, G., Du, Z., Wang, Y., Wang, J., et al. (2024) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.65.3.12 · Cited by 19
Self-citationImmunological aspects of central neurodegeneration
Niso‐Santano, M., Fuentes, J. M., & Galluzzi, L. (2024) · Cell Discovery · doi:10.1038/s41421-024-00666-z · Cited by 17
Jellinger, K. A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26072942 · Cited by 18
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Yamamoto, K., & Okada, Y. (2019) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2019-215099 · Cited by 17
Activation of the immunoproteasome protects SH-SY5Y cells from the toxicity of rotenone
Sun, C., Mo, M., Wang, Y., Yu, W., Song, C., Wang, X., Chen, S., & Liu, Y. (2019) · NeuroToxicology · doi:10.1016/j.neuro.2019.03.004 · Cited by 17
Self-citationFerreira, I. R., Cunha, W. D. D. S., Gomes, L. H. F., Cintra, H. A., da Fonseca, L. L. C. G., Bastos, E. F., Llerena, J. C., de Vasconcelos, Z. F. M., & Guida, L. D. C. (2019) · Molecular Genetics & Genomic Medicine · doi:10.1002/mgg3.637 · Cited by 17
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Soto‐Beasley, A. I., Walton, R. L., Valentino, R. R., Hook, P. W., Labbé, C., Heckman, M. G., Johnson, P. W., Goff, L. A., Uitti, R. J., McLean, P. J., et al. (2020) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2020.07.022 · Cited by 17
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Kang, X., Ploner, A., Roelstraete, B., Khalili, H., Williams, D. M., Pedersen, N. L., Ludvigsson, J. F., & Wirdefeldt, K. (2021) · Movement Disorders · doi:10.1002/mds.28594 · Cited by 17
The etiopathogenetic and pathophysiological spectrum of parkinsonism
Bologna, M., Truong, D. D., & Jankovic, J. J. (2021) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2021.120012 · Cited by 18
Grathwohl, S., Quansah, E., Maroof, N., Steiner, J. A., Spycher, L., Benmansour, F., Duran-Pacheco, G., Siebourg-Polster, J., Oroszlan-Szovik, K., Remy, H., et al. (2020) · doi:10.21203/rs.3.rs-100199/v1 · Cited by 17
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Lin, S.-R., Chen, S., Yang, Y., Hsu, C. Y., & Shen, Y. (2020) · Endocrine Connections · doi:10.1530/ec-20-0554 · Cited by 16
Hassanzadeh, K., Rahimmi, A., Moloudi, M. R., Maccarone, R., Corbo, M., Izadpanah, E., & Feligioni, M. (2021) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2021.05.011 · Cited by 16
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González-Latapí, P., & Marras, C. (2022) · Journal of Parkinson s Disease · doi:10.3233/jpd-223180 · Cited by 17
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Senkevich, K. A., Alipour, P., Chernyavskaya, E. А., Yu, E., Noyce, A. J., & Gan‐Or, Z. (2023) · Movement Disorders · doi:10.1002/mds.29424 · Cited by 16
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Hey, G. E., Vedam‐Mai, V., Beke, M., Amaris, M. A., & Ramirez‐Zamora, A. (2023) · Seminars in Neurology · doi:10.1055/s-0043-1771467 · Cited by 16
Candelario, K. M., Balaj, L., Zheng, T., Skog, J., Scheffler, B., Breakefield, X. O., Schüle, B., & Steindler, D. A. (2019) · The Journal of Comparative Neurology · doi:10.1002/cne.24819 · Cited by 16
Li, C., Ou, R., Chen, Y., Gu, X., Wei, Q., Cao, B., Zhang, L., Hou, Y., Liu, K., Chen, X., et al. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.02.022 · Cited by 16
Mamais, A., Kaganovich, A., & Harvey, K. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105721 · Cited by 16
Jiang, Z., Huang, H., Chen, Y., Xie, H., Lu, Y., Ge, Y., Yao, R., Wang, L., Wu, Z., Bu, Y., et al. (2024) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2024.578484 · Cited by 15
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Wang, N., Xiao, X., Chen, Z., Xu, K., Cao, X., Kou, D., & Zeng, J. (2025) · Fundamental Research · doi:10.1016/j.fmre.2024.12.023 · Cited by 18
Yeh, F., Chen, H., Chou, Y., Lin, C., Kao, C., Lo, H., Liu, F., & Yang, T.-Y. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-020-02629-w · Cited by 15
Bull, D., Schweitzer, C., Bichsel, C. A., Britschgi, M., & Gutbier, S. (2022) · Cells · doi:10.3390/cells11030419 · Cited by 15
Fisher, R. M. A., & Torrente, M. P. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1456052 · Cited by 18
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Liu, X., Li, F., Czosnyka, M., Czosnyka, Z. H., Yu, H., Tong, X., Xing, Y., Li, H., Pu, K., Feng, K., et al. (2025) · GigaScience · doi:10.1093/gigascience/giaf137 · Cited by 16
Bačelis, J., Compagno, M., George, S., Pospisilik, J. A., Brundin, P., Naluai, Å. T., & Brundin, L. (2021) · Journal of Parkinson s Disease · doi:10.3233/jpd-202418 · Cited by 16
Dudley-Fraser, J., & Rittinger, K. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1287257 · Cited by 15
Shared (epi)genomic background connecting neurodegenerative diseases and type 2 diabetes
Caputo, V., Termine, A., Strafella, C., Giardina, E., & Cascella, R. (2020) · World Journal of Diabetes · doi:10.4239/wjd.v11.i5.155 · Cited by 17
Il-10 signaling reduces survival in mouse models of synucleinopathy
Cockey, S. G., McFarland, K. N., Koller, E. J., Brooks, M., Cruz, E. G. D. L., Cruz, P. E., Ceballos‐Diaz, C., Rosario, A. M., Levites, Y., Borchelt, D., et al. (2021) · npj Parkinson s Disease · doi:10.1038/s41531-021-00169-8 · Cited by 14
Changing views after 200 years of Parkinson disease
Maetzler, W., & Berg, D. (2018) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.183 · Cited by 14
A genome-wide scan for pleiotropy between bone mineral density and nonbone phenotypes
Christou, M., Ntritsos, G., Markozannes, G., Koskeridis, F., Nikas, S. N., Karasik, D., Kiel, D. P., Εvangelou, Ε., & Ntzani, E. (2020) · Bone Research · doi:10.1038/s41413-020-0101-8 · Cited by 13
de Fàbregues, O., Sellés, M. C., Ramos-Vicente, D., Roch, G., Vila, M., & Bové, J. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106308 · Cited by 12
Yang, J., Liu, T., Lu, H., Tsai, S., Liao, W., Chiu, Y., Wang, Y., & Tsai, F. (2024) · Molecular Medicine Reports · doi:10.3892/mmr.2024.13239 · Cited by 13
Self-citationNarayanan, S., Loganathan, G., Mokshagundam, S. L., Hughes, M. G., Williams, S. K., & Balamurugan, A. N. (2018) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2018.06.018 · Cited by 13
Influence of aging, mitochondrial dysfunction, and inflammation on Parkinson’s disease
Cossu, D., & Hattori, N. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.385873 · Cited by 12
Geng, C., Meng, K., Zhao, B., Liu, X., & Tang, Y. (2024) · European journal of medical research · doi:10.1186/s40001-023-01628-z · Cited by 13
Song, J., Qin, Y., Wang, L., Quan, W., Xu, J., Li, J., & Chen, J. (2024) · Scientific Reports · doi:10.1038/s41598-024-53287-7 · Cited by 13
Angulo-Aguado, M., Carrillo-Martínez, J. C., Contreras-Bravo, N. C., Morel, A., Abaunza, K. P., Usaquén, W., Fonseca, D. J., & Ortega‐Recalde, O. (2024) · Scientific Reports · doi:10.1038/s41598-024-57982-3 · Cited by 13
Sun, Q., Li, Y., & Ning, S. (2024) · Scientific Reports · doi:10.1038/s41598-024-67890-1 · Cited by 12
Autoimmune Disease Associated CLEC16A Variants Convey Risk of Parkinson’s Disease in Han Chinese
Fan, H.-H., Cui, L., Jiang, X.-X., Song, Y.-D., Liu, S.-S., Wu, K.-Y., Dong, H., Mao, M., Ovlyakulov, B., Wu, H., et al. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.856493 · Cited by 13
Nowowiejska, J., Baran, A. M., Hermanowicz, J. M., Sieklucka, B., Krahel, J. A., Kiluk, P., Pawlak, D., & Flisiak, I. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11092430 · Cited by 12
New Perspectives on Immune Involvement in Parkinson’s Disease Pathogenesis
Gate, D. (2022) · Journal of Parkinson s Disease · doi:10.3233/jpd-223240 · Cited by 13
The interplay between monocytes, α-synuclein and LRRK2 in Parkinson's disease
Strader, S., & West, A. B. (2023) · Biochemical Society Transactions · doi:10.1042/bst20201091 · Cited by 13
Getting Started with the IDG KMC Datasets and Tools
Kropiwnicki, E., Binder, J., Yang, J. J., Holmes, J., Lachmann, A., Clarke, D. J. B., Sheils, T. K., Kelleher, K. J., Metzger, V. T., Bologa, C., et al. (2022) · Current Protocols · doi:10.1002/cpz1.355 · Cited by 12
Experimental colitis drives enteric alpha-synuclein accumulation and Parkinson-like brain pathologyPreprint
Grathwohl, S. A., Quansah, E., Maroof, N., Steiner, J. A., Spycher, L., Benmansour, F., Durán-Pacheco, G., Siebourg‐Polster, J., Oroszlan‐Szovik, K., Remy, H., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/505164 · Cited by 13
Cui, H., Elford, J. D., Alitalo, O., Perez‐Pardo, P., Tampio, J., Huttunen, K. M., Kraneveld, A. D., Forsberg, M., Myöhänen, T. T., & Jalkanen, A. J. (2023) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2023.05.007 · Cited by 14
Lona‐Durazo, F., Reynolds, R. H., Scholz, S. W., Ryten, M., & Taliun, S. A. G. (2023) · Communications Biology · doi:10.1038/s42003-023-05113-5 · Cited by 12
Nigrostriatal degeneration determines dynamics of glial inflammatory and phagocytic activity
Ayerra, L., Abellanas, M. A., Basurco, L., Tamayo, I., Conde, E., Tavira, A., Trigo, A., Vidaurre, C., Vilas‐Zornoza, A., Martín‐Úriz, P. S., et al. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03091-x · Cited by 12
Ma, W., Geng, Y., Liu, Y., Pan, H., Wang, Q., Zhang, Y., & Wang, L. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1345918 · Cited by 11
Metadata
- Authors
- Witoelar, A., Jansen, I. E., Wang, Y., Desikan, R. S., Gibbs, J. R., Blauwendraat, C., Thompson, W. K., Hernandez, D. G., Djurovic, S., Schork, A. J., Bettella, F., Ellinghaus, D., Franke, A., Lie, B. A., McEvoy, L. K., Karlsen, T. H., Lesage, S., Morris, H. R., Brice, A., Wood, N. W., Heutink, P., Hardy, J., Singleton, A. B., Dale, A. M., Gasser, T., Andreassen, O. A., Sharma, M., & for the International Parkinson’s Disease Genomics Consortium (IPDGC), N. A. B. E. C. (.
- Affiliations
- Oslo University Hospital (NO)
- German Center for Neurodegenerative Diseases (DE)
- University of Oslo (NO)
- University of California, San Francisco (US)
- National Institutes of Health (US)
- University of Copenhagen (DK)
- University of California San Diego (US)
- Christian-Albrechts-Universität zu Kiel (DE)
- Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany
- Centre National de la Recherche Scientifique (FR)
- National Hospital for Neurology and Neurosurgery (GB)
- UCL Queen Square Institute of Neurology (GB)
- University College London (GB)
- Hertie Institute for Clinical Brain Research (DE)
- Corresponding author
- Sharma, Manu
- ORCID
- Witoelar, Aree
- Jansen, Iris E.
- Wang, Yunpeng
- Desikan, Rahul S.
- Gibbs, J. Raphael
- Blauwendraat, Cornelis
- Thompson, Wesley K.
- Hernandez, Dena G.
- Djurovic, Srdjan
- Schork, Andrew J.
- Bettella, Francesco
- Ellinghaus, David
- Lie, Benedicte A.
- McEvoy, Linda K.
- Karlsen, Tom H.
- Lesage, Suzanne
- Morris, Huw R.
- Brice, Alexis
- Wood, Nicholas W.
- Heutink, Peter
- Hardy, John
- Singleton, Andrew B.
- Dale, Anders M.
- Gasser, Thomas
- Andreassen, Ole A.
- Sharma, Manu
- Venue
- JAMA Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 2017-07-01
- Volume
- 74
- Issue
- 7
- Pages
- 780
- ISSN
- 2168-6149 (ISSN-L)
- PMC
- PMC5710535
- OpenAlex
- W2622719965
- Semantic Scholar
- 77f8aa61d1d32875fc37fcce3fe356cd20cd596e
- Cited by
- 352
- References
- 84
- Citations by year
- 2026: 14 · 2025: 39 · 2024: 60 · 2023: 41 · 2022: 39 · 2021: 62 · 2020: 34 · 2019: 30 · 2018: 24 · 2017: 7
- FWCI
- 18.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JAMA Neurology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion, cc-by)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- HAL (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Site cant be reached (submittedVersion)
- DZNE Pub (submittedVersion)
- PuSH - Publication Server of Helmholtz Zentrum München (submittedVersion)
- Explore Bristol Research (submittedVersion)
- Bristol Research (University of Bristol) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Funders
- Biogen
- Washington University in St. Louis
- Johns Hopkins University
- University of Rochester
- Wellcome Trust
- Sandwell and West Birmingham Hospitals NHS Trust
- University Hospitals Birmingham NHS Foundation Trust
- Université de Lille
- Parkinson's UK (G-0907, J-0901, J-1402, K-1501)
- Imperial College London
- University College London
- University of Oxford
- Newcastle University
- Cardiff University
- University of Aberdeen
- Institut National de la Santé et de la Recherche Médicale
- Universiteit Leiden
- Universiteit van Amsterdam
- Radboud Universiteit
- Vrije Universiteit Amsterdam
- Eberhard Karls Universität Tübingen
- Centre National de la Recherche Scientifique
- Leids Universitair Medisch Centrum
- Deutsches Zentrum für Neurodegenerative Erkrankungen
- Université Pierre et Marie Curie
- National Institutes of Health
- Genentech
- Medical Research Council
- Erasmus Universitair Medisch Centrum Rotterdam
- Helmholtz Zentrum München
- National Human Genome Research Institute
- National Institute of General Medical Sciences (R01GM104400)
- National Institute of Neurological Disorders and Stroke
- NIH Clinical Center
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Keywords
- Parkinson's disease, autoimmune disease, pleiotropy, type 1 diabetes, Crohn's disease, ulcerative colitis, rheumatoid arthritis, celiac disease, psoriasis, multiple sclerosis, LRRK2, HLA, MAPT, SETD1A, protein-protein interaction network, DNA methylation, gene expression, anti-inflammatory therapy
- MeSH terms
- Arthritis, Rheumatoid, Autoimmune Diseases, Celiac Disease, Colitis, Ulcerative, Crohn Disease, Diabetes Mellitus, Type 1, Humans, Multiple Sclerosis, Parkinson Disease, Psoriasis, Risk Factors, Genetic Predisposition to Disease, Genome-Wide Association Study, Genetic Loci, Genetic Pleiotropy
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