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Cited by 985

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

Characteristics and Outcomes of Children With Coronavirus Disease 2019 (COVID-19) Infection Admitted to US and Canadian Pediatric Intensive Care Units

Open access
Shekerdemian, Lara S., Mahmood, Nabihah R., Wolfe, Katie K., Riggs, Becky J., Ross, Catherine E., McKiernan, Christine A., Heidemann, Sabrina M., Kleinman, Lawrence C., Sen, Anita I., Hall, Mark W., Priestley, Margaret A., McGuire, John K., Boukas, Konstantinos, Sharron, Matthew P., Burns, Jeffrey P., for the International COVID-19 PICU Collaborative·2020·JAMA Pediatrics
DOI 10.1001/jamapediatrics.2020.1948
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Abstract

IMPORTANCE: The recent and ongoing coronavirus disease 2019 (COVID-19) pandemic has taken an unprecedented toll on adults critically ill with COVID-19 infection. While there is evidence that the burden of COVID-19 infection in hospitalized children is lesser than in their adult counterparts, to date, there are only limited reports describing COVID-19 in pediatric intensive care units (PICUs). OBJECTIVE: To provide an early description and characterization of COVID-19 infection in North American PICUs, focusing on mode of presentation, presence of comorbidities, severity of disease, therapeutic interventions, clinical trajectory, and early outcomes. DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study included children positive for COVID-19 admitted to 46 North American PICUs between March 14 and April 3, 2020. with follow-up to April 10, 2020. MAIN OUTCOMES AND MEASURES: Prehospital characteristics, clinical trajectory, and hospital outcomes of children admitted to PICUs with confirmed COVID-19 infection. RESULTS: Of the 48 children with COVID-19 admitted to participating PICUs, 25 (52%) were male, and the median (range) age was 13 (4.2-16.6) years. Forty patients (83%) had significant preexisting comorbidities; 35 (73%) presented with respiratory symptoms and 18 (38%) required invasive ventilation. Eleven patients (23%) had failure of 2 or more organ systems. Extracorporeal membrane oxygenation was required for 1 patient (2%). Targeted therapies were used in 28 patients (61%), with hydroxychloroquine being the most commonly used agent either alone (11 patients) or in combination (10 patients). At the completion of the follow-up period, 2 patients (4%) had died and 15 (31%) were still hospitalized, with 3 still requiring ventilatory support and 1 receiving extracorporeal membrane oxygenation. The median (range) PICU and hospital lengths of stay for those who had been discharged were 5 (3-9) days and 7 (4-13) days, respectively. CONCLUSIONS AND RELEVANCE: This early report describes the burden of COVID-19 infection in North American PICUs and confirms that severe illness in children is significant but far less frequent than in adults. Prehospital comorbidities appear to be an important factor in children. These preliminary observations provide an important platform for larger and more extensive studies of children with COVID-19 infection.

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Metadata

Authors
Shekerdemian, L. S., Mahmood, N. R., Wolfe, K. K., Riggs, B. J., Ross, C. E., McKiernan, C. A., Heidemann, S. M., Kleinman, L. C., Sen, A. I., Hall, M. W., Priestley, M. A., McGuire, J. K., Boukas, K., Sharron, M. P., Burns, J. P., & Collaborative, F. T. I. C.-1. P.
Venue
JAMA Pediatrics
Publisher
American Medical Association (AMA)
Published
2020-09-01
Volume
174
Issue
9
Pages
868
ISSN
  • 1072-4710 (ISSN-L)
  • 2168-6203
DOI
10.1001/jamapediatrics.2020.1948
OpenAlex
W3022770671
Cited by
985
References
11
FWCI
27.25
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Characteristics and Outcomes of Children With Coronavirus Disease 2019 (COVID-19) Infection Admitted to US and Canadian Pediatric Intensive Care Units. https://app.cochat.ai/papers/10.1001/jamapediatrics.2020.1948
The paper
Shekerdemian, L. S., Mahmood, N. R., Wolfe, K. K., Riggs, B. J., Ross, C. E., McKiernan, C. A., Heidemann, S. M., Kleinman, L. C., Sen, A. I., Hall, M. W., Priestley, M. A., McGuire, J. K., Boukas, K., Sharron, M. P., Burns, J. P., & Collaborative, F. T. I. C.-1. P. (2020). Characteristics and Outcomes of Children With Coronavirus Disease 2019 (COVID-19) Infection Admitted to US and Canadian Pediatric Intensive Care Units. JAMA Pediatrics. https://doi.org/10.1001/jamapediatrics.2020.1948

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.